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FAS-associated death domain protein (FAS-associating death domain-containing protein) (Protein FADD)

 Q56VC2_PIG              Unreviewed;       211 AA.
Q56VC2; K7GRF6;
10-MAY-2005, integrated into UniProtKB/TrEMBL.
10-MAY-2005, sequence version 1.
23-MAY-2018, entry version 72.
RecName: Full=FAS-associated death domain protein {ECO:0000256|PIRNR:PIRNR018586};
AltName: Full=FAS-associating death domain-containing protein {ECO:0000256|PIRNR:PIRNR018586};
AltName: Full=Protein FADD {ECO:0000256|PIRNR:PIRNR018586};
Name=FADD {ECO:0000313|Ensembl:ENSSSCP00000030483};
Synonyms=TNFRSF6 {ECO:0000313|EMBL:JAA53587.1};
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Sus.
NCBI_TaxID=9823 {ECO:0000313|EMBL:AAS91711.1};
[1] {ECO:0000313|EMBL:AAS91711.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Lymph node {ECO:0000313|EMBL:AAS91711.1};
PubMed=17179649; DOI=10.1262/jrd.18136;
Inoue N., Matsuda-Minehata F., Goto Y., Sakamaki K., Manabe N.;
"Molecular characteristics of porcine Fas-associated death domain
(FADD) and procaspase-8.";
J. Reprod. Dev. 53:427-436(2007).
[2] {ECO:0000313|Ensembl:ENSSSCP00000030483, ECO:0000313|Proteomes:UP000008227}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000030483};
Porcine genome sequencing project;
Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|Ensembl:ENSSSCP00000030483}
IDENTIFICATION.
Ensembl;
Submitted (NOV-2012) to UniProtKB.
[4] {ECO:0000313|EMBL:JAA53587.1}
NUCLEOTIDE SEQUENCE.
Dawson H.D., Chen C.T.;
"Global Gene Expression Profiling of Alveolar Macrophages by Deep
Sequencing.";
Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Apoptotic adaptor molecule that recruits caspase-8 or
caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The
resulting aggregate called the death-inducing signaling complex
(DISC) performs caspase-8 proteolytic activation. Active caspase-8
initiates the subsequent cascade of caspases mediating apoptosis.
Involved in interferon-mediated antiviral immune response, playing
a role in the positive regulation of interferon signaling.
{ECO:0000256|PIRNR:PIRNR018586}.
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EMBL; AEMK02000006; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AY519264; AAS91711.1; -; mRNA.
EMBL; GACC01000220; JAA53587.1; -; mRNA.
RefSeq; NP_001026967.1; NM_001031797.1.
UniGene; Ssc.1947; -.
STRING; 9823.ENSSSCP00000030483; -.
Ensembl; ENSSSCT00000035749; ENSSSCP00000030483; ENSSSCG00000030888.
GeneID; 595129; -.
KEGG; ssc:595129; -.
CTD; 8772; -.
eggNOG; ENOG410J0KM; Eukaryota.
eggNOG; ENOG41122TX; LUCA.
GeneTree; ENSGT00390000002105; -.
HOGENOM; HOG000208015; -.
HOVERGEN; HBG000853; -.
KO; K02373; -.
OrthoDB; EOG091G0SHT; -.
Reactome; R-SSC-140534; Ligand-dependent caspase activation.
Reactome; R-SSC-2562578; TRIF-mediated programmed cell death.
Reactome; R-SSC-3371378; Regulation by c-FLIP.
Reactome; R-SSC-5213460; RIPK1-mediated regulated necrosis.
Reactome; R-SSC-5218900; CASP8 activity is inhibited.
Reactome; R-SSC-5357786; TNFR1-induced proapoptotic signaling.
Reactome; R-SSC-69416; Dimerization of procaspase-8.
Reactome; R-SSC-75157; FasL/ CD95L signaling.
Reactome; R-SSC-75158; TRAIL signaling.
Proteomes; UP000008227; Chromosome 2.
Bgee; ENSSSCG00000030888; -.
GO; GO:0031265; C:CD95 death-inducing signaling complex; IEA:Ensembl.
GO; GO:0097342; C:ripoptosome; ISS:UniProtKB.
GO; GO:0089720; F:caspase binding; IEA:Ensembl.
GO; GO:0035877; F:death effector domain binding; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0032813; F:tumor necrosis factor receptor superfamily binding; IEA:Ensembl.
GO; GO:0097202; P:activation of cysteine-type endopeptidase activity; IEA:Ensembl.
GO; GO:0006915; P:apoptotic process; ISS:UniProtKB.
GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO; GO:0048535; P:lymph node development; ISS:UniProtKB.
GO; GO:0097049; P:motor neuron apoptotic process; IEA:Ensembl.
GO; GO:0097527; P:necroptotic signaling pathway; IEA:Ensembl.
GO; GO:0070236; P:negative regulation of activation-induced cell death of T cells; ISS:UniProtKB.
GO; GO:0060546; P:negative regulation of necroptotic process; IEA:Ensembl.
GO; GO:0042104; P:positive regulation of activated T cell proliferation; ISS:UniProtKB.
GO; GO:0002821; P:positive regulation of adaptive immune response; ISS:UniProtKB.
GO; GO:2000454; P:positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation; ISS:UniProtKB.
GO; GO:1902043; P:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
GO; GO:0032729; P:positive regulation of interferon-gamma production; ISS:UniProtKB.
GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
GO; GO:0045651; P:positive regulation of macrophage differentiation; IEA:Ensembl.
GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; ISS:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
GO; GO:0060340; P:positive regulation of type I interferon-mediated signaling pathway; IEA:Ensembl.
GO; GO:0048536; P:spleen development; ISS:UniProtKB.
GO; GO:0033077; P:T cell differentiation in thymus; ISS:UniProtKB.
GO; GO:0043029; P:T cell homeostasis; ISS:UniProtKB.
GO; GO:0048538; P:thymus development; ISS:UniProtKB.
GO; GO:0036462; P:TRAIL-activated apoptotic signaling pathway; IEA:Ensembl.
InterPro; IPR011029; DEATH-like_dom_sf.
InterPro; IPR000488; Death_domain.
InterPro; IPR001875; DED_dom.
InterPro; IPR016729; FADD.
Pfam; PF00531; Death; 1.
Pfam; PF01335; DED; 1.
PIRSF; PIRSF018586; FADD; 1.
SMART; SM00005; DEATH; 1.
SMART; SM00031; DED; 1.
SUPFAM; SSF47986; SSF47986; 1.
PROSITE; PS50017; DEATH_DOMAIN; 1.
PROSITE; PS50168; DED; 1.
1: Evidence at protein level;
Apoptosis {ECO:0000256|PIRNR:PIRNR018586};
Complete proteome {ECO:0000313|Proteomes:UP000008227};
Immunity {ECO:0000256|PIRNR:PIRNR018586};
Innate immunity {ECO:0000256|PIRNR:PIRNR018586};
Proteomics identification {ECO:0000213|PeptideAtlas:Q56VC2};
Receptor {ECO:0000313|EMBL:JAA53587.1};
Reference proteome {ECO:0000313|Proteomes:UP000008227}.
DOMAIN 3 81 DED. {ECO:0000259|PROSITE:PS50168}.
DOMAIN 97 181 Death. {ECO:0000259|PROSITE:PS50017}.
SEQUENCE 211 AA; 23589 MW; 2AE54F3ECAEA8FE1 CRC64;
MDPFLVLLHS VSASLSSSEL TELKFLCQGR VGKRKLERVQ SGVDLFSVLL EQNELSPEHT
ALLRELLVSL RRQDLLRRLD AFEAGAAGGA APEERDLRAA FDIICDNVGK DWRRLARQLK
VSDAKIDAIE EKYPRNLTEQ VRESLRVWKN SRREDAAVSH LVDALRACRL NLVADLVEEE
QQARASRRES GSSDPVSLIS WDEDVPGSGA S


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