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Exonuclease mut-7 (EC 3.1.-.-) (Exonuclease 3'-5' domain-containing protein 3 homolog)

 MUT7_CAEEL              Reviewed;         910 AA.
P34607;
01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
01-FEB-1994, sequence version 1.
12-SEP-2018, entry version 128.
RecName: Full=Exonuclease mut-7;
EC=3.1.-.-;
AltName: Full=Exonuclease 3'-5' domain-containing protein 3 homolog;
Name=mut-7; ORFNames=ZK1098.8;
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
NCBI_TaxID=6239;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
PubMed=7906398; DOI=10.1038/368032a0;
Wilson R., Ainscough R., Anderson K., Baynes C., Berks M.,
Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A.,
Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A.,
Fulton L., Gardner A., Green P., Hawkins T., Hillier L., Jier M.,
Johnston L., Jones M., Kershaw J., Kirsten J., Laisster N.,
Latreille P., Lightning J., Lloyd C., Mortimore B., O'Callaghan M.,
Parsons J., Percy C., Rifken L., Roopra A., Saunders D., Shownkeen R.,
Sims M., Smaldon N., Smith A., Smith M., Sonnhammer E., Staden R.,
Sulston J., Thierry-Mieg J., Thomas K., Vaudin M., Vaughan K.,
Waterston R., Watson A., Weinstock L., Wilkinson-Sproat J.,
Wohldman P.;
"2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
elegans.";
Nature 368:32-38(1994).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
[3]
FUNCTION.
PubMed=10535732; DOI=10.1016/S0092-8674(00)81645-1;
Ketting R.F., Haverkamp T.H., van Luenen H.G., Plasterk R.H.;
"Mut-7 of C. elegans, required for transposon silencing and RNA
interference, is a homolog of Werner syndrome helicase and RNaseD.";
Cell 99:133-141(1999).
-!- FUNCTION: Represses the transposition of Tc1, Tc3, Tc4, and Tc5,
perhaps by degrading transposon-specific messages. Also affects
sperm development, sensitivity to RNAi of mainly germline
expressed genes, silencing of some germline transgenes, X
chromosome loss, and is required for cosuppression (functional
silencing of chromosomal loci induced by transgenes) and for
silencing induced by antisense RNA oligomers.
{ECO:0000269|PubMed:10535732}.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
-!- INTERACTION:
Q19672:rde-2; NbExp=8; IntAct=EBI-476365, EBI-476355;
-!- SIMILARITY: Belongs to the mut-7 family. {ECO:0000305}.
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EMBL; Z22176; CAA80137.1; -; Genomic_DNA.
PIR; S40930; S40930.
RefSeq; NP_499105.1; NM_066704.6.
UniGene; Cel.22480; -.
ProteinModelPortal; P34607; -.
BioGrid; 41542; 2.
IntAct; P34607; 1.
STRING; 6239.ZK1098.8; -.
EPD; P34607; -.
PaxDb; P34607; -.
PeptideAtlas; P34607; -.
PRIDE; P34607; -.
EnsemblMetazoa; ZK1098.8; ZK1098.8; WBGene00003504.
GeneID; 176347; -.
KEGG; cel:CELE_ZK1098.8; -.
UCSC; ZK1098.8; c. elegans.
CTD; 176347; -.
WormBase; ZK1098.8; CE00370; WBGene00003504; mut-7.
eggNOG; KOG2207; Eukaryota.
eggNOG; ENOG410YV3M; LUCA.
GeneTree; ENSGT00390000006843; -.
HOGENOM; HOG000019149; -.
InParanoid; P34607; -.
OMA; NDIFSRC; -.
OrthoDB; EOG091G04KJ; -.
PhylomeDB; P34607; -.
PRO; PR:P34607; -.
Proteomes; UP000001940; Chromosome III.
Bgee; WBGene00003504; Expressed in 5 organ(s), highest expression level in adult organism.
GO; GO:0005737; C:cytoplasm; IDA:WormBase.
GO; GO:0005829; C:cytosol; IDA:WormBase.
GO; GO:0005634; C:nucleus; IDA:WormBase.
GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:WormBase.
GO; GO:0008408; F:3'-5' exonuclease activity; IBA:GO_Central.
GO; GO:0044748; F:3'-5'-exoribonuclease activity involved in mature miRNA 3'-end processing; ISS:WormBase.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
GO; GO:0008306; P:associative learning; IMP:WormBase.
GO; GO:0044747; P:mature miRNA 3'-end processing; ISS:WormBase.
GO; GO:0000335; P:negative regulation of transposition, DNA-mediated; IMP:WormBase.
GO; GO:0008355; P:olfactory learning; IMP:WormBase.
GO; GO:0016441; P:posttranscriptional gene silencing; IMP:WormBase.
GO; GO:0016246; P:RNA interference; IMP:WormBase.
CDD; cd06146; mut-7_like_exo; 1.
Gene3D; 3.30.420.10; -; 1.
InterPro; IPR002562; 3'-5'_exonuclease_dom.
InterPro; IPR037432; Mut-7_DEDDy_dom.
InterPro; IPR002782; Mut7-C_RNAse_dom.
InterPro; IPR012337; RNaseH-like_sf.
InterPro; IPR036397; RNaseH_sf.
Pfam; PF01612; DNA_pol_A_exo1; 1.
Pfam; PF01927; Mut7-C; 1.
SMART; SM00474; 35EXOc; 1.
SUPFAM; SSF53098; SSF53098; 1.
1: Evidence at protein level;
Complete proteome; Exonuclease; Hydrolase; Magnesium; Metal-binding;
Nuclease; Reference proteome; RNA-mediated gene silencing.
CHAIN 1 910 Exonuclease mut-7.
/FTId=PRO_0000096650.
DOMAIN 404 605 3'-5' exonuclease.
SEQUENCE 910 AA; 105569 MW; 5512D15423517FCD CRC64;
MEEEPYKRKL TKAEKKAKYR TDYAEPLKSR REVLKAIMNG PESERERKVR AKNREFFNED
YRSGVNIYGM AVDMMKAMPD RGKTSGQSLA VWYLEDFGVW LKESGQETEL RQKYLTGTIQ
INALDVCTIG QKQLLSEIFD ITKEKFTEDI TQLLDAAIKK QDFSVAADMA IQYNLLRDHH
FEHLVLPLML SGKDQTAYKL ISNNERMQQQ LVEFFDRMVG ISVVAVEEML KPYKETKIMT
IPMEKLTGKT LDKLISTIIN KNTHEYNFSR ELSKFAKNHS QNGNLKALKF NISERYEKGK
SDDNYFQHMV ETFTKAEDVR EPILFYLWSS NDTEKQIDAI CFAIYLGIAS SSSYQLPNVM
RDFFRQPDSK LREAKELLVR RKTLQVPLNG EQLFVFENER RTQIHMVKTE SEMNYLCSEI
KSLSDEPAPV YVGFDSEWKP SNLTAVHDSK IAIIQLFFKN CVWLVDCVEL EKANMADDWW
QKFASRLFGD SPVKVVGFDM RNDLDAMATI PALKSSMKIE DTKNAFDLKR LAENVCDIDM
EILELPKKTF KLADLTHYLL GLELDKTEQC SNWQCRPLRK KQIVYAALDA VVVVETFKKI
LSIVEEKNKD ADIEKIVRES NVMAPKKDKG HKSYRKLKTI PWLELYDILR SHRNPTRSPQ
RPHDIKVIVD TMLIGFGKNL RRVGIDVILP KDVSDFRKYL KEIERVGGEH LRHIITVPSK
SYEALKMDYD NYTIAIPELN NMSPVDQLIE FFDLFNVDIR PEDVYPRCTE CNSRLQIKFP
GPVLHFLHQY CVIHVQNVYR ADMSEFPLEE WWNRMLHINP DDYDGVKVEM SRPSPTSKWI
VATVPTGCLH ITRQTALHTN LPDGIEVRIH KVPDDEFKRR NLSFYVCGEC GTVACDGRGN
QASESTSQEC


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