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FI11917p (KEAP1) (Keap1, isoform B)

 Q7KSF5_DROME            Unreviewed;       776 AA.
Q7KSF5;
05-JUL-2004, integrated into UniProtKB/TrEMBL.
05-JUL-2004, sequence version 1.
23-MAY-2018, entry version 134.
SubName: Full=FI11917p {ECO:0000313|EMBL:ACX37659.1};
SubName: Full=KEAP1 {ECO:0000313|EMBL:ABD14408.1};
SubName: Full=Keap1, isoform B {ECO:0000313|EMBL:AAN13732.2};
Name=Keap1 {ECO:0000313|EMBL:AAN13732.2,
ECO:0000313|FlyBase:FBgn0038475};
Synonyms=dkeap-1 {ECO:0000313|EMBL:AAN13732.2},
dKEAP1 {ECO:0000313|EMBL:AAN13732.2},
dKeap1 {ECO:0000313|EMBL:AAN13732.2},
dkeap1 {ECO:0000313|EMBL:AAN13732.2},
Dmel\CG3962 {ECO:0000313|EMBL:AAN13732.2},
DmKeap1 {ECO:0000313|EMBL:AAN13732.2},
Keap-1 {ECO:0000313|EMBL:AAN13732.2},
KEAP1 {ECO:0000313|EMBL:AAN13732.2},
keap1 {ECO:0000313|EMBL:AAN13732.2},
Keap1-RB {ECO:0000313|EMBL:ACX37659.1},
Nrf-2 {ECO:0000313|EMBL:AAN13732.2};
ORFNames=CG3962 {ECO:0000313|EMBL:AAN13732.2,
ECO:0000313|FlyBase:FBgn0038475},
Dmel_CG3962 {ECO:0000313|EMBL:AAN13732.2};
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227 {ECO:0000313|EMBL:AAN13732.2, ECO:0000313|Proteomes:UP000000803};
[1] {ECO:0000313|EMBL:AAN13732.2, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D.,
Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L.,
Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D.,
Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J.,
Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C.,
Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X.,
Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J.,
Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[2] {ECO:0000313|EMBL:AAN13732.2, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=12537568;
Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
"Finishing a whole-genome shotgun: release 3 of the Drosophila
melanogaster euchromatic genome sequence.";
Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
[3] {ECO:0000313|EMBL:AAN13732.2, ECO:0000313|Proteomes:UP000000803}
GENOME REANNOTATION.
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[4] {ECO:0000313|EMBL:AAN13732.2, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=12537573;
Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M.,
Ashburner M., Celniker S.E.;
"The transposable elements of the Drosophila melanogaster euchromatin:
a genomics perspective.";
Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
[5] {ECO:0000313|EMBL:AAN13732.2, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=12537574;
Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
Karpen G.H.;
"Heterochromatic sequences in a Drosophila whole-genome shotgun
assembly.";
Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
[6] {ECO:0000313|EMBL:AAN13732.2, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
Ashburner M., Anxolabehere D.;
"Combined evidence annotation of transposable elements in genome
sequences.";
PLoS Comput. Biol. 1:166-175(2005).
[7] {ECO:0000313|EMBL:ABD14408.1}
NUCLEOTIDE SEQUENCE.
Avedisov S.N.;
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
[8] {ECO:0000313|EMBL:AAN13732.2}
NUCLEOTIDE SEQUENCE.
Berkeley Drosophila Genome Project;
Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R.,
Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E.,
Yu C., Rubin G.;
"Drosophila melanogaster release 4 sequence.";
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
[9] {ECO:0000313|EMBL:AAN13732.2}
NUCLEOTIDE SEQUENCE.
Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S.,
Svirskas R., Rubin G.;
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
[10] {ECO:0000313|EMBL:AAN13732.2, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=17569856; DOI=10.1126/science.1139815;
Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
"The Release 5.1 annotation of Drosophila melanogaster
heterochromatin.";
Science 316:1586-1591(2007).
[11] {ECO:0000313|EMBL:AAN13732.2, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=17569867; DOI=10.1126/science.1139816;
Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
Dimitri P., Karpen G.H., Celniker S.E.;
"Sequence finishing and mapping of Drosophila melanogaster
heterochromatin.";
Science 316:1625-1628(2007).
[12] {ECO:0000313|EMBL:ACX37659.1}
NUCLEOTIDE SEQUENCE.
Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
[13] {ECO:0000313|EMBL:AAN13732.2}
NUCLEOTIDE SEQUENCE.
FlyBase;
Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
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EMBL; AE014297; AAN13732.2; -; Genomic_DNA.
EMBL; DQ372684; ABD14408.1; -; mRNA.
EMBL; BT099945; ACX37659.1; -; mRNA.
RefSeq; NP_732202.2; NM_169744.3.
UniGene; Dm.1228; -.
SMR; Q7KSF5; -.
STRING; 7227.FBpp0082864; -.
PRIDE; Q7KSF5; -.
EnsemblMetazoa; FBtr0083423; FBpp0082864; FBgn0038475.
GeneID; 42062; -.
UCSC; CG3962-RB; d. melanogaster.
CTD; 9817; -.
FlyBase; FBgn0038475; Keap1.
eggNOG; KOG4441; Eukaryota.
eggNOG; ENOG410XNX8; LUCA.
OrthoDB; EOG091G02T3; -.
Reactome; R-DME-8951664; Neddylation.
Reactome; R-DME-983168; Antigen processing: Ubiquitination & Proteasome degradation.
GenomeRNAi; 42062; -.
Proteomes; UP000000803; Chromosome 3R.
Bgee; FBgn0038475; -.
ExpressionAtlas; Q7KSF5; baseline and differential.
GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; IBA:GO_Central.
GO; GO:0005634; C:nucleus; IDA:FlyBase.
GO; GO:0005703; C:polytene chromosome puff; IDA:FlyBase.
GO; GO:0003779; F:actin binding; ISS:FlyBase.
GO; GO:0042803; F:protein homodimerization activity; IDA:FlyBase.
GO; GO:0051865; P:protein autoubiquitination; IDA:FlyBase.
GO; GO:0006979; P:response to oxidative stress; IMP:FlyBase.
Gene3D; 2.120.10.80; -; 1.
InterPro; IPR011705; BACK.
InterPro; IPR000210; BTB/POZ_dom.
InterPro; IPR015915; Kelch-typ_b-propeller.
InterPro; IPR006652; Kelch_1.
InterPro; IPR011333; SKP1/BTB/POZ_sf.
Pfam; PF07707; BACK; 1.
Pfam; PF00651; BTB; 1.
Pfam; PF01344; Kelch_1; 5.
SMART; SM00875; BACK; 1.
SMART; SM00225; BTB; 1.
SMART; SM00612; Kelch; 6.
SUPFAM; SSF117281; SSF117281; 1.
SUPFAM; SSF54695; SSF54695; 1.
PROSITE; PS50097; BTB; 1.
2: Evidence at transcript level;
Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000000803};
Kelch repeat {ECO:0000256|SAAS:SAAS00752720};
Reference proteome {ECO:0000313|Proteomes:UP000000803};
Repeat {ECO:0000256|SAAS:SAAS00752774}.
DOMAIN 90 157 BTB. {ECO:0000259|PROSITE:PS50097}.
COILED 730 750 {ECO:0000256|SAM:Coils}.
SEQUENCE 776 AA; 87391 MW; 053C55649CF7B356 CRC64;
MQTQMHSPMQ YETHISDMPN HKGYPCRPEE AEMSNTSESC SISCGGRFGS AHSTLDDHDA
TDDDMTFCMS NYAKEALKMM YMMRSHGMLT DVVLEVKKEL FPAHKVVLSA ASPYFKAMFT
GGLKESEMSR VQLQGVCPTA MSRILYFMYT GQIRVTEVTV CQLLPAATMF QVPNVIDACC
AFLERQLDPT NAIGIAHFAE QHGCVELQKK ANVFIERNFT QVCQEEEFLQ LSAYQLIALI
RRDELNVQEE REVYNAVLKW VKYDEDNRHC KMEHILGAVR CQFLTPNFLK EQMKNCDVLR
KVPACREYLA KIFKDLTLHK CPGVKERTPN TTRMIFVAGG FFRHSLDILE AYNVDDMTWT
TLANLRIPRS GLGAAFLKGK FYAVGGRNNN IGSSYDSDWV DRYSAVTETW RPCAPMSVPR
HRVGVAVMDE LMYAVGGSAG MEYHNTVEYY DPDLDRWTLV QPMHAKRLGV GVVVVNRLLY
AIGGFDGNER LASVECYHPE NNEWSFLPPL QTGRSGAGVA AINQYIYVVG GFDGTRQLAT
VERYDTENDT WDMVAPIQIA RSALSLTPLD EKLYAIGGFD GNNFLSIVEV YDPRTNTWTT
GTPLKSGRSG HASAVIYQPA CSTTFMDYED SDAPHPDGSN NGERNAHTPQ NTYGSGSPHY
PGTASNMQFH TSYGMSGCNN CDSEMDIKPY IPAEHHSFQI PAIRSEELVN PNCPWSRMQE
RFRRTPPASF TDDERNANDM RHKLKKAQKE CLFSTAAKVF HHHIEGRLRK LTSAAT


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