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Exportin-2 (Exp2) (Cellular apoptosis susceptibility protein) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)

 XPO2_PAGMA              Reviewed;         971 AA.
Q9PTU3;
23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
10-MAY-2017, entry version 60.
RecName: Full=Exportin-2;
Short=Exp2;
AltName: Full=Cellular apoptosis susceptibility protein;
AltName: Full=Chromosome segregation 1-like protein;
AltName: Full=Importin-alpha re-exporter;
Name=cse1l; Synonyms=cas, xpo2;
Pagrus major (Red sea bream) (Chrysophrys major).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
Eupercaria; Spariformes; Sparidae; Pagrus.
NCBI_TaxID=143350;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Choi C.Y., Yoshizaki G., Takashima F.;
"Cellular apoptosis susceptibility gene messenger ribonucleic acid in
the ovary of red seabream.";
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Export receptor for importin alpha. Mediates importin-
alpha re-export from the nucleus to the cytoplasm after import
substrates have been released into the nucleoplasm (By
similarity). Negatively regulates fluid secretion and plays a role
in fluid homeostasis by downregulating cftr activity (By
similarity). {ECO:0000250|UniProtKB:P55060,
ECO:0000250|UniProtKB:Q7SZC2}.
-!- SUBUNIT: Interacts with cftr. {ECO:0000250|UniProtKB:Q7SZC2}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P55060}.
Nucleus {ECO:0000250|UniProtKB:P55060}. Note=Shuttles between the
nucleus and the cytoplasm. {ECO:0000250|UniProtKB:P55060}.
-!- SIMILARITY: Belongs to the XPO2/CSE1 family. {ECO:0000305}.
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EMBL; AB036757; BAA89430.1; -; mRNA.
ProteinModelPortal; Q9PTU3; -.
SMR; Q9PTU3; -.
PRIDE; Q9PTU3; -.
HOVERGEN; HBG080050; -.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0008536; F:Ran GTPase binding; IEA:InterPro.
GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
Gene3D; 1.25.10.10; -; 1.
InterPro; IPR011989; ARM-like.
InterPro; IPR016024; ARM-type_fold.
InterPro; IPR005043; CAS_CSE1_C.
InterPro; IPR013713; Cse1.
InterPro; IPR001494; Importin-beta_N.
Pfam; PF03378; CAS_CSE1; 1.
Pfam; PF08506; Cse1; 1.
Pfam; PF03810; IBN_N; 1.
SMART; SM00913; IBN_N; 1.
SUPFAM; SSF48371; SSF48371; 1.
PROSITE; PS50166; IMPORTIN_B_NT; 1.
2: Evidence at transcript level;
Cytoplasm; Nucleus; Protein transport; Transport.
CHAIN 1 971 Exportin-2.
/FTId=PRO_0000117289.
DOMAIN 29 102 Importin N-terminal.
{ECO:0000255|PROSITE-ProRule:PRU00115}.
SEQUENCE 971 AA; 109972 MW; C74E9277C50E5A38 CRC64;
MELNDANLQT LTEFLRKALD PDPTVRRPAE KFLESVEGNQ NYPLLLLTLL EKSQDNVIRV
CAAVTFKNYI KRNWRVIEDE PNKVSDPDRT AIKANIVNLM LSSPEQIQKQ LSDAISIIGR
EDFPQKWPDL LTEMVTRFRS GDFHIINGVL RTAHSLFKRY RHEFKSNELW SEIKLVLDTF
ALPLTELFKA TIELCQTHAT DVNALKVLFS SLTLISKLFY SLNFQDLPEF FEDNMETWMT
NFHGLLTLDN KLLQTDDEEE AGLLELLKSQ ICDNAALYAQ KYDEEFQPYL PRFVTAIWNL
LVSTGQEVKY DLLVSNAIQF LASVCERPHY KHLFEDQNTL TSICEKVIVP NMEFRSADEE
AFEDNSEEYI RRDLEGSDID TRRRAACDLV RGLCKFFEGP VTAIFSGYVN SMLAEYAKNP
GENWKHKDAA IYLVTSLASK AQTQKHGITQ ANELVNLNEF FVNHILSDLK SHNVNEFPVL
KADAIKYVMI FRSQLPKEQL LQAVPLLISH LQAESTVEHT YAAHALERLF TMRGPNNTTL
ITPVEMAPFT EQLLNNLFKS LALPGSAENE YIMKAIMRTF SLLQEAIVPY IPTLIGQLTH
KLLLVSKNPS KPHFNHYLFE SLCLSVRITC KANPATVSSF EEALFPVFTE ILQNDVQEFL
PYVFQVMSLL LEIHSSSIPS SYMALFPHLL QPALWERTGN IPPLVRLLQA YLEKGGATIA
ASAADKIPGL LGVFQKLIAS KANDHQGFYL LNSIIEHMPP ESITQYRKQI FILLFQRLQS
SKTTKFIKSF LVFVNLYSVK YGAIALQEIF DSIQPKMFGM VLEKIIIPEV QKVSGAVEKK
ICAVGITKVL TECPAMMDTE YTKLWTPLLQ ALIGLFELPE DDSIPDDEHF IDIEDTPGYQ
TAFSQLAFAG KKEHDPIGDA VGNPKILLAQ SLHKLSTACP GRVPSMLSTS LNAEALQFLQ
GYLQAATVQL V


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