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Fe(2 ) transporter FeoB (Ferrous iron transport protein B)

 FEOB_LEGPN              Reviewed;         751 AA.
Q8GNS3;
22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
05-JUL-2017, entry version 74.
RecName: Full=Fe(2+) transporter FeoB {ECO:0000305};
AltName: Full=Ferrous iron transport protein B;
Name=feoB;
Legionella pneumophila.
Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales;
Legionellaceae; Legionella.
NCBI_TaxID=446;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
STRAIN=130b / Wadsworth / Serogroup 1;
PubMed=12228295; DOI=10.1128/IAI.70.10.5659-5669.2002;
Robey M., Cianciotto N.P.;
"Legionella pneumophila feoAB promotes ferrous iron uptake and
intracellular infection.";
Infect. Immun. 70:5659-5669(2002).
-!- FUNCTION: Probable transporter of a GTP-driven Fe(2+) uptake
system. Seems to be required for optimal intracellular infection
of macrophages, to be important for growth and/or survival in
iron-restricted amoebae. It also plays a key role in extracellular
growth under iron-limited conditions.
{ECO:0000269|PubMed:12228295}.
-!- SUBCELLULAR LOCATION: Cell inner membrane
{ECO:0000250|UniProtKB:P33650}; Multi-pass membrane protein
{ECO:0000250|UniProtKB:P33650}.
-!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-
like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
{ECO:0000255|PROSITE-ProRule:PRU01048}.
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EMBL; AF492466; AAN17185.1; -; Genomic_DNA.
RefSeq; WP_038839664.1; NZ_LT632617.1.
PDB; 3IBY; X-ray; 2.50 A; A/B/C/D=1-256.
PDBsum; 3IBY; -.
ProteinModelPortal; Q8GNS3; -.
SMR; Q8GNS3; -.
eggNOG; ENOG4105CE1; Bacteria.
eggNOG; COG0370; LUCA.
EvolutionaryTrace; Q8GNS3; -.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:InterPro.
GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
CDD; cd01879; FeoB; 1.
InterPro; IPR003373; Fe2_transport_prot-B.
InterPro; IPR011640; Fe2_transport_prot_B_C.
InterPro; IPR030389; G_FEOB_dom.
InterPro; IPR011642; Gate_dom.
InterPro; IPR006073; GTP_binding_domain.
InterPro; IPR027417; P-loop_NTPase.
Pfam; PF07664; FeoB_C; 1.
Pfam; PF02421; FeoB_N; 1.
Pfam; PF07670; Gate; 2.
PRINTS; PR00326; GTP1OBG.
SUPFAM; SSF52540; SSF52540; 1.
TIGRFAMs; TIGR00437; feoB; 1.
PROSITE; PS51711; G_FEOB; 1.
1: Evidence at protein level;
3D-structure; Cell inner membrane; Cell membrane; GTP-binding;
Ion transport; Iron; Iron transport; Membrane; Nucleotide-binding;
Transmembrane; Transmembrane helix; Transport.
CHAIN 1 751 Fe(2+) transporter FeoB.
/FTId=PRO_0000210832.
TRANSMEM 276 296 Helical. {ECO:0000255}.
TRANSMEM 341 361 Helical. {ECO:0000255}.
TRANSMEM 385 405 Helical. {ECO:0000255}.
TRANSMEM 422 442 Helical. {ECO:0000255}.
TRANSMEM 447 467 Helical. {ECO:0000255}.
TRANSMEM 512 532 Helical. {ECO:0000255}.
TRANSMEM 539 559 Helical. {ECO:0000255}.
TRANSMEM 657 677 Helical. {ECO:0000255}.
TRANSMEM 685 705 Helical. {ECO:0000255}.
TRANSMEM 715 735 Helical. {ECO:0000255}.
DOMAIN 1 167 FeoB-type G. {ECO:0000255|PROSITE-
ProRule:PRU01048}.
NP_BIND 8 15 GTP 1. {ECO:0000255|PROSITE-
ProRule:PRU01048}.
NP_BIND 33 37 GTP 2. {ECO:0000255|PROSITE-
ProRule:PRU01048}.
NP_BIND 54 57 GTP 3. {ECO:0000255|PROSITE-
ProRule:PRU01048}.
NP_BIND 118 121 GTP. {ECO:0000255|PROSITE-
ProRule:PRU01048}.
NP_BIND 147 149 GTP. {ECO:0000255|PROSITE-
ProRule:PRU01048}.
STRAND 3 9 {ECO:0000244|PDB:3IBY}.
HELIX 14 22 {ECO:0000244|PDB:3IBY}.
STRAND 25 30 {ECO:0000244|PDB:3IBY}.
STRAND 34 45 {ECO:0000244|PDB:3IBY}.
STRAND 48 54 {ECO:0000244|PDB:3IBY}.
STRAND 65 67 {ECO:0000244|PDB:3IBY}.
HELIX 70 81 {ECO:0000244|PDB:3IBY}.
STRAND 85 92 {ECO:0000244|PDB:3IBY}.
HELIX 93 95 {ECO:0000244|PDB:3IBY}.
HELIX 96 106 {ECO:0000244|PDB:3IBY}.
STRAND 113 118 {ECO:0000244|PDB:3IBY}.
HELIX 120 125 {ECO:0000244|PDB:3IBY}.
HELIX 132 139 {ECO:0000244|PDB:3IBY}.
STRAND 143 145 {ECO:0000244|PDB:3IBY}.
HELIX 148 150 {ECO:0000244|PDB:3IBY}.
HELIX 154 162 {ECO:0000244|PDB:3IBY}.
HELIX 177 193 {ECO:0000244|PDB:3IBY}.
HELIX 197 209 {ECO:0000244|PDB:3IBY}.
HELIX 214 217 {ECO:0000244|PDB:3IBY}.
HELIX 219 229 {ECO:0000244|PDB:3IBY}.
HELIX 234 253 {ECO:0000244|PDB:3IBY}.
SEQUENCE 751 AA; 82514 MW; 46DB2FD7C9986192 CRC64;
MTHALLIGNP NCGKTTLFNA LTNANQRVGN WPGVTVEKKT GEFLLGEHLI EITDLPGVYS
LVANAEGISQ DEQIAAQSVI DLEYDCIINV IDACHLERHL YLTSQLFELG KPVVVALNMM
DIAEHRGISI DTEKLESLLG CSVIPIQAHK NIGIPALQQS LLHCSQKIKP LKLSLSVAAQ
QILNDLENQL ISKGYKNSFA YYFSRRLAEG DTLIGEKAFT ESLLIKLQET EQNLDVLLAD
ARYQKIHEIV TLVQKKHSDA SEHFTAKLDK LVLHRFLALP IFFAMMYLMF LFAINIGGAF
QDFFDISTET IFVQGSGWLL QQLHAPNWVI ALVANGVGKG INTTITFIPV IAAMFFFLSL
LETSGYMARA AFVVDKAMRA MGLPGKSFVP MIVGFGCNVP AIMAARTLDS ERDRLLTVMM
SPFMSCSARL AIYAVFVAAF FPSGGHNVVF SLYLIGILMA VFTGYILRKT TLKGHASPLI
LELPAYHRPS LRRLLRETSL RLRFFVYRAG KLIIPICVIL GGLNAITWGG GISSGEANTD
SLLSIIGQWI TPLFAPMGIH QDNWPATVGL LTGMLAKEVV VGTLNSLYAQ VGHVGEITAA
HFDFWGGIKA AFGSIPANLS ELGSALWNPV SASAADSELS QSVYGIMSRR FDGAVGAYAY
LLFVLLYIPC VSTMAVIRQE ANKRFMWTSI VWSFVVAYAT SVVFYQGAKF LDHPQQSMVW
ILAMSLSLLF VLAVFRYSQY GMGRQNAAAN T


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