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FAS-associated death domain protein (FAS-associating death domain-containing protein) (Protein FADD)

 FADD_BOVIN              Reviewed;         209 AA.
03-APR-2007, integrated into UniProtKB/Swiss-Prot.
25-OCT-2004, sequence version 1.
22-NOV-2017, entry version 88.
RecName: Full=FAS-associated death domain protein;
AltName: Full=FAS-associating death domain-containing protein;
AltName: Full=Protein FADD;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
PubMed=15670133; DOI=10.1111/j.1365-2052.2004.01207.x;
Szperka M.E., Connor E.E., Paape M.J., Williams J.L., Bannerman D.D.;
"Characterization of bovine FAS-associated death domain gene.";
Anim. Genet. 36:63-66(2005).
STRAIN=Hereford; TISSUE=Fetal medulla;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Apoptotic adaptor molecule that recruits caspase-8 or
caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The
resulting aggregate called the death-inducing signaling complex
(DISC) performs caspase-8 proteolytic activation. Active caspase-8
initiates the subsequent cascade of caspases mediating apoptosis
(By similarity). Involved in interferon-mediated antiviral immune
response, playing a role in the positive regulation of interferon
signaling (By similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with CFLAR, PEA15 and MBD4. When
phosphorylated, part of a complex containing HIPK3 and FAS. May
interact with MAVS/IPS1. Interacts with PIDD1 (By similarity).
Interacts with FAS (By similarity). Interacts directly (via DED
domain) with NOL3 (via CARD domain); inhibits death-inducing
signaling complex (DISC) assembly by inhibiting the increase in
FAS-FADD binding induced by FAS activation (By similarity).
{ECO:0000250, ECO:0000250|UniProtKB:Q61160}.
-!- DOMAIN: Contains a death domain involved in the binding of the
corresponding domain within Fas receptor. {ECO:0000250}.
-!- PTM: Phosphorylated. {ECO:0000250}.
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
EMBL; AY725483; AAU20801.1; -; mRNA.
EMBL; BC120180; AAI20181.1; -; mRNA.
RefSeq; NP_001007817.1; NM_001007816.1.
UniGene; Bt.88785; -.
ProteinModelPortal; Q645M6; -.
SMR; Q645M6; -.
STRING; 9913.ENSBTAP00000024322; -.
PaxDb; Q645M6; -.
PRIDE; Q645M6; -.
Ensembl; ENSBTAT00000024322; ENSBTAP00000024322; ENSBTAG00000018274.
GeneID; 493720; -.
KEGG; bta:493720; -.
CTD; 8772; -.
eggNOG; ENOG410J0KM; Eukaryota.
eggNOG; ENOG41122TX; LUCA.
GeneTree; ENSGT00390000002105; -.
HOGENOM; HOG000112490; -.
HOVERGEN; HBG000853; -.
InParanoid; Q645M6; -.
KO; K02373; -.
OrthoDB; EOG091G0SHT; -.
TreeFam; TF102046; -.
Reactome; R-BTA-140534; Ligand-dependent caspase activation.
Reactome; R-BTA-2562578; TRIF-mediated programmed cell death.
Reactome; R-BTA-3371378; Regulation by c-FLIP.
Reactome; R-BTA-5213460; RIPK1-mediated regulated necrosis.
Reactome; R-BTA-5218900; CASP8 activity is inhibited.
Reactome; R-BTA-5357786; TNFR1-induced proapoptotic signaling.
Reactome; R-BTA-69416; Dimerization of procaspase-8.
Reactome; R-BTA-75157; FasL/ CD95L signaling.
Reactome; R-BTA-75158; TRAIL signaling.
Proteomes; UP000009136; Chromosome 29.
Bgee; ENSBTAG00000018274; -.
GO; GO:0031265; C:CD95 death-inducing signaling complex; IEA:Ensembl.
GO; GO:0097342; C:ripoptosome; ISS:UniProtKB.
GO; GO:0089720; F:caspase binding; IEA:Ensembl.
GO; GO:0035877; F:death effector domain binding; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0032813; F:tumor necrosis factor receptor superfamily binding; IEA:Ensembl.
GO; GO:0097202; P:activation of cysteine-type endopeptidase activity; IEA:Ensembl.
GO; GO:0006915; P:apoptotic process; ISS:UniProtKB.
GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO; GO:0048535; P:lymph node development; ISS:UniProtKB.
GO; GO:0097049; P:motor neuron apoptotic process; IEA:Ensembl.
GO; GO:0097527; P:necroptotic signaling pathway; IEA:Ensembl.
GO; GO:0070236; P:negative regulation of activation-induced cell death of T cells; ISS:UniProtKB.
GO; GO:0060546; P:negative regulation of necroptotic process; IEA:Ensembl.
GO; GO:0042104; P:positive regulation of activated T cell proliferation; ISS:UniProtKB.
GO; GO:0002821; P:positive regulation of adaptive immune response; ISS:UniProtKB.
GO; GO:2000454; P:positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation; ISS:UniProtKB.
GO; GO:1902043; P:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
GO; GO:0032729; P:positive regulation of interferon-gamma production; ISS:UniProtKB.
GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
GO; GO:0045651; P:positive regulation of macrophage differentiation; IEA:Ensembl.
GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; ISS:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
GO; GO:0060340; P:positive regulation of type I interferon-mediated signaling pathway; IEA:Ensembl.
GO; GO:0048536; P:spleen development; ISS:UniProtKB.
GO; GO:0033077; P:T cell differentiation in thymus; ISS:UniProtKB.
GO; GO:0043029; P:T cell homeostasis; ISS:UniProtKB.
GO; GO:0048538; P:thymus development; ISS:UniProtKB.
GO; GO:0036462; P:TRAIL-activated apoptotic signaling pathway; IEA:Ensembl.
InterPro; IPR011029; DEATH-like_dom_sf.
InterPro; IPR000488; Death_domain.
InterPro; IPR001875; DED_dom.
InterPro; IPR016729; FADD.
Pfam; PF00531; Death; 1.
Pfam; PF01335; DED; 1.
PIRSF; PIRSF018586; FADD; 1.
SMART; SM00005; DEATH; 1.
SMART; SM00031; DED; 1.
SUPFAM; SSF47986; SSF47986; 1.
PROSITE; PS50168; DED; 1.
2: Evidence at transcript level;
Apoptosis; Complete proteome; Immunity; Innate immunity;
Phosphoprotein; Reference proteome.
CHAIN 1 209 FAS-associated death domain protein.
DOMAIN 3 81 DED. {ECO:0000255|PROSITE-
DOMAIN 97 181 Death. {ECO:0000255|PROSITE-
SEQUENCE 209 AA; 23002 MW; 2EB6BA41F6DB0F9D CRC64;

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