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Envelope small membrane protein (Protein E) (Glycoprotein 2b) (Protein GP2b) (Gs)

 E_PRRSL                 Reviewed;          70 AA.
P0C6Y6;
14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
14-OCT-2008, sequence version 1.
25-OCT-2017, entry version 32.
RecName: Full=Envelope small membrane protein;
Short=Protein E;
AltName: Full=Glycoprotein 2b;
Short=Protein GP2b;
AltName: Full=Gs;
Name=GP2b; ORFNames=2b;
Porcine reproductive and respiratory syndrome virus (strain Lelystad)
(PRRSV).
Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage;
Nidovirales; Arteriviridae; unclassified Arteriviridae.
NCBI_TaxID=11049;
NCBI_TaxID=9823; Sus scrofa (Pig).
[1]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
PubMed=8517032; DOI=10.1006/viro.1993.1008;
Meulenberg J.J.M., Hulst M.M., de Meijer E.J., Moonen P.L.J.M.,
den Besten A., de Kluyver E.P., Wensvoort G., Moormann R.J.M.;
"Lelystad virus, the causative agent of porcine epidemic abortion and
respiratory syndrome (PEARS), is related to LDV and EAV.";
Virology 192:62-72(1993).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate Boxmeer 10;
PubMed=8438574; DOI=10.1006/viro.1993.1129;
Conzelmann K.K., Visser N., van Woensel P., Thiel H.J.;
"Molecular characterization of porcine reproductive and respiratory
syndrome virus, a member of the arterivirus group.";
Virology 193:329-339(1993).
[3]
SUBCELLULAR LOCATION, AND SUBUNIT.
PubMed=16160177; DOI=10.1128/JVI.79.19.12495-12506.2005;
Wissink E.H., Kroese M.V., van Wijk H.A., Rijsewijk F.A.,
Meulenberg J.J., Rottier P.J.;
"Envelope protein requirements for the assembly of infectious virions
of porcine reproductive and respiratory syndrome virus.";
J. Virol. 79:12495-12506(2005).
[4]
CHARACTERIZATION, AND FUNCTION.
STRAIN=PA8;
PubMed=16904148; DOI=10.1016/j.virol.2006.07.013;
Lee C., Yoo D.;
"The small envelope protein of porcine reproductive and respiratory
syndrome virus possesses ion channel protein-like properties.";
Virology 355:30-43(2006).
[5]
MYRISTOYLATION AT GLY-2.
PubMed=19951726; DOI=10.1016/j.virusres.2009.11.016;
Du Y., Zuckermann F.A., Yoo D.;
"Myristoylation of the small envelope protein of porcine reproductive
and respiratory syndrome virus is non-essential for virus infectivity
but promotes its growth.";
Virus Res. 147:294-299(2010).
-!- FUNCTION: Minor envelope protein. May function as a viroporin in
the virion envelope that facilitates uncoating of the virus in
order to release the genomic RNA into the cytoplasm for subsequent
replication. {ECO:0000269|PubMed:16904148}.
-!- SUBUNIT: Homooligomer. Associates with itself into higher-order
structures, including dimers, trimers and tetramers. Associates
with the GP2a-GP3-GP4 complex (Probable).
{ECO:0000305|PubMed:16160177}.
-!- SUBCELLULAR LOCATION: Virion membrane
{ECO:0000269|PubMed:16160177}; Single-pass type I membrane protein
{ECO:0000269|PubMed:16160177}. Host endoplasmic reticulum membrane
{ECO:0000269|PubMed:16160177}; Single-pass type I membrane protein
{ECO:0000269|PubMed:16160177}. Host Golgi apparatus membrane
{ECO:0000269|PubMed:16160177}; Single-pass type I membrane protein
{ECO:0000269|PubMed:16160177}. Secreted
{ECO:0000269|PubMed:16160177}.
-!- PTM: Myristoylated. {ECO:0000269|PubMed:19951726}.
-!- PTM: Not glycosylated. {ECO:0000250}.
-!- SIMILARITY: Belongs to the arteriviridae E protein family.
{ECO:0000305}.
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EMBL; M96262; -; NOT_ANNOTATED_CDS; Genomic_RNA.
iPTMnet; P0C6Y6; -.
OrthoDB; VOG090002RN; -.
Proteomes; UP000006687; Genome.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0044385; C:integral to membrane of host cell; IEA:UniProtKB-KW.
GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
GO; GO:0005216; F:ion channel activity; IEA:UniProtKB-KW.
GO; GO:0039707; P:pore formation by virus in membrane of host cell; IEA:UniProtKB-KW.
GO; GO:0051259; P:protein oligomerization; IEA:UniProtKB-KW.
InterPro; IPR009775; GP2b.
Pfam; PF07069; PRRSV_2b; 1.
1: Evidence at protein level;
Complete proteome; Glycoprotein; Host endoplasmic reticulum;
Host Golgi apparatus; Host membrane; Ion channel; Ion transport;
Lipoprotein; Membrane; Myristate; Reference proteome; Secreted;
Transmembrane; Transmembrane helix; Transport; Viral envelope protein;
Viral ion channel; Virion.
INIT_MET 1 1 Removed; by host.
{ECO:0000269|PubMed:19951726}.
CHAIN 2 70 Envelope small membrane protein.
/FTId=PRO_0000351500.
TOPO_DOM 2 25 Virion surface. {ECO:0000255}.
TRANSMEM 26 46 Helical. {ECO:0000255}.
TOPO_DOM 47 70 Intravirion. {ECO:0000255}.
REGION 2 15 Endoplasmic reticulum retention signal.
{ECO:0000255}.
LIPID 2 2 N-myristoyl glycine; by host.
{ECO:0000269|PubMed:19951726}.
SEQUENCE 70 AA; 7743 MW; 02090C6445777C53 CRC64;
MGSLWSKISQ LFVDAFTEFL VSVVDIAIFL AILFGFTVAG WLLVFLLRVV CSALLRSRSA
IHSPELSKVL


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