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Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); Glycoprotein C (Gc) (Glycoprotein G2)]

 GP_NYV                  Reviewed;        1140 AA.
Q83887; Q83886; Q83888;
16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
05-JUL-2017, entry version 81.
RecName: Full=Envelopment polyprotein;
AltName: Full=M polyprotein;
Contains:
RecName: Full=Glycoprotein N {ECO:0000250|UniProtKB:P08668};
Short=Gn;
AltName: Full=Glycoprotein G1;
Contains:
RecName: Full=Glycoprotein C {ECO:0000250|UniProtKB:P08668};
Short=Gc;
AltName: Full=Glycoprotein G2;
Flags: Precursor;
Name=GP;
New York virus (NYV).
Viruses; ssRNA viruses; ssRNA negative-strand viruses; Bunyavirales;
Hantaviridae; Orthohantavirus; unclassified Orthohantavirus.
NCBI_TaxID=44755;
NCBI_TaxID=9606; Homo sapiens (Human).
NCBI_TaxID=10041; Peromyscus leucopus (White-footed mouse).
[1]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate New York-1, Isolate New York-2, and
Isolate Rhode Island-1;
PubMed=7494337;
Hjelle B., Lee S.-W., Song W., Torrez-Martinez N., Song J.-W.,
Yanagihara R., Gavrilovskaya I.N., Mackow E.R.;
"Molecular linkage of hantavirus pulmonary syndrome to the white-
footed mouse, Peromyscus leucopus: genetic characterization of the M
genome of New York virus.";
J. Virol. 69:8137-8141(1995).
[2]
INTERACTION WITH HUMAN LYN; HUMAN SYK AND HUMAN ZAP70.
PubMed=12502882; DOI=10.1128/JVI.77.2.1638-1643.2003;
Geimonen E., LaMonica R., Springer K., Farooqui Y.,
Gavrilovskaya I.N., Mackow E.R.;
"Hantavirus pulmonary syndrome-associated hantaviruses contain
conserved and functional ITAM signaling elements.";
J. Virol. 77:1638-1643(2003).
-!- FUNCTION: Glycoprotein C and Glycoprotein N interact with each
other and are present at the surface of the virion. They are able
to attach the virion to a cell receptor and to promote fusion of
membranes after endocytosis of the virion. Glycoprotein C contains
an ITAM motif which is likely to dysregulate normal immune and
endothelial cell responses and contribute to virus pathogenesis.
-!- SUBUNIT: Glycoprotein C and Glycoprotein N interacts with each
other (By similarity). Glycoprotein C interacts with human LYN,
SYK and ZAP70. {ECO:0000250, ECO:0000269|PubMed:12502882}.
-!- SUBCELLULAR LOCATION: Glycoprotein N: Virion membrane
{ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Host Golgi apparatus membrane {ECO:0000305}; Single-pass type I
membrane protein {ECO:0000305}. Host endoplasmic reticulum
membrane {ECO:0000305}; Single-pass type I membrane protein
{ECO:0000305}. Note=Interaction between Glycoprotein C and
Glycoprotein N is essential for proper targeting of Glycoprotein C
to the Golgi complex, where virion budding occurs. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Glycoprotein C: Virion membrane
{ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Host Golgi apparatus membrane {ECO:0000305}; Single-pass type I
membrane protein {ECO:0000305}.
-!- PTM: Envelope polyprotein precursor is quickly cleaved in vivo
just after synthesis, presumably by host signal peptidase.
{ECO:0000250}.
-!- SIMILARITY: Belongs to the hantavirus envelope glycoprotein
family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; U36802; AAC54560.1; -; Genomic_RNA.
EMBL; U36801; AAC54559.1; -; Genomic_RNA.
EMBL; U36803; AAC54561.1; -; Genomic_RNA.
SMR; Q83887; -.
GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
GO; GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:UniProtKB-KW.
GO; GO:0007165; P:signal transduction; IEA:InterPro.
GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
GO; GO:0039547; P:suppression by virus of host TRAF activity; IEA:UniProtKB-KW.
GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
InterPro; IPR016402; Envelope_glycoprot_Hantavirus.
InterPro; IPR002534; Hanta_G1.
InterPro; IPR002532; Hanta_G2.
InterPro; IPR012316; ITAM_motif_hantavir-typ.
Pfam; PF01567; Hanta_G1; 1.
Pfam; PF01561; Hanta_G2; 1.
Pfam; PF10538; ITAM_Cys-rich; 1.
PIRSF; PIRSF003945; M_poly_HantaV; 1.
ProDom; PD001813; Hanta_G2; 1.
PROSITE; PS51056; ITAM_2; 1.
1: Evidence at protein level;
Fusion of virus membrane with host endosomal membrane;
Fusion of virus membrane with host membrane; Glycoprotein;
Host endoplasmic reticulum; Host Golgi apparatus; Host membrane;
Host-virus interaction;
Inhibition of host innate immune response by virus;
Inhibition of host RLR pathway by virus;
Inhibition of host TRAFs by virus; Membrane; Phosphoprotein; Signal;
Transmembrane; Transmembrane helix; Viral attachment to host cell;
Viral immunoevasion; Viral penetration into host cytoplasm; Virion;
Virus entry into host cell.
SIGNAL 1 17 {ECO:0000255}.
CHAIN 18 1140 Envelopment polyprotein.
/FTId=PRO_0000235995.
CHAIN 18 652 Glycoprotein N. {ECO:0000250}.
/FTId=PRO_0000235996.
CHAIN 653 1140 Glycoprotein C. {ECO:0000250}.
/FTId=PRO_0000235997.
TOPO_DOM 18 489 Lumenal. {ECO:0000255}.
TRANSMEM 490 510 Helical. {ECO:0000255}.
TOPO_DOM 511 652 Cytoplasmic. {ECO:0000255}.
TOPO_DOM 653 1108 Lumenal. {ECO:0000255}.
TRANSMEM 1109 1129 Helical. {ECO:0000255}.
TOPO_DOM 1130 1140 Cytoplasmic. {ECO:0000255}.
DOMAIN 615 638 ITAM. {ECO:0000255|PROSITE-
ProRule:PRU00379}.
SITE 652 653 Cleavage; by host signal peptidase.
{ECO:0000250}.
MOD_RES 619 619 Phosphotyrosine; by host.
{ECO:0000255|PROSITE-ProRule:PRU00379}.
MOD_RES 632 632 Phosphotyrosine; by host.
{ECO:0000255|PROSITE-ProRule:PRU00379}.
CARBOHYD 138 138 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
CARBOHYD 351 351 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
CARBOHYD 403 403 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
CARBOHYD 931 931 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
VARIANT 4 4 W -> F (in strain: Isolate New York-2).
VARIANT 8 8 S -> F (in strain: Isolate New York-2 and
Isolate Rhode Island-1).
VARIANT 46 46 E -> G (in strain: Isolate New York-2).
VARIANT 141 141 H -> Y (in strain: Isolate Rhode Island-
1).
VARIANT 238 238 S -> G (in strain: Isolate New York-2).
VARIANT 261 261 F -> S (in strain: Isolate Rhode Island-
1).
VARIANT 314 314 T -> A (in strain: Isolate New York-2).
VARIANT 325 325 M -> T (in strain: Isolate Rhode Island-
1).
VARIANT 359 359 T -> A (in strain: Isolate Rhode Island-
1).
VARIANT 394 394 E -> K (in strain: Isolate Rhode Island-
1).
VARIANT 452 452 V -> I (in strain: Isolate Rhode Island-
1).
VARIANT 489 489 T -> A (in strain: Isolate Rhode Island-
1).
VARIANT 551 551 V -> A (in strain: Isolate Rhode Island-
1).
VARIANT 589 589 Q -> L (in strain: Isolate Rhode Island-
1).
VARIANT 618 618 C -> R (in strain: Isolate Rhode Island-
1).
VARIANT 697 697 N -> D (in strain: Isolate New York-2).
VARIANT 794 794 V -> G (in strain: Isolate Rhode Island-
1).
VARIANT 1043 1043 G -> S (in strain: Isolate Rhode Island-
1).
SEQUENCE 1140 AA; 125619 MW; BD3CCFDB0417AC42 CRC64;
MVGWVCISLV VLATTTAGLT RNLYELKIEC PHTVGLGQGY VTGSVETTPI LLTQVTDLKI
ESSCNFDLHV PSTSIQKYNQ VEWAKKSSTT ESTSAGATTF EAKTKEVSLK GTCNIPVTTF
EAAYKSRKTV ICYDLACNQT HCLPTVHLIA PVQTCMSVRS CMIGLLSSRI QVIYEKTYCV
TGQLVEGLCF IPTHTIALTQ PGHTYDTMTL PITCFLVAKK LGTQLKIAVE LEKLITASGC
TENSFQGYYI CFLGKHSEPL FVPMMDDYRS AELFTRMVLN PRGEDHDPDQ NGQGLMRIAG
PITAKVPSTE TTETMQGIAF AGAPMYSSFS TLVRKADPDY VFSPGIIAES NHSVCDKKTI
PLTWTGFLAV SGEIEKITGC TVFCTLVGPG ASCEAYSETG IFNISSPTCL VNKVQKFRGS
EQRINFMCQR VDQDVIVYCN GQKKVILTKT LVIGQCIYTF TSLFSLIPGV AHSLAVELCV
PGLHGWATTA LLITFCFGWL LIPTITMIIL KILRLLTFSC SHYSTESKFK AILERVKVEY
QKTMGSMVCD VCHHECETAK ELETHKKSCP EGQCPYCMTM TESTESALQA HFSICKLTNR
FQENLKKSLK RPEVKQGCYR TLGVFRYKSR CYVGLVWGVL LTTELIVWAA SADTPLMESG
WSDTAHGVGI VPMKTDLELD FALASSSSYS YRRKLVNPAN KEETLPFHFQ LDKQVVHAEI
QNLGHWMDGT FNIKTAFHCY GECKKYAYPW QTAKCFFEKD YQYETSWGCN PPDCPGVGTG
CTACGVYLDK LRSVGKAYKI VSLKFTRKVC IQLGTEQTCK HIDVNDCLVT PSVKVCLIGT
ISKLQPGDTL LFLGPLEQGG IILKQWCTTS CVFGDPGDIM STTTGMKCPE HTGSFRKICG
FATTPTCEYQ GNTISGFQRM MATRDSFQSF NVTEPHITSN RLEWIDPDSS IKDHINMVLN
RDVSFQDLSD NPCKVDLHTQ SIDGAWGSGV GFTLVCTVGL TECANFITSI KACDSAMCYG
ATVTNLLRGS NTVKVVGKGG HSGSLFKCCH DTDCTEEGLA ASPPHLDRVT GYNQIDSDKV
YDDGAPPCTI KCWFTKSGEW LLGILNGNWV VVAVLIVILI LSILLFSFFC PIRGRKNKSN


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