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Ephrin-4 (Protein male abnormal 26)
EFN4_CAEEL Reviewed; 348 AA.
O44516;
05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 2.
20-DEC-2017, entry version 124.
RecName: Full=Ephrin-4;
AltName: Full=Protein male abnormal 26;
Flags: Precursor;
Name=efn-4; Synonyms=mab-26; ORFNames=F56A11.3;
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
NCBI_TaxID=6239;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, AND
DISRUPTION PHENOTYPE.
STRAIN=Bristol N2;
PubMed=12403719; DOI=10.1242/dev.00122;
Chin-Sang I.D., Moseley S.L., Ding M., Harrington R.J., George S.E.,
Chisholm A.D.;
"The divergent C. elegans ephrin EFN-4 functions in embryonic
morphogenesis in a pathway independent of the VAB-1 Eph receptor.";
Development 129:5499-5510(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
[3]
IDENTIFICATION, AND NOMENCLATURE.
PubMed=10635316; DOI=10.1016/S1097-2765(00)80220-8;
Wang X., Roy P.J., Holland S.J., Zhang L.W., Culotti J.G., Pawson T.;
"Multiple ephrins control cell organization in C. elegans using
kinase-dependent and -independent functions of the VAB-1 Eph
receptor.";
Mol. Cell 4:903-913(1999).
[4]
FUNCTION.
PubMed=12679110; DOI=10.1016/S0012-1606(02)00129-X;
Hahn A.C., Emmons S.W.;
"The roles of an ephrin and a semaphorin in patterning cell-cell
contacts in C. elegans sensory organ development.";
Dev. Biol. 256:379-388(2003).
[5]
FUNCTION.
PubMed=15030761; DOI=10.1016/S1534-5807(04)00057-7;
Ikegami R., Zheng H., Ong S.-H., Culotti J.G.;
"Integration of semaphorin-2A/MAB-20, ephrin-4, and UNC-129 TGF-beta
signaling pathways regulates sorting of distinct sensory rays in C.
elegans.";
Dev. Cell 6:383-395(2004).
[6]
FUNCTION, INTERACTION WITH LAD-2, DEVELOPMENTAL STAGE, AND MUTAGENESIS
OF 328-SER--TYR-348.
PubMed=26903502; DOI=10.1242/dev.128934;
Dong B., Moseley-Alldredge M., Schwieterman A.A., Donelson C.J.,
McMurry J.L., Hudson M.L., Chen L.;
"EFN-4 functions in LAD-2-mediated axon guidance in Caenorhabditis
elegans.";
Development 143:1182-1191(2016).
-!- FUNCTION: Regulates the formation or stabilization of cell-cell
contacts at several stages of epithelial morphogenesis
(PubMed:12679110). In early embryonic development, involved in
ventral closure of the epidermis (PubMed:12403719). During male
tail morphogenesis, regulates precursor cell sorting together with
mab-20 and allows the formation of distinct sensory rays
(PubMed:15030761). Probably acts as a ligand for lad-2 to regulate
axon guidance of several neurons including SDQL, SDQR, SMD and PLN
neurons during neurogenesis (PubMed:26903502).
{ECO:0000269|PubMed:12403719, ECO:0000269|PubMed:12679110,
ECO:0000269|PubMed:15030761, ECO:0000269|PubMed:26903502}.
-!- SUBUNIT: Interacts with lat-2. {ECO:0000269|PubMed:26903502}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor,
GPI-anchor {ECO:0000305}.
-!- DEVELOPMENTAL STAGE: Expressed in the developing nervous system
(PubMed:12403719). Expressed in head and tail neurons, nerve ring,
ventral nerve cord, lateral neurons, CAN neuron, seam cells and
vulva cells (PubMed:26903502). {ECO:0000269|PubMed:12403719,
ECO:0000269|PubMed:26903502}.
-!- PTM: May undergo proteolysis by metalloprotease sup-17 to give
rise to a soluble form. {ECO:0000305|PubMed:26903502}.
-!- DISRUPTION PHENOTYPE: Worms have widespread defects in embryonic
morphogenesis of the posterior body and defects in postembryonic
male tail morphogenesis. {ECO:0000269|PubMed:12403719}.
-!- MISCELLANEOUS: In contrast to other ephrins, does not seem to
signal through the vab-1 receptor. {ECO:0000269|PubMed:12403719}.
-!- SIMILARITY: Belongs to the ephrin family. {ECO:0000255|PROSITE-
ProRule:PRU00884}.
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EMBL; AF410936; AAL05561.1; -; mRNA.
EMBL; FO080624; CCD65257.1; -; Genomic_DNA.
PIR; T32645; T32645.
RefSeq; NP_499947.1; NM_067546.4.
UniGene; Cel.19328; -.
ProteinModelPortal; O44516; -.
SMR; O44516; -.
BioGrid; 42043; 3.
STRING; 6239.F56A11.3; -.
EPD; O44516; -.
PaxDb; O44516; -.
EnsemblMetazoa; F56A11.3; F56A11.3; WBGene00001165.
GeneID; 176882; -.
KEGG; cel:CELE_F56A11.3; -.
UCSC; F56A11.3; c. elegans.
CTD; 176882; -.
WormBase; F56A11.3; CE29503; WBGene00001165; efn-4.
eggNOG; KOG3858; Eukaryota.
eggNOG; ENOG4111FMJ; LUCA.
HOGENOM; HOG000112341; -.
InParanoid; O44516; -.
OMA; PIPNGKE; -.
OrthoDB; EOG091G0LSC; -.
PhylomeDB; O44516; -.
SignaLink; O44516; -.
PRO; PR:O44516; -.
Proteomes; UP000001940; Chromosome IV.
Bgee; WBGene00001165; -.
GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
GO; GO:0030424; C:axon; IDA:WormBase.
GO; GO:0043025; C:neuronal cell body; IDA:WormBase.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0046875; F:ephrin receptor binding; IBA:GO_Central.
GO; GO:0007411; P:axon guidance; IBA:GO_Central.
GO; GO:0042074; P:cell migration involved in gastrulation; IMP:WormBase.
GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
GO; GO:0048013; P:ephrin receptor signaling pathway; IBA:GO_Central.
GO; GO:0016331; P:morphogenesis of embryonic epithelium; IMP:WormBase.
GO; GO:0045138; P:nematode male tail tip morphogenesis; IMP:WormBase.
GO; GO:1902667; P:regulation of axon guidance; IMP:UniProtKB.
GO; GO:0030155; P:regulation of cell adhesion; IMP:WormBase.
Gene3D; 2.60.40.420; -; 1.
InterPro; IPR008972; Cupredoxin.
InterPro; IPR031328; Ephrin.
InterPro; IPR001799; Ephrin_RBD.
PANTHER; PTHR11304; PTHR11304; 1.
Pfam; PF00812; Ephrin; 1.
ProDom; PD002533; Ephrin; 1.
SUPFAM; SSF49503; SSF49503; 1.
PROSITE; PS51551; EPHRIN_RBD_2; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Developmental protein;
Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
Neurogenesis; Reference proteome; Signal.
SIGNAL 1 20 {ECO:0000255}.
CHAIN 21 329 Ephrin-4.
/FTId=PRO_0000248550.
PROPEP 330 348 Removed in mature form. {ECO:0000255}.
/FTId=PRO_0000248551.
DOMAIN 21 178 Ephrin RBD. {ECO:0000255|PROSITE-
ProRule:PRU00884}.
LIPID 329 329 GPI-anchor amidated serine.
{ECO:0000255}.
CARBOHYD 28 28 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 157 157 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 53 91 {ECO:0000255|PROSITE-ProRule:PRU00884}.
DISULFID 79 167 {ECO:0000255|PROSITE-ProRule:PRU00884}.
MUTAGEN 328 348 Missing: No defect in SDQL axon
migration. Restores SDQL axon migration
in a sup-17 (n316) mutant background.
{ECO:0000269|PubMed:26903502}.
SEQUENCE 348 AA; 39593 MW; 851E9EB07C0048FF CRC64;
MKQFFEFLIT TFLLLGLAAA DEHIVYWNST NSLFRNRQPT IEVRMGDVVR FVCPDNEEGR
NDGEYLIVYE VTEFAMDDCA LESHSREVIR CAPEGTAEKV LRTQQLSGGR REDWKKQKVP
PKNVAQLIRQ LNPIPNGKEY QPGQTYYYMT TSTGKANGTN HRMYGLCESQ NMRLSMKVSA
SQPHPTRRAP TRRQEDFVTT ASAELMGGQE DEDSDNDNAH LLPRDLEGST NPKFRRPSQL
ETAGVENQQF MKVVQMAQAG KTGTFENEKE AIAQKSSEKD GWHPVNVQYV ADLMNNAYQN
ADERISYQRD FEIHEENDLA VKSLEYSSSS TSLSTNFAIL LAVIYVLY
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Pathways :
WP2199: Seed Development
WP1049: G Protein Signaling Pathways
WP1165: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways
WP1438: Influenza A virus infection
WP1493: Carbon assimilation C4 pathway
WP1502: Mitochondrial biogenesis
WP1531: Vitamin D synthesis
WP1566: Citrate cycle (TCA cycle)
WP1613: 1,4-Dichlorobenzene degradation
WP1616: ABC transporters
WP1624: Bacterial secretion system
WP1625: Base excision repair
WP1644: DNA replication
WP1650: Fluorobenzoate degradation
WP1654: gamma-Hexachlorocyclohexane degradation
WP1657: Glycerolipid metabolism
WP1659: Glycine, serine and threonine metabolism
WP1661: Glyoxylate and dicarboxylate metabolism
WP1663: Homologous recombination
WP1665: Limonene and pinene degradation
WP1672: Mismatch repair
WP1673: Naphthalene and anthracene degradation
WP1675: Nitrogen metabolism
WP1676: Non-homologous end-joining
Related Genes :
[EFNA1 EPLG1 LERK1 TNFAIP4] Ephrin-A1 (EPH-related receptor tyrosine kinase ligand 1) (LERK-1) (Immediate early response protein B61) (Tumor necrosis factor alpha-induced protein 4) (TNF alpha-induced protein 4) [Cleaved into: Ephrin-A1, secreted form]
[EFNA4 EPLG4 LERK4] Ephrin-A4 (EPH-related receptor tyrosine kinase ligand 4) (LERK-4)
[EPHA3 ETK ETK1 HEK TYRO4] Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1)
[Epha3 Etk1 Mek4 Tyro4] Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (mEK4) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1)
[EPHA4 HEK8 SEK TYRO1] Ephrin type-A receptor 4 (EC 2.7.10.1) (EPH-like kinase 8) (EK8) (hEK8) (Tyrosine-protein kinase TYRO1) (Tyrosine-protein kinase receptor SEK)
[Epha4 Sek Sek1] Ephrin type-A receptor 4 (EC 2.7.10.1) (Tyrosine-protein kinase receptor MPK-3) (Tyrosine-protein kinase receptor SEK-1)
[EPHB4 HTK MYK1 TYRO11] Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11)
[EPHA3 CEK4 ETK1] Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (cEK4) (Tyrosine-protein kinase receptor ETK1)
[Ephb4 Htk Mdk2 Myk1] Ephrin type-B receptor 4 (EC 2.7.10.1) (Developmental kinase 2) (mDK-2) (Hepatoma transmembrane kinase) (Tyrosine kinase MYK-1)
[Efna1 Epgl1 Epl1 Lerk1] Ephrin-A1 (EPH-related receptor tyrosine kinase ligand 1) (LERK-1) (Immediate early response protein B61) [Cleaved into: Ephrin-A1, secreted form]
[EPHA4 CEK8] Ephrin type-A receptor 4 (EC 2.7.10.1) (EPH-like kinase 8) (EK8) (cEK8)
[Ephb3 Etk2 Mdk5 Sek4] Ephrin type-B receptor 3 (EC 2.7.10.1) (Developmental kinase 5) (mDK-5) (Tyrosine-protein kinase receptor SEK-4)
[efn-4 mab-26 F56A11.3] Ephrin-4 (Protein male abnormal 26)
[Epha3 Rek4 Tyro4] Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (rEK4) (Tyrosine-protein kinase TYRO4)
[Efna1 Epgl1 Lerk1] Ephrin-A1 (EPH-related receptor tyrosine kinase ligand 1) (LERK-1) (Immediate early response protein B61) [Cleaved into: Ephrin-A1, secreted form]
[EFNA1] Ephrin-A1 [Cleaved into: Ephrin-A1, secreted form]
[EPHA5 BSK EHK1 HEK7 TYRO4] Ephrin type-A receptor 5 (EC 2.7.10.1) (Brain-specific kinase) (EPH homology kinase 1) (EHK-1) (EPH-like kinase 7) (EK7) (hEK7)
[EPHA4 EGK_04837] EPH receptor A4 (Ephrin type-A receptor 4)
[EPHA4] EPH receptor A4 (Ephrin type-A receptor 4)
[EPHA4] Ephrin type-A receptor 4 precursor
[efna5b al1 efna5 eplg7 lerk7] Ephrin-A5b (AL-1) (EPH-related receptor tyrosine kinase ligand 7) (LERK-7) (ZfEPHL4)
[EFNB2 EPLG5 HTKL LERK5] Ephrin-B2 (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L)
[EPHA2 ECK] Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
[Efnb2 Elf2 Epl5 Eplg5 Htkl Lerk5] Ephrin-B2 (ELF-2) (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L)
[Ephb2 Epth3 Nuk Sek3] Ephrin type-B receptor 2 (EC 2.7.10.1) (Neural kinase) (Nuk receptor tyrosine kinase) (Tyrosine-protein kinase receptor EPH-3) (Tyrosine-protein kinase receptor SEK-3)
[Epha7 Ebk Ehk3 Mdk1] Ephrin type-A receptor 7 (EC 2.7.10.1) (Developmental kinase 1) (mDK-1) (EPH homology kinase 3) (EHK-3) (Embryonic brain kinase) (EBK)
[Epha2 Eck Myk2 Sek2] Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) (Tyrosine-protein kinase receptor MPK-5) (Tyrosine-protein kinase receptor SEK-2)
[Efna2 Elf1 Epl6 Eplg6 Lerk6] Ephrin-A2 (CEK7-ligand) (CEK7-L) (ELF-1) (EPH-related receptor tyrosine kinase ligand 6) (LERK-6)
[EPHB1 ELK EPHT2 HEK6 NET] Ephrin type-B receptor 1 (EC 2.7.10.1) (ELK) (EPH tyrosine kinase 2) (EPH-like kinase 6) (EK6) (hEK6) (Neuronally-expressed EPH-related tyrosine kinase) (NET) (Tyrosine-protein kinase receptor EPH-2)
[EPHB6] Ephrin type-B receptor 6 (HEP) (Tyrosine-protein kinase-defective receptor EPH-6)
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