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Ephrin type-B receptor 3

 E0CYA3_MOUSE            Unreviewed;       739 AA.
E0CYA3;
05-OCT-2010, integrated into UniProtKB/TrEMBL.
10-OCT-2018, sequence version 2.
16-JAN-2019, entry version 46.
SubName: Full=Ephrin type-B receptor 3 {ECO:0000313|Ensembl:ENSMUSP00000124375};
Name=Ephb3 {ECO:0000313|Ensembl:ENSMUSP00000124375,
ECO:0000313|MGI:MGI:104770};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000124375, ECO:0000313|Proteomes:UP000000589};
[1] {ECO:0000313|Ensembl:ENSMUSP00000124375, ECO:0000313|Proteomes:UP000000589}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000124375,
ECO:0000313|Proteomes:UP000000589};
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[2] {ECO:0000213|PubMed:21183079}
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[3] {ECO:0000313|Ensembl:ENSMUSP00000124375}
IDENTIFICATION.
STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000124375};
Ensembl;
Submitted (MAY-2011) to UniProtKB.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-
tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136,
Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
EC=2.7.10.1; Evidence={ECO:0000256|SAAS:SAAS01124082};
-!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
kinase family. {ECO:0000256|SAAS:SAAS00941529}.
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EMBL; AC168061; -; NOT_ANNOTATED_CDS; Genomic_DNA.
PRIDE; E0CYA3; -.
Ensembl; ENSMUST00000161063; ENSMUSP00000124375; ENSMUSG00000005958.
MGI; MGI:104770; Ephb3.
GeneTree; ENSGT00940000158024; -.
ChiTaRS; Ephb3; mouse.
Proteomes; UP000000589; Chromosome 16.
Bgee; ENSMUSG00000005958; Expressed in 260 organ(s), highest expression level in membranous labyrinth.
ExpressionAtlas; E0CYA3; baseline and differential.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0008046; F:axon guidance receptor activity; IEA:Ensembl.
GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
GO; GO:0007413; P:axonal fasciculation; IEA:Ensembl.
GO; GO:0016477; P:cell migration; IEA:Ensembl.
GO; GO:0021952; P:central nervous system projection neuron axonogenesis; IEA:Ensembl.
GO; GO:0022038; P:corpus callosum development; IEA:Ensembl.
GO; GO:0060997; P:dendritic spine morphogenesis; IEA:Ensembl.
GO; GO:0048546; P:digestive tract morphogenesis; IEA:Ensembl.
GO; GO:0051965; P:positive regulation of synapse assembly; IEA:Ensembl.
GO; GO:0050770; P:regulation of axonogenesis; IEA:Ensembl.
GO; GO:0031290; P:retinal ganglion cell axon guidance; IEA:Ensembl.
GO; GO:0060021; P:roof of mouth development; IEA:Ensembl.
GO; GO:0048538; P:thymus development; IEA:Ensembl.
GO; GO:0001655; P:urogenital system development; IEA:Ensembl.
CDD; cd00063; FN3; 2.
Gene3D; 2.60.40.10; -; 2.
InterPro; IPR027936; Eph_TM.
InterPro; IPR003961; FN3_dom.
InterPro; IPR036116; FN3_sf.
InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR001660; SAM.
InterPro; IPR013761; SAM/pointed_sf.
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
InterPro; IPR008266; Tyr_kinase_AS.
InterPro; IPR020635; Tyr_kinase_cat_dom.
Pfam; PF14575; EphA2_TM; 1.
Pfam; PF07699; Ephrin_rec_like; 1.
Pfam; PF00041; fn3; 2.
Pfam; PF07714; Pkinase_Tyr; 1.
Pfam; PF00536; SAM_1; 1.
PRINTS; PR00109; TYRKINASE.
SMART; SM01411; Ephrin_rec_like; 1.
SMART; SM00060; FN3; 2.
SMART; SM00454; SAM; 1.
SMART; SM00219; TyrKc; 1.
SUPFAM; SSF47769; SSF47769; 1.
SUPFAM; SSF49265; SSF49265; 1.
SUPFAM; SSF56112; SSF56112; 1.
SUPFAM; SSF57184; SSF57184; 1.
PROSITE; PS50853; FN3; 2.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PROSITE; PS50105; SAM_DOMAIN; 1.
1: Evidence at protein level;
ATP-binding {ECO:0000256|SAAS:SAAS00708816};
Complete proteome {ECO:0000313|Proteomes:UP000000589};
Kinase {ECO:0000256|SAAS:SAAS00582553};
Membrane {ECO:0000256|SAAS:SAAS00602683, ECO:0000256|SAM:Phobius};
Nucleotide-binding {ECO:0000256|SAAS:SAAS00708816};
Proteomics identification {ECO:0000213|MaxQB:E0CYA3,
ECO:0000213|PeptideAtlas:E0CYA3};
Receptor {ECO:0000256|SAAS:SAAS00600436};
Reference proteome {ECO:0000313|Proteomes:UP000000589};
Repeat {ECO:0000256|SAAS:SAAS01054641};
Transferase {ECO:0000256|SAAS:SAAS00582553};
Transmembrane {ECO:0000256|SAAS:SAAS00602683,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00602683,
ECO:0000256|SAM:Phobius};
Tyrosine-protein kinase {ECO:0000256|SAAS:SAAS00582553}.
TRANSMEM 300 323 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 77 192 Fibronectin type-III.
{ECO:0000259|PROSITE:PS50853}.
DOMAIN 193 286 Fibronectin type-III.
{ECO:0000259|PROSITE:PS50853}.
DOMAIN 374 637 Protein kinase.
{ECO:0000259|PROSITE:PS50011}.
DOMAIN 666 730 SAM. {ECO:0000259|PROSITE:PS50105}.
SEQUENCE 739 AA; 81563 MW; CA87665288905B59 CRC64;
MVPVGACTCA TGHEPAAKES QCRACPPGSY KAKQGEGPCL PCPPNSRTTS PAASICTCHN
NFYRADSDSA DSACTTVPSP PRGVISNVNE TSLILEWSEP RDLGGRDDLL YNVICKKCRG
SSGAGGPATC SRCDDNVEFV PRQLGLTERR VHISHLLAHT RYTFEVQAVN GVSGKSPLPP
RYAAVNITTN QAAPSEVPTL HLHSSSGSSL TLSWAPPERP NGVILDYEMK YFEKSKGIAS
TVTSQKNSVQ LDGLQPDARY VVQVRARTVA GYGQYSHPAE FETTSERGSG AQQLQEQLPL
IVGSTVAGFV FMVVVVVIAL VCLRKQRHGP DAEYTEKLQQ YIAPGMKVYI DPFTYEDPNE
AVREFAKEID VSCVKIEEVI GAGEFGEVCR GRLKLPGRRE VFVAIKTLKV GYTERQRRDF
LSEASIMGQF DHPNIIRLEG VVTKSRPVMI LTEFMENCAL DSFLRLNDGQ FTVIQLVGML
RGIAAGMKYL SEMNYVHRDL AARNILVNSN LVCKVSDFGL SRFLEDDPSD PTYTSSLGGK
IPIRWTAPEA IAYRKFTSAS DVWSYGIVMW EVMSYGERPY WDMSNQDVIN AVEQDYRLPP
PMDCPTALHQ LMLDCWVRDR NLRPKFSQIV NTLDKLIRNA ASLKVTASAP SGMSQPLLDR
TVPDYTTFTT VGDWLDAIKM GRYKESFVGA GFASFDLVAQ MTAEDLLRIG VTLAGHQKKI
LCSIQDMRLQ MNQTLPVQV


Related products :

Catalog number Product name Quantity
LF-PA41414 anti-Ephrin Type A Receptor 2, Rabbit polyclonal to Ephrin Type A Receptor 2, Isotype IgG, Host Rabbit 100 ul
LF-PA40385 anti-Ephrin Type A Receptor 4 (EPHA4) , Rabbit polyclonal to Ephrin Type A Receptor 4 (EPHA4), Isotype IgG, Host Rabbit 50 ug
LF-PA40384 anti-Ephrin Type A Receptor 4 (EPHA4) , Rabbit polyclonal to Ephrin Type A Receptor 4 (EPHA4), Isotype IgG, Host Rabbit 50 ug
EIAAB13101 ELK,Elk,Ephb1,Ephrin type-B receptor 1,Epth2,Rat,Rattus norvegicus,Tyrosine-protein kinase receptor EPH-2
EIAAB13112 Ephb6,Ephrin type-B receptor 6,Rat,Rattus norvegicus,Tyrosine-protein kinase-defective receptor EPH-6
EIAAB13113 EPHB6,Ephrin type-B receptor 6,HEP,Homo sapiens,Human,Tyrosine-protein kinase-defective receptor EPH-6
EIAAB13114 Cekl,Ephb6,Ephrin type-B receptor 6,MEP,Mouse,Mus musculus,Tyrosine-protein kinase-defective receptor EPH-6
X2112P Ephrin Type A Receptor 4 (EPHA4) type: Antigen Immunoaffinity Purified Polyclonal host: Rabbit Isotype: IgG 50
X2247P Ephrin Type A Receptor 4 (EPHA4) type: Antigen Immunoaffinity Purified Polyclonal host: Rabbit Isotype: IgG 50
EH831 Ephrin type-A receptor 4 Elisa Kit 96T
EM640 Ephrin type-B receptor 4 Elisa Kit 96T
EH3007 Ephrin Type A Receptor 10 Elisa Kit 96T
CD11 Ephrin Type-B Receptor 1 EphB1 500
EPHA8_RAT Rat ELISA Kit FOR Ephrin type-A receptor 8 96T
Y105065 Ephrin Type A Receptor 4 (EPHA4) 50ug
EH3006 Ephrin Type A Receptor 1 Elisa Kit 96T
CD11 Ephrin Type-B Receptor 1 EphB1 lmg
EPHA6_RAT Rat ELISA Kit FOR Ephrin type-A receptor 6 96T
C519 Ephrin Type-A Receptor 7 EPHA7 500
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