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Estradiol 17-beta-dehydrogenase 8 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 8) (17-beta-HSD 8) (3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit) (KAR alpha subunit) (3-oxoacyl-[acyl-carrier-protein] reductase) (EC 1.1.1.-) (Testosterone 17-beta-dehydrogenase 8) (EC 1.1.1.239) (Fragment)

 DHB8_CALJA              Reviewed;         134 AA.
Q9GME3;
20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
01-MAR-2001, sequence version 1.
25-OCT-2017, entry version 97.
RecName: Full=Estradiol 17-beta-dehydrogenase 8;
EC=1.1.1.62;
AltName: Full=17-beta-hydroxysteroid dehydrogenase 8;
Short=17-beta-HSD 8;
AltName: Full=3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit {ECO:0000250|UniProtKB:Q92506};
Short=KAR alpha subunit {ECO:0000250|UniProtKB:Q92506};
AltName: Full=3-oxoacyl-[acyl-carrier-protein] reductase;
EC=1.1.1.- {ECO:0000250|UniProtKB:Q92506};
AltName: Full=Testosterone 17-beta-dehydrogenase 8;
EC=1.1.1.239;
Flags: Fragment;
Name=HSD17B8;
Callithrix jacchus (White-tufted-ear marmoset).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix.
NCBI_TaxID=9483;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=11165027; DOI=10.1016/S0303-7207(00)00421-4;
Husen B., Adamski J., Rune G.M., Einspanier A.;
"Mechanisms of estradiol inactivation in primate endometrium.";
Mol. Cell. Endocrinol. 171:179-185(2001).
-!- FUNCTION: NAD-dependent 17-beta-hydroxysteroid dehydrogenase with
highest activity towards estradiol. Has very low activity towards
testosterone. The heterotetramer with CBR4 has NADH-dependent 3-
ketoacyl-acyl carrier protein reductase activity, and thereby
plays a role in mitochondrial fatty acid biosynthesis. Within the
heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD.
{ECO:0000250|UniProtKB:Q92506}.
-!- CATALYTIC ACTIVITY: 17-beta-estradiol + NAD(P)(+) = estrone +
NAD(P)H. {ECO:0000250|UniProtKB:Q92506}.
-!- CATALYTIC ACTIVITY: Testosterone + NAD(+) = androstenedione +
NADH. {ECO:0000250|UniProtKB:Q92506}.
-!- PATHWAY: Steroid biosynthesis; estrogen biosynthesis.
{ECO:0000250|UniProtKB:Q92506}.
-!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
{ECO:0000250|UniProtKB:Q92506}.
-!- SUBUNIT: Heterotetramer with CBR4; contains two molecules of
HSD17B8 and CBR4. {ECO:0000250|UniProtKB:Q92506}.
-!- SUBCELLULAR LOCATION: Mitochondrion matrix
{ECO:0000250|UniProtKB:Q92506}.
-!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
(SDR) family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AF272012; AAG01114.1; -; mRNA.
ProteinModelPortal; Q9GME3; -.
SMR; Q9GME3; -.
STRING; 9483.ENSCJAP00000040269; -.
eggNOG; KOG1200; Eukaryota.
eggNOG; COG1028; LUCA.
HOVERGEN; HBG002145; -.
InParanoid; Q9GME3; -.
OrthoDB; EOG091G0N2V; -.
UniPathway; UPA00094; -.
UniPathway; UPA00769; -.
Proteomes; UP000008225; Unplaced.
GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
GO; GO:0047025; F:3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity; ISS:UniProtKB.
GO; GO:0004303; F:estradiol 17-beta-dehydrogenase activity; ISS:UniProtKB.
GO; GO:0070404; F:NADH binding; ISS:UniProtKB.
GO; GO:0047035; F:testosterone dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
GO; GO:0006703; P:estrogen biosynthetic process; ISS:UniProtKB.
GO; GO:0006633; P:fatty acid biosynthetic process; ISS:UniProtKB.
GO; GO:0055114; P:oxidation-reduction process; ISS:UniProtKB.
GO; GO:0051290; P:protein heterotetramerization; ISS:UniProtKB.
InterPro; IPR036291; NAD(P)-bd_dom_sf.
InterPro; IPR020904; Sc_DH/Rdtase_CS.
InterPro; IPR002347; SDR_fam.
PRINTS; PR00081; GDHRDH.
PRINTS; PR00080; SDRFAMILY.
SUPFAM; SSF51735; SSF51735; 1.
PROSITE; PS00061; ADH_SHORT; 1.
2: Evidence at transcript level;
Complete proteome; Fatty acid biosynthesis; Fatty acid metabolism;
Lipid biosynthesis; Lipid metabolism; Mitochondrion; NAD;
Oxidoreductase; Reference proteome; Steroid biosynthesis.
CHAIN <1 >134 Estradiol 17-beta-dehydrogenase 8.
/FTId=PRO_0000054596.
NP_BIND 51 55 NAD. {ECO:0000250|UniProtKB:Q92506}.
NP_BIND 84 86 NAD. {ECO:0000250|UniProtKB:Q92506}.
ACT_SITE 51 51 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU10001}.
BINDING 38 38 Substrate. {ECO:0000250}.
MOD_RES 42 42 N6-succinyllysine.
{ECO:0000250|UniProtKB:P50171}.
MOD_RES 55 55 N6-succinyllysine.
{ECO:0000250|UniProtKB:P50171}.
NON_TER 1 1
NON_TER 134 134
SEQUENCE 134 AA; 13763 MW; 1D351CCF6D6181FF CRC64;
DWDKVIAVNL KGTFLVTQAA GQALVSSGCS GSIINISSIV GKVGNMGQTN YAASKAGVIG
LTQTAARELG RHGIRCNSVL PGFIATPMTQ KVPQKVMNKI TGMIPMGHLG DPEDVADVVA
FLASEDSGYI TGAS


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