Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Exendin-4 (Exenatide)

 EXE4_HELSU              Reviewed;          87 AA.
P26349;
01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
15-JUL-1998, sequence version 2.
07-NOV-2018, entry version 92.
RecName: Full=Exendin-4;
AltName: INN=Exenatide;
Flags: Precursor;
Heloderma suspectum (Gila monster).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
Toxicofera; Anguimorpha; Neoanguimorpha; Helodermatidae; Heloderma.
NCBI_TaxID=8554;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=9020121;
Chen Y.E., Drucker D.J.;
"Tissue-specific expression of unique mRNAs that encode proglucagon-
derived peptides or exendin 4 in the lizard.";
J. Biol. Chem. 272:4108-4115(1997).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=9545315; DOI=10.1074/jbc.273.16.9778;
Pohl M., Wank S.A.;
"Molecular cloning of the helodermin and exendin-4 cDNAs in the
lizard. Relationship to vasoactive intestinal polypeptide/pituitary
adenylate cyclase activating polypeptide and glucagon-like peptide 1
and evidence against the existence of mammalian homologues.";
J. Biol. Chem. 273:9778-9784(1998).
[3]
NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 48-86, AND MASS
SPECTROMETRY.
TISSUE=Venom;
PubMed=16386282; DOI=10.1016/j.toxicon.2005.11.004;
Chen T., Kwok H., Ivanyi C., Shaw C.;
"Isolation and cloning of exendin precursor cDNAs from single samples
of venom from the Mexican beaded lizard (Heloderma horridum) and the
Gila monster (Heloderma suspectum).";
Toxicon 47:288-295(2006).
[4]
PROTEIN SEQUENCE OF 48-86, AND AMIDATION AT SER-86.
TISSUE=Venom;
PubMed=1313797;
Eng J., Kleinman W.A., Singh L., Singh G., Raufman J.-P.;
"Isolation and characterization of exendin-4, an exendin-3 analogue,
from Heloderma suspectum venom. Further evidence for an exendin
receptor on dispersed acini from guinea pig pancreas.";
J. Biol. Chem. 267:7402-7405(1992).
[5]
FUNCTION.
PubMed=8405712; DOI=10.2337/diab.42.11.1678;
Thorens B., Porret A., Buehler L., Deng S., Morel P., Widmann C.;
"Cloning and functional expression of the human islet GLP-1 receptor.
Demonstration that exendin-4 is an agonist and exendin-(9-39) an
antagonist of the receptor.";
Diabetes 42:1678-1682(1993).
[6]
SYNTHESIS OF 48-86, AND FUNCTION.
PubMed=19837656; DOI=10.1093/molbev/msp251;
Fry B.G., Roelants K., Winter K., Hodgson W.C., Griesman L.,
Kwok H.F., Scanlon D., Karas J., Shaw C., Wong L., Norman J.A.;
"Novel venom proteins produced by differential domain-expression
strategies in beaded lizards and gila monsters (genus Heloderma).";
Mol. Biol. Evol. 27:395-407(2010).
[7]
REVIEW, AND PHARMACEUTICAL.
PubMed=21194543; DOI=10.1016/j.toxicon.2010.12.016;
Furman B.L.;
"The development of Byetta (exenatide) from the venom of the Gila
monster as an anti-diabetic agent.";
Toxicon 59:464-471(2012).
[8]
REVIEW, AND PHARMACEUTICAL.
PubMed=25018644; DOI=10.2147/DMSO.S35331;
Mann K.V., Raskin P.;
"Exenatide extended-release: a once weekly treatment for patients with
type 2 diabetes.";
Diabetes Metab. Syndr. Obes. 7:229-239(2014).
[9]
STRUCTURE BY NMR OF 48-86.
PubMed=11683627; DOI=10.1021/bi010902s;
Neidigh J.W., Fesinmeyer R.M., Prickett K.S., Andersen N.H.;
"Exendin-4 and glucagon-like-peptide-1: NMR structural comparisons in
the solution and micelle-associated states.";
Biochemistry 40:13188-13200(2001).
-!- FUNCTION: Venom protein that mimics the incretin hormone glucagon-
like peptide 1 (GLP-1). It stimulates insulin synthesis and
secretion, protects against beta-cell apoptosis in response to
different insults, and promotes beta-cell proliferation. It also
promotes satiety, reduces food intake, reduces fat deposition,
reduces body weight and inhibits gastric emptying. Interacts with
GLP-1 receptor (GLP1R). Induces hypotension that is mediated by
relaxation of cardiac smooth muscle. {ECO:0000269|PubMed:19837656,
ECO:0000269|PubMed:8405712}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Expressed by the venom gland.
-!- MASS SPECTROMETRY: Mass=4186.02; Method=MALDI; Range=48-86;
Evidence={ECO:0000269|PubMed:16386282};
-!- PHARMACEUTICAL: Available under the name Byetta and Bydureon
(extended-release exenatide) (Amylin Pharmaceuticals). Used for
the treatment of type 2 diabetes. Enhances insulin secretion in
response to elevated plasma glucose levels.
-!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; U77613; AAB51130.1; -; mRNA.
PIR; A42486; HWGH4G.
PDB; 1JRJ; NMR; -; A=48-86.
PDB; 2MJ9; NMR; -; A=48-86.
PDB; 2NAV; NMR; -; A=48-56.
PDB; 2NAW; NMR; -; A=48-77.
PDB; 3C59; X-ray; 2.30 A; B=56-86.
PDB; 3C5T; X-ray; 2.10 A; B=56-86.
PDB; 5NIQ; NMR; -; A=48-86.
PDB; 5OTT; X-ray; 1.92 A; B=48-86.
PDB; 6GDZ; NMR; -; A=48-86.
PDB; 6GE2; NMR; -; A=48-86.
PDBsum; 1JRJ; -.
PDBsum; 2MJ9; -.
PDBsum; 2NAV; -.
PDBsum; 2NAW; -.
PDBsum; 3C59; -.
PDBsum; 3C5T; -.
PDBsum; 5NIQ; -.
PDBsum; 5OTT; -.
PDBsum; 6GDZ; -.
PDBsum; 6GE2; -.
ProteinModelPortal; P26349; -.
SMR; P26349; -.
Allergome; 11965; Hel su Exenatide.
HOVERGEN; HBG081487; -.
EvolutionaryTrace; P26349; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005179; F:hormone activity; IEA:InterPro.
GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
Pfam; PF00123; Hormone_2; 1.
SMART; SM00070; GLUCA; 1.
PROSITE; PS00260; GLUCAGON; 1.
1: Evidence at protein level;
3D-structure; Amidation; Cleavage on pair of basic residues;
Direct protein sequencing; G-protein coupled receptor impairing toxin;
Hypotensive agent; Pharmaceutical; Secreted; Signal; Toxin.
SIGNAL 1 23 {ECO:0000255}.
PROPEP 24 45
/FTId=PRO_0000011421.
PEPTIDE 48 86 Exendin-4.
/FTId=PRO_0000011422.
MOD_RES 86 86 Serine amide.
{ECO:0000269|PubMed:1313797}.
CONFLICT 13 13 F -> G (in Ref. 2; no nucleotide entry).
{ECO:0000305}.
HELIX 57 74 {ECO:0000244|PDB:5OTT}.
HELIX 77 79 {ECO:0000244|PDB:5OTT}.
STRAND 80 82 {ECO:0000244|PDB:1JRJ}.
SEQUENCE 87 AA; 9479 MW; 656BA6E3D87454A2 CRC64;
MKIILWLCVF GLFLATLFPI SWQMPVESGL SSEDSASSES FASKIKRHGE GTFTSDLSKQ
MEEEAVRLFI EWLKNGGPSS GAPPPSG


Related products :

Catalog number Product name Quantity
orb60035 Exenatide Exenatide(Byetta,Exendin-4) is an incretin mimic that acts as an agonist at the glucagon-like peptide 1 receptor. (ED50=74 25 mg
PP-1250 Exenatide Acetate (Exendin-4) 100mg
PP-1250 Exenatide Acetate (Exendin-4) Species Reactivity: 100mg Product tipe: Chemicals/Drugs
E-0902 Exendin-4 Exenatide 98 percent C184H282N50O60S CAS: 141758-74-9 5mg
orb80712 Exenatide protein Exenatide is a single, non-glycosylated, peptide containing 39 amino acids and having a molecular mass of 4186.6 Dalton. Exenatide has the empirical formula C184H282N50O60S. For rese 1 mg
H-8730.0500 Exenatide Salt Acetate Binding _ Synonym Exenatide, Exendin_4 SumFormula C184H282N50O60S 0.5 mg
H-8730.1000 Exenatide Salt Acetate Binding _ Synonym Exenatide, Exendin_4 SumFormula C184H282N50O60S 1.0 mg
orb82655 Exendin 4 protein Recombinant Exendin-4 is single non-glycosylated polypeptide chain containing 39 amino acids. Exendin-4 is a novel 39-amino acid peptide isolated from the venom of the Gila monster H 1 mg
E11E0022 Bovine Exendin 4 ELISA , EXENDIN-4 96 Tests/kit
E08E0022 Canine Exendin 4 ELISA , EXENDIN-4 96 Tests/kit
E07E0022 Porcine Exendin 4 ELISA , EXENDIN-4 96 Tests/kit
E06E0022 Goat Exendin 4 ELISA , EXENDIN-4 96 Tests/kit
E03E0022 Mouse Exendin 4 ELISA ,EXENDIN-4 96 Tests/kit
E08E0022 Canine Exendin 4 ELISA , EXENDIN-4
E01E0022 Human Exendin 4 ELISA , EXENDIN-4 96 Tests/kit
E04E0022 Rabbit Exendin 4 ELISA , EXENDIN-4 96 Tests/kit
E12E0022 Chicken Exendin 4 ELISA , EXENDIN-4 96 Tests/kit
E14E0022 Sheep Exendin 4 ELISA , EXENDIN-4
E04E0022 Rabbit Exendin 4 ELISA , EXENDIN-4
E09E0022 Monkey Exendin 4 ELISA , EXENDIN-4 96 Tests/kit
E03E0022 Mouse Exendin 4 ELISA , EXENDIN-4
E14E0022 Sheep Exendin 4 ELISA , EXENDIN-4 96 Tests/kit
E06E0022 Goat Exendin 4 ELISA , EXENDIN-4
E07E0022 Porcine Exendin 4 ELISA , EXENDIN-4
E01E0022 Human Exendin 4 ELISA , EXENDIN-4


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur