Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

FKBP12-associated protein 1

 FAP1_YEAST              Reviewed;         965 AA.
P53971; D6W1F6;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
12-SEP-2018, entry version 155.
RecName: Full=FKBP12-associated protein 1;
Name=FAP1; OrderedLocusNames=YNL023C; ORFNames=N2812;
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
NCBI_TaxID=559292;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=9169873;
Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K.,
Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K.,
Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M.,
Beinhauer J.D., Boskovic J., Buitrago M.J., Bussereau F., Coster F.,
Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F.,
Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M.,
Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N.,
Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D.,
Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A.,
Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A.,
Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C.,
Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M.,
Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J.,
Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L.,
Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M.,
Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P.,
Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A.,
Wambutt R., Wedler H., Zollner A., Hani J.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV
and its evolutionary implications.";
Nature 387:93-98(1997).
[2]
GENOME REANNOTATION.
STRAIN=ATCC 204508 / S288c;
PubMed=24374639; DOI=10.1534/g3.113.008995;
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
Cherry J.M.;
"The reference genome sequence of Saccharomyces cerevisiae: Then and
now.";
G3 (Bethesda) 4:389-398(2014).
[3]
LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
PubMed=14562106; DOI=10.1038/nature02046;
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A.,
Dephoure N., O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
[4]
FUNCTION, INTERACTION WITH FPR1, AND SUBCELLULAR LOCATION.
PubMed=10998178; DOI=10.1046/j.1365-2958.2000.02105.x;
Kunz J., Loeschmann A., Deuter-Reinhard M., Hall M.N.;
"FAP1, a homologue of human transcription factor NF-X1, competes with
rapamycin for binding to FKBP12 in yeast.";
Mol. Microbiol. 37:1480-1493(2000).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-958, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=18407956; DOI=10.1074/mcp.M700468-MCP200;
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
"A multidimensional chromatography technology for in-depth
phosphoproteome analysis.";
Mol. Cell. Proteomics 7:1389-1396(2008).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-951, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19779198; DOI=10.1126/science.1172867;
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
"Global analysis of Cdk1 substrate phosphorylation sites provides
insights into evolution.";
Science 325:1682-1686(2009).
-!- FUNCTION: May play a role in transcription regulation.
{ECO:0000250, ECO:0000269|PubMed:10998178}.
-!- SUBUNIT: Interacts with FPR1. {ECO:0000269|PubMed:10998178}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10998178}.
Nucleus {ECO:0000269|PubMed:10998178}. Note=Translocates to the
nucleus in response to rapamycin.
-!- MISCELLANEOUS: Present with 589 molecules/cell in log phase SD
medium. {ECO:0000269|PubMed:14562106}.
-!- SIMILARITY: Belongs to the NFX1 family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; Z71299; CAA95885.1; -; Genomic_DNA.
EMBL; BK006947; DAA10522.1; -; Genomic_DNA.
PIR; S62935; S62935.
RefSeq; NP_014375.1; NM_001182862.1.
ProteinModelPortal; P53971; -.
BioGrid; 35803; 88.
DIP; DIP-967N; -.
IntAct; P53971; 14.
MINT; P53971; -.
STRING; 4932.YNL023C; -.
iPTMnet; P53971; -.
MaxQB; P53971; -.
PaxDb; P53971; -.
PRIDE; P53971; -.
EnsemblFungi; YNL023C; YNL023C; YNL023C.
GeneID; 855708; -.
KEGG; sce:YNL023C; -.
EuPathDB; FungiDB:YNL023C; -.
SGD; S000004968; FAP1.
GeneTree; ENSGT00400000022083; -.
HOGENOM; HOG000112499; -.
InParanoid; P53971; -.
KO; K12236; -.
OMA; HPCNILC; -.
OrthoDB; EOG092C0AK7; -.
BioCyc; YEAST:G3O-33061-MONOMER; -.
PRO; PR:P53971; -.
Proteomes; UP000002311; Chromosome XIV.
GO; GO:0005737; C:cytoplasm; IDA:SGD.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:SGD.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0001078; F:transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
GO; GO:0006366; P:transcription by RNA polymerase II; IBA:GO_Central.
CDD; cd06006; R3H_unknown_2; 1.
Gene3D; 3.30.1370.50; -; 1.
InterPro; IPR034078; NFX1_fam.
InterPro; IPR001374; R3H_dom.
InterPro; IPR036867; R3H_dom_sf.
InterPro; IPR034077; R3H_FAP1.
InterPro; IPR000967; Znf_NFX1.
InterPro; IPR001841; Znf_RING.
PANTHER; PTHR12360; PTHR12360; 1.
Pfam; PF01424; R3H; 1.
Pfam; PF01422; zf-NF-X1; 5.
SMART; SM00393; R3H; 1.
SMART; SM00438; ZnF_NFX; 7.
SUPFAM; SSF82708; SSF82708; 1.
PROSITE; PS51061; R3H; 1.
PROSITE; PS50089; ZF_RING_2; 1.
1: Evidence at protein level;
Complete proteome; Cytoplasm; Metal-binding; Nucleus; Phosphoprotein;
Reference proteome; Repeat; Transcription; Transcription regulation;
Zinc; Zinc-finger.
CHAIN 1 965 FKBP12-associated protein 1.
/FTId=PRO_0000056343.
DOMAIN 733 796 R3H. {ECO:0000255|PROSITE-
ProRule:PRU00382}.
ZN_FING 68 118 RING-type; degenerate.
{ECO:0000255|PROSITE-ProRule:PRU00175}.
ZN_FING 159 177 NF-X1-type 1.
ZN_FING 216 235 NF-X1-type 2.
ZN_FING 362 382 NF-X1-type 3.
ZN_FING 468 487 NF-X1-type 4.
ZN_FING 586 606 NF-X1-type 5.
MOD_RES 951 951 Phosphothreonine.
{ECO:0000244|PubMed:19779198}.
MOD_RES 958 958 Phosphoserine.
{ECO:0000244|PubMed:18407956}.
SEQUENCE 965 AA; 108495 MW; 121C57BB07C6FA9D CRC64;
MTEHESLGLE QNQDGGDTYR HHNLSDGCIS SVEDANEQPS SYEEESDDDM QYYERAIQEI
SSGDSYVCMI CTVEMDYTCQ MFACKRCYRV FDYGCIREWA LKSTEKTVDR IWKCPNCYYV
SKRVPVKNRP TCWCGKVVNP DPNPLDPNSC GQTCNASTCM HGCSKICHLG PHPECTRMVE
IMCHCGKHSK SIFCYQSKVM KKNFNCQEVC GLPLSCSIHT CKKKCHPGLC GPCPEMIISK
DSPKKQIKCY CGNHTRANIK CSETKFPKSG KSSKDENGNR WIGVFACADN RVVDYSCRKH
SFIESCISPP TINGEKACPF LPSSLKTCPC GRTALEELTK PRKHCDDPIP TCDSRCGKPL
KCGKHSCPFT CHDKACMEPC LQIDSVKCAC EQSTFSVPCG FQGRPRCNIK CESLMSCRRH
RCTDRCCSGR PSAIRRKKNL FRTQDLLDES LVEAKHICLK PCNLTLSCGI HKCQRKCHPG
KCPPCLESDS NDLVCPCGNT VVPAPVRCGT KLPTCNHPCI KVVRGESTCG HKPMPHTCHS
LDVSCPPCTE TVFKPCKCGK KTKVRTVCFQ TDVSCGIKCG IPLSYCYHTC QKTCHLPGNC
QKVCKQTCGQ KRLNCNHECP KPCHGKTECP DLPCATLVKI YCKCGRIKKS VTCGAKSDRV
SVTESSVLDC NEECEALKRL KELKEAFGIK EETNNFTSNE LDALKKLVSV ATTFEELQLP
FTEAALSVYS KQERWCSQIE AILNKLMDDK TRSSLHFKPM RPPQRHFIRE LAKAYGLYSE
SQDREPMRSV FIKKEDNGAS NKPVLSLAEA YPLYESFKQL QKERKAQEFQ ARTTAKLINF
EVQDTEPKVE VAKKNGFLVQ NLVAGNTAED LRRFFEPHLK HTLVVNPQYL ILDDGKTALV
YPENYETASV NTERDMELLV GHFDFMAKEA FLADSISLCS TEEELERRLD TPVIQEDSPV
MDNNT


Related products :

Catalog number Product name Quantity
orb83918 Mouse FKBP12 His tag protein Recombinant Mouse FKBP12 His tag protein. For research use only. 200
orb83004 Human FKBP12 His tag protein Recombinant Human FKBP12 His tag protein. For research use only. 200
3635BP-50 FKBP12 Blocking Peptide target: FKBP12 50 μg
10268-H08E FKBP12 Protein (His Tag) 200
orb83918 Mouse FKBP12 His tag protein Proteins 200
orb83004 Human FKBP12 His tag protein Proteins 200
40550 FKBP12, Active Human Recombinant Protein 200 µg
40550 FKBP12, Active Human Recombinant Protein 200
GWB-D2E2E9 FKBP12, Active Human Recombinant Protein
40550 FKBP12 Active Human Recombinant Protein 200
50265-M07E Mouse FKBP1A _ FKBP12 _ FKBP1 Protein 200
10958-H01E Human FKBP1A_ FKBP12 Protein (His Tag) Vector: E.Coli 200μg
10968-M02E Mouse FKBP1A_ FKBP12 Protein (His Tag) Vector: E.Coli 200μg
orb92963 Mouse FKBP12 gene Mouse FKBP12 gene is a cDNA gene. For research use only. 10
orb90859 Human FKBP12 gene Human FKBP12 gene is a cDNA gene. For research use only. 10
EIAAB25744 FK506-binding protein 12-rapamycin complex-associated protein 1,FKBP12-rapamycin complex-associated protein,FRAP,FRAP1,FRAP2,Homo sapiens,Human,Mammalian target of rapamycin,Mechanistic target of rapa
18-661-15231 FKBP12-rapamycin complex-associated protein - FK506-binding protein 12-rapamycin complex-associated protein 1; Rapamycin target protein; RAPT1; Mammalian target of rapamycin; mTOR Polyclonal 0.1 mg
000366A FKBP12 250ul
40550 FKBP12 200 µg
EIAAB25746 FK506-binding protein 12-rapamycin complex-associated protein 1,FKBP12-rapamycin complex-associated protein,Frap,Frap1,Mammalian target of rapamycin,Mechanistic target of rapamycin,Mouse,mTOR,Mtor,Mus
EIAAB25745 FK506-binding protein 12-rapamycin complex-associated protein 1,FKBP12-rapamycin complex-associated protein,Frap1,Mammalian target of rapamycin,Mechanistic target of rapamycin,mTOR,Mtor,Raft1,Rapamyci
7789 FKBP12 Antibody 0.05 mg
orb38476 FKBP12 antibody 100 ug
NB300-508 FKBP1A _ FKBP12 0.1 ml
GTX101808 FKBP1A _ FKBP12 100 µl


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur