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Epididymal-specific lipocalin-5 (Epididymal retinoic acid-binding protein) (E-RABP) (mE-RABP) (Epididymal secretory protein 10) (MEP 10) [Cleaved into: Epididymal-specific lipocalin-5, major form; Epididymal-specific lipocalin-5, minor form]

 LCN5_MOUSE              Reviewed;         192 AA.
A2AJB7; O88787; Q3TS05; Q3UW42; Q9R2C6;
10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
20-FEB-2007, sequence version 1.
28-FEB-2018, entry version 82.
RecName: Full=Epididymal-specific lipocalin-5;
AltName: Full=Epididymal retinoic acid-binding protein;
Short=E-RABP;
Short=mE-RABP;
AltName: Full=Epididymal secretory protein 10;
Short=MEP 10;
Contains:
RecName: Full=Epididymal-specific lipocalin-5, major form;
Contains:
RecName: Full=Epididymal-specific lipocalin-5, minor form;
Flags: Precursor;
Name=Lcn5 {ECO:0000312|MGI:MGI:1277241};
Synonyms=Mep10 {ECO:0000312|EMBL:AAD09351.1};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1] {ECO:0000305, ECO:0000312|EMBL:AAC24316.1}
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), AND INDUCTION.
STRAIN=SWR/J {ECO:0000269|PubMed:9607808};
PubMed=9607808; DOI=10.1210/endo.139.6.6074;
Lareyre J.-J., Zheng W.-L., Zhao G.-Q., Kasper S., Newcomer M.E.,
Matusik R.J., Ong D.E., Orgebin-Crist M.-C.;
"Molecular cloning and hormonal regulation of a murine epididymal
retinoic acid-binding protein messenger ribonucleic acid.";
Endocrinology 139:2971-2981(1998).
[2] {ECO:0000305, ECO:0000312|EMBL:AAD09351.1}
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ALTERNATIVE SPLICING (ISOFORM
1).
STRAIN=129 {ECO:0000312|EMBL:AAD09351.1};
PubMed=9669522;
DOI=10.1002/(SICI)1098-2795(199808)50:4<387::AID-MRD2>3.0.CO;2-E;
Lareyre J.-J., Mattei M.-G., Kasper S., Ong D.E., Matusik R.J.,
Orgebin-Crist M.-C.;
"Genomic organization and chromosomal localization of the murine
epididymal retinoic acid-binding protein (mE-RABP) gene.";
Mol. Reprod. Dev. 50:387-395(1998).
[3] {ECO:0000305, ECO:0000312|EMBL:BAE23077.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
STRAIN=C57BL/6J {ECO:0000312|EMBL:BAE23077.1};
TISSUE=Epididymis {ECO:0000312|EMBL:BAE23077.1};
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[5] {ECO:0000305}
PROTEIN SEQUENCE OF 27-39, FUNCTION, AND SUBCELLULAR LOCATION.
STRAIN=C57BL/6J {ECO:0000269|PubMed:1591332};
PubMed=1591332; DOI=10.1095/biolreprod46.5.747;
Rankin T.L., Tsuruta K.J., Holland M.K., Griswold M.D.,
Orgebin-Crist M.-C.;
"Isolation, immunolocalization, and sperm-association of three
proteins of 18, 25, and 29 kilodaltons secreted by the mouse
epididymis.";
Biol. Reprod. 46:747-766(1992).
[6] {ECO:0000305}
SUBCELLULAR LOCATION.
PubMed=2393684; DOI=10.1095/biolreprod43.1.113;
Vreeburg J.T.M., Holland M.K., Cornwall G.A., Orgebin-Crist M.-C.;
"Secretion and transport of mouse epididymal proteins after injection
of 35S-methionine.";
Biol. Reprod. 43:113-120(1990).
[7] {ECO:0000305}
FUNCTION.
PubMed=1591333; DOI=10.1095/biolreprod46.5.767;
Rankin T.L., Ong D.E., Orgebin-Crist M.-C.;
"The 18-kDa mouse epididymal protein (MEP 10) binds retinoic acid.";
Biol. Reprod. 46:767-771(1992).
[8] {ECO:0000305}
TISSUE SPECIFICITY.
PubMed=14595821; DOI=10.1002/pmic.200300474;
Chaurand P., Fouchecourt S., DaGue B.B., Xu B.J., Reyzer M.L.,
Orgebin-Crist M.-C., Caprioli R.M.;
"Profiling and imaging proteins in the mouse epididymis by imaging
mass spectrometry.";
Proteomics 3:2221-2239(2003).
-!- FUNCTION: Associates with spermatozoa in the epididymal fluid but
does not bind tightly to them. Binds both all-trans and 13-cis
retinoic acid. May act as a retinoid carrier protein which is
required for epididymal function and/or sperm maturation.
{ECO:0000269|PubMed:1591332, ECO:0000269|PubMed:1591333}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1591332,
ECO:0000269|PubMed:2393684}. Note=Synthesized by the mid and
distal caput of the epididymis and secreted into the epididymal
lumen. {ECO:0000269|PubMed:1591332, ECO:0000269|PubMed:2393684}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=4;
Name=1 {ECO:0000269|PubMed:9669522};
IsoId=A2AJB7-1; Sequence=Displayed;
Name=2 {ECO:0000269|PubMed:16141072};
IsoId=A2AJB7-2; Sequence=VSP_052839;
Note=No experimental confirmation available. {ECO:0000305};
Name=3 {ECO:0000269|PubMed:16141072};
IsoId=A2AJB7-3; Sequence=VSP_052840;
Note=No experimental confirmation available. {ECO:0000305};
Name=4 {ECO:0000269|PubMed:9607808};
IsoId=A2AJB7-4; Sequence=VSP_052838;
-!- TISSUE SPECIFICITY: Epididymal fluid of the caudal and corpus
regions (at protein level). {ECO:0000269|PubMed:14595821}.
-!- INDUCTION: Down-regulated to 11% of control levels 5 days after
castration and is not detectable by 20 days (at protein level).
Levels are partially restored by subsequent testosterone
treatment. {ECO:0000269|PubMed:9607808}.
-!- PTM: 2 different forms with differently processed N-termini exist.
-!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
{ECO:0000255}.
-!- SEQUENCE CAUTION:
Sequence=AAD09351.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; U68546; AAC24316.1; -; mRNA.
EMBL; U68381; AAD09351.1; ALT_INIT; Genomic_DNA.
EMBL; AK136629; BAE23077.1; -; mRNA.
EMBL; AK162355; BAE36871.1; -; mRNA.
EMBL; AL732590; CAM25179.1; -; Genomic_DNA.
EMBL; AL732590; CAM25180.1; -; Genomic_DNA.
EMBL; AL732590; CAM25181.1; -; Genomic_DNA.
CCDS; CCDS38078.1; -. [A2AJB7-3]
CCDS; CCDS38079.1; -. [A2AJB7-1]
CCDS; CCDS71003.1; -. [A2AJB7-2]
RefSeq; NP_001036095.1; NM_001042630.2. [A2AJB7-3]
RefSeq; NP_001263186.1; NM_001276257.1. [A2AJB7-2]
RefSeq; NP_031973.2; NM_007947.3. [A2AJB7-1]
UniGene; Mm.12867; -.
ProteinModelPortal; A2AJB7; -.
SMR; A2AJB7; -.
STRING; 10090.ENSMUSP00000028306; -.
PhosphoSitePlus; A2AJB7; -.
PaxDb; A2AJB7; -.
PRIDE; A2AJB7; -.
DNASU; 13863; -.
Ensembl; ENSMUST00000028306; ENSMUSP00000028306; ENSMUSG00000026937. [A2AJB7-1]
Ensembl; ENSMUST00000100312; ENSMUSP00000097887; ENSMUSG00000026937. [A2AJB7-2]
Ensembl; ENSMUST00000100313; ENSMUSP00000097888; ENSMUSG00000026937. [A2AJB7-3]
GeneID; 13863; -.
KEGG; mmu:13863; -.
UCSC; uc008itb.2; mouse. [A2AJB7-1]
UCSC; uc033hlx.1; mouse. [A2AJB7-2]
CTD; 13863; -.
MGI; MGI:1277241; Lcn5.
eggNOG; ENOG410J0UJ; Eukaryota.
eggNOG; ENOG411140G; LUCA.
GeneTree; ENSGT00900000141601; -.
HOGENOM; HOG000113294; -.
HOVERGEN; HBG096015; -.
InParanoid; A2AJB7; -.
OMA; MGAMVVE; -.
OrthoDB; EOG091G0SHZ; -.
PhylomeDB; A2AJB7; -.
TreeFam; TF336103; -.
PRO; PR:A2AJB7; -.
Proteomes; UP000000589; Chromosome 2.
Bgee; ENSMUSG00000026937; -.
Genevisible; A2AJB7; MM.
GO; GO:0005615; C:extracellular space; TAS:MGI.
GO; GO:0005501; F:retinoid binding; TAS:MGI.
GO; GO:0036094; F:small molecule binding; IEA:InterPro.
GO; GO:0042573; P:retinoic acid metabolic process; TAS:MGI.
Gene3D; 2.40.128.20; -; 1.
InterPro; IPR012674; Calycin.
InterPro; IPR002345; Lipocalin.
InterPro; IPR022272; Lipocalin_CS.
InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
PANTHER; PTHR11430; PTHR11430; 1.
Pfam; PF00061; Lipocalin; 1.
SUPFAM; SSF50814; SSF50814; 1.
PROSITE; PS00213; LIPOCALIN; 1.
1: Evidence at protein level;
Alternative splicing; Complete proteome; Direct protein sequencing;
Disulfide bond; Reference proteome; Secreted; Signal; Transport.
SIGNAL 1 26 {ECO:0000269|PubMed:1591332}.
CHAIN 27 192 Epididymal-specific lipocalin-5, major
form. {ECO:0000269|PubMed:1591332}.
/FTId=PRO_0000339292.
CHAIN 30 192 Epididymal-specific lipocalin-5, minor
form. {ECO:0000269|PubMed:1591332}.
/FTId=PRO_0000339293.
DISULFID 89 183 {ECO:0000250|UniProtKB:P06911}.
VAR_SEQ 1 29 MCSVARHMESIMLFTLLGLCVGLAAGTEA -> M (in
isoform 4). {ECO:0000303|PubMed:9607808}.
/FTId=VSP_052838.
VAR_SEQ 181 192 LTCVNALQSGQI -> YIEIKALPKPGS (in isoform
2). {ECO:0000303|PubMed:16141072}.
/FTId=VSP_052839.
VAR_SEQ 181 192 Missing (in isoform 3).
{ECO:0000303|PubMed:16141072}.
/FTId=VSP_052840.
SEQUENCE 192 AA; 21013 MW; E91DA019DEF21F5B CRC64;
MCSVARHMES IMLFTLLGLC VGLAAGTEAA VVKDFDVNKF LGFWYEIALA SKMGAYGLAH
KEEKMGAMVV ELKENLLALT TTYYNEGHCV LEKVAATQVD GSAKYKVTRI SGEKEVVVVA
TDYMTYTVID ITSLVAGAVH RAMKLYSRSL DNNGEALNNF QKIALKHGFS ETDIHILKHD
LTCVNALQSG QI


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