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Envelope glycoprotein I (gI) (Glycoprotein IV) (GPIV)

 GI_VZVO                 Reviewed;         354 AA.
Q77NN4;
22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
28-FEB-2018, entry version 60.
RecName: Full=Envelope glycoprotein I;
Short=gI;
AltName: Full=Glycoprotein IV;
Short=GPIV;
Flags: Precursor;
Name=gI; ORFNames=ORF67;
Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus
3).
Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
Alphaherpesvirinae; Varicellovirus.
NCBI_TaxID=341980;
NCBI_TaxID=9606; Homo sapiens (Human).
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Oka varicella vaccine Biken (V-Oka-Biken);
PubMed=10720545; DOI=10.1086/315335;
Argaw T., Cohen J.I., Klutch M., Lekstrom K., Yoshikawa T., Asano Y.,
Krause P.R.;
"Nucleotide sequences that distinguish Oka vaccine from parental Oka
and other varicella-zoster virus isolates.";
J. Infect. Dis. 181:1153-1157(2000).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Oka varicella vaccine Biken (V-Oka-Biken);
PubMed=11162813; DOI=10.1006/viro.2000.0775;
Faga B., Maury W., Bruckner D.A., Grose C.;
"Identification and mapping of single nucleotide polymorphisms in the
varicella-zoster virus genome.";
Virology 280:1-6(2001).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Isolate Human/Japan/P-Oka/1970, and
Oka varicella vaccine Biken (V-Oka-Biken);
PubMed=12388706; DOI=10.1128/JVI.76.22.11447-11459.2002;
Gomi Y., Sunamachi H., Mori Y., Nagaike K., Takahashi M.,
Yamanishi K.;
"Comparison of the complete DNA sequences of the Oka varicella vaccine
and its parental virus.";
J. Virol. 76:11447-11459(2002).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Oka varicella vaccine VarilRix (V-Oka-GSK), and
Oka varicella vaccine Varivax (V-Oka-Merk);
PubMed=18787000; DOI=10.1128/JVI.00777-08;
Tillieux S.L., Halsey W.S., Thomas E.S., Voycik J.J., Sathe G.M.,
Vassilev V.;
"Complete DNA sequences of two oka strain varicella-zoster virus
genomes.";
J. Virol. 82:11023-11044(2008).
-!- FUNCTION: In epithelial cells, the heterodimer gE/gI is required
for the cell-to-cell spread of the virus, by sorting nascent
virions to cell junctions. Once the virus reaches the cell
junctions, virus particles can spread to adjacent cells extremely
rapidly through interactions with cellular receptors that
accumulate at these junctions. Implicated in basolateral spread in
polarized cells. In neuronal cells, gE/gI is essential for the
anterograde spread of the infection throughout the host nervous
system. Together with US9, the heterodimer gE/gI is involved in
the sorting and transport of viral structural components toward
axon tips (By similarity). {ECO:0000250}.
-!- FUNCTION: The heterodimer gE/gI serves as a receptor for the Fc
part of human IgG. Dissociation of gE/gI from IgG occurs at acidic
pH. May thus be involved in anti-VZV antibodies bipolar bridging,
followed by intracellular endocytosis and degradation, thereby
interfering with host Ig-mediated immune responses (By
similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with gE; this interaction enhances the Fc
receptor function of gE. {ECO:0000250}.
-!- INTERACTION:
Q9J3M8:gE; NbExp=3; IntAct=EBI-2533019, EBI-2532305;
-!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}; Single-pass
membrane protein {ECO:0000250}. Host cell membrane {ECO:0000305};
Single-pass type I membrane protein {ECO:0000305}. Host cell
junction {ECO:0000250}. Host Golgi apparatus membrane
{ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Note=During virion morphogenesis, this protein probably
accumulates in the endosomes and trans-Golgi where secondary
envelopment occurs. It is probably transported to the cell surface
from where it is endocytosed and directed to the trans-Golgi
network (TGN). The heterodimer gE/gI then redistribute to cell
junctions to promote cell-cell spread later in the infection (By
similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the alphaherpesvirinae glycoprotein I
family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AF206304; AAF61668.1; -; Genomic_DNA.
EMBL; AY016450; AAK19945.1; -; Genomic_DNA.
EMBL; AB097932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AB097933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; DQ008354; AAY57676.1; -; Genomic_DNA.
EMBL; DQ008355; AAY57747.1; -; Genomic_DNA.
RefSeq; NP_040189.1; NC_001348.1.
SMR; Q77NN4; -.
DIP; DIP-45062N; -.
IntAct; Q77NN4; 9.
MINT; Q77NN4; -.
GeneID; 1487689; -.
KEGG; vg:1487689; -.
OrthoDB; VOG090000E2; -.
Proteomes; UP000002603; Genome.
Proteomes; UP000008504; Genome.
Proteomes; UP000008505; Genome.
Proteomes; UP000008506; Genome.
GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
GO; GO:0044156; C:host cell junction; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
GO; GO:0030683; P:evasion or tolerance by virus of host immune response; IEA:UniProtKB-KW.
InterPro; IPR002874; Herpes_gI.
Pfam; PF01688; Herpes_gI; 1.
1: Evidence at protein level;
Complete proteome; Glycoprotein; Host cell junction;
Host cell membrane; Host Golgi apparatus; Host membrane;
Host-virus interaction; Membrane; Phosphoprotein; Signal;
Transmembrane; Transmembrane helix; Viral envelope protein;
Viral immunoevasion; Virion.
SIGNAL 1 20 {ECO:0000255}.
CHAIN 21 354 Envelope glycoprotein I.
/FTId=PRO_0000385500.
TOPO_DOM 21 274 Virion surface. {ECO:0000255}.
TRANSMEM 275 295 Helical. {ECO:0000255}.
TOPO_DOM 296 354 Intravirion. {ECO:0000255}.
MOD_RES 343 343 Phosphoserine. {ECO:0000250}.
CARBOHYD 33 33 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
CARBOHYD 47 47 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
CARBOHYD 67 67 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
CARBOHYD 116 116 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
SEQUENCE 354 AA; 39364 MW; E52B0B60BF52E666 CRC64;
MFLIQCLISA VIFYIQVTNA LIFKGDHVSL QVNSSLTSIL IPMQNDNYTE IKGQLVFIGE
QLPTGTNYSG TLELLYADTV AFCFRSVQVI RYDGCPRIRT SAFISCRYKH SWHYGNSTDR
ISTEPDAGVM LKITKPGIND AGVYVLLVRL DHSRSTDGFI LGVNVYTAGS HHNIHGVIYT
SPSLQNGYST RALFQQARLC DLPATPKGSG TSLFQHMLDL RAGKSLEDNP WLHEDVVTTE
TKSVVKEGIE NHVYPTDMST LPEKSLNDPP ENLLIIIPIV ASVMILTAMV IVIVISVKRR
RIKKHPIYRP NTKTRRGIQN ATPESDVMLE AAIAQLATIR EESPPHSVVN PFVK


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