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Fatty acid oxidation complex subunit alpha [Includes: Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase (EC 4.2.1.17) (EC 5.1.2.3); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)]

 A0A0B1K858_ECOLX        Unreviewed;       714 AA.
A0A0B1K858;
04-MAR-2015, integrated into UniProtKB/TrEMBL.
04-MAR-2015, sequence version 1.
20-JUN-2018, entry version 32.
RecName: Full=Fatty acid oxidation complex subunit alpha {ECO:0000256|HAMAP-Rule:MF_01617};
Includes:
RecName: Full=Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase {ECO:0000256|HAMAP-Rule:MF_01617};
EC=4.2.1.17 {ECO:0000256|HAMAP-Rule:MF_01617};
EC=5.1.2.3 {ECO:0000256|HAMAP-Rule:MF_01617};
Includes:
RecName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000256|HAMAP-Rule:MF_01617};
EC=1.1.1.35 {ECO:0000256|HAMAP-Rule:MF_01617};
Name=fadJ {ECO:0000256|HAMAP-Rule:MF_01617,
ECO:0000313|EMBL:KNF70032.1};
ORFNames=WR15_08390 {ECO:0000313|EMBL:KNF70032.1};
Escherichia coli.
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
Enterobacteriaceae; Escherichia.
NCBI_TaxID=562 {ECO:0000313|EMBL:KNF70032.1, ECO:0000313|Proteomes:UP000037564};
[1] {ECO:0000313|EMBL:KNF70032.1, ECO:0000313|Proteomes:UP000037564}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CFSAN026843 {ECO:0000313|EMBL:KNF70032.1,
ECO:0000313|Proteomes:UP000037564};
Gonzalez-Escalona N., Toro M., Timme R., Payne J.;
"Genome sequences of 64 non-O157:H7 Shiga toxin-producing Escherichia
coli strains.";
Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Catalyzes the formation of a hydroxyacyl-CoA by addition
of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase
and 3-hydroxyacyl-CoA dehydrogenase activities.
{ECO:0000256|HAMAP-Rule:MF_01617, ECO:0000256|SAAS:SAAS00643143}.
-!- CATALYTIC ACTIVITY: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-
CoA + H(2)O. {ECO:0000256|HAMAP-Rule:MF_01617,
ECO:0000256|SAAS:SAAS00999126}.
-!- CATALYTIC ACTIVITY: (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA
+ NADH. {ECO:0000256|HAMAP-Rule:MF_01617,
ECO:0000256|SAAS:SAAS00379695}.
-!- CATALYTIC ACTIVITY: (S)-3-hydroxybutanoyl-CoA = (R)-3-
hydroxybutanoyl-CoA. {ECO:0000256|HAMAP-Rule:MF_01617,
ECO:0000256|SAAS:SAAS00643142}.
-!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
{ECO:0000256|HAMAP-Rule:MF_01617, ECO:0000256|SAAS:SAAS00649747}.
-!- SUBUNIT: Heterotetramer of two alpha chains (FadJ) and two beta
chains (FadI). {ECO:0000256|HAMAP-Rule:MF_01617,
ECO:0000256|SAAS:SAAS00643147}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01617,
ECO:0000256|SAAS:SAAS00643134}.
-!- SIMILARITY: In the N-terminal section; belongs to the enoyl-CoA
hydratase/isomerase family. {ECO:0000256|HAMAP-Rule:MF_01617,
ECO:0000256|SAAS:SAAS00649729}.
-!- SIMILARITY: In the central section; belongs to the 3-hydroxyacyl-
CoA dehydrogenase family. {ECO:0000256|HAMAP-Rule:MF_01617,
ECO:0000256|SAAS:SAAS00643136}.
-!- CAUTION: The sequence shown here is derived from an
EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
preliminary data. {ECO:0000313|EMBL:KNF70032.1}.
-----------------------------------------------------------------------
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EMBL; LGZN01000022; KNF70032.1; -; Genomic_DNA.
RefSeq; WP_016247436.1; NZ_NOPZ01000038.1.
EnsemblBacteria; KHH09135; KHH09135; PU69_11705.
EnsemblBacteria; KNF70032; KNF70032; WR15_08390.
PATRIC; fig|562.7396.peg.1556; -.
UniPathway; UPA00659; -.
Proteomes; UP000037564; Unassembled WGS sequence.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-UniRule.
GO; GO:0008692; F:3-hydroxybutyryl-CoA epimerase activity; IEA:UniProtKB-UniRule.
GO; GO:0004300; F:enoyl-CoA hydratase activity; IEA:UniProtKB-UniRule.
GO; GO:0051287; F:NAD binding; IEA:InterPro.
GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
HAMAP; MF_01617; FadJ; 1.
InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
InterPro; IPR006108; 3HC_DH_C.
InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
InterPro; IPR001753; Enoyl-CoA_hydra/iso.
InterPro; IPR012802; FadJ.
InterPro; IPR036291; NAD(P)-bd_dom_sf.
Pfam; PF00725; 3HCDH; 2.
Pfam; PF02737; 3HCDH_N; 1.
Pfam; PF00378; ECH_1; 1.
SUPFAM; SSF48179; SSF48179; 2.
SUPFAM; SSF51735; SSF51735; 1.
SUPFAM; SSF52096; SSF52096; 1.
TIGRFAMs; TIGR02440; FadJ; 1.
PROSITE; PS00067; 3HCDH; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000037564};
Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01617,
ECO:0000256|SAAS:SAAS00643137};
Fatty acid metabolism {ECO:0000256|HAMAP-Rule:MF_01617,
ECO:0000256|SAAS:SAAS00456821};
Isomerase {ECO:0000256|HAMAP-Rule:MF_01617,
ECO:0000256|SAAS:SAAS00656496, ECO:0000313|EMBL:KNF70032.1};
Lipid degradation {ECO:0000256|HAMAP-Rule:MF_01617,
ECO:0000256|SAAS:SAAS00643150};
Lipid metabolism {ECO:0000256|HAMAP-Rule:MF_01617,
ECO:0000256|SAAS:SAAS00456821, ECO:0000256|SAAS:SAAS00643150};
Lyase {ECO:0000256|HAMAP-Rule:MF_01617, ECO:0000256|SAAS:SAAS00999128,
ECO:0000313|EMBL:KNF70032.1};
Multifunctional enzyme {ECO:0000256|HAMAP-Rule:MF_01617,
ECO:0000256|SAAS:SAAS00999134};
NAD {ECO:0000256|HAMAP-Rule:MF_01617, ECO:0000256|SAAS:SAAS00830857};
Oxidoreductase {ECO:0000256|HAMAP-Rule:MF_01617,
ECO:0000256|SAAS:SAAS00649305, ECO:0000313|EMBL:KNF70032.1}.
REGION 1 190 Enoyl-CoA hydratase. {ECO:0000256|HAMAP-
Rule:MF_01617}.
REGION 306 714 3-hydroxyacyl-CoA dehydrogenase.
{ECO:0000256|HAMAP-Rule:MF_01617}.
SITE 118 118 Important for catalytic activity.
{ECO:0000256|HAMAP-Rule:MF_01617}.
SITE 140 140 Important for catalytic activity.
{ECO:0000256|HAMAP-Rule:MF_01617}.
SEQUENCE 714 AA; 77041 MW; 65A76603EFFCF1FF CRC64;
MEMASAFTLN VRLDNIAVIT IDVPGEKMNT LKAEFASQVR AIIKQLRENK ELRGVVFVSA
KPDNFIAGAD INMIGNCKTA QEAEALARQG QQLMAEIHAL PIPVIAAIHG ACLGGGLELA
LACHGRVCTD DPKTVLGLPE VQLGLLPGSG GTQRLPRLIG VSTALEMILT GKQLRAKQAL
KLGLVDDVVP HSILLEAAVE LVKQDRPSSR PLPVRERILA GPLGRALLFK MVGKKTEHKT
QGNYPATERI LEVVETGLAQ GTSSGYDAEA RAFGELAMTP QSQALRSIFF ASTDVKKDPG
SDAPPAPLNS VGILGGGLMG GGIAYVTACK AGLPVRIKDT NPQGINHALK YSWDQLEGKV
RRRHLKASER DKQLALISGT TDYRGFAHRD LIIEAVFENL ELKQQMVAEV EQNCAAHTIF
ASNTSSLPIG DIAAHAARPE QVIGLHFFSP VEKMPLVEII PHAGTSAQTI ATTVKLAKKQ
GKTPIVVRDK AGFYVNRILA PYINEAIRML TEGERVEHID AALVKFGFPV GPIQLLDEVG
IDTGTKIIPV LEAAYGERFS APANVVSSIL NDDRKGRKNG RGFYLYGQKG RKSKKQVDPA
IYPLIGAQGQ GRLSAPQVAE RCVMLMLNEA VRCVDEQVIR SVRDGDIGAV FGIGFPPFLG
GPFRYIDSLG AGEVVAIMQR LATQYGSRFT PCERLVEMSK RGESFWKTTA TDLQ


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