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External core antigen (HBeAg) (Precore protein) (p25)

 HBEAG_HBVD3             Reviewed;         212 AA.
P0C573;
18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
18-MAR-2008, sequence version 1.
23-MAY-2018, entry version 39.
RecName: Full=External core antigen {ECO:0000255|HAMAP-Rule:MF_04076};
AltName: Full=HBeAg {ECO:0000255|HAMAP-Rule:MF_04076};
AltName: Full=Precore protein {ECO:0000255|HAMAP-Rule:MF_04076};
AltName: Full=p25 {ECO:0000255|HAMAP-Rule:MF_04076};
Flags: Precursor;
Name=C {ECO:0000255|HAMAP-Rule:MF_04076};
Hepatitis B virus genotype D subtype ayw (isolate
France/Tiollais/1979) (HBV-D).
Viruses; Retro-transcribing viruses; Hepadnaviridae;
Orthohepadnavirus.
NCBI_TaxID=490133;
NCBI_TaxID=9606; Homo sapiens (Human).
NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=399327; DOI=10.1038/281646a0;
Galibert F., Mandart E., Fitoussi F., Tiollais P., Charnay P.;
"Nucleotide sequence of the hepatitis B virus genome (subtype ayw)
cloned in E. coli.";
Nature 281:646-650(1979).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Latvia;
PubMed=3996597; DOI=10.1016/0014-5793(85)80771-7;
Bichko V., Pushko P., Dreilina D., Pumpen P., Gren E.Y.;
"Subtype ayw variant of hepatitis B virus. DNA primary structure
analysis.";
FEBS Lett. 185:208-212(1985).
[3]
CLEAVAGE BY HOST FURIN, AND MUTAGENESIS OF ARG-180; ARG-183; ARG-186;
ARG-188; ARG-193; ARG-196; ARG-201 AND ARG-204.
PubMed=17881438; DOI=10.1128/JVI.00846-07;
Nassal M., Leifer I., Wingert I., Dallmeier K., Prinz S.,
Vorreiter J.;
"A structural model for duck hepatitis B virus core protein derived by
extensive mutagenesis.";
J. Virol. 81:13218-13229(2007).
-!- FUNCTION: May regulate immune response to the intracellular capsid
in acting as a T-cell tolerogen, by having an immunoregulatory
effect which prevents destruction of infected cells by cytotoxic
T-cells. This immune regulation may predispose to chronicity
during perinatal infections and prevent severe liver injury during
adult infections. {ECO:0000255|HAMAP-Rule:MF_04076}.
-!- SUBUNIT: Homodimerizes. {ECO:0000255|HAMAP-Rule:MF_04076}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000255|HAMAP-Rule:MF_04076}.
Host nucleus {ECO:0000255|HAMAP-Rule:MF_04076}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative initiation; Named isoforms=2;
Name=External core antigen;
IsoId=P0C573-1; Sequence=Displayed;
Name=Capsid protein;
IsoId=P03146-1; Sequence=External;
-!- PTM: Phosphorylated. {ECO:0000255|HAMAP-Rule:MF_04076}.
-!- PTM: Cleaved by host furin. {ECO:0000255|HAMAP-Rule:MF_04076}.
-!- SIMILARITY: Belongs to the orthohepadnavirus precore antigen
family. {ECO:0000255|HAMAP-Rule:MF_04076}.
-!- WEB RESOURCE: Name=HepSEQ; Note=Hepatitis virus B database;
URL="http://www.hpa-bioinformatics.org.uk/HepSEQ/main.php";
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EMBL; V01460; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; X02496; -; NOT_ANNOTATED_CDS; Genomic_DNA.
ProteinModelPortal; P0C573; -.
SMR; P0C573; -.
OrthoDB; VOG090000IS; -.
Proteomes; UP000007930; Genome.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
GO; GO:0030683; P:evasion or tolerance by virus of host immune response; IEA:UniProtKB-KW.
GO; GO:0009405; P:pathogenesis; IEA:InterPro.
Gene3D; 1.10.4090.10; -; 1.
HAMAP; MF_04076; HBV_HBEAG; 1.
InterPro; IPR013195; Hepatitis_B_virus_capsid_N.
InterPro; IPR002006; Hepatitis_core.
InterPro; IPR036459; Viral_capsid_core_dom_sf_HBV.
Pfam; PF08290; Hep_core_N; 1.
Pfam; PF00906; Hepatitis_core; 3.
ProDom; PD000874; Vir_capsid_Znf-put_N_Hepatitis; 1.
SUPFAM; SSF47852; SSF47852; 1.
1: Evidence at protein level;
Alternative initiation; Complete proteome; Disulfide bond;
Host nucleus; Host-virus interaction; Repeat; Secreted; Signal;
Viral immunoevasion.
SIGNAL 1 19 {ECO:0000255|HAMAP-Rule:MF_04076}.
CHAIN 20 212 External core antigen.
{ECO:0000255|HAMAP-Rule:MF_04076}.
/FTId=PRO_0000324724.
PROPEP 184 212
/FTId=PRO_0000324725.
REPEAT 184 190 1; half-length.
REPEAT 191 198 2.
REPEAT 199 206 3.
REGION 25 27 HBEAG. {ECO:0000255|HAMAP-Rule:MF_04076}.
REGION 184 206 3 X 8 AA repeats of S-P-R-R-R-R-S-Q.
SITE 183 184 Cleavage; by host. {ECO:0000255|HAMAP-
Rule:MF_04076}.
DISULFID 77 77 Interchain. {ECO:0000255|HAMAP-
Rule:MF_04076}.
DISULFID 90 90 Interchain. {ECO:0000255|HAMAP-
Rule:MF_04076}.
MUTAGEN 180 180 R->G: Complete loss of cleavage.
{ECO:0000269|PubMed:17881438}.
MUTAGEN 183 183 R->G: Complete loss of cleavage.
{ECO:0000269|PubMed:17881438}.
MUTAGEN 186 186 R->G: No effect on cleavage.
{ECO:0000269|PubMed:17881438}.
MUTAGEN 188 188 R->G: No effect on cleavage.
{ECO:0000269|PubMed:17881438}.
MUTAGEN 193 193 R->G: No effect on cleavage.
{ECO:0000269|PubMed:17881438}.
MUTAGEN 196 196 R->G: No effect on cleavage.
{ECO:0000269|PubMed:17881438}.
MUTAGEN 201 201 R->G: No effect on cleavage.
{ECO:0000269|PubMed:17881438}.
MUTAGEN 204 204 R->G: No effect on cleavage.
{ECO:0000269|PubMed:17881438}.
SEQUENCE 212 AA; 24350 MW; D3016A4E8B05A1B8 CRC64;
MQLFHLCLII SCSCPTVQAS KLCLGWLWGM DIDPYKEFGA TVELLSFLPS DFFPSVRDLL
DTASALYREA LESPEHCSPH HTALRQAILC WGELMTLATW VGVNLEDPAS RDLVVSYVNT
NMGLKFRQLL WFHISCLTFG RETVIEYLVS FGVWIRTPPA YRPPNAPILS TLPETTVVRR
RGRSPRRRTP SPRRRRSQSP RRRRSQSRES QC


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