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Etoposide-induced protein 2.4 homolog

 EI24_RAT                Reviewed;         340 AA.
Q4KM77;
29-APR-2008, integrated into UniProtKB/Swiss-Prot.
02-AUG-2005, sequence version 1.
22-NOV-2017, entry version 70.
RecName: Full=Etoposide-induced protein 2.4 homolog;
Name=Ei24;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Liver;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[2]
FUNCTION.
PubMed=20550938; DOI=10.1016/j.cell.2010.04.034;
Tian Y., Li Z., Hu W., Ren H., Tian E., Zhao Y., Lu Q., Huang X.,
Yang P., Li X., Wang X., Kovacs A.L., Yu L., Zhang H.;
"C. elegans screen identifies autophagy genes specific to
multicellular organisms.";
Cell 141:1042-1055(2010).
[3]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46; SER-47; SER-326 AND
SER-330, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Acts as a negative growth regulator via p53-mediated
apoptosis pathway. Regulates formation of degradative
autolysosomes during autophagy. {ECO:0000269|PubMed:20550938}.
-!- SUBUNIT: Interacts with BCL2. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250}; Multi-pass
membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}.
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane
protein {ECO:0000250}.
-!- SIMILARITY: Belongs to the EI24 family. {ECO:0000305}.
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EMBL; BC098721; AAH98721.1; -; mRNA.
RefSeq; NP_001020831.1; NM_001025660.1.
RefSeq; XP_006242862.1; XM_006242800.3.
RefSeq; XP_006242863.1; XM_006242801.3.
UniGene; Rn.6593; -.
iPTMnet; Q4KM77; -.
PhosphoSitePlus; Q4KM77; -.
PaxDb; Q4KM77; -.
PRIDE; Q4KM77; -.
Ensembl; ENSRNOT00000046590; ENSRNOP00000042710; ENSRNOG00000030391.
GeneID; 300514; -.
KEGG; rno:300514; -.
UCSC; RGD:1309868; rat.
CTD; 9538; -.
RGD; 1309868; Ei24.
eggNOG; KOG3966; Eukaryota.
eggNOG; ENOG410XRPU; LUCA.
GeneTree; ENSGT00390000018633; -.
HOGENOM; HOG000293197; -.
HOVERGEN; HBG001857; -.
InParanoid; Q4KM77; -.
KO; K10134; -.
OMA; VMIGIGE; -.
OrthoDB; EOG091G0E3F; -.
PhylomeDB; Q4KM77; -.
PRO; PR:Q4KM77; -.
Proteomes; UP000002494; Chromosome 8.
Bgee; ENSRNOG00000030391; -.
Genevisible; Q4KM77; RN.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0016020; C:membrane; ISO:RGD.
GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
GO; GO:0061676; F:importin-alpha family protein binding; ISO:RGD.
GO; GO:0006915; P:apoptotic process; IBA:GO_Central.
GO; GO:0006914; P:autophagy; ISO:RGD.
GO; GO:0071494; P:cellular response to UV-C; ISO:RGD.
GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; ISO:RGD.
GO; GO:0016236; P:macroautophagy; IBA:GO_Central.
GO; GO:0030308; P:negative regulation of cell growth; ISO:RGD.
GO; GO:0042308; P:negative regulation of protein import into nucleus; ISO:RGD.
GO; GO:0050885; P:neuromuscular process controlling balance; ISO:RGD.
GO; GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; ISO:RGD.
GO; GO:0042493; P:response to drug; ISO:RGD.
InterPro; IPR009890; EI24.
PANTHER; PTHR21389; PTHR21389; 1.
1: Evidence at protein level;
Acetylation; Apoptosis; Autophagy; Complete proteome; Cytoplasm;
Endoplasmic reticulum; Membrane; Nucleus; Phosphoprotein;
Reference proteome; Transmembrane; Transmembrane helix.
INIT_MET 1 1 Removed. {ECO:0000250|UniProtKB:O14681}.
CHAIN 2 340 Etoposide-induced protein 2.4 homolog.
/FTId=PRO_0000331478.
TRANSMEM 77 97 Helical. {ECO:0000255}.
TRANSMEM 117 137 Helical. {ECO:0000255}.
TRANSMEM 179 199 Helical. {ECO:0000255}.
TRANSMEM 238 255 Helical. {ECO:0000255}.
TRANSMEM 257 277 Helical. {ECO:0000255}.
COMPBIAS 41 44 Poly-Arg.
COMPBIAS 316 320 Poly-Ser.
MOD_RES 2 2 N-acetylalanine.
{ECO:0000250|UniProtKB:O14681}.
MOD_RES 46 46 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 47 47 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 56 56 Phosphoserine.
{ECO:0000250|UniProtKB:O14681}.
MOD_RES 320 320 Phosphoserine.
{ECO:0000250|UniProtKB:Q61070}.
MOD_RES 326 326 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 330 330 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
SEQUENCE 340 AA; 38893 MW; 624D4BCFE2917C9C CRC64;
MADSVKTFLQ DLGRGIKDSI WGICTISKLD ARIQQKREEQ RRRRASSLLA QRRAQSVERK
QESEPRIVSR IFQCCAWNGG VFWFSLLLFY RVFIPVLQSV TARVIGDPSL HGDVWSWLEF
FLTSIFSALW VLPLFVLSKV VNAIWFQDIA DLAFEVSGRK PHPFPSVSKI IADMLFNLLL
QALFLIQGMF VSLFPIHLVG QLVSLLHMSL LYSLYCFEYR WFNKGIEMHQ RLSNIERNWP
YYFGFGLPLA FLTAMQSSYI ISGCLFSILF PLFIISANEA KTPGKAYLFQ LRLFSLVVFL
SNRLFHKTVY LQSALSSSSS AEKFPSPHPS PAKLKAAAGH


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