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Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)

 G7P4Y2_MACFA            Unreviewed;       595 AA.
G7P4Y2;
25-JAN-2012, integrated into UniProtKB/TrEMBL.
25-JAN-2012, sequence version 1.
28-MAR-2018, entry version 43.
RecName: Full=Estrogen receptor {ECO:0000256|PIRNR:PIRNR002527};
Short=ER {ECO:0000256|PIRNR:PIRNR002527};
AltName: Full=ER-alpha {ECO:0000256|PIRNR:PIRNR002527};
AltName: Full=Estradiol receptor {ECO:0000256|PIRNR:PIRNR002527};
AltName: Full=Nuclear receptor subfamily 3 group A member 1 {ECO:0000256|PIRNR:PIRNR002527};
Name=ESR1 {ECO:0000313|Ensembl:ENSMFAP00000043221};
ORFNames=EGM_13911 {ECO:0000313|EMBL:EHH53300.1};
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130};
[1] {ECO:0000313|EMBL:EHH53300.1, ECO:0000313|Proteomes:UP000009130}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CE-4 {ECO:0000313|EMBL:EHH53300.1};
PubMed=22002653; DOI=10.1038/nbt.1992;
Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N.,
Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P.,
Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T.,
Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D.,
Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X.,
Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J.,
Wang X., Wang J.;
"Genome sequencing and comparison of two nonhuman primate animal
models, the cynomolgus and Chinese rhesus macaques.";
Nat. Biotechnol. 29:1019-1023(2011).
[2] {ECO:0000313|Ensembl:ENSMFAP00000043221}
NUCLEOTIDE SEQUENCE.
Huang N.-L., Huang M.-D., Chen T.-L.L., Huang A.H.;
Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|Ensembl:ENSMFAP00000043221}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2018) to UniProtKB.
-!- FUNCTION: The steroid hormones and their receptors are involved in
the regulation of eukaryotic gene expression and affect cellular
proliferation and differentiation in target tissues.
{ECO:0000256|PIRNR:PIRNR002527}.
-!- SUBUNIT: Binds DNA as a homodimer.
{ECO:0000256|PIRNR:PIRNR002527}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR002527,
ECO:0000256|PROSITE-ProRule:PRU00407,
ECO:0000256|SAAS:SAAS00982927}.
-!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
subfamily. {ECO:0000256|PIRNR:PIRNR002527}.
-----------------------------------------------------------------------
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EMBL; AQIA01050292; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AQIA01050293; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CM001279; EHH53300.1; -; Genomic_DNA.
RefSeq; XP_005552209.1; XM_005552152.2.
RefSeq; XP_005552211.1; XM_005552154.2.
RefSeq; XP_015304461.1; XM_015448975.1.
RefSeq; XP_015304462.1; XM_015448976.1.
UniGene; Mfa.8130; -.
Ensembl; ENSMFAT00000017511; ENSMFAP00000043221; ENSMFAG00000033966.
GeneID; 102115223; -.
KEGG; mcf:102115223; -.
CTD; 2099; -.
GeneTree; ENSGT00760000118887; -.
KO; K08550; -.
Proteomes; UP000009130; Chromosome 4.
GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
GO; GO:0000790; C:nuclear chromatin; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
GO; GO:0043234; C:protein complex; IEA:Ensembl.
GO; GO:0097550; C:transcriptional preinitiation complex; IEA:Ensembl.
GO; GO:0035327; C:transcriptionally active chromatin; IEA:Ensembl.
GO; GO:0051117; F:ATPase binding; IEA:Ensembl.
GO; GO:0008013; F:beta-catenin binding; IEA:Ensembl.
GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
GO; GO:0001046; F:core promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0030331; F:estrogen receptor binding; IEA:Ensembl.
GO; GO:0034056; F:estrogen response element binding; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0038052; F:RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
GO; GO:0017025; F:TBP-class protein binding; IEA:Ensembl.
GO; GO:0001093; F:TFIIB-class transcription factor binding; IEA:Ensembl.
GO; GO:0001223; F:transcription coactivator binding; IEA:Ensembl.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0008209; P:androgen metabolic process; IEA:Ensembl.
GO; GO:0001547; P:antral ovarian follicle growth; IEA:Ensembl.
GO; GO:0071392; P:cellular response to estradiol stimulus; IEA:Ensembl.
GO; GO:0071391; P:cellular response to estrogen stimulus; IEA:Ensembl.
GO; GO:0002064; P:epithelial cell development; IEA:Ensembl.
GO; GO:0060750; P:epithelial cell proliferation involved in mammary gland duct elongation; IEA:Ensembl.
GO; GO:0008584; P:male gonad development; IEA:Ensembl.
GO; GO:0060749; P:mammary gland alveolus development; IEA:Ensembl.
GO; GO:0060745; P:mammary gland branching involved in pregnancy; IEA:Ensembl.
GO; GO:0043433; P:negative regulation of DNA binding transcription factor activity; IEA:Ensembl.
GO; GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
GO; GO:1903799; P:negative regulation of production of miRNAs involved in gene silencing by miRNA; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0051091; P:positive regulation of DNA binding transcription factor activity; IEA:Ensembl.
GO; GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl.
GO; GO:0045899; P:positive regulation of RNA polymerase II transcriptional preinitiation complex assembly; IEA:Ensembl.
GO; GO:0060527; P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; IEA:Ensembl.
GO; GO:0060523; P:prostate epithelial cord elongation; IEA:Ensembl.
GO; GO:0071168; P:protein localization to chromatin; IEA:Ensembl.
GO; GO:0042981; P:regulation of apoptotic process; IEA:Ensembl.
GO; GO:0060687; P:regulation of branching involved in prostate gland morphogenesis; IEA:Ensembl.
GO; GO:0050727; P:regulation of inflammatory response; IEA:Ensembl.
GO; GO:0034121; P:regulation of toll-like receptor signaling pathway; IEA:Ensembl.
GO; GO:0048863; P:stem cell differentiation; IEA:Ensembl.
GO; GO:0060065; P:uterus development; IEA:Ensembl.
GO; GO:0060068; P:vagina development; IEA:Ensembl.
Gene3D; 3.30.50.10; -; 1.
InterPro; IPR035500; NHR_like_dom_sf.
InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
InterPro; IPR001723; Nuclear_hrmn_rcpt.
InterPro; IPR024178; Oest_rcpt/oest-rel_rcp.
InterPro; IPR001292; Oestr_rcpt.
InterPro; IPR024736; Oestrogen-typ_rcpt_final_C_dom.
InterPro; IPR001628; Znf_hrmn_rcpt.
InterPro; IPR013088; Znf_NHR/GATA.
Pfam; PF12743; ESR1_C; 1.
Pfam; PF00104; Hormone_recep; 1.
Pfam; PF02159; Oest_recep; 1.
Pfam; PF00105; zf-C4; 1.
PIRSF; PIRSF500101; ER-a; 1.
PIRSF; PIRSF002527; ER-like_NR; 1.
PRINTS; PR00543; OESTROGENR.
PRINTS; PR00398; STRDHORMONER.
PRINTS; PR00047; STROIDFINGER.
SMART; SM00430; HOLI; 1.
SMART; SM00399; ZnF_C4; 1.
SUPFAM; SSF48508; SSF48508; 2.
PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000009130};
DNA-binding {ECO:0000256|PIRNR:PIRNR002527, ECO:0000256|PROSITE-
ProRule:PRU00407, ECO:0000256|SAAS:SAAS00517091};
Lipid-binding {ECO:0000256|PIRNR:PIRNR002527};
Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00407,
ECO:0000256|SAAS:SAAS00517125};
Nucleus {ECO:0000256|PIRNR:PIRNR002527, ECO:0000256|PROSITE-
ProRule:PRU00407, ECO:0000256|SAAS:SAAS00983050};
Receptor {ECO:0000256|PIRNR:PIRNR002527,
ECO:0000256|SAAS:SAAS00982657};
Reference proteome {ECO:0000313|Proteomes:UP000009130};
Steroid-binding {ECO:0000256|PIRNR:PIRNR002527};
Transcription {ECO:0000256|PIRNR:PIRNR002527, ECO:0000256|PROSITE-
ProRule:PRU00407, ECO:0000256|SAAS:SAAS00982829};
Transcription regulation {ECO:0000256|PIRNR:PIRNR002527,
ECO:0000256|PROSITE-ProRule:PRU00407, ECO:0000256|SAAS:SAAS00982829};
Zinc {ECO:0000256|PROSITE-ProRule:PRU00407,
ECO:0000256|SAAS:SAAS00517125};
Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00407,
ECO:0000256|SAAS:SAAS00517125}.
DOMAIN 182 257 Nuclear receptor.
{ECO:0000259|PROSITE:PS51030}.
DNA_BIND 182 257 Nuclear receptor. {ECO:0000256|PROSITE-
ProRule:PRU00407}.
SEQUENCE 595 AA; 66223 MW; F6B27DE9DB00B66E CRC64;
MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKIPLERPLG EVYVDSSKPA VYNYPEGAAY
EFNAAAAANA QVYGQTGLPY GPGSEAAAFG SNGLGGFPPL NSVSPSPLML LHPPPQLSPF
LQPHGQQVPY YLENEPSGYT VREAGPPAFY RPNSDNRRQG GRERLASTND KGSMAMESAK
ETRYCAVCND YASGYHYGVW SCEGCKAFFK RSIQGHNDYM CPATNQCTID KNRRKSCQAC
RLRKCYEVGM MKGGIRKDRR GGRMLKHKRQ RDDGEGRGEV GSAGDMRAAN LWPSPLMIKH
SKKNSPALSL TADQMVSALL DAEPPILYSE YDPTRPFSEA SMMGLLTNLA DRELVHMINW
AKRVPGFVDL TLHDQVHLLE CAWLEILMIG LVWRSMEHPG KLLFAPNLLL DRNQGKCVEG
MVEIFDMLLA TSSRFRMMNL QGEEFVCLKS IILLNSGVYT FLSSTLKSLE EKDHIHRVLD
KITDTLIHLM AKAGLTLQQQ HRRLAQLLLI LSHIRHMSNK GMEHLYSMKC KNVVPLYDLL
LEMLDAHRLH APTSRGGAPM EETDQSHLAT AGSTSSHSLQ KYYITGDAEG FPATV


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