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Envelope glycoprotein M (gM)

 GM_VZVO                 Reviewed;         435 AA.
Q77NP2;
22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
28-FEB-2018, entry version 58.
RecName: Full=Envelope glycoprotein M {ECO:0000255|HAMAP-Rule:MF_04035};
Short=gM {ECO:0000255|HAMAP-Rule:MF_04035};
Name=gM {ECO:0000255|HAMAP-Rule:MF_04035}; ORFNames=ORF50;
Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus
3).
Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
Alphaherpesvirinae; Varicellovirus.
NCBI_TaxID=341980;
NCBI_TaxID=9606; Homo sapiens (Human).
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Oka varicella vaccine Biken (V-Oka-Biken);
PubMed=10720545; DOI=10.1086/315335;
Argaw T., Cohen J.I., Klutch M., Lekstrom K., Yoshikawa T., Asano Y.,
Krause P.R.;
"Nucleotide sequences that distinguish Oka vaccine from parental Oka
and other varicella-zoster virus isolates.";
J. Infect. Dis. 181:1153-1157(2000).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Isolate Human/Japan/P-Oka/1970, and
Oka varicella vaccine Biken (V-Oka-Biken);
PubMed=12388706; DOI=10.1128/JVI.76.22.11447-11459.2002;
Gomi Y., Sunamachi H., Mori Y., Nagaike K., Takahashi M.,
Yamanishi K.;
"Comparison of the complete DNA sequences of the Oka varicella vaccine
and its parental virus.";
J. Virol. 76:11447-11459(2002).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Oka varicella vaccine VarilRix (V-Oka-GSK), and
Oka varicella vaccine Varivax (V-Oka-Merk);
PubMed=18787000; DOI=10.1128/JVI.00777-08;
Tillieux S.L., Halsey W.S., Thomas E.S., Voycik J.J., Sathe G.M.,
Vassilev V.;
"Complete DNA sequences of two oka strain varicella-zoster virus
genomes.";
J. Virol. 82:11023-11044(2008).
[4]
FUNCTION, GLYCOSYLATION, AND SUBCELLULAR LOCATION.
STRAIN=Isolate Human/Japan/P-Oka/1970;
PubMed=17977964; DOI=10.1128/JVI.01722-07;
Yamagishi Y., Sadaoka T., Yoshii H., Somboonthum P., Imazawa T.,
Nagaike K., Ozono K., Yamanishi K., Mori Y.;
"Varicella-zoster virus glycoprotein M homolog is glycosylated, is
expressed on the viral envelope, and functions in virus cell-to-cell
and/or virus entry spread.";
J. Virol. 82:795-804(2008).
[5]
SUBCELLULAR LOCATION, AND INTERACTION WITH GN.
STRAIN=Isolate Human/Japan/P-Oka/1970;
PubMed=20106918; DOI=10.1128/JVI.01838-09;
Sadaoka T., Yanagi T., Yamanishi K., Mori Y.;
"Characterization of the varicella-zoster virus ORF50 gene, which
encodes glycoprotein M.";
J. Virol. 84:3488-3502(2010).
-!- FUNCTION: Envelope glycoprotein important for virion assembly and
egress. Plays a role in the correct incorporation of gH-gL into
virion membrane. Directs the glycoprotein N (gN) to the host
trans-Golgi network. {ECO:0000255|HAMAP-Rule:MF_04035,
ECO:0000269|PubMed:17977964}.
-!- SUBUNIT: Interacts (via N-terminus) with gN (via N-terminus). The
gM-gN heterodimer forms the gCII complex. {ECO:0000255|HAMAP-
Rule:MF_04035}.
-!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000255|HAMAP-
Rule:MF_04035}; Multi-pass membrane protein {ECO:0000255|HAMAP-
Rule:MF_04035}. Host Golgi apparatus, host trans-Golgi network
{ECO:0000255|HAMAP-Rule:MF_04035}. Host endosome membrane
{ECO:0000255|HAMAP-Rule:MF_04035}; Multi-pass membrane protein
{ECO:0000255|HAMAP-Rule:MF_04035}. Host nucleus inner membrane
{ECO:0000255|HAMAP-Rule:MF_04035}; Multi-pass membrane protein
{ECO:0000255|HAMAP-Rule:MF_04035}. Note=During virion
morphogenesis, this protein accumulates in the trans-Golgi network
where secondary envelopment occurs. {ECO:0000255|HAMAP-
Rule:MF_04035}.
-!- PTM: N-glycosylated. {ECO:0000269|PubMed:17977964}.
-!- SIMILARITY: Belongs to the herpesviridae glycoprotein M family.
{ECO:0000255|HAMAP-Rule:MF_04035}.
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EMBL; AB097932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AB097933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AF206304; AAF61651.1; -; Genomic_DNA.
EMBL; DQ008354; AAY57659.1; -; Genomic_DNA.
EMBL; DQ008355; AAY57730.1; -; Genomic_DNA.
RefSeq; NP_040172.1; NC_001348.1.
IntAct; Q77NP2; 11.
MINT; Q77NP2; -.
GeneID; 1487658; -.
KEGG; vg:1487658; -.
OrthoDB; VOG090000D2; -.
Proteomes; UP000002603; Genome.
Proteomes; UP000008504; Genome.
Proteomes; UP000008505; Genome.
Proteomes; UP000008506; Genome.
GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
GO; GO:0044201; C:host cell nuclear inner membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
HAMAP; MF_04035; HSV_GM; 1.
InterPro; IPR000785; Herpes_glycop_M.
Pfam; PF01528; Herpes_glycop; 1.
PRINTS; PR00333; HSVINTEGRLMP.
1: Evidence at protein level;
Complete proteome; Disulfide bond; Glycoprotein; Host endosome;
Host Golgi apparatus; Host membrane; Host nucleus; Membrane;
Transmembrane; Transmembrane helix; Viral envelope protein; Virion.
CHAIN 1 435 Envelope glycoprotein M.
/FTId=PRO_0000385482.
TOPO_DOM 1 36 Intravirion. {ECO:0000255|HAMAP-
Rule:MF_04035}.
TRANSMEM 37 57 Helical. {ECO:0000255|HAMAP-
Rule:MF_04035}.
TOPO_DOM 58 111 Virion surface. {ECO:0000255|HAMAP-
Rule:MF_04035}.
TRANSMEM 112 132 Helical. {ECO:0000255|HAMAP-
Rule:MF_04035}.
TOPO_DOM 133 155 Intravirion. {ECO:0000255|HAMAP-
Rule:MF_04035}.
TRANSMEM 156 176 Helical. {ECO:0000255|HAMAP-
Rule:MF_04035}.
TOPO_DOM 177 178 Virion surface. {ECO:0000255|HAMAP-
Rule:MF_04035}.
TRANSMEM 179 199 Helical. {ECO:0000255|HAMAP-
Rule:MF_04035}.
TOPO_DOM 200 233 Intravirion. {ECO:0000255|HAMAP-
Rule:MF_04035}.
TRANSMEM 234 254 Helical. {ECO:0000255|HAMAP-
Rule:MF_04035}.
TOPO_DOM 255 265 Virion surface. {ECO:0000255|HAMAP-
Rule:MF_04035}.
TRANSMEM 266 288 Helical. {ECO:0000255|HAMAP-
Rule:MF_04035}.
TOPO_DOM 289 294 Intravirion. {ECO:0000255|HAMAP-
Rule:MF_04035}.
TRANSMEM 295 317 Helical. {ECO:0000255|HAMAP-
Rule:MF_04035}.
TOPO_DOM 318 334 Virion surface. {ECO:0000255|HAMAP-
Rule:MF_04035}.
TRANSMEM 335 355 Helical. {ECO:0000255|HAMAP-
Rule:MF_04035}.
TOPO_DOM 356 435 Intravirion. {ECO:0000255|HAMAP-
Rule:MF_04035}.
DISULFID 68 68 Interchain (with gN). {ECO:0000255|HAMAP-
Rule:MF_04035}.
SEQUENCE 435 AA; 48672 MW; F74EC830584DA2C2 CRC64;
MGTQKKGPRS EKVSPYDTTT PEVEALDHQM DTLNWRIWII QVMMFTLGAV MLLATLIAAS
SEYTGIPCFY AAVVDYELFN ATLDGGVWSG NRGGYSAPVL FLEPHSVVAF TYYTALTAMA
MAVYTLITAA IIHRETKNQR VRQSSGVAWL VVDPTTLFWG LLSLWLLNAV VLLLAYKQIG
VAATLYLGHF ATSVIFTTYF CGRGKLDETN IKAVANLRQQ SVFLYRLAGP TRAVFVNLMA
ALMAICILFV SLMLELVVAN HLHTGLWSSV SVAMSTFSTL SVVYLIVSEL ILAHYIHVLI
GPSLGTLVAC ATLGTAAHSY MDRLYDPISV QSPRLIPTTR GTLACLAVFS VVMLLLRLMR
AYVYHRQKRS RFYGAVRRVP ERVRGYIRKV KPAHRNSRRT NYPSQGYGYV YENDSTYETD
REDELLYERS NSGWE


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