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Envelopment polyprotein (M polyprotein) [Cleaved into: NSm-Gn protein; Glycoprotein N (Gn) (Glycoprotein G1); Glycoprotein C (Gc) (Glycoprotein G2)]

 GP_RVFV                 Reviewed;        1206 AA.
P03518; Q86494; Q86495;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 2.
07-JUN-2017, entry version 84.
RecName: Full=Envelopment polyprotein;
AltName: Full=M polyprotein;
Contains:
RecName: Full=NSm-Gn protein {ECO:0000250|UniProtKB:P21401};
Contains:
RecName: Full=Glycoprotein N {ECO:0000250|UniProtKB:P21401};
Short=Gn;
AltName: Full=Glycoprotein G1;
Contains:
RecName: Full=Glycoprotein C {ECO:0000250|UniProtKB:P21401};
Short=Gc;
AltName: Full=Glycoprotein G2;
Flags: Precursor;
Name=GP;
Rift valley fever virus (RVFV).
Viruses; ssRNA viruses; ssRNA negative-strand viruses; Bunyavirales;
Phenuiviridae; Phlebovirus.
NCBI_TaxID=11588;
NCBI_TaxID=7158; Aedes.
NCBI_TaxID=9913; Bos taurus (Bovine).
NCBI_TaxID=297284; Bos taurus x Bison bison (beefalo).
NCBI_TaxID=9837; Camelus bactrianus (Bactrian camel).
NCBI_TaxID=9925; Capra hircus (Goat).
NCBI_TaxID=9606; Homo sapiens (Human).
NCBI_TaxID=9940; Ovis aries (Sheep).
NCBI_TaxID=29031; Phlebotomus papatasi (Sandfly).
[1]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
PubMed=2998042; DOI=10.1016/0042-6822(85)90320-4;
Collett M.S., Purchio A.F., Keegan K., Frazier S., Hays W.,
Anderson D.K., Parker M.D., Schmaljohn C.S., Schmidt J.,
Dalrymple J.M.;
"Complete nucleotide sequence of the M RNA segment of Rift Valley
fever virus.";
Virology 144:228-245(1985).
-!- FUNCTION: Glycoprotein N: interact with each other and are present
at the surface of the virion. They are able to attach the virion
to a cell receptor and to promote fusion of membranes after
endocytosis of the virion (By similarity). {ECO:0000250}.
-!- FUNCTION: Glycoprotein C: interact with each other and are present
at the surface of the virion. Together they play a role in
attachment of the virion to a cell receptor. Promotes fusion of
membranes after endocytosis of the virion (By similarity).
{ECO:0000250}.
-!- FUNCTION: NSm protein: Plays a role for virus dissemination in
mouse. {ECO:0000250|UniProtKB:P21401}.
-!- FUNCTION: NSm-Gn protein: Plays a role for virus dissemination in
mosquitoes. {ECO:0000250|UniProtKB:P21401}.
-!- SUBUNIT: Glycoprotein C and Glycoprotein N interacts with each
other. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Glycoprotein N: Virion membrane
{ECO:0000250|UniProtKB:P21401}; Single-pass type I membrane
protein {ECO:0000250|UniProtKB:P21401}. Host Golgi apparatus
membrane {ECO:0000250|UniProtKB:P21401}; Single-pass type I
membrane protein {ECO:0000250|UniProtKB:P21401}. Host endoplasmic
reticulum membrane {ECO:0000250|UniProtKB:P21401}; Single-pass
type I membrane protein {ECO:0000250|UniProtKB:P21401}.
Note=Interaction between G1 and G2 is essential for proper
targeting of G1 to the Golgi complex, where virion budding occurs.
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Glycoprotein C: Virion membrane
{ECO:0000250|UniProtKB:P21401}; Single-pass type I membrane
protein {ECO:0000250|UniProtKB:P21401}. Host Golgi apparatus
membrane {ECO:0000250|UniProtKB:P21401}; Single-pass type I
membrane protein {ECO:0000250|UniProtKB:P21401}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative initiation; Named isoforms=3;
Name=1;
IsoId=P03518-1; Sequence=Displayed;
Name=NSm protein {ECO:0000250|UniProtKB:P21401}; Synonyms=P14;
IsoId=P03518-2; Sequence=VSP_057986, VSP_057987;
Name=NSm' protein {ECO:0000250|UniProtKB:P21401}; Synonyms=P13;
IsoId=P03518-3; Sequence=VSP_057985, VSP_057987;
-!- PTM: Specific enzymatic cleavages in vivo yield mature proteins
including NSm protein, Glycoprotein C, and Glycoprotein N.
{ECO:0000250|UniProtKB:P21401}.
-!- SIMILARITY: Belongs to the phlebovirus envelope glycoprotein
family. {ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; M11157; AAA47450.1; -; Genomic_RNA.
PIR; A04110; VGVURV.
PDB; 4HJ1; X-ray; 1.90 A; A/B/C/D=691-1119.
PDB; 4HJC; X-ray; 4.15 A; A=691-1118.
PDBsum; 4HJ1; -.
PDBsum; 4HJC; -.
SMR; P03518; -.
PRIDE; P03518; -.
GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
GO; GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:UniProtKB-KW.
GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
InterPro; IPR016404; M_polyprot_prcur_phlebovir.
InterPro; IPR010826; Phlebovirus_G1.
InterPro; IPR009878; Phlebovirus_G2.
InterPro; IPR009879; Phlebovirus_NSM.
Pfam; PF07243; Phlebovirus_G1; 1.
Pfam; PF07245; Phlebovirus_G2; 1.
Pfam; PF07246; Phlebovirus_NSM; 2.
PIRSF; PIRSF003961; M_poly_PhleboV; 1.
1: Evidence at protein level;
3D-structure; Alternative initiation;
Fusion of virus membrane with host endosomal membrane;
Fusion of virus membrane with host membrane; Glycoprotein;
Host endoplasmic reticulum; Host Golgi apparatus; Host membrane;
Host-virus interaction; Membrane; Signal; Transmembrane;
Transmembrane helix; Viral attachment to host cell;
Viral penetration into host cytoplasm; Virion;
Virus entry into host cell.
SIGNAL 1 16 {ECO:0000255}.
CHAIN 17 1206 Envelopment polyprotein.
/FTId=PRO_0000247009.
CHAIN 17 153 NSm-Gn protein.
/FTId=PRO_0000036847.
CHAIN 154 690 Glycoprotein N. {ECO:0000255}.
/FTId=PRO_0000036848.
CHAIN 691 1206 Glycoprotein C. {ECO:0000255}.
/FTId=PRO_0000036849.
TOPO_DOM 17 582 Lumenal. {ECO:0000255}.
TRANSMEM 583 603 Helical. {ECO:0000255}.
TOPO_DOM 604 690 Cytoplasmic. {ECO:0000255}.
TOPO_DOM 691 1136 Lumenal. {ECO:0000255}.
TRANSMEM 1137 1157 Helical. {ECO:0000255}.
TOPO_DOM 1158 1206 Cytoplasmic. {ECO:0000255}.
SITE 690 691 Cleavage; by host signal peptidase.
{ECO:0000250}.
CARBOHYD 88 88 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
CARBOHYD 438 438 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
CARBOHYD 794 794 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
CARBOHYD 1035 1035 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
CARBOHYD 1077 1077 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
VAR_SEQ 1 51 Missing (in isoform NSm' protein).
/FTId=VSP_057985.
VAR_SEQ 1 38 Missing (in isoform NSm protein).
/FTId=VSP_057986.
VAR_SEQ 154 1197 Missing (in isoform NSm protein and
isoform NSm' protein).
/FTId=VSP_057987.
STRAND 691 696 {ECO:0000244|PDB:4HJ1}.
HELIX 699 701 {ECO:0000244|PDB:4HJ1}.
STRAND 702 709 {ECO:0000244|PDB:4HJ1}.
STRAND 711 722 {ECO:0000244|PDB:4HJ1}.
STRAND 728 735 {ECO:0000244|PDB:4HJ1}.
STRAND 742 764 {ECO:0000244|PDB:4HJ1}.
STRAND 767 776 {ECO:0000244|PDB:4HJ1}.
TURN 785 790 {ECO:0000244|PDB:4HJ1}.
HELIX 798 803 {ECO:0000244|PDB:4HJ1}.
STRAND 810 817 {ECO:0000244|PDB:4HJ1}.
HELIX 821 823 {ECO:0000244|PDB:4HJ1}.
STRAND 826 829 {ECO:0000244|PDB:4HJ1}.
STRAND 831 844 {ECO:0000244|PDB:4HJ1}.
STRAND 847 864 {ECO:0000244|PDB:4HJ1}.
STRAND 870 875 {ECO:0000244|PDB:4HJ1}.
STRAND 880 883 {ECO:0000244|PDB:4HJ1}.
STRAND 886 893 {ECO:0000244|PDB:4HJ1}.
HELIX 900 902 {ECO:0000244|PDB:4HJ1}.
STRAND 904 908 {ECO:0000244|PDB:4HJ1}.
TURN 909 911 {ECO:0000244|PDB:4HJ1}.
STRAND 912 918 {ECO:0000244|PDB:4HJ1}.
STRAND 931 936 {ECO:0000244|PDB:4HJ1}.
HELIX 937 941 {ECO:0000244|PDB:4HJ1}.
STRAND 947 949 {ECO:0000244|PDB:4HJ1}.
STRAND 954 959 {ECO:0000244|PDB:4HJ1}.
STRAND 962 967 {ECO:0000244|PDB:4HJ1}.
HELIX 972 978 {ECO:0000244|PDB:4HJ1}.
STRAND 980 985 {ECO:0000244|PDB:4HJ1}.
STRAND 988 992 {ECO:0000244|PDB:4HJ1}.
STRAND 994 996 {ECO:0000244|PDB:4HJ1}.
STRAND 999 1003 {ECO:0000244|PDB:4HJ1}.
STRAND 1009 1021 {ECO:0000244|PDB:4HJ1}.
STRAND 1030 1044 {ECO:0000244|PDB:4HJ1}.
STRAND 1046 1056 {ECO:0000244|PDB:4HJ1}.
STRAND 1058 1064 {ECO:0000244|PDB:4HJ1}.
STRAND 1070 1075 {ECO:0000244|PDB:4HJ1}.
STRAND 1077 1086 {ECO:0000244|PDB:4HJ1}.
STRAND 1089 1103 {ECO:0000244|PDB:4HJ1}.
STRAND 1106 1113 {ECO:0000244|PDB:4HJ1}.
SEQUENCE 1206 AA; 132053 MW; D2E8017179285924 CRC64;
MYVLLTILIS VLVCEAVIRV SLSSTREETC FGDSTNPEMI EGAWDSLREE EMPEELSCSI
SGIREVKTSS QELYRALKAI IAADGLNNIT CHGKDPEDKI SLIKGPPHKK RVGIVRCERR
RDAKQIGRET MAGIAMTVLP ALAVFALAPV VFAEDPHLRN RPGKGHNYID GMTQEDATCK
PVTYAGACSS FDVLLEKGKF PLFQSYAHHR TLLEAVHDTI IAKADPPSCD LQSAHGNPCM
KEKLVMKTHC PNDYQSAHYL NNDGKMASVK CPPKYGLTED CNFCRQMTGA SLKKGSYPLQ
DLFCQSSEDD GSKLKTKMKG VCEVGVQAHK KCDGQLSTAH EVVPFAVFKN SKKVYLDKLD
LKTEENLLPD SFVCFEHKGQ YKGTMDSGQT KRELKSFDIS QCPKIGGHGS KKCTGDAAFC
SAYECTAQYA NAYCSHANGS GIVQIQVSGV WKKPLCVGYE RVVVKRELSA KPIQRVEPCT
TCITKCEPHG LVVRSTGFKI SSAVACASGV CVTGSQSPST EITLKYPGIS QSSGGDIGVH
MAHDDQSVSS KIVAHCPPQD PCLVHGCIVC AHGLINYQCH TALSAFVVVF VFSSIAIICL
AVLYRVLKCL KIAPRKVLNP LMWITAFIRW IYKKMVARVA HNINQVNREI GWMEGGQLVL
GNPAPIPRHA PIPRYSTYLM LLLIVSYASA CSELIQASSR ITTCSTEGVN TKCRLSGTAL
IRAGSVGAEA CLMLKGVKED QTKFLKIKTV SSELSCREGQ SYWTGSISPK CLSSRRCHLV
GECHVNRCLS WRDNETSAEF SFVGESTTMR ENKCFEQCGG WGCGCFNVNP SCLFVHTYLQ
SVRKEALRVF NCIDWVHKLT LEITDFDGSV STIDLGASSS RFTNWGSVSL SLDAEGISGS
NSFSFIESPS KGYAIVDEPF SEIPRQGFLG EIRCNSESSV LSAHESCLRA PNLISYKPMI
DQLECTTNLI DPFVVFERGS LPQTRNDKTF AASKGNRGVQ AFSKGSVQAD LTLMFDNFEV
DFVGAAVSCD AAFLNLTGCY SCNAGARVCL SITSTGTGSL SAHNKDGSLH IVLPSENGTK
DQCQILHFTV PEVEEEFMYS CDGDERPLLV KGTLIAIDPF DDRREAGGES TVVNPKSGSW
NFFDWFSGLM SWFGGPLKLY SSFACMLHYQ LGSFSSLYIL EEQASLKCGL LPLRRPHRSV
RVKVIC


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