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Erythropoietin

 EPO_SHEEP               Reviewed;         194 AA.
P33709; Q28572;
01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
01-FEB-1994, sequence version 1.
23-MAY-2018, entry version 86.
RecName: Full=Erythropoietin;
Flags: Precursor;
Name=EPO;
Ovis aries (Sheep).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Ovis.
NCBI_TaxID=9940;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Kidney;
PubMed=8349021; DOI=10.1016/0303-7207(93)90113-X;
Fu P., Evans B., Lim G.B., Moritz K., Wintour M.E.;
"The sheep erythropoietin gene: molecular cloning and effect of
hemorrhage on plasma erythropoietin and renal/liver messenger RNA in
adult sheep.";
Mol. Cell. Endocrinol. 93:107-116(1993).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 4-194.
TISSUE=Kidney;
PubMed=8364201;
Wen D., Boissel J.-P.R., Tracy T.E., Gruninger R.H., Mulcahy L.S.,
Czelusniak J., Goodman M., Bunn H.F.;
"Erythropoietin structure-function relationships: high degree of
sequence homology among mammals.";
Blood 82:1507-1516(1993).
-!- FUNCTION: Hormone involved in the regulation of erythrocyte
proliferation and differentiation and the maintenance of a
physiological level of circulating erythrocyte mass. Binds to EPOR
leading to EPOR dimerization and JAK2 activation thereby
activating specific downstream effectors, including STAT1 and
STAT3. {ECO:0000250|UniProtKB:P01588}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Produced by kidney or liver of adult mammals
and by liver of fetal or neonatal mammals.
-!- SIMILARITY: Belongs to the EPO/TPO family. {ECO:0000305}.
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EMBL; Z24681; CAA80848.1; -; mRNA.
EMBL; L10610; AAA31518.1; -; mRNA.
PIR; I46401; I46401.
RefSeq; NP_001019908.1; NM_001024737.1.
UniGene; Oar.368; -.
ProteinModelPortal; P33709; -.
Ensembl; ENSOART00000017473; ENSOARP00000017231; ENSOARG00000016044.
GeneID; 443302; -.
KEGG; oas:443302; -.
CTD; 2056; -.
GeneTree; ENSGT00390000017226; -.
HOVERGEN; HBG003978; -.
KO; K05437; -.
OMA; EAENVTM; -.
OrthoDB; EOG091G0PMA; -.
Proteomes; UP000002356; Chromosome 24.
GO; GO:0009986; C:cell surface; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0005125; F:cytokine activity; IEA:Ensembl.
GO; GO:0005128; F:erythropoietin receptor binding; ISS:UniProtKB.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0030295; F:protein kinase activator activity; IEA:Ensembl.
GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
GO; GO:0008283; P:cell proliferation; ISS:UniProtKB.
GO; GO:0071474; P:cellular hyperosmotic response; IEA:Ensembl.
GO; GO:0007566; P:embryo implantation; IEA:Ensembl.
GO; GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.
GO; GO:0043249; P:erythrocyte maturation; IEA:UniProtKB-KW.
GO; GO:0038162; P:erythropoietin-mediated signaling pathway; ISS:UniProtKB.
GO; GO:0042541; P:hemoglobin biosynthetic process; IEA:Ensembl.
GO; GO:0010523; P:negative regulation of calcium ion transport into cytosol; IEA:Ensembl.
GO; GO:2001258; P:negative regulation of cation channel activity; IEA:Ensembl.
GO; GO:1902251; P:negative regulation of erythrocyte apoptotic process; IEA:Ensembl.
GO; GO:1902219; P:negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0018105; P:peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IEA:Ensembl.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR019767; EPO/TPO_CS.
InterPro; IPR001323; EPO_TPO.
InterPro; IPR003013; Erythroptn.
PANTHER; PTHR10370; PTHR10370; 1.
Pfam; PF00758; EPO_TPO; 1.
PIRSF; PIRSF001951; EPO; 1.
PRINTS; PR00272; ERYTHROPTN.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00817; EPO_TPO; 1.
2: Evidence at transcript level;
Complete proteome; Disulfide bond; Erythrocyte maturation;
Glycoprotein; Hormone; Reference proteome; Secreted; Signal.
SIGNAL 1 27 {ECO:0000250}.
CHAIN 28 194 Erythropoietin.
/FTId=PRO_0000008409.
CARBOHYD 51 51 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 65 65 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 110 110 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 34 189 {ECO:0000250}.
DISULFID 56 60 {ECO:0000250}.
CONFLICT 16 16 F -> L (in Ref. 2; AAA31518).
{ECO:0000305}.
CONFLICT 108 108 L -> P (in Ref. 2; AAA31518).
{ECO:0000305}.
SEQUENCE 194 AA; 21335 MW; C025AAB0528131A9 CRC64;
MGARDCTPLL LLLLSFLLFP LGLPVLGAPP RLICDSRVLE RYILEAREAE NATMGCAEGC
SFSENITVPD TKVNFYAWKR MEVQQQALEV WQGLALLSEA IFRGQALLAN ASQPCEALRL
HVDKAVSGLR SLTSLLRALG AQKEAIPLPD ATPSAAPLRI FTVDALSKLF RIYSNFLRGK
LTLYTGEACR RGDR


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