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Envelope polyprotein (M polyprotein)

 K0A1P6_9VIRU            Unreviewed;      1133 AA.
K0A1P6;
28-NOV-2012, integrated into UniProtKB/TrEMBL.
28-NOV-2012, sequence version 1.
07-JUN-2017, entry version 17.
RecName: Full=Envelope polyprotein {ECO:0000256|PIRNR:PIRNR003945};
AltName: Full=M polyprotein {ECO:0000256|PIRNR:PIRNR003945};
Seoul orthohantavirus.
Viruses; ssRNA viruses; ssRNA negative-strand viruses; Bunyavirales;
Hantaviridae; Orthohantavirus.
NCBI_TaxID=1980490 {ECO:0000313|EMBL:AFS64905.1};
[1] {ECO:0000313|EMBL:AFS64905.1}
NUCLEOTIDE SEQUENCE.
STRAIN=WuhanRf07 {ECO:0000313|EMBL:AFS64904.1}, and
WuhanRf08 {ECO:0000313|EMBL:AFS64905.1};
PubMed=22910184; DOI=10.1016/j.meegid.2012.07.017;
Kang Y.J., Zhou D.J., Tian J.H., Yu B., Guo W.P., Wang W., Li M.H.,
Wu T.P., Peng J.S., Plyusnin A., Zhang Y.Z.;
"Dynamics of hantavirus infections in humans and animals in Wuhan
city, Hubei, China.";
Infect. Genet. Evol. 12:1614-1621(2012).
-!- SIMILARITY: Belongs to the hantavirus envelope glycoprotein
family. {ECO:0000256|PIRNR:PIRNR003945}.
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EMBL; JQ665889; AFS64904.1; -; Viral_cRNA.
EMBL; JQ665890; AFS64905.1; -; Viral_cRNA.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0055036; C:virion membrane; IEA:UniProtKB-UniRule.
GO; GO:0030683; P:evasion or tolerance by virus of host immune response; IEA:InterPro.
GO; GO:0007165; P:signal transduction; IEA:InterPro.
InterPro; IPR016402; Envelope_glycoprot_Hantavirus.
InterPro; IPR002534; Hanta_G1.
InterPro; IPR002532; Hanta_G2.
InterPro; IPR012316; ITAM_motif_hantavir-typ.
Pfam; PF01567; Hanta_G1; 1.
Pfam; PF01561; Hanta_G2; 1.
Pfam; PF10538; ITAM_Cys-rich; 1.
PIRSF; PIRSF003945; M_poly_HantaV; 1.
ProDom; PD001813; Hanta_G2; 1.
3: Inferred from homology;
Membrane {ECO:0000256|SAM:Phobius};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius};
Virion {ECO:0000256|PIRNR:PIRNR003945}.
TRANSMEM 491 514 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 626 644 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 1104 1127 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 18 540 Hanta_G1. {ECO:0000259|Pfam:PF01567}.
DOMAIN 610 632 ITAM_2. {ECO:0000259|Pfam:PF10538}.
DOMAIN 649 1133 Hanta_G2. {ECO:0000259|Pfam:PF01561}.
SEQUENCE 1133 AA; 125572 MW; 5D2F70C1132C012E CRC64;
MWSLLLLAAL VGQGFALKNV FDMRIQCPHS VNFGETSVSG YTELPPLSLQ EAEQLVPESS
CNMDNHQSLS TINKLTKVIW RKKANQESAN QNSFEVIESE VSFKGLCMLK HRMVEESYRN
RRSVICYDLA CNSTFCKPTV YMIVPIHACN MMKSCLIGLG PYRIQVVYER TYCTTGILTE
GKCFVPDKAV VSALKRGMYA VASIETICFF IHQKGNTYKI VTAITSAMGS KCNNTDTKVQ
GYYICIIGGN SAPVYAPAGE DFRAMEVFSG IITSPHGEDH DLPGEEIATY QISGQIEAKI
PHTVSSKNLK LTAFAGIPSY SSTSILAASE DGRFIFSPGL FPNLNQSVCD NNALPLIWRG
LIDLTGYYEA VHPCNVFCVL SGPGASCEAF SEGGIFNITS PMCLVSKQNR FRAAEQQISF
VCQRVDMDII VYCNGQKKTI LTKTLVIGQC IYTITSLFSL LPGVAHSIAI ELCVPGFHGW
ATAALLTTFC FGWVLIPACT LAILLVLKFF ANILHTSNQE NRFKAILRKI KEEFEKTKGS
MVCEICKYEC ETLKELKAHN LSCVQGECPY CFTHCEPTET AIQAHYKVCQ ATHRFREDLK
KTVTPQNIGP GCYRTLNLFR YKSRPYILTM WTILLIIESI LWAASAAEIP LVPLWTDNAH
GVGSVPMHTD LELDFSLPSS SKYTYKRHLT NPVNDQQSVS LHIEIESQGI GADVHHLGHW
YDARLNLKTS FHCYGACTKY QYPWHTAKCH FEKDYEYENS WACNPPDCPG VGTGCTACGL
YLDQLKPVGT AFKIISVRYS RKVCVQFGEE YLCKTIDMND CFVTRHAKIC IIGTVSKFSQ
GDTLLFLGPM EGGGIIFKHW CTSTCHFGDP GDVMGPKDKP FICPEFPGQF RKKCNFATTP
VCEYDGNIIS GYKKVLATID SFQSFNTSNI HFTDERIEWR DPDGMLRDHI NIVISKDIDF
ENLAENPCKV GLQAANIEGA WGSGVGFTLT CQVSLTECPT FLTSIKACDM AICYGAESVT
LSRGQNTVKI TGKGGHSGSS FKCCHGKECS STGLQASAPH LDKVNGISEL ENEKVYDDGA
PECGITCWFK KSGEWVMGII NGNWVVLIAL CVLLLFSLIL LSILCPVRKH KKS


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