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Epithelial cell adhesion molecule (Ep-CAM) (Epithelial glycoprotein 314) (EGP314) (mEGP314) (Protein 289A) (Tumor-associated calcium signal transducer 1) (CD antigen CD326)

 EPCAM_MOUSE             Reviewed;         315 AA.
Q99JW5; Q61512;
28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
01-JUN-2001, sequence version 1.
07-NOV-2018, entry version 123.
RecName: Full=Epithelial cell adhesion molecule;
Short=Ep-CAM;
AltName: Full=Epithelial glycoprotein 314;
Short=EGP314;
Short=mEGP314;
AltName: Full=Protein 289A;
AltName: Full=Tumor-associated calcium signal transducer 1;
AltName: CD_antigen=CD326;
Flags: Precursor;
Name=Epcam; Synonyms=Tacstd1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1729376;
Bergsagel P.L., Victor-Kobrin C., Timblin C.R., Trepel J., Kuehl W.M.;
"A murine cDNA encodes a pan-epithelial glycoprotein that is also
expressed on plasma cells.";
J. Immunol. 148:590-596(1992).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N; TISSUE=Mammary tumor;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Kidney, Lung, Pancreas, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: May act as a physical homophilic interaction molecule
between intestinal epithelial cells (IECs) and intraepithelial
lymphocytes (IELs) at the mucosal epithelium for providing
immunological barrier as a first line of defense against mucosal
infection. Plays a role in embryonic stem cells proliferation and
differentiation. Up-regulates the expression of FABP5, MYC and
cyclins A and E (By similarity). {ECO:0000250}.
-!- SUBUNIT: Monomer. Interacts with phosphorylated CLDN7 (By
similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Lateral cell membrane
{ECO:0000250|UniProtKB:P16422}; Single-pass type I membrane
protein {ECO:0000250|UniProtKB:P16422}. Cell junction, tight
junction {ECO:0000250|UniProtKB:P16422}. Note=Colocalizes with
CLDN7 at the lateral cell membrane and tight junction.
{ECO:0000250|UniProtKB:P16422}.
-!- PTM: Glycosylation at Asn-198 is crucial for protein stability.
{ECO:0000250}.
-!- SIMILARITY: Belongs to the EPCAM family. {ECO:0000305}.
-----------------------------------------------------------------------
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-----------------------------------------------------------------------
EMBL; M76124; AAA37543.1; -; mRNA.
EMBL; AK145752; BAE26627.1; -; mRNA.
EMBL; AK167182; BAE39317.1; -; mRNA.
EMBL; BC005618; AAH05618.1; -; mRNA.
EMBL; BC094465; AAH94465.1; -; mRNA.
CCDS; CCDS29018.1; -.
RefSeq; NP_032558.2; NM_008532.2.
UniGene; Mm.4259; -.
ProteinModelPortal; Q99JW5; -.
SMR; Q99JW5; -.
IntAct; Q99JW5; 3.
STRING; 10090.ENSMUSP00000061935; -.
iPTMnet; Q99JW5; -.
PhosphoSitePlus; Q99JW5; -.
MaxQB; Q99JW5; -.
PaxDb; Q99JW5; -.
PeptideAtlas; Q99JW5; -.
PRIDE; Q99JW5; -.
Ensembl; ENSMUST00000053577; ENSMUSP00000061935; ENSMUSG00000045394.
GeneID; 17075; -.
KEGG; mmu:17075; -.
UCSC; uc008duy.1; mouse.
CTD; 4072; -.
MGI; MGI:106653; Epcam.
eggNOG; ENOG410IFI6; Eukaryota.
eggNOG; ENOG4111M3B; LUCA.
GeneTree; ENSGT00390000018245; -.
HOGENOM; HOG000074086; -.
InParanoid; Q99JW5; -.
KO; K06737; -.
OMA; REKPYDV; -.
OrthoDB; EOG091G0G1E; -.
PhylomeDB; Q99JW5; -.
TreeFam; TF332767; -.
Reactome; R-MMU-202733; Cell surface interactions at the vascular wall.
PRO; PR:Q99JW5; -.
Proteomes; UP000000589; Chromosome 17.
Bgee; ENSMUSG00000045394; Expressed in 247 organ(s), highest expression level in intestine.
Genevisible; Q99JW5; MM.
GO; GO:0016324; C:apical plasma membrane; ISS:MGI.
GO; GO:0016323; C:basolateral plasma membrane; ISS:MGI.
GO; GO:0005923; C:bicellular tight junction; ISS:UniProtKB.
GO; GO:0009986; C:cell surface; IDA:MGI.
GO; GO:0016021; C:integral component of membrane; ISO:MGI.
GO; GO:0016328; C:lateral plasma membrane; ISS:UniProtKB.
GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO; GO:0098641; F:cadherin binding involved in cell-cell adhesion; ISO:MGI.
GO; GO:0044877; F:protein-containing complex binding; ISO:MGI.
GO; GO:0098742; P:cell-cell adhesion via plasma-membrane adhesion molecules; ISO:MGI.
GO; GO:0043066; P:negative regulation of apoptotic process; ISO:MGI.
GO; GO:2000048; P:negative regulation of cell-cell adhesion mediated by cadherin; ISO:MGI.
GO; GO:2000147; P:positive regulation of cell motility; ISO:MGI.
GO; GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.
GO; GO:2000648; P:positive regulation of stem cell proliferation; ISO:MGI.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
GO; GO:0023019; P:signal transduction involved in regulation of gene expression; ISO:MGI.
GO; GO:0048863; P:stem cell differentiation; ISO:MGI.
GO; GO:0001657; P:ureteric bud development; IEP:UniProtKB.
CDD; cd00191; TY; 1.
Gene3D; 4.10.800.10; -; 1.
InterPro; IPR000716; Thyroglobulin_1.
InterPro; IPR036857; Thyroglobulin_1_sf.
Pfam; PF00086; Thyroglobulin_1; 1.
SMART; SM00211; TY; 1.
SUPFAM; SSF57610; SSF57610; 1.
PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
1: Evidence at protein level;
Cell junction; Cell membrane; Complete proteome; Disulfide bond;
Glycoprotein; Membrane; Reference proteome; Repeat; Signal;
Tight junction; Transmembrane; Transmembrane helix.
SIGNAL 1 23 {ECO:0000255}.
CHAIN 24 315 Epithelial cell adhesion molecule.
/FTId=PRO_0000380183.
TOPO_DOM 24 266 Extracellular. {ECO:0000255}.
TRANSMEM 267 289 Helical. {ECO:0000255}.
TOPO_DOM 290 315 Cytoplasmic. {ECO:0000255}.
DOMAIN 63 135 Thyroglobulin type-1.
{ECO:0000255|PROSITE-ProRule:PRU00500}.
CARBOHYD 111 111 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 198 198 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 27 46 {ECO:0000255|PROSITE-ProRule:PRU00500}.
DISULFID 29 59 {ECO:0000255|PROSITE-ProRule:PRU00500}.
DISULFID 38 48 {ECO:0000255|PROSITE-ProRule:PRU00500}.
DISULFID 66 99 {ECO:0000255|PROSITE-ProRule:PRU00500}.
DISULFID 110 116 {ECO:0000255|PROSITE-ProRule:PRU00500}.
DISULFID 118 135 {ECO:0000255|PROSITE-ProRule:PRU00500}.
CONFLICT 87 87 Missing (in Ref. 1; AAA37543).
{ECO:0000305}.
SEQUENCE 315 AA; 35019 MW; FDA853E165BA8906 CRC64;
MAGPQALAFG LLLAVVTATL AAAQRDCVCD NYKLATSCSL NEYGECQCTS YGTQNTVICS
KLASKCLAMK AEMTHSKSGR RIKPEGAIQN NDGLYDPDCD EQGLFKAKQC NGTATCWCVN
TAGVRRTDKD TEITCSERVR TYWIIIELKH KERESPYDHQ SLQTALQEAF TSRYKLNQKF
IKNIMYENNV ITIDLMQNSS QKTQDDVDIA DVAYYFEKDV KGESLFHSSK SMDLRVNGEP
LDLDPGQTLI YYVDEKAPEF SMQGLTAGII AVIVVVSLAV IAGIVVLVIS TRKKSAKYEK
AEIKEMGEIH RELNA


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