Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Epidermal growth factor-like protein 7 (EGF-like protein 7) (Multiple epidermal growth factor-like domains protein 7) (Multiple EGF-like domains protein 7) (NOTCH4-like protein) (Vascular endothelial statin) (VE-statin) (Zneu1)

 EGFL7_MOUSE             Reviewed;         275 AA.
Q9QXT5; Q6XD35; Q9DCP5;
25-OCT-2004, integrated into UniProtKB/Swiss-Prot.
04-JAN-2005, sequence version 2.
07-NOV-2018, entry version 130.
RecName: Full=Epidermal growth factor-like protein 7;
Short=EGF-like protein 7;
AltName: Full=Multiple epidermal growth factor-like domains protein 7;
Short=Multiple EGF-like domains protein 7;
AltName: Full=NOTCH4-like protein;
AltName: Full=Vascular endothelial statin;
Short=VE-statin;
AltName: Full=Zneu1;
Flags: Precursor;
Name=Egfl7; Synonyms=Megf7;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR
LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
STRAIN=B6SJL;
PubMed=14592969; DOI=10.1093/emboj/cdg549;
Soncin F., Mattot V., Lionneton F., Spruyt N., Lepretre F., Begue A.,
Stehelin D.;
"VE-statin, an endothelial repressor of smooth muscle cell
migration.";
EMBO J. 22:5700-5711(2003).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE
SPECIFICITY, AND DEVELOPMENTAL STAGE.
STRAIN=CD-1;
PubMed=15162510; DOI=10.1002/dvdy.20063;
Fitch M.J., Campagnolo L., Kuhnert F., Stuhlmann H.;
"Egfl7, a novel epidermal growth factor-domain gene expressed in
endothelial cells.";
Dev. Dyn. 230:316-324(2004).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Sheppard P., Jelinek L., Whitmore T., Blumberg H., Lehner J.,
O'Hara P.;
Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
STRAIN=C57BL/6J; TISSUE=Kidney;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
STRAIN=FVB/N; TISSUE=Liver;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
FUNCTION.
PubMed=15085134; DOI=10.1038/nature02416;
Parker L.H., Schmidt M., Jin S.-W., Gray A.M., Beis D., Pham T.,
Frantz G., Palmieri S., Hillan K., Stainier D.Y.R., De Sauvage F.J.,
Ye W.;
"The endothelial-cell-derived secreted factor Egfl7 regulates vascular
tube formation.";
Nature 428:754-758(2004).
-!- FUNCTION: Regulates vascular tubulogenesis in vivo. Inhibits
platelet-derived growth factor (PDGF)-BB-induced smooth muscle
cell migration and promotes endothelial cell adhesion to the
extracellular matrix and angiogenesis.
{ECO:0000269|PubMed:14592969, ECO:0000269|PubMed:15085134}.
-!- SUBUNIT: Interacts with ITGAV/ITGB3 in an RGD-dependent manner,
increasing endothelial cell's motility. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted, extracellular space
{ECO:0000269|PubMed:14592969, ECO:0000269|PubMed:15162510}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q9QXT5-1; Sequence=Displayed;
Name=2;
IsoId=Q9QXT5-2; Sequence=VSP_011765;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Expressed specifically by endothelial cells of
the highly vascularized organs heart, lung and kidney.
{ECO:0000269|PubMed:14592969, ECO:0000269|PubMed:15162510}.
-!- DEVELOPMENTAL STAGE: Expressed early during mouse embryogenesis in
the yolk sac mesoderm and in the developing vascular system. At
E7.5, it is expressed in the primitive blood islands where the
first endothelial cells differentiate. At E10.5 and E13.5
expression is restricted to endothelial cells.
{ECO:0000269|PubMed:14592969, ECO:0000269|PubMed:15162510}.
-!- SEQUENCE CAUTION:
Sequence=AAF01322.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=AAP74732.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=BAB22222.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AY239289; AAP69825.1; -; mRNA.
EMBL; AY239290; AAP69826.1; -; mRNA.
EMBL; AY309459; AAP74732.1; ALT_INIT; mRNA.
EMBL; AF184973; AAF01322.1; ALT_INIT; mRNA.
EMBL; AK002601; BAB22222.1; ALT_INIT; mRNA.
EMBL; BC024610; AAH24610.2; -; mRNA.
RefSeq; NP_001158036.1; NM_001164564.1.
RefSeq; NP_848538.3; NM_178444.4.
RefSeq; NP_942017.2; NM_198724.2.
RefSeq; NP_942018.2; NM_198725.2.
UniGene; Mm.268933; -.
ProteinModelPortal; Q9QXT5; -.
SMR; Q9QXT5; -.
BioGrid; 237257; 4.
IntAct; Q9QXT5; 5.
MINT; Q9QXT5; -.
STRING; 10090.ENSMUSP00000099971; -.
iPTMnet; Q9QXT5; -.
PhosphoSitePlus; Q9QXT5; -.
PaxDb; Q9QXT5; -.
PRIDE; Q9QXT5; -.
GeneID; 353156; -.
KEGG; mmu:353156; -.
UCSC; uc008ivq.2; mouse. [Q9QXT5-2]
CTD; 51162; -.
MGI; MGI:2449923; Egfl7.
eggNOG; KOG1217; Eukaryota.
eggNOG; ENOG410XP6K; LUCA.
HOGENOM; HOG000231494; -.
HOVERGEN; HBG051453; -.
InParanoid; Q9QXT5; -.
PRO; PR:Q9QXT5; -.
Proteomes; UP000000589; Unplaced.
CleanEx; MM_EGFL7; -.
GO; GO:0009986; C:cell surface; IBA:GO_Central.
GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL.
GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
GO; GO:0005615; C:extracellular space; IDA:MGI.
GO; GO:0005509; F:calcium ion binding; NAS:UniProtKB.
GO; GO:0005112; F:Notch binding; IPI:MGI.
GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
GO; GO:0001568; P:blood vessel development; IEP:UniProtKB.
GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
GO; GO:0030336; P:negative regulation of cell migration; IDA:MGI.
GO; GO:0045746; P:negative regulation of Notch signaling pathway; ISO:MGI.
GO; GO:0001938; P:positive regulation of endothelial cell proliferation; ISO:MGI.
GO; GO:0030334; P:regulation of cell migration; TAS:UniProtKB.
GO; GO:0001570; P:vasculogenesis; IEP:UniProtKB.
InterPro; IPR001881; EGF-like_Ca-bd_dom.
InterPro; IPR013032; EGF-like_CS.
InterPro; IPR000742; EGF-like_dom.
InterPro; IPR018097; EGF_Ca-bd_CS.
InterPro; IPR011489; EMI_domain.
Pfam; PF07645; EGF_CA; 1.
Pfam; PF07546; EMI; 1.
SMART; SM00181; EGF; 2.
SMART; SM00179; EGF_CA; 1.
PROSITE; PS00022; EGF_1; 1.
PROSITE; PS01186; EGF_2; 1.
PROSITE; PS50026; EGF_3; 1.
PROSITE; PS01187; EGF_CA; 1.
PROSITE; PS51041; EMI; 1.
2: Evidence at transcript level;
Alternative splicing; Angiogenesis; Calcium; Cell adhesion;
Coiled coil; Complete proteome; Developmental protein;
Differentiation; Disulfide bond; EGF-like domain; Reference proteome;
Repeat; Secreted; Signal.
SIGNAL 1 21 {ECO:0000255}.
CHAIN 22 275 Epidermal growth factor-like protein 7.
/FTId=PRO_0000007529.
DOMAIN 28 105 EMI. {ECO:0000255|PROSITE-
ProRule:PRU00384}.
DOMAIN 104 136 EGF-like 1. {ECO:0000255|PROSITE-
ProRule:PRU00076}.
DOMAIN 138 178 EGF-like 2; calcium-binding.
{ECO:0000255|PROSITE-ProRule:PRU00076}.
COILED 196 220 {ECO:0000255}.
MOTIF 131 133 Cell attachment site. {ECO:0000250}.
DISULFID 32 90 {ECO:0000250}.
DISULFID 57 63 {ECO:0000250}.
DISULFID 89 103 {ECO:0000250}.
DISULFID 108 118 {ECO:0000250}.
DISULFID 112 124 {ECO:0000250}.
DISULFID 126 135 {ECO:0000250}.
DISULFID 142 153 {ECO:0000250}.
DISULFID 149 162 {ECO:0000250}.
VAR_SEQ 257 269 Missing (in isoform 2).
{ECO:0000303|PubMed:16141072}.
/FTId=VSP_011765.
SEQUENCE 275 AA; 29765 MW; 54A888CB51CFAA13 CRC64;
MWGSGELLVA WFLVLAADGT TEHVYRPSRR VCTVGISGGS ISETFVQRVY QPYLTTCDGH
RACSTYRTIY RTAYRRSPGV TPARPRYACC PGWKRTSGLP GACGAAICQP PCGNGGSCIR
PGHCRCPVGW QGDTCQTDVD ECSTGEASCP QRCVNTVGSY WCQGWEGQSP SADGTRCLSK
EGPSPVAPNP TAGVDSMARE EVYRLQARVD VLEQKLQLVL APLHSLASRS TEHGLQDPGS
LLAHSFQQLD RIDSLSEQVS FLEEHLGSCS CKKDL


Related products :

Catalog number Product name Quantity
EIAAB12605 EGFL7,EGF-like protein 7,Epidermal growth factor-like protein 7,Homo sapiens,Human,MEGF7,Multiple EGF-like domains protein 7,Multiple epidermal growth factor-like domains protein 7,NOTCH4-like protein
EIAAB12603 Egfl7,EGF-like protein 7,Epidermal growth factor-like protein 7,Megf7,Mouse,Multiple EGF-like domains protein 7,Multiple epidermal growth factor-like domains protein 7,Mus musculus,NOTCH4-like protein
18-003-43746 EGF-like domain-containing protein 8 - Epidermal growth factor-like protein 8; Multiple EGF-like domain protein 8; Vascular endothelial-statin 2; VE-statin-2 Polyclonal 0.1 mg Protein A
EIAAB12604 Cbl20,Egfl7,EGF-like protein 7,Epidermal growth factor-like protein 7,Megf7,Multiple EGF-like domains protein 7,Multiple epidermal growth factor-like domains protein 7,Rat,Rattus norvegicus
EIAAB30506 Jagged and Delta protein,Jedi,Megf12,Mouse,mPEAR1,Multiple EGF-like domains protein 12,Multiple epidermal growth factor-like domains protein 12,Mus musculus,Pear1,Platelet endothelial aggregation rece
EIAAB12608 C6orf8,EGFL8,EGF-like protein 8,Epidermal growth factor-like protein 8,Homo sapiens,Human,NG3,UNQ8752_PRO29920,Vascular endothelial statin-2,VE-statin-2
EIAAB30505 Homo sapiens,hPEAR1,Human,MEGF12,Multiple EGF-like domains protein 12,Multiple epidermal growth factor-like domains protein 12,PEAR1,Platelet endothelial aggregation receptor 1
EIAAB14453 Fat2,Fath2,Megf1,Multiple EGF-like domains protein 1,Multiple epidermal growth factor-like domains protein 1,Protocadherin Fat 2,Rat,Rattus norvegicus
EIAAB06748 Cadherin EGF LAG seven-pass G-type receptor 2,Celsr2,Megf3,Multiple EGF-like domains protein 3,Multiple epidermal growth factor-like domains protein 3,Rat,Rattus norvegicus
EIAAB06751 Cadherin EGF LAG seven-pass G-type receptor 3,Celsr3,Megf2,Multiple EGF-like domains protein 2,Multiple epidermal growth factor-like domains protein 2,Rat,Rattus norvegicus
EIAAB14452 Cadherin family member 8,CDHF8,FAT2,hFat2,Homo sapiens,Human,KIAA0811,MEGF1,Multiple EGF-like domains protein 1,Multiple epidermal growth factor-like domains protein 1,Protocadherin Fat 2
EIAAB38673 Homo sapiens,Human,KIAA0814,MEGF5,Multiple EGF-like domains protein 5,Multiple epidermal growth factor-like domains protein 5,SLIL2,Slit homolog 3 protein,SLIT3,Slit-3,UNQ691_PRO1336
EIAAB38670 Homo sapiens,Human,KIAA0813,MEGF4,Multiple EGF-like domains protein 4,Multiple epidermal growth factor-like domains protein 4,SLIL1,Slit homolog 1 protein,SLIT1,Slit-1
EIAAB38671 Megf4,Multiple EGF-like domains protein 4,Multiple epidermal growth factor-like domains protein 4,Rat,Rattus norvegicus,Slit homolog 1 protein,Slit1,Slit-1
EIAAB38674 Megf5,Multiple EGF-like domains protein 5,Multiple epidermal growth factor-like domains protein 5,Rat,Rattus norvegicus,Slit homolog 3 protein,Slit3,Slit-3
102-PA14 VE-Statin_EGFL-7 Anti-Human Host: Rabbit EGFL7; NEU1; ZNEU1; VE-STATIN; RP11-251M1.2; NOTCH4-like protein; Vascular endothelial statin 200
102-PA16 VE-Statin_EGFL-7 Anti-Human Host: Rabbit EGFL7; NEU1; ZNEU1; VE-STATIN; RP11-251M1.2; NOTCH4-like protein; Vascular endothelial statin 200
102-PA16S VE-Statin_EGFL-7 Anti-Human Host: Rabbit EGFL7; NEU1; ZNEU1; VE-STATIN; RP11-251M1.2; NOTCH4-like protein; Vascular endothelial statin 100
102-PA15 VE-Statin_EGFL-7 Anti-Human Host: Rabbit EGFL7; NEU1; ZNEU1; VE-STATIN; RP11-251M1.2; NOTCH4-like protein; Vascular endothelial statin 200
102-PA15S VE-Statin_EGFL-7 Anti-Human Host: Rabbit EGFL7; NEU1; ZNEU1; VE-STATIN; RP11-251M1.2; NOTCH4-like protein; Vascular endothelial statin 100
102-PA14S VE-Statin_EGFL-7 Anti-Human Host: Rabbit EGFL7; NEU1; ZNEU1; VE-STATIN; RP11-251M1.2; NOTCH4-like protein; Vascular endothelial statin 100
E0590Ge Rat ELISA Kit FOR Multiple epidermal growth factor-like domains protein 8 96T
TRM2A_MOUSE Rat ELISA Kit FOR Multiple epidermal growth factor-like domains protein 8 96T
TRPC7_MOUSE Mouse ELISA Kit FOR Multiple epidermal growth factor-like domains protein 11 96T
TRI25_HUMAN Human ELISA Kit FOR Multiple epidermal growth factor-like domains protein 6 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: +49 0241 40 08 90 86, +49 0241 95 78 94 78, +49 0241 40 08 90 86
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur