Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

FAS-associated death domain protein (FAS-associating death domain-containing protein) (Protein FADD)

 FADD_BOVIN              Reviewed;         209 AA.
03-APR-2007, integrated into UniProtKB/Swiss-Prot.
25-OCT-2004, sequence version 1.
05-DEC-2018, entry version 92.
RecName: Full=FAS-associated death domain protein;
AltName: Full=FAS-associating death domain-containing protein;
AltName: Full=Protein FADD;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
PubMed=15670133; DOI=10.1111/j.1365-2052.2004.01207.x;
Szperka M.E., Connor E.E., Paape M.J., Williams J.L., Bannerman D.D.;
"Characterization of bovine FAS-associated death domain gene.";
Anim. Genet. 36:63-66(2005).
STRAIN=Hereford; TISSUE=Fetal medulla;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Apoptotic adaptor molecule that recruits caspase-8 or
caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The
resulting aggregate called the death-inducing signaling complex
(DISC) performs caspase-8 proteolytic activation. Active caspase-8
initiates the subsequent cascade of caspases mediating apoptosis
(By similarity). Involved in interferon-mediated antiviral immune
response, playing a role in the positive regulation of interferon
signaling (By similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with CFLAR, PEA15 and MBD4. When
phosphorylated, part of a complex containing HIPK3 and FAS. May
interact with MAVS/IPS1. Interacts with PIDD1 (By similarity).
Interacts with FAS (By similarity). Interacts directly (via DED
domain) with NOL3 (via CARD domain); inhibits death-inducing
signaling complex (DISC) assembly by inhibiting the increase in
FAS-FADD binding induced by FAS activation (By similarity).
{ECO:0000250, ECO:0000250|UniProtKB:Q61160}.
-!- DOMAIN: Contains a death domain involved in the binding of the
corresponding domain within Fas receptor. {ECO:0000250}.
-!- PTM: Phosphorylated. {ECO:0000250}.
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
EMBL; AY725483; AAU20801.1; -; mRNA.
EMBL; BC120180; AAI20181.1; -; mRNA.
RefSeq; NP_001007817.1; NM_001007816.1.
UniGene; Bt.88785; -.
ProteinModelPortal; Q645M6; -.
SMR; Q645M6; -.
STRING; 9913.ENSBTAP00000024322; -.
PaxDb; Q645M6; -.
PRIDE; Q645M6; -.
Ensembl; ENSBTAT00000024322; ENSBTAP00000024322; ENSBTAG00000018274.
GeneID; 493720; -.
KEGG; bta:493720; -.
CTD; 8772; -.
eggNOG; ENOG410J0KM; Eukaryota.
eggNOG; ENOG41122TX; LUCA.
GeneTree; ENSGT00390000002105; -.
HOGENOM; HOG000112490; -.
HOVERGEN; HBG000853; -.
InParanoid; Q645M6; -.
KO; K02373; -.
OrthoDB; EOG091G0SHT; -.
TreeFam; TF102046; -.
Reactome; R-BTA-140534; Caspase activation via Death Receptors in the presence of ligand.
Reactome; R-BTA-2562578; TRIF-mediated programmed cell death.
Reactome; R-BTA-3371378; Regulation by c-FLIP.
Reactome; R-BTA-5213460; RIPK1-mediated regulated necrosis.
Reactome; R-BTA-5218900; CASP8 activity is inhibited.
Reactome; R-BTA-5357786; TNFR1-induced proapoptotic signaling.
Reactome; R-BTA-69416; Dimerization of procaspase-8.
Reactome; R-BTA-75157; FasL/ CD95L signaling.
Reactome; R-BTA-75158; TRAIL signaling.
Proteomes; UP000009136; Chromosome 29.
Bgee; ENSBTAG00000018274; Expressed in 9 organ(s), highest expression level in liver.
GO; GO:0031265; C:CD95 death-inducing signaling complex; IEA:Ensembl.
GO; GO:0097342; C:ripoptosome; ISS:UniProtKB.
GO; GO:0089720; F:caspase binding; IEA:Ensembl.
GO; GO:0035877; F:death effector domain binding; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0032813; F:tumor necrosis factor receptor superfamily binding; IEA:Ensembl.
GO; GO:0097202; P:activation of cysteine-type endopeptidase activity; IEA:Ensembl.
GO; GO:0006915; P:apoptotic process; ISS:UniProtKB.
GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO; GO:0048535; P:lymph node development; ISS:UniProtKB.
GO; GO:0097049; P:motor neuron apoptotic process; IEA:Ensembl.
GO; GO:0097527; P:necroptotic signaling pathway; IEA:Ensembl.
GO; GO:0070236; P:negative regulation of activation-induced cell death of T cells; ISS:UniProtKB.
GO; GO:0060546; P:negative regulation of necroptotic process; IEA:Ensembl.
GO; GO:0042104; P:positive regulation of activated T cell proliferation; ISS:UniProtKB.
GO; GO:0002821; P:positive regulation of adaptive immune response; ISS:UniProtKB.
GO; GO:2000454; P:positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation; ISS:UniProtKB.
GO; GO:1902043; P:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
GO; GO:0032729; P:positive regulation of interferon-gamma production; ISS:UniProtKB.
GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
GO; GO:0045651; P:positive regulation of macrophage differentiation; IEA:Ensembl.
GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; ISS:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
GO; GO:0060340; P:positive regulation of type I interferon-mediated signaling pathway; IEA:Ensembl.
GO; GO:0048536; P:spleen development; ISS:UniProtKB.
GO; GO:0033077; P:T cell differentiation in thymus; ISS:UniProtKB.
GO; GO:0043029; P:T cell homeostasis; ISS:UniProtKB.
GO; GO:0048538; P:thymus development; ISS:UniProtKB.
GO; GO:0036462; P:TRAIL-activated apoptotic signaling pathway; IEA:Ensembl.
InterPro; IPR011029; DEATH-like_dom_sf.
InterPro; IPR000488; Death_domain.
InterPro; IPR001875; DED_dom.
InterPro; IPR016729; FADD.
Pfam; PF00531; Death; 1.
Pfam; PF01335; DED; 1.
PIRSF; PIRSF018586; FADD; 1.
SMART; SM00005; DEATH; 1.
SMART; SM00031; DED; 1.
SUPFAM; SSF47986; SSF47986; 1.
PROSITE; PS50168; DED; 1.
2: Evidence at transcript level;
Apoptosis; Complete proteome; Immunity; Innate immunity;
Phosphoprotein; Reference proteome.
CHAIN 1 209 FAS-associated death domain protein.
DOMAIN 3 81 DED. {ECO:0000255|PROSITE-
DOMAIN 97 181 Death. {ECO:0000255|PROSITE-
SEQUENCE 209 AA; 23002 MW; 2EB6BA41F6DB0F9D CRC64;

Related products :

Catalog number Product name Quantity
EIAAB14324 Fadd,FAS-associated death domain protein,FAS-associating death domain-containing protein,Mediator of receptor induced toxicity,Mort1,Mouse,Mus musculus,Protein FADD
EIAAB14326 FADD,FAS-associated death domain protein,FAS-associating death domain-containing protein,GIG3,Growth-inhibiting gene 3 protein,Homo sapiens,Human,Mediator of receptor induced toxicity,MORT1,Protein FA
18-003-43791 Protein FADD - FAS-associated death domain protein; FAS-associating death domain-containing protein; Mediator of receptor induced toxicity Polyclonal 0.05 mg Aff Pur
20-272-190237 FADD - Mouse monoclonal [FD19] to FADD; FAS-associated death domain protein; FAS-associating death domain-containing protein; Mediator of receptor induced toxicity Monoclonal 0.1 ml
18-272-196807 FADD - Rabbit polyclonal to FADD; FAS-associated death domain protein; FAS-associating death domain-containing protein; Mediator of receptor induced toxicity Polyclonal 0.25 mg
EIAAB14325 Bos taurus,Bovine,FADD,FAS-associated death domain protein,FAS-associating death domain-containing protein,Protein FADD
18-003-42868 FADD protein - FAS-associating death domain-containing protein; Mediator of receptor induced toxicity Polyclonal 0.05 mg Aff Pur
EIAAB43761 Homo sapiens,Human,TNFR1-associated DEATH domain protein,TNFRSF1A-associated via death domain,TRADD,Tumor necrosis factor receptor type 1-associated DEATH domain protein
EIAAB43759 Mouse,Mus musculus,TNFR1-associated DEATH domain protein,TNFRSF1A-associated via death domain,Tradd,Tumor necrosis factor receptor type 1-associated DEATH domain protein
EIAAB43760 Bos taurus,Bovine,TNFR1-associated DEATH domain protein,TNFRSF1A-associated via death domain,TRADD,Tumor necrosis factor receptor type 1-associated DEATH domain protein
18-661-15009 Death domain-containing protein CRADD - Caspase and RIP adapter with death domain; RIP-associated protein with a death domain Polyclonal 0.1 mg
18-661-15008 Death domain-containing protein CRADD - Caspase and RIP adapter with death domain; RIP-associated protein with a death domain Polyclonal 0.1 mg
EIAAB09252 Caspase and RIP adapter with death domain,CRADD,Death domain-containing protein CRADD,Homo sapiens,Human,RAIDD,RIP-associated protein with a death domain
EIAAB09251 Caspase and RIP adapter with death domain,Cradd,Death domain-containing protein CRADD,Mouse,Mus musculus,Raidd,RIP-associated protein with a death domain
EIAAB31046 Homo sapiens,Human,Leucine-rich repeat and death domain-containing protein,LRDD,p53-induced protein with a death domain,PIDD
EIAAB31045 Leucine-rich repeat and death domain-containing protein,Lrdd,Mouse,Mus musculus,p53-induced protein with a death domain,Pidd
EIAAB10423 BING2,DAP6,Daxx,DAXX,Death domain-associated protein 6,EAP1,ETS1-associated protein 1,Fas death domain-associated protein,hDaxx,Homo sapiens,Human
bs-0511P Peptides: FADD (Fas-associated protein with death domain) Protein Length:12-25 amino acids. 200ug lyophilized
orb81113 Human Fas-Associated Death Domain protein FADD produced in E.coli is a single, non-glycosylated polypeptide chain containing 244 amino acids (1-208 a.a.) and having a molecular mass of 27.4 kDa.FADD i 2
BPA1052 Fas-Associated protein with Death Domain, FADD Polyclonal Antibodie 100 μg
EIAAB10849 DED-containing protein FLAME-3,Dedd2,DNA-binding death effector domain-containing protein 2,FADD-like anti-apoptotic molecule 3,Flame3,Mouse,Mus musculus
BPA1052 Fas-Associated protein with Death Domain, FADD, Polyclonal primary Antibodies 100 μg
FADD-381H Protein: Recombinant Human Fas (TNFRSF6)-associated Via Death Domain, GST tagged 20ug
FADD-381H Protein Recombinant Human Fas (TNFRSF6)-associated Via Death Domain, GST tagged 20ug
EIAAB10848 DED-containing protein FLAME-3,DEDD2,DNA-binding death effector domain-containing protein 2,FADD-like anti-apoptotic molecule 3,FLAME3,Homo sapiens,Human,PSEC0004


GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur

Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur



9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: +49 0241 40 08 90 86, +49 0241 95 78 94 78, +49 0241 40 08 90 86
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123

GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U

spain@gentaur.com | Gentaur | Gentaur

ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636

GENTAUR Poland Sp. z o.o.

ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556


Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur