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Extracellular serine/threonine protein kinase FAM20C (EC 2.7.11.1) (Dentin matrix protein 4) (DMP-4) (Golgi casein kinase) (Golgi-enriched fraction casein kinase) (GEF-CK)
FA20C_HUMAN Reviewed; 584 AA.
Q8IXL6; A4D2Q5; L8B5W8; Q5I0W9; Q7Z4I0; Q9NPT2;
19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
05-APR-2011, sequence version 2.
28-MAR-2018, entry version 126.
RecName: Full=Extracellular serine/threonine protein kinase FAM20C {ECO:0000305};
EC=2.7.11.1 {ECO:0000269|PubMed:22582013, ECO:0000269|PubMed:23754375, ECO:0000269|PubMed:25789606};
AltName: Full=Dentin matrix protein 4 {ECO:0000250|UniProtKB:Q5MJS3};
Short=DMP-4 {ECO:0000250|UniProtKB:Q5MJS3};
AltName: Full=Golgi casein kinase {ECO:0000303|PubMed:22582013};
AltName: Full=Golgi-enriched fraction casein kinase {ECO:0000303|PubMed:22582013};
Short=GEF-CK {ECO:0000303|PubMed:22582013};
Flags: Precursor;
Name=FAM20C {ECO:0000312|HGNC:HGNC:22140};
Synonyms=DMP4 {ECO:0000250|UniProtKB:Q5MJS3};
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Brain;
Wu C., Ding P., Han W., Rui M., Wang Y., Song Q., Ma D.;
Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Kitagawa H., Izumikawa T., Koike T.;
"Molecular cloning and characterization of a novel xylosylkinase.";
Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=12853948; DOI=10.1038/nature01782;
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
Waterston R.H., Wilson R.K.;
"The DNA sequence of human chromosome 7.";
Nature 424:157-164(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=12690205; DOI=10.1126/science.1083423;
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
Kanematsu E., Gentles S., Christopoulos C.C., Choufani S.,
Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z.,
Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C.,
Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J.,
Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F.,
Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F.,
Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H.,
Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G.,
Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P.,
Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J.,
Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F.,
Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B.,
Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W.,
Mural R.J., Adams M.D., Tsui L.-C.;
"Human chromosome 7: DNA sequence and biology.";
Science 300:767-772(2003).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Brain;
PubMed=17974005; DOI=10.1186/1471-2164-8-399;
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
"The full-ORF clone resource of the German cDNA consortium.";
BMC Genomics 8:399-399(2007).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[8]
PROTEIN SEQUENCE OF N-TERMINUS, FUNCTION, SUBCELLULAR LOCATION,
AUTOPHOSPHORYLATION, GLYCOSYLATION AT ASN-101; ASN-335 AND ASN-470,
AND MUTAGENESIS OF 93-LEU--ASP-95; ASN-101; ASN-335; ASN-470 AND
ASP-478.
PubMed=26091039; DOI=10.1016/j.cell.2015.05.028;
Tagliabracci V.S., Wiley S.E., Guo X., Kinch L.N., Durrant E., Wen J.,
Xiao J., Cui J., Nguyen K.B., Engel J.L., Coon J.J., Grishin N.,
Pinna L.A., Pagliarini D.J., Dixon J.E.;
"A single kinase generates the majority of the secreted
phosphoproteome.";
Cell 161:1619-1632(2015).
[9]
TISSUE SPECIFICITY.
PubMed=15676076; DOI=10.1186/1471-2164-6-11;
Nalbant D., Youn H., Nalbant S.I., Sharma S., Cobos E., Beale E.G.,
Du Y., Williams S.C.;
"FAM20: an evolutionarily conserved family of secreted proteins
expressed in hematopoietic cells.";
BMC Genomics 6:11-11(2005).
[10]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-470.
TISSUE=Liver;
PubMed=19159218; DOI=10.1021/pr8008012;
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
"Glycoproteomics analysis of human liver tissue by combination of
multiple enzyme digestion and hydrazide chemistry.";
J. Proteome Res. 8:651-661(2009).
[11]
FUNCTION, CATALYTIC ACTIVITY, MANGANESE-BINDING, MUTAGENESIS OF
ASP-478, VARIANTS RNS ASN-258; ARG-280; SER-328; ARG-379; GLU-379;
ARG-388; ASN-451 AND TRP-549, AND CHARACTERIZATION OF VARIANTS RNS
SER-328 AND ASN-451.
PubMed=22582013; DOI=10.1126/science.1217817;
Tagliabracci V.S., Engel J.L., Wen J., Wiley S.E., Worby C.A.,
Kinch L.N., Xiao J., Grishin N.V., Dixon J.E.;
"Secreted kinase phosphorylates extracellular proteins that regulate
biomineralization.";
Science 336:1150-1153(2012).
[12]
FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, COFACTOR,
ACTIVE SITE, AND MUTAGENESIS OF LYS-271; LYS-285; GLU-306; GLU-311;
ARG-408; ASP-458 AND ASP-458.
PubMed=23754375; DOI=10.1073/pnas.1309211110;
Xiao J., Tagliabracci V.S., Wen J., Kim S.A., Dixon J.E.;
"Crystal structure of the Golgi casein kinase.";
Proc. Natl. Acad. Sci. U.S.A. 110:10574-10579(2013).
[13]
FUNCTION, CATALYTIC ACTIVITY, ENZYME REGULATION, INTERACTION WITH
FAM20A, MUTAGENESIS OF GLU-306 AND ASP-478, VARIANTS RNS MET-268 AND
SER-328, AND CHARACTERIZATION OF VARIANTS RNS MET-268 AND SER-328.
PubMed=25789606; DOI=10.7554/eLife.06120;
Cui J., Xiao J., Tagliabracci V.S., Wen J., Rahdar M., Dixon J.E.;
"A secretory kinase complex regulates extracellular protein
phosphorylation.";
Elife 4:0-0(2015).
[14]
VARIANTS RNS ARG-379; GLU-379; ARG-388 AND TRP-549.
PubMed=17924334; DOI=10.1086/522240;
Simpson M.A., Hsu R., Keir L.S., Hao J., Sivapalan G., Ernst L.M.,
Zackai E.H., Al-Gazali L.I., Hulskamp G., Kingston H.M.,
Prescott T.E., Ion A., Patton M.A., Murday V., George A., Crosby A.H.;
"Mutations in FAM20C are associated with lethal osteosclerotic bone
dysplasia (Raine syndrome), highlighting a crucial molecule in bone
development.";
Am. J. Hum. Genet. 81:906-912(2007).
-!- FUNCTION: Golgi serine/threonine protein kinase that
phosphorylates secretory pathway proteins within Ser-x-Glu/pSer
motifs and plays a key role in biomineralization of bones and
teeth (PubMed:22582013, PubMed:23754375, PubMed:25789606).
Constitutes the main protein kinase for extracellular proteins,
generating the majority of the extracellular phosphoproteome
(PubMed:26091039). Mainly phosphorylates proteins within the Ser-
x-Glu/pSer motif, but also displays a broader substrate
specificity (PubMed:26091039). Phosphorylates casein as well as a
number of proteins involved in biomineralization such as AMELX,
AMTN, ENAM and SPP1 (PubMed:22582013, PubMed:25789606). In
addition to its role in biomineralization, also plays a role in
lipid homeostasis, wound healing and cell migration and adhesion
(PubMed:26091039). {ECO:0000269|PubMed:22582013,
ECO:0000269|PubMed:23754375, ECO:0000269|PubMed:25789606,
ECO:0000269|PubMed:26091039}.
-!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
{ECO:0000269|PubMed:22582013, ECO:0000269|PubMed:23754375,
ECO:0000269|PubMed:25789606}.
-!- COFACTOR:
Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
Evidence={ECO:0000269|PubMed:23754375,
ECO:0000305|PubMed:22582013};
-!- ENZYME REGULATION: Serine/threonine protein kinase activity is
increased upon interaction with FAM20A.
{ECO:0000269|PubMed:25789606}.
-!- BIOPHYSICOCHEMICAL PROPERTIES:
Kinetic parameters:
KM=0.8 uM for manganese/ATP {ECO:0000269|PubMed:23754375};
-!- SUBUNIT: Interacts with FAM20A; probably forming a heterotetramer
of 2 subunits of FAM20A and 2 subunits of FAM20C.
{ECO:0000269|PubMed:25789606}.
-!- INTERACTION:
Q9NP70:AMBN; NbExp=2; IntAct=EBI-7147442, EBI-11893530;
Q6UX39:AMTN; NbExp=2; IntAct=EBI-7147442, EBI-11892684;
O14791:APOL1; NbExp=2; IntAct=EBI-7147442, EBI-1221934;
P05060:CHGB; NbExp=2; IntAct=EBI-7147442, EBI-712619;
P02666:CSN2 (xeno); NbExp=3; IntAct=EBI-7147442, EBI-5260183;
Q9NRM1:ENAM; NbExp=2; IntAct=EBI-7147442, EBI-11892601;
Q96MK3:FAM20A; NbExp=3; IntAct=EBI-7147442, EBI-11892970;
P02671:FGA; NbExp=2; IntAct=EBI-7147442, EBI-348571;
P08833:IGFBP1; NbExp=2; IntAct=EBI-7147442, EBI-13646303;
P02810:PRH2; NbExp=2; IntAct=EBI-7147442, EBI-738601;
P01008:SERPINC1; NbExp=2; IntAct=EBI-7147442, EBI-1039832;
P10451:SPP1; NbExp=3; IntAct=EBI-7147442, EBI-723648;
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:26091039}.
Golgi apparatus {ECO:0000250|UniProtKB:Q5MJS3}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q8IXL6-1; Sequence=Displayed;
Name=2;
IsoId=Q8IXL6-2; Sequence=VSP_040834;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Widely expressed.
{ECO:0000269|PubMed:15676076}.
-!- PTM: N-glycosylation is required for folding.
{ECO:0000305|PubMed:26091039}.
-!- PTM: Autophosphorylated. {ECO:0000269|PubMed:26091039}.
-!- DISEASE: Raine syndrome (RNS) [MIM:259775]: Autosomal recessive
osteosclerotic bone dysplasia with neonatal lethal outcome.
Clinical features include generalized osteosclerosis, craniofacial
dysplasia and microcephaly. {ECO:0000269|PubMed:17924334,
ECO:0000269|PubMed:22582013, ECO:0000269|PubMed:25789606}.
Note=The disease is caused by mutations affecting the gene
represented in this entry.
-!- SIMILARITY: Belongs to the FAM20 family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAH40074.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Sequence=EAL23705.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
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EMBL; AF533706; AAQ09019.1; -; mRNA.
EMBL; AB545605; BAM78534.1; -; mRNA.
EMBL; AC093627; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC145676; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC187652; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH236966; EAL23705.1; ALT_INIT; Genomic_DNA.
EMBL; CH471144; EAW87149.1; -; Genomic_DNA.
EMBL; BC040074; AAH40074.1; ALT_INIT; mRNA.
EMBL; BC087853; AAH87853.1; -; mRNA.
EMBL; AL390147; CAB99089.2; -; mRNA.
CCDS; CCDS47522.1; -. [Q8IXL6-1]
PIR; T51872; T51872.
RefSeq; NP_064608.2; NM_020223.3. [Q8IXL6-1]
UniGene; Hs.134742; -.
UniGene; Hs.733582; -.
ProteinModelPortal; Q8IXL6; -.
SMR; Q8IXL6; -.
BioGrid; 121294; 8.
IntAct; Q8IXL6; 71.
MINT; Q8IXL6; -.
STRING; 9606.ENSP00000322323; -.
iPTMnet; Q8IXL6; -.
PhosphoSitePlus; Q8IXL6; -.
BioMuta; FAM20C; -.
DMDM; 327478506; -.
MaxQB; Q8IXL6; -.
PaxDb; Q8IXL6; -.
PeptideAtlas; Q8IXL6; -.
PRIDE; Q8IXL6; -.
Ensembl; ENST00000313766; ENSP00000322323; ENSG00000177706. [Q8IXL6-1]
GeneID; 56975; -.
KEGG; hsa:56975; -.
UCSC; uc003sip.4; human. [Q8IXL6-1]
CTD; 56975; -.
DisGeNET; 56975; -.
EuPathDB; HostDB:ENSG00000177706.8; -.
GeneCards; FAM20C; -.
H-InvDB; HIX0019573; -.
HGNC; HGNC:22140; FAM20C.
HPA; HPA019823; -.
MalaCards; FAM20C; -.
MIM; 259775; phenotype.
MIM; 611061; gene.
neXtProt; NX_Q8IXL6; -.
OpenTargets; ENSG00000177706; -.
Orphanet; 1832; Lethal osteosclerotic bone dysplasia.
PharmGKB; PA134898453; -.
eggNOG; KOG3829; Eukaryota.
eggNOG; ENOG410XQEJ; LUCA.
GeneTree; ENSGT00390000007484; -.
HOGENOM; HOG000231437; -.
HOVERGEN; HBG051635; -.
InParanoid; Q8IXL6; -.
KO; K21958; -.
OMA; LPLRQCC; -.
OrthoDB; EOG091G1BEO; -.
PhylomeDB; Q8IXL6; -.
TreeFam; TF313276; -.
Reactome; R-HSA-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
Reactome; R-HSA-8957275; Post-translational protein phosphorylation.
ChiTaRS; FAM20C; human.
GeneWiki; FAM20C; -.
GenomeRNAi; 56975; -.
PRO; PR:Q8IXL6; -.
Proteomes; UP000005640; Chromosome 7.
Bgee; ENSG00000177706; -.
CleanEx; HS_FAM20C; -.
Genevisible; Q8IXL6; HS.
GO; GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
GO; GO:0030145; F:manganese ion binding; IDA:UniProtKB.
GO; GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO; GO:0046034; P:ATP metabolic process; IEA:Ensembl.
GO; GO:0031214; P:biomineral tissue development; IMP:UniProtKB.
GO; GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO; GO:0097187; P:dentinogenesis; IEA:Ensembl.
GO; GO:0070166; P:enamel mineralization; IEA:Ensembl.
GO; GO:0071895; P:odontoblast differentiation; IEA:Ensembl.
GO; GO:0036179; P:osteoclast maturation; IEA:Ensembl.
GO; GO:0030501; P:positive regulation of bone mineralization; IEA:Ensembl.
GO; GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Ensembl.
GO; GO:0043687; P:post-translational protein modification; TAS:Reactome.
GO; GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO; GO:0040036; P:regulation of fibroblast growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:0051174; P:regulation of phosphorus metabolic process; IEA:Ensembl.
InterPro; IPR024869; FAM20.
InterPro; IPR009581; FAM20_C.
PANTHER; PTHR12450; PTHR12450; 1.
Pfam; PF06702; Fam20C; 1.
1: Evidence at protein level;
Alternative splicing; ATP-binding; Biomineralization; Calcium;
Complete proteome; Direct protein sequencing; Disease mutation;
Disulfide bond; Glycoprotein; Golgi apparatus; Kinase; Manganese;
Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome;
Secreted; Serine/threonine-protein kinase; Signal; Transferase.
SIGNAL 1 22 {ECO:0000255}.
PROPEP 23 92 {ECO:0000269|PubMed:26091039}.
/FTId=PRO_0000433883.
CHAIN 93 584 Extracellular serine/threonine protein
kinase FAM20C.
/FTId=PRO_0000008747.
NP_BIND 389 392 ATP. {ECO:0000250|UniProtKB:Q9XTW2}.
REGION 354 565 Kinase domain.
{ECO:0000305|PubMed:22582013}.
ACT_SITE 458 458 {ECO:0000269|PubMed:23754375}.
METAL 306 306 Manganese.
{ECO:0000250|UniProtKB:Q9XTW2}.
METAL 478 478 Manganese. {ECO:0000305|PubMed:22582013}.
BINDING 269 269 ATP; via amide nitrogen.
{ECO:0000250|UniProtKB:Q9XTW2}.
BINDING 285 285 ATP. {ECO:0000250|UniProtKB:Q9XTW2}.
BINDING 306 306 ATP. {ECO:0000250|UniProtKB:Q9XTW2}.
BINDING 463 463 ATP. {ECO:0000250|UniProtKB:Q9XTW2}.
BINDING 478 478 ATP. {ECO:0000250|UniProtKB:Q9XTW2}.
CARBOHYD 101 101 N-linked (GlcNAc...) asparagine.
{ECO:0000269|PubMed:26091039}.
CARBOHYD 335 335 N-linked (GlcNAc...) asparagine.
{ECO:0000269|PubMed:26091039}.
CARBOHYD 470 470 N-linked (GlcNAc...) asparagine.
{ECO:0000269|PubMed:19159218,
ECO:0000269|PubMed:26091039}.
DISULFID 362 378 {ECO:0000250|UniProtKB:Q9XTW2}.
DISULFID 367 371 {ECO:0000250|UniProtKB:Q9XTW2}.
DISULFID 426 500 {ECO:0000250|UniProtKB:Q9XTW2}.
DISULFID 501 560 {ECO:0000250|UniProtKB:Q9XTW2}.
VAR_SEQ 1 332 Missing (in isoform 2).
{ECO:0000303|PubMed:17974005}.
/FTId=VSP_040834.
VARIANT 258 258 I -> N (in RNS).
{ECO:0000269|PubMed:22582013}.
/FTId=VAR_073660.
VARIANT 268 268 T -> M (in RNS; mild non-lethal form;
decreased protein kinase activity;
dbSNP:rs778899041).
{ECO:0000269|PubMed:25789606}.
/FTId=VAR_073661.
VARIANT 280 280 G -> R (in RNS; dbSNP:rs779708323).
{ECO:0000269|PubMed:22582013}.
/FTId=VAR_073662.
VARIANT 328 328 P -> S (in RNS; mild non-lethal form;
decreased protein kinase activity; FAM20A
is still able to increase remaining
protein kinase activity;
dbSNP:rs797044462).
{ECO:0000269|PubMed:22582013,
ECO:0000269|PubMed:25789606}.
/FTId=VAR_073663.
VARIANT 379 379 G -> E (in RNS; dbSNP:rs796051852).
{ECO:0000269|PubMed:17924334,
ECO:0000269|PubMed:22582013}.
/FTId=VAR_037530.
VARIANT 379 379 G -> R (in RNS).
{ECO:0000269|PubMed:17924334,
ECO:0000269|PubMed:22582013}.
/FTId=VAR_037531.
VARIANT 388 388 L -> R (in RNS; dbSNP:rs796051849).
{ECO:0000269|PubMed:17924334,
ECO:0000269|PubMed:22582013}.
/FTId=VAR_037532.
VARIANT 451 451 D -> N (in RNS; mild non-lethal form;
decreased protein kinase activity).
{ECO:0000269|PubMed:22582013}.
/FTId=VAR_073664.
VARIANT 549 549 R -> W (in RNS; dbSNP:rs796051850).
{ECO:0000269|PubMed:17924334,
ECO:0000269|PubMed:22582013}.
/FTId=VAR_037533.
MUTAGEN 91 93 LQD->AAA: Does not affect secretion or
activity. {ECO:0000269|PubMed:26091039}.
MUTAGEN 101 101 N->A: Impaired secretion; when associated
with A-335 and A-470.
{ECO:0000269|PubMed:26091039}.
MUTAGEN 271 271 K->A: Reduced kinase activity.
{ECO:0000269|PubMed:23754375}.
MUTAGEN 285 285 K->A: Reduced kinase activity.
{ECO:0000269|PubMed:23754375}.
MUTAGEN 306 306 E->A,Q: Strongly reduced kinase activity.
{ECO:0000269|PubMed:23754375,
ECO:0000269|PubMed:25789606}.
MUTAGEN 311 311 E->A: Reduced kinase activity.
{ECO:0000269|PubMed:23754375}.
MUTAGEN 335 335 N->A: Impaired secretion; when associated
with A-101 and A-470.
{ECO:0000269|PubMed:26091039}.
MUTAGEN 408 408 R->A: Reduced kinase activity.
{ECO:0000269|PubMed:23754375}.
MUTAGEN 458 458 D->A: Abrogates kinase activity.
{ECO:0000269|PubMed:23754375}.
MUTAGEN 470 470 N->A: Impaired secretion; when associated
with A-101 and A-335.
{ECO:0000269|PubMed:26091039}.
MUTAGEN 478 478 D->A: Unable to bind manganese; abrogates
kinase activity.
{ECO:0000269|PubMed:22582013,
ECO:0000269|PubMed:23754375,
ECO:0000269|PubMed:25789606,
ECO:0000269|PubMed:26091039}.
CONFLICT 274 288 MTFQNYGQALFKPMK -> FLSDKPFLFLSCFLR (in
Ref. 6; CAB99089). {ECO:0000305}.
CONFLICT 564 564 N -> D (in Ref. 5; AAH87853 and 6;
CAB99089). {ECO:0000305}.
SEQUENCE 584 AA; 66234 MW; ECD278B5EA681FEF CRC64;
MKMMLVRRFR VLILMVFLVA CALHIALDLL PRLERRGARP SGEPGCSCAQ PAAEVAAPGW
AQVRGRPGEP PAASSAAGDA GWPNKHTLRI LQDFSSDPSS NLSSHSLEKL PPAAEPAERA
LRGRDPGALR PHDPAHRPLL RDPGPRRSES PPGPGGDASL LARLFEHPLY RVAVPPLTEE
DVLFNVNSDT RLSPKAAENP DWPHAGAEGA EFLSPGEAAV DSYPNWLKFH IGINRYELYS
RHNPAIEALL HDLSSQRITS VAMKSGGTQL KLIMTFQNYG QALFKPMKQT REQETPPDFF
YFSDYERHNA EIAAFHLDRI LDFRRVPPVA GRMVNMTKEI RDVTRDKKLW RTFFISPANN
ICFYGECSYY CSTEHALCGK PDQIEGSLAA FLPDLSLAKR KTWRNPWRRS YHKRKKAEWE
VDPDYCEEVK QTPPYDSSHR ILDVMDMTIF DFLMGNMDRH HYETFEKFGN ETFIIHLDNG
RGFGKYSHDE LSILVPLQQC CRIRKSTYLR LQLLAKEEYK LSLLMAESLR GDQVAPVLYQ
PHLEALDRRL RVVLKAVRDC VERNGLHSVV DDDLDTEHRA ASAR
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Pathways :
WP1493: Carbon assimilation C4 pathway
WP1659: Glycine, serine and threonine metabolism
WP1438: Influenza A virus infection
WP1567: Glycolysis and Gluconeogenesis
WP1619: Amino sugar and nucleotide sugar metabolism
WP1653: Galactose metabolism
WP1681: Pantothenate and CoA biosynthesis
WP1701: Starch and sucrose metabolism
WP1703: Streptomycin biosynthesis
WP1844: MAP kinase cascade
WP1946: Cori Cycle
WP2199: Seed Development
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP253: Glycolysis
WP32: Translation Factors
WP1049: G Protein Signaling Pathways
WP1165: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways
WP1502: Mitochondrial biogenesis
WP1531: Vitamin D synthesis
WP1566: Citrate cycle (TCA cycle)
WP1613: 1,4-Dichlorobenzene degradation
WP1616: ABC transporters
WP1624: Bacterial secretion system
Related Genes :
[EFEMP1 FBLN3 FBNL] EGF-containing fibulin-like extracellular matrix protein 1 (Extracellular protein S1-5) (Fibrillin-like protein) (Fibulin-3) (FIBL-3)
[arbA] Extracellular exo-alpha-(1->5)-L-arabinofuranosidase ArbA (ABF) (EC 3.2.1.55) (Extracellular arabinan exo-alpha-(1->5)-L-arabinosidase ArbA) (Arabinosidase)
[fbpB Rv1886c MTCY180.32] Diacylglycerol acyltransferase/mycolyltransferase Ag85B (DGAT) (EC 2.3.1.122) (EC 2.3.1.20) (30 kDa extracellular protein) (Acyl-CoA:diacylglycerol acyltransferase) (Antigen 85 complex B) (85B) (Ag85B) (Extracellular alpha-antigen) (Fibronectin-binding protein B) (Fbps B)
[MAPK15 ERK7 ERK8] Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8)
[CASR GPRC2A PCAR1] Extracellular calcium-sensing receptor (CaR) (CaSR) (hCasR) (Parathyroid cell calcium-sensing receptor 1) (PCaR1)
[SOD3] Extracellular superoxide dismutase [Cu-Zn] (EC-SOD) (EC 1.15.1.1)
[ECM1] Extracellular matrix protein 1 (Secretory component p85)
[XPR2 YALI0F31889g] Alkaline extracellular protease (AEP) (EC 3.4.21.62)
[Casr Gprc2a] Extracellular calcium-sensing receptor (CaSR) (Parathyroid cell calcium-sensing receptor) (PCaR1)
[Casr Gprc2a Pcar1] Extracellular calcium-sensing receptor (CaSR) (Parathyroid cell calcium-sensing receptor) (PCaR1) (RaKCaR)
[MAPK1 ERK2 PRKM1 PRKM2] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[ADGRG1 GPR56] Adhesion G-protein coupled receptor G1 (G-protein coupled receptor 56) [Cleaved into: ADGRG1 N-terminal fragment (ADGRG1 NT) (GPR56 N-terminal fragment) (GPR56 NT) (GPR56(N)) (GPR56 extracellular subunit) (GPR56 subunit alpha); ADGRG1 C-terminal fragment (ADGRG1 CT) (GPR56 C-terminal fragment) (GPR56 CT) (GPR56(C)) (GPR56 seven-transmembrane subunit) (GPR56 7TM) (GPR56 subunit beta)]
[ADGRG1 GPR56 TM7LN4 TM7XN1 UNQ540/PRO1083] Adhesion G-protein coupled receptor G1 (G-protein coupled receptor 56) (Protein TM7XN1) [Cleaved into: ADGRG1 N-terminal fragment (ADGRG1 NT) (GPR56 N-terminal fragment) (GPR56 NT) (GPR56(N)) (GPR56 extracellular subunit) (GPR56 subunit alpha); ADGRG1 C-terminal fragment (ADGRG1 CT) (GPR56 C-terminal fragment) (GPR56 CT) (GPR56(C)) (GPR56 seven-transmembrane subunit) (GPR56 7TM) (GPR56 subunit beta)]
[Adgrg1 Cyt28 Gpr56] Adhesion G-protein coupled receptor G1 (G-protein coupled receptor 56) (Serpentine receptor cyt28) [Cleaved into: ADGRG1 N-terminal fragment (ADGRG1 NT) (GPR56 N-terminal fragment) (GPR56 NT) (GPR56(N)) (GPR56 extracellular subunit) (GPR56 subunit alpha); ADGRG1 C-terminal fragment (ADGRG1-CT) (GPR56 C-terminal fragment) (GPR56 CT) (GPR56(C)) (GPR56 seven-transmembrane subunit) (GPR56 7TM) (GPR56 subunit beta)]
[ADGRG1 GPR56] Adhesion G-protein coupled receptor G1 (G-protein coupled receptor 56) [Cleaved into: ADGRG1 N-terminal fragment (ADGRG1 NT) (GPR56 N-terminal fragment) (GPR56 NT) (GPR56(N)) (GPR56 extracellular subunit) (GPR56 subunit alpha); ADGRG1 C-terminal fragment (ADGRG1 CT) (GPR56 C-terminal fragment) (GPR56 CT) (GPR56(C)) (GPR56 seven-transmembrane subunit) (GPR56 7TM) (GPR56 subunit beta)]
[ADGRG1 GPR56] Adhesion G-protein coupled receptor G1 (G-protein coupled receptor 56) [Cleaved into: ADGRG1 N-terminal fragment (ADGRG1 NT) (GPR56 N-terminal fragment) (GPR56 NT) (GPR56(N)) (GPR56 extracellular subunit) (GPR56 subunit alpha); ADGRG1 C-terminal fragment (ADGRG1 CT) (GPR56 C-terminal fragment) (GPR56 CT) (GPR56(C)) (GPR56 seven-transmembrane subunit) (GPR56 7TM) (GPR56 subunit beta)]
[Adgrg1 Gpr56] Adhesion G-protein coupled receptor G1 (G-protein coupled receptor 56) [Cleaved into: ADGRG1 N-terminal fragment (ADGRG1 NT) (GPR56 N-terminal fragment) (GPR56 NT) (GPR56(N)) (GPR56 extracellular subunit) (GPR56 subunit alpha); ADGRG1 C-terminal fragment (ADGRG1 CT) (GPR56 C-terminal fragment) (GPR56 CT) (GPR56(C)) (GPR56 seven-transmembrane subunit) (GPR56 7TM) (GPR56 subunit beta)]
[ADGRG1 GPR56] Adhesion G-protein coupled receptor G1 (G-protein coupled receptor 56) [Cleaved into: ADGRG1 N-terminal fragment (ADGRG1 NT) (GPR56 N-terminal fragment) (GPR56 NT) (GPR56(N)) (GPR56 extracellular subunit) (GPR56 subunit alpha); ADGRG1 C-terminal fragment (ADGRG1 CT) (GPR56 C-terminal fragment) (GPR56 CT) (GPR56(C)) (GPR56 seven-transmembrane subunit) (GPR56 7TM) (GPR56 subunit beta)]
[CD44 LHR MDU2 MDU3 MIC4] CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)
[zwf b1852 JW1841] Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49) [Cleaved into: Extracellular death factor (EDF)]
[Sod3 Sod-3] Extracellular superoxide dismutase [Cu-Zn] (EC-SOD) (EC 1.15.1.1) (Superoxide dismutase B)
[FAM20C DMP4] Extracellular serine/threonine protein kinase FAM20C (EC 2.7.11.1) (Dentin matrix protein 4) (DMP-4) (Golgi casein kinase) (Golgi-enriched fraction casein kinase) (GEF-CK)
[Notch1 Motch] Neurogenic locus notch homolog protein 1 (Notch 1) (Motch A) (mT14) (p300) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]
[MAPK3 ERK1 PRKM3] Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1)
[NOTCH1 TAN1] Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]
[TNC HXB] Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C)
[CASR GPRC2A PCAR1] Extracellular calcium-sensing receptor (CaSR) (Parathyroid cell calcium-sensing receptor) (BoPCaR1) (PCaR1)
[Efemp1 Fbln3] EGF-containing fibulin-like extracellular matrix protein 1 (Fibulin-3) (FIBL-3) (T16 protein)
[EFEMP2 FBLN4 UNQ200/PRO226] EGF-containing fibulin-like extracellular matrix protein 2 (Fibulin-4) (FIBL-4) (Protein UPH1)
[Ecm1] Extracellular matrix protein 1 (Secretory component p85)
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