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Epithiospecifier protein (AtESP) (Protein EPITHIOSPECIFYING SENESCENCE REGULATOR) (AtESR)

 ESP_ARATH               Reviewed;         341 AA.
Q8RY71; B0LYN4; B0LYN5; B0LYN6; B0LYN7; B0LYN8; B0LYP0; B0LYP2;
B0LYP4; B0LYP6; B0LYS4; B0LYT0; B0LYT3; B0LYT8; B0LYT9; B0LYU6;
B0LYU8; B0LYV4; B0LYW2; B0LYW3; B0LYW5; B0LYW7; B0LYX3; B0LYX4;
B0LYX6; B0LYX7; Q39104; Q93VB6; Q9SYG0;
10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
10-FEB-2009, sequence version 2.
25-OCT-2017, entry version 99.
RecName: Full=Epithiospecifier protein;
Short=AtESP;
AltName: Full=Protein EPITHIOSPECIFYING SENESCENCE REGULATOR;
Short=AtESR;
Name=ESP; Synonyms=ESR, TASTY; OrderedLocusNames=At1g54040;
ORFNames=F15I1.12;
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=cv. C24;
Quigley F.R.;
Submitted (MAY-1993) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND POLYMORPHISM.
STRAIN=cv. Columbia, cv. Da(1)-12, cv. Ei-2, cv. Landsberg erecta,
cv. Ru-0, and cv. Tac-0;
PubMed=11752388; DOI=10.1105/tpc.13.12.2793;
Lambrix V., Reichelt M., Mitchell-Olds T., Kliebenstein D.J.,
Gershenzon J.;
"The Arabidopsis epithiospecifier protein promotes the hydrolysis of
glucosinolates to nitriles and influences Trichoplusia ni herbivory.";
Plant Cell 13:2793-2807(2001).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=11130712; DOI=10.1038/35048500;
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S.,
White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y.,
Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W.,
Chung M.K., Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K.,
Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y.,
Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L.,
Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E.,
Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B.,
Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P.,
Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A.,
Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I.,
Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D.,
Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M.,
Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M.,
Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.;
"Sequence and analysis of chromosome 1 of the plant Arabidopsis
thaliana.";
Nature 408:816-820(2000).
[4]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
The Arabidopsis Information Portal (Araport);
Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
STRAIN=cv. Columbia;
PubMed=14593172; DOI=10.1126/science.1088305;
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis
genome.";
Science 302:842-846(2003).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
STRAIN=cv. Columbia;
De Los Reyes C., Quan R., Chen H., Bautista V.R., Kim C.J.,
Ecker J.R.;
"Arabidopsis ORF clones.";
Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 99-312, AND POLYMORPHISM.
STRAIN=cv. Ag-0, cv. An-1, cv. Bay-0, cv. Bil-5, cv. Bil-7, cv. Bor-1,
cv. Bor-4, cv. Br-0, cv. Bur-0, cv. C24, cv. CIBC-17, cv. CIBC-5,
cv. Columbia, cv. Ct-1, cv. Cvi-0, cv. Ed-1, cv. Ed-2, cv. Edi-0,
cv. Ei-2, cv. Fab-2, cv. Fab-4, cv. Fei-0, cv. Ga-0,
cv. Goettingen-22, cv. Goettingen-7, cv. Gu-0, cv. Gy-0, cv. HR-10,
cv. HR-5, cv. Kas-2, cv. Kin-0, cv. KNO-10, cv. KNO-18, cv. Kon,
cv. KZ-1, cv. KZ-9, cv. Ler-1, cv. Ll-0, cv. Lov-1, cv. Lov-5,
cv. Lp2-2, cv. Lp2-6, cv. Lz-0, cv. Mr-0, cv. Mrk-0, cv. Ms-0,
cv. Mt-0, cv. N13 Konchezero, cv. Nd-1, cv. NFA-10, cv. NFA-8,
cv. Nok-3, cv. Omo2-1, cv. Omo2-3, cv. Oy-0, cv. Pna-10, cv. Pna-17,
cv. Pro-0, cv. Pu2-23, cv. Pu2-7, cv. Ra-0, cv. REN-1, cv. REN-11,
cv. Rmx-A02, cv. Rmx-A180, cv. RRS-10, cv. RRS-7, cv. Se-0, cv. Sha,
cv. Sorbo, cv. Spr1-2, cv. Spr1-6, cv. Sq-1, cv. Sq-8, cv. Tamm-2,
cv. Tamm-27, cv. Ts-1, cv. Ts-5, cv. Tsu-1, cv. Ull2-3, cv. Ull2-5,
cv. Uod-1, cv. Uod-7, cv. Van-0, cv. Var2-1, cv. Var2-6, cv. Wa-1,
cv. Wassilewskija, cv. Wassilewskija-2, cv. Wei-0, cv. Wt-5, cv. Yo-0,
cv. Zdr-1, and cv. Zdr-6;
PubMed=18245336; DOI=10.1534/genetics.107.083279;
Bakker E.G., Traw M.B., Toomajian C., Kreitman M., Bergelson J.;
"Low levels of polymorphism in genes that control the activation of
defense response in Arabidopsis thaliana.";
Genetics 178:2031-2043(2008).
[8]
INDUCTION BY JASMONATE.
PubMed=13677466; DOI=10.1023/A:1025045217859;
Mandaokar A., Kumar V.D., Amway M., Browse J.;
"Microarray and differential display identify genes involved in
jasmonate-dependent anther development.";
Plant Mol. Biol. 52:775-786(2003).
[9]
FUNCTION, AND POLYMORPHISM.
STRAIN=cv. Columbia, and cv. Ei-2;
PubMed=15845404; DOI=10.1016/j.phytochem.2005.02.026;
de Torres-Zabala M., Grant M., Bones A.M., Bennett R., Lim Y.S.,
Kissen R., Rossiter J.T.;
"Characterisation of recombinant epithiospecifier protein and its
over-expression in Arabidopsis thaliana.";
Phytochemistry 66:859-867(2005).
[10]
FUNCTION.
PubMed=17061170; DOI=10.1007/s10886-006-9149-1;
Burow M., Muller R., Gershenzon J., Wittstock U.;
"Altered glucosinolate hydrolysis in genetically engineered
Arabidopsis thaliana and its influence on the larval development of
Spodoptera littoralis.";
J. Chem. Ecol. 32:2333-2349(2006).
[11]
TISSUE SPECIFICITY.
PubMed=17390109; DOI=10.1007/s11103-007-9143-1;
Burow M., Rice M., Hause B., Gershenzon J., Wittstock U.;
"Cell- and tissue-specific localization and regulation of the
epithiospecifier protein in Arabidopsis thaliana.";
Plant Mol. Biol. 64:173-185(2007).
[12]
FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, AND INTERACTION
WITH WRKY53.
PubMed=17369373; DOI=10.1105/tpc.106.042705;
Miao Y., Zentgraf U.;
"The antagonist function of Arabidopsis WRKY53 and ESR/ESP in leaf
senescence is modulated by the jasmonic and salicylic acid
equilibrium.";
Plant Cell 19:819-830(2007).
[13]
FUNCTION.
PubMed=17920088; DOI=10.1016/j.phytochem.2007.08.027;
Burow M., Zhang Z.-Y., Ober J.A., Lambrix V.M., Wittstock U.,
Gershenzon J., Kliebenstein D.J.;
"ESP and ESM1 mediate indol-3-acetonitrile production from indol-3-
ylmethyl glucosinolate in Arabidopsis.";
Phytochemistry 69:663-671(2008).
[14]
CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22223895; DOI=10.1074/mcp.M111.015131;
Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C.,
Meinnel T., Giglione C.;
"Comparative large-scale characterisation of plant vs. mammal proteins
reveals similar and idiosyncratic N-alpha acetylation features.";
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).
-!- FUNCTION: Converts glucosinolates both to epithionitriles and to
simple nitriles in the presence of myrosinase. Promotes the
formation of epithionitriles after hydrolysis of
alkenylglucosinolates containing a terminal double bond. Mediates
indol-3-acetonitrile (IACN) production from indol-3-ylmethyl
glucosinolate. Acts as a negative regulator of senescence.
{ECO:0000269|PubMed:11752388, ECO:0000269|PubMed:15845404,
ECO:0000269|PubMed:17061170, ECO:0000269|PubMed:17369373,
ECO:0000269|PubMed:17920088}.
-!- SUBUNIT: Interacts with WRKY53. {ECO:0000269|PubMed:17369373}.
-!- INTERACTION:
Q9SUP6:WRKY53; NbExp=6; IntAct=EBI-1997188, EBI-1235980;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17369373}.
Nucleus {ECO:0000269|PubMed:17369373}. Note=Brought to the nucleus
after interaction with WRKY53.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q8RY71-1; Sequence=Displayed;
Name=2;
IsoId=Q8RY71-2; Sequence=VSP_036395;
-!- TISSUE SPECIFICITY: Expressed in epidermal cells of all above-
ground organs except the anthers, in cambial cells of leaf and
stem vascular bundles, and in glucosinolates rich S-cells found in
stems just below the inflorescence. Absent from roots.
{ECO:0000269|PubMed:17390109}.
-!- INDUCTION: By jasmonate. {ECO:0000269|PubMed:13677466}.
-!- DISRUPTION PHENOTYPE: Accelerated leaf senescence and increased
pathogen damages. {ECO:0000269|PubMed:17369373}.
-!- MISCELLANEOUS: ESP is functional in cv. Landsberg erecta while the
gene encoding the protein is not expressed in cv. Columbia, cv.
Da(1)-12 and cv. Ru-0. ESP activity is regulated at the
transcriptional, the post-transcriptional and the post-
translational levels.
-!- MISCELLANEOUS: Not dependent on the presence of Fe(2+) although
supplemental Fe(2+) increases nitriles formation.
-!- SEQUENCE CAUTION:
Sequence=AAD25776.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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EMBL; X71915; CAA50730.1; -; mRNA.
EMBL; AF416786; AAL14622.1; -; Genomic_DNA.
EMBL; AF416790; AAL14625.1; -; Genomic_DNA.
EMBL; AF416785; AAL14621.1; -; Genomic_DNA.
EMBL; AF416787; AAL14623.1; -; Genomic_DNA.
EMBL; AF416789; AAL14624.1; -; Genomic_DNA.
EMBL; AC006577; AAD25776.1; ALT_SEQ; Genomic_DNA.
EMBL; CP002684; AEE33039.1; -; Genomic_DNA.
EMBL; CP002684; AEE33040.1; -; Genomic_DNA.
EMBL; AY074550; AAL69516.1; -; mRNA.
EMBL; BT033156; ACF75545.1; -; mRNA.
EMBL; EU404377; ABY88775.1; -; Genomic_DNA.
EMBL; EU404378; ABY88776.1; -; Genomic_DNA.
EMBL; EU404379; ABY88777.1; -; Genomic_DNA.
EMBL; EU404380; ABY88778.1; -; Genomic_DNA.
EMBL; EU404381; ABY88779.1; -; Genomic_DNA.
EMBL; EU404382; ABY88780.1; -; Genomic_DNA.
EMBL; EU404383; ABY88781.1; -; Genomic_DNA.
EMBL; EU404384; ABY88782.1; -; Genomic_DNA.
EMBL; EU404385; ABY88783.1; -; Genomic_DNA.
EMBL; EU404386; ABY88784.1; -; Genomic_DNA.
EMBL; EU404387; ABY88785.1; -; Genomic_DNA.
EMBL; EU404388; ABY88786.1; -; Genomic_DNA.
EMBL; EU404389; ABY88787.1; -; Genomic_DNA.
EMBL; EU404390; ABY88788.1; -; Genomic_DNA.
EMBL; EU404391; ABY88789.1; -; Genomic_DNA.
EMBL; EU404392; ABY88790.1; -; Genomic_DNA.
EMBL; EU404393; ABY88791.1; -; Genomic_DNA.
EMBL; EU404394; ABY88792.1; -; Genomic_DNA.
EMBL; EU404395; ABY88793.1; -; Genomic_DNA.
EMBL; EU404396; ABY88794.1; -; Genomic_DNA.
EMBL; EU404397; ABY88795.1; -; Genomic_DNA.
EMBL; EU404398; ABY88796.1; -; Genomic_DNA.
EMBL; EU404399; ABY88797.1; -; Genomic_DNA.
EMBL; EU404400; ABY88798.1; -; Genomic_DNA.
EMBL; EU404401; ABY88799.1; -; Genomic_DNA.
EMBL; EU404402; ABY88800.1; -; Genomic_DNA.
EMBL; EU404403; ABY88801.1; -; Genomic_DNA.
EMBL; EU404404; ABY88802.1; -; Genomic_DNA.
EMBL; EU404405; ABY88803.1; -; Genomic_DNA.
EMBL; EU404406; ABY88804.1; -; Genomic_DNA.
EMBL; EU404407; ABY88805.1; -; Genomic_DNA.
EMBL; EU404408; ABY88806.1; -; Genomic_DNA.
EMBL; EU404409; ABY88807.1; -; Genomic_DNA.
EMBL; EU404410; ABY88808.1; -; Genomic_DNA.
EMBL; EU404411; ABY88809.1; -; Genomic_DNA.
EMBL; EU404412; ABY88810.1; -; Genomic_DNA.
EMBL; EU404413; ABY88811.1; -; Genomic_DNA.
EMBL; EU404414; ABY88812.1; -; Genomic_DNA.
EMBL; EU404415; ABY88813.1; -; Genomic_DNA.
EMBL; EU404416; ABY88814.1; -; Genomic_DNA.
EMBL; EU404417; ABY88815.1; -; Genomic_DNA.
EMBL; EU404418; ABY88816.1; -; Genomic_DNA.
EMBL; EU404419; ABY88817.1; -; Genomic_DNA.
EMBL; EU404420; ABY88818.1; -; Genomic_DNA.
EMBL; EU404421; ABY88819.1; -; Genomic_DNA.
EMBL; EU404422; ABY88820.1; -; Genomic_DNA.
EMBL; EU404423; ABY88821.1; -; Genomic_DNA.
EMBL; EU404424; ABY88822.1; -; Genomic_DNA.
EMBL; EU404425; ABY88823.1; -; Genomic_DNA.
EMBL; EU404426; ABY88824.1; -; Genomic_DNA.
EMBL; EU404427; ABY88825.1; -; Genomic_DNA.
EMBL; EU404428; ABY88826.1; -; Genomic_DNA.
EMBL; EU404429; ABY88827.1; -; Genomic_DNA.
EMBL; EU404430; ABY88828.1; -; Genomic_DNA.
EMBL; EU404431; ABY88829.1; -; Genomic_DNA.
EMBL; EU404432; ABY88830.1; -; Genomic_DNA.
EMBL; EU404433; ABY88831.1; -; Genomic_DNA.
EMBL; EU404434; ABY88832.1; -; Genomic_DNA.
EMBL; EU404435; ABY88833.1; -; Genomic_DNA.
EMBL; EU404436; ABY88834.1; -; Genomic_DNA.
EMBL; EU404437; ABY88835.1; -; Genomic_DNA.
EMBL; EU404438; ABY88836.1; -; Genomic_DNA.
EMBL; EU404439; ABY88837.1; -; Genomic_DNA.
EMBL; EU404440; ABY88838.1; -; Genomic_DNA.
EMBL; EU404441; ABY88839.1; -; Genomic_DNA.
EMBL; EU404443; ABY88840.1; -; Genomic_DNA.
EMBL; EU404444; ABY88841.1; -; Genomic_DNA.
EMBL; EU404445; ABY88842.1; -; Genomic_DNA.
EMBL; EU404446; ABY88843.1; -; Genomic_DNA.
EMBL; EU404447; ABY88844.1; -; Genomic_DNA.
EMBL; EU404448; ABY88845.1; -; Genomic_DNA.
EMBL; EU404450; ABY88846.1; -; Genomic_DNA.
EMBL; EU404451; ABY88847.1; -; Genomic_DNA.
EMBL; EU404452; ABY88848.1; -; Genomic_DNA.
EMBL; EU404453; ABY88849.1; -; Genomic_DNA.
EMBL; EU404454; ABY88850.1; -; Genomic_DNA.
EMBL; EU404455; ABY88851.1; -; Genomic_DNA.
EMBL; EU404456; ABY88852.1; -; Genomic_DNA.
EMBL; EU404457; ABY88853.1; -; Genomic_DNA.
EMBL; EU404458; ABY88854.1; -; Genomic_DNA.
EMBL; EU404459; ABY88855.1; -; Genomic_DNA.
EMBL; EU404460; ABY88856.1; -; Genomic_DNA.
EMBL; EU404461; ABY88857.1; -; Genomic_DNA.
EMBL; EU404462; ABY88858.1; -; Genomic_DNA.
EMBL; EU404463; ABY88859.1; -; Genomic_DNA.
EMBL; EU404464; ABY88860.1; -; Genomic_DNA.
EMBL; EU404465; ABY88861.1; -; Genomic_DNA.
EMBL; EU404466; ABY88862.1; -; Genomic_DNA.
EMBL; EU404467; ABY88863.1; -; Genomic_DNA.
EMBL; EU404468; ABY88864.1; -; Genomic_DNA.
EMBL; EU404469; ABY88865.1; -; Genomic_DNA.
EMBL; EU404470; ABY88866.1; -; Genomic_DNA.
EMBL; EU404471; ABY88867.1; -; Genomic_DNA.
EMBL; EU404472; ABY88868.1; -; Genomic_DNA.
PIR; A96581; A96581.
PIR; S33464; S33464.
RefSeq; NP_175806.3; NM_104281.3. [Q8RY71-1]
RefSeq; NP_850963.1; NM_180632.2. [Q8RY71-2]
UniGene; At.24494; -.
UniGene; At.68103; -.
PDB; 5GQ0; X-ray; 2.31 A; A/B=1-341.
PDBsum; 5GQ0; -.
ProteinModelPortal; Q8RY71; -.
SMR; Q8RY71; -.
BioGrid; 27067; 1.
IntAct; Q8RY71; 1.
STRING; 3702.AT1G54040.2; -.
PaxDb; Q8RY71; -.
PRIDE; Q8RY71; -.
EnsemblPlants; AT1G54040.1; AT1G54040.1; AT1G54040. [Q8RY71-2]
EnsemblPlants; AT1G54040.2; AT1G54040.2; AT1G54040. [Q8RY71-1]
GeneID; 841842; -.
Gramene; AT1G54040.1; AT1G54040.1; AT1G54040.
Gramene; AT1G54040.2; AT1G54040.2; AT1G54040.
KEGG; ath:AT1G54040; -.
Araport; AT1G54040; -.
TAIR; locus:2014400; AT1G54040.
eggNOG; KOG0379; Eukaryota.
eggNOG; ENOG410Y5WM; LUCA.
InParanoid; Q8RY71; -.
OMA; LPTNERT; -.
OrthoDB; EOG09360B2K; -.
PhylomeDB; Q8RY71; -.
BioCyc; ARA:AT1G54040-MONOMER; -.
BioCyc; MetaCyc:AT1G54040-MONOMER; -.
PRO; PR:Q8RY71; -.
Proteomes; UP000006548; Chromosome 1.
ExpressionAtlas; Q8RY71; baseline and differential.
Genevisible; Q8RY71; AT.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; IDA:TAIR.
GO; GO:0030234; F:enzyme regulator activity; IDA:TAIR.
GO; GO:0042742; P:defense response to bacterium; IMP:TAIR.
GO; GO:0019762; P:glucosinolate catabolic process; IDA:TAIR.
GO; GO:0010150; P:leaf senescence; IMP:TAIR.
GO; GO:0009753; P:response to jasmonic acid; IMP:TAIR.
Gene3D; 2.130.10.80; -; 3.
InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
InterPro; IPR015915; Kelch-typ_b-propeller.
InterPro; IPR006652; Kelch_1.
Pfam; PF01344; Kelch_1; 3.
SMART; SM00612; Kelch; 2.
SUPFAM; SSF117281; SSF117281; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; Complete proteome; Cytoplasm;
Kelch repeat; Nucleus; Reference proteome; Repeat.
INIT_MET 1 1 Removed. {ECO:0000244|PubMed:22223895}.
CHAIN 2 341 Epithiospecifier protein.
/FTId=PRO_0000363988.
REPEAT 34 82 Kelch 1.
REPEAT 87 133 Kelch 2.
REPEAT 139 194 Kelch 3.
REPEAT 203 249 Kelch 4.
VAR_SEQ 1 80 Missing (in isoform 2).
{ECO:0000303|PubMed:14593172,
ECO:0000303|Ref.6}.
/FTId=VSP_036395.
VARIANT 13 13 G -> E (in strain: cv. Ei-2 and cv. Tac-
0).
VARIANT 18 18 T -> S (in strain: cv. Ei-2 and cv. Tac-
0).
VARIANT 308 308 A -> P (in strain: cv. Ag-0, cv. Br-0,
cv. CIBC-5, cv. Ei-2, cv. Gy-0, cv. HR-
10, cv. HR-5, cv. Kin-0, cv. KNO-10, cv.
KNO-18, cv. Lz-0, cv. NFA-8, cv. NFA-10,
cv. Pna-10, cv. Ra-0, cv. Rmx-A180, cv.
RRS-10, cv. Se-0, cv. Sq-1, cv. Tac-0,
cv. Van-0, cv. Var2-6 and cv. Yo-0).
STRAND 7 11 {ECO:0000244|PDB:5GQ0}.
STRAND 27 31 {ECO:0000244|PDB:5GQ0}.
STRAND 34 38 {ECO:0000244|PDB:5GQ0}.
STRAND 41 43 {ECO:0000244|PDB:5GQ0}.
STRAND 53 56 {ECO:0000244|PDB:5GQ0}.
TURN 57 60 {ECO:0000244|PDB:5GQ0}.
STRAND 61 64 {ECO:0000244|PDB:5GQ0}.
STRAND 68 70 {ECO:0000244|PDB:5GQ0}.
STRAND 80 84 {ECO:0000244|PDB:5GQ0}.
STRAND 87 91 {ECO:0000244|PDB:5GQ0}.
STRAND 103 107 {ECO:0000244|PDB:5GQ0}.
TURN 108 111 {ECO:0000244|PDB:5GQ0}.
STRAND 112 117 {ECO:0000244|PDB:5GQ0}.
STRAND 128 130 {ECO:0000244|PDB:5GQ0}.
STRAND 132 136 {ECO:0000244|PDB:5GQ0}.
STRAND 139 143 {ECO:0000244|PDB:5GQ0}.
STRAND 151 153 {ECO:0000244|PDB:5GQ0}.
STRAND 161 165 {ECO:0000244|PDB:5GQ0}.
TURN 166 169 {ECO:0000244|PDB:5GQ0}.
STRAND 170 173 {ECO:0000244|PDB:5GQ0}.
STRAND 184 186 {ECO:0000244|PDB:5GQ0}.
STRAND 188 192 {ECO:0000244|PDB:5GQ0}.
STRAND 195 203 {ECO:0000244|PDB:5GQ0}.
STRAND 214 223 {ECO:0000244|PDB:5GQ0}.
TURN 224 227 {ECO:0000244|PDB:5GQ0}.
STRAND 228 231 {ECO:0000244|PDB:5GQ0}.
STRAND 235 237 {ECO:0000244|PDB:5GQ0}.
STRAND 246 250 {ECO:0000244|PDB:5GQ0}.
STRAND 253 262 {ECO:0000244|PDB:5GQ0}.
TURN 265 268 {ECO:0000244|PDB:5GQ0}.
STRAND 273 282 {ECO:0000244|PDB:5GQ0}.
TURN 283 286 {ECO:0000244|PDB:5GQ0}.
STRAND 287 290 {ECO:0000244|PDB:5GQ0}.
STRAND 301 303 {ECO:0000244|PDB:5GQ0}.
STRAND 305 311 {ECO:0000244|PDB:5GQ0}.
STRAND 314 320 {ECO:0000244|PDB:5GQ0}.
STRAND 333 338 {ECO:0000244|PDB:5GQ0}.
SEQUENCE 341 AA; 37008 MW; 2423B2AD685E72DF CRC64;
MAPTLQGQWI KVGQKGGTGP GPRSSHGIAA VGDKLYSFGG ELTPNKHIDK DLYVFDFNTQ
TWSIAQPKGD APTVSCLGVR MVAVGTKIYI FGGRDENRNF ENFRSYDTVT SEWTFLTKLD
EVGGPEARTF HSMASDENHV YVFGGVSKGG TMNTPTRFRT IEAYNIADGK WAQLPDPGDN
FEKRGGAGFA VVQGKIWVVY GFATSIVPGG KDDYESNAVQ FYDPASKKWT EVETTGAKPS
ARSVFAHAVV GKYIIIFAGE VWPDLNGHYG PGTLSNEGYA LDTETLVWEK LGEEGAPAIP
RGWTAYTAAT VDGKNGLLMH GGKLPTNERT DDLYFYAVNS A


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