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Exosome complex component Csl4

 CSL4_ARCFU              Reviewed;         179 AA.
O30033;
11-DEC-2013, integrated into UniProtKB/Swiss-Prot.
01-JAN-1998, sequence version 1.
15-MAR-2017, entry version 101.
RecName: Full=Exosome complex component Csl4 {ECO:0000255|HAMAP-Rule:MF_00975};
Name=csl4 {ECO:0000255|HAMAP-Rule:MF_00975};
OrderedLocusNames=AF_0206;
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM
9628 / NBRC 100126).
Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales;
Archaeoglobaceae; Archaeoglobus.
NCBI_TaxID=224325;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126;
PubMed=9389475; DOI=10.1038/37052;
Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E.,
Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D.,
Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C.,
Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G., Gill S.R.,
Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J.,
Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A.,
Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A.,
Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P.,
Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C.,
Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O.,
Woese C.R., Venter J.C.;
"The complete genome sequence of the hyperthermophilic, sulphate-
reducing archaeon Archaeoglobus fulgidus.";
Nature 390:364-370(1997).
[2]
X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) IN COMPLEX WITH RRP41; RRP42
AND ZINC, FUNCTION, SUBUNIT, AND DOMAIN.
PubMed=16285927; DOI=10.1016/j.molcel.2005.10.018;
Buttner K., Wenig K., Hopfner K.P.;
"Structural framework for the mechanism of archaeal exosomes in RNA
processing.";
Mol. Cell 20:461-471(2005).
[3]
X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) IN COMPLEX WITH RRP41; RRP42
AND ZINC, FUNCTION, AND SUBUNIT.
PubMed=20392821; DOI=10.1093/nar/gkq238;
Hartung S., Niederberger T., Hartung M., Tresch A., Hopfner K.P.;
"Quantitative analysis of processive RNA degradation by the archaeal
RNA exosome.";
Nucleic Acids Res. 38:5166-5176(2010).
-!- FUNCTION: Non-catalytic component of the exosome, which is a
complex involved in RNA degradation. Increases the RNA binding and
the efficiency of RNA degradation. Helpful for the interaction of
the exosome with A-poor RNAs (Probable).
{ECO:0000305|PubMed:16285927, ECO:0000305|PubMed:20392821}.
-!- SUBUNIT: Component of the archaeal exosome complex. Forms a trimer
of Rrp4 and/or Csl4 subunits. The trimer associates with a
hexameric ring-like arrangement composed of 3 Rrp41-Rrp42
heterodimers. Interacts with DnaG (Probable).
{ECO:0000305|PubMed:16285927, ECO:0000305|PubMed:20392821}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00975}.
-!- DOMAIN: Contains an N-terminal domain that mediates interactions
with the hexameric ring, a central S1 domain and a C-terminal
zinc-ribbon domain. {ECO:0000269|PubMed:16285927}.
-!- MISCELLANEOUS: The zinc ion has probably a structural role.
{ECO:0000305|PubMed:16285927}.
-!- SIMILARITY: Belongs to the CSL4 family. {ECO:0000255|HAMAP-
Rule:MF_00975}.
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EMBL; AE000782; AAB91036.1; -; Genomic_DNA.
PIR; F69275; F69275.
RefSeq; WP_010877717.1; NC_000917.1.
PDB; 2BA1; X-ray; 2.70 A; A/B/C=1-179.
PDB; 3M7N; X-ray; 2.40 A; A/B/C=1-179.
PDB; 3M85; X-ray; 3.00 A; A/B/C=1-179.
PDBsum; 2BA1; -.
PDBsum; 3M7N; -.
PDBsum; 3M85; -.
ProteinModelPortal; O30033; -.
SMR; O30033; -.
STRING; 224325.AF0206; -.
EnsemblBacteria; AAB91036; AAB91036; AF_0206.
GeneID; 24793740; -.
KEGG; afu:AF_0206; -.
eggNOG; arCOG00676; Archaea.
eggNOG; COG1096; LUCA.
KO; K07573; -.
OMA; CGNVETR; -.
OrthoDB; POG093Z0LVA; -.
EvolutionaryTrace; O30033; -.
Proteomes; UP000002199; Chromosome.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0003723; F:RNA binding; IEA:InterPro.
GO; GO:0006396; P:RNA processing; IEA:InterPro.
HAMAP; MF_00975; Exosome_Csl4; 1.
InterPro; IPR019495; EXOSC1.
InterPro; IPR025721; Exosome_cplx_N_dom.
InterPro; IPR030850; Exosome_Csl4_arc.
InterPro; IPR012340; NA-bd_OB-fold.
InterPro; IPR022967; S1_dom.
Pfam; PF14382; ECR1_N; 1.
Pfam; PF10447; EXOSC1; 1.
SMART; SM00316; S1; 1.
SUPFAM; SSF50249; SSF50249; 1.
1: Evidence at protein level;
3D-structure; Complete proteome; Cytoplasm; Exosome; Metal-binding;
Reference proteome; Zinc.
CHAIN 1 179 Exosome complex component Csl4.
/FTId=PRO_0000424720.
DOMAIN 58 137 S1 motif. {ECO:0000255|HAMAP-
Rule:MF_00975}.
METAL 143 143 Zinc. {ECO:0000255|HAMAP-Rule:MF_00975,
ECO:0000269|PubMed:16285927,
ECO:0000269|PubMed:20392821}.
METAL 146 146 Zinc. {ECO:0000255|HAMAP-Rule:MF_00975,
ECO:0000269|PubMed:16285927,
ECO:0000269|PubMed:20392821}.
METAL 159 159 Zinc. {ECO:0000255|HAMAP-Rule:MF_00975,
ECO:0000269|PubMed:16285927,
ECO:0000269|PubMed:20392821}.
METAL 162 162 Zinc. {ECO:0000255|HAMAP-Rule:MF_00975,
ECO:0000269|PubMed:16285927,
ECO:0000269|PubMed:20392821}.
STRAND 9 12 {ECO:0000244|PDB:3M7N}.
TURN 13 15 {ECO:0000244|PDB:3M7N}.
STRAND 16 18 {ECO:0000244|PDB:3M7N}.
STRAND 22 25 {ECO:0000244|PDB:3M7N}.
STRAND 28 40 {ECO:0000244|PDB:3M7N}.
STRAND 43 50 {ECO:0000244|PDB:3M7N}.
STRAND 60 68 {ECO:0000244|PDB:3M7N}.
STRAND 70 80 {ECO:0000244|PDB:3M7N}.
STRAND 91 96 {ECO:0000244|PDB:3M7N}.
HELIX 97 99 {ECO:0000244|PDB:3M7N}.
HELIX 108 110 {ECO:0000244|PDB:3M7N}.
STRAND 117 124 {ECO:0000244|PDB:3M7N}.
TURN 125 127 {ECO:0000244|PDB:3M7N}.
STRAND 128 130 {ECO:0000244|PDB:3M7N}.
STRAND 133 135 {ECO:0000244|PDB:3M85}.
STRAND 137 140 {ECO:0000244|PDB:3M7N}.
TURN 144 146 {ECO:0000244|PDB:3M7N}.
STRAND 151 153 {ECO:0000244|PDB:2BA1}.
STRAND 154 158 {ECO:0000244|PDB:3M7N}.
STRAND 160 162 {ECO:0000244|PDB:3M7N}.
TURN 172 177 {ECO:0000244|PDB:3M7N}.
SEQUENCE 179 AA; 19597 MW; 3106D5592EF6EAF7 CRC64;
MRFVMPGDRI GSAEEYVKGE GVYEEGGELF AAVAGKLIIK DRVAKVESIS PIPEIVKGDV
VLGRVVDLRN SIALIEVSSK KGENRGPSNR GIGILHVSNV DEGYVKEISE AVGYLDILKA
RVIGDNLRLS TKEEEMGVLR ALCSNCKTEM VREGDILKCP ECGRVEKRKI STDYGKGEW


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