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Feline leukemia virus subgroup C receptor-related protein 1 (Feline leukemia virus subgroup C receptor) (Major facilitator superfamily domain containing 7B) (Mfsd7b)

 FLVC1_MOUSE             Reviewed;         560 AA.
B2RXV4;
18-SEP-2013, integrated into UniProtKB/Swiss-Prot.
01-JUL-2008, sequence version 1.
25-OCT-2017, entry version 79.
RecName: Full=Feline leukemia virus subgroup C receptor-related protein 1;
Short=Feline leukemia virus subgroup C receptor;
AltName: Full=Major facilitator superfamily domain containing 7B;
Short=Mfsd7b;
Name=Flvcr1; Synonyms=Mfsd7b;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
FUNCTION (ISOFORM 1), AND DISRUPTION PHENOTYPE.
PubMed=18258918; DOI=10.1126/science.1151133;
Keel S.B., Doty R.T., Yang Z., Quigley J.G., Chen J., Knoblaugh S.,
Kingsley P.D., De Domenico I., Vaughn M.B., Kaplan J., Palis J.,
Abkowitz J.L.;
"A heme export protein is required for red blood cell differentiation
and iron homeostasis.";
Science 319:825-828(2008).
[4]
ALTERNATIVE SPLICING (ISOFORM 2), FUNCTION (ISOFORM 2), SUBCELLULAR
LOCATION (ISOFORM 2), AND DISRUPTION PHENOTYPE.
PubMed=23187127; DOI=10.1172/JCI62422;
Chiabrando D., Marro S., Mercurio S., Giorgi C., Petrillo S.,
Vinchi F., Fiorito V., Fagoonee S., Camporeale A., Turco E.,
Merlo G.R., Silengo L., Altruda F., Pinton P., Tolosano E.;
"The mitochondrial heme exporter FLVCR1b mediates erythroid
differentiation.";
J. Clin. Invest. 122:4569-4579(2012).
-!- FUNCTION: Isoform 1: Heme transporter that exports cytoplasmic
heme. It can also export coproporphyrin and protoporphyrin IX,
which are both intermediate products in the heme biosynthetic
pathway. Does not export bilirubin. Heme export depends on the
presence of HPX and is required to maintain intracellular free
heme balance, protecting cells from heme toxicity. Heme export
provides protection from heme or ferrous iron toxicities in liver,
brain, sensory neurons and during erythtopoiesis, a process in
which heme synthesis intensifies. Causes susceptibility to FeLV-C
in vitro. {ECO:0000250|UniProtKB:Q9Y5Y0,
ECO:0000269|PubMed:18258918}.
-!- FUNCTION: Isoform 2: Heme transporter that promotes heme efflux
from the mitochondrion to the cytoplasm. Essential for erythroid
differentiation.
-!- SUBUNIT: Interacts with HPX. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Isoform 1: Cell membrane {ECO:0000250};
Multi-pass membrane protein {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Isoform 2: Mitochondrion membrane
{ECO:0000269|PubMed:23187127}; Multi-pass membrane protein
{ECO:0000269|PubMed:23187127}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1; Synonyms=Flvcr1a;
IsoId=B2RXV4-1; Sequence=Displayed;
Name=2; Synonyms=Flvcr1b, mitochondrial;
IsoId=B2RXV4-2; Sequence=VSP_047867;
Note=Has a probable mitochondrial transit peptide at positions
1-38.;
-!- PTM: N-Glycosylated. {ECO:0000250}.
-!- DISRUPTION PHENOTYPE: Lack definitive erythropoiesis, have
craniofacial and limb deformities, and die in midgestation. Mice
with FLVCR1 that is deleted neonatally develop a severe macrocytic
anemia with proerythroblast maturation arrest. Mice lacking the
plasma membrane isoform (Flvcr1a) but expressing Flvcr1b had
normal erythropoiesis, but exhibited hemorrhages, edema, and
skeletal abnormalities. {ECO:0000269|PubMed:18258918,
ECO:0000269|PubMed:23187127}.
-!- SIMILARITY: Belongs to the major facilitator superfamily. Feline
leukemia virus subgroup C receptor (TC 2.A.1.28.1) family.
{ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AC138229; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC157992; AAI57993.1; -; mRNA.
CCDS; CCDS35823.1; -. [B2RXV4-1]
RefSeq; NP_001074728.1; NM_001081259.1. [B2RXV4-1]
RefSeq; NP_001300676.1; NM_001313747.1.
UniGene; Mm.134053; -.
UniGene; Mm.472263; -.
ProteinModelPortal; B2RXV4; -.
STRING; 10090.ENSMUSP00000082777; -.
iPTMnet; B2RXV4; -.
PhosphoSitePlus; B2RXV4; -.
EPD; B2RXV4; -.
MaxQB; B2RXV4; -.
PaxDb; B2RXV4; -.
PeptideAtlas; B2RXV4; -.
PRIDE; B2RXV4; -.
Ensembl; ENSMUST00000085635; ENSMUSP00000082777; ENSMUSG00000066595. [B2RXV4-1]
GeneID; 226844; -.
KEGG; mmu:226844; -.
UCSC; uc007ebv.1; mouse. [B2RXV4-1]
UCSC; uc011wyn.1; mouse. [B2RXV4-2]
CTD; 226844; -.
MGI; MGI:2444881; Mfsd7b.
eggNOG; KOG2563; Eukaryota.
eggNOG; ENOG410XSTK; LUCA.
GeneTree; ENSGT00530000062892; -.
HOGENOM; HOG000019717; -.
HOVERGEN; HBG051631; -.
InParanoid; B2RXV4; -.
KO; K08220; -.
OMA; ITYGIMT; -.
OrthoDB; EOG091G0FJM; -.
PhylomeDB; B2RXV4; -.
TreeFam; TF314292; -.
Reactome; R-MMU-917937; Iron uptake and transport.
PRO; PR:B2RXV4; -.
Proteomes; UP000000589; Chromosome 1.
Bgee; ENSMUSG00000066595; -.
ExpressionAtlas; B2RXV4; baseline and differential.
Genevisible; B2RXV4; MM.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
GO; GO:0005739; C:mitochondrion; ISO:MGI.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0015232; F:heme transporter activity; ISO:MGI.
GO; GO:0001568; P:blood vessel development; IMP:MGI.
GO; GO:0042733; P:embryonic digit morphogenesis; IMP:MGI.
GO; GO:0048704; P:embryonic skeletal system morphogenesis; IMP:MGI.
GO; GO:0030218; P:erythrocyte differentiation; IMP:MGI.
GO; GO:0043249; P:erythrocyte maturation; IEA:UniProtKB-KW.
GO; GO:0060323; P:head morphogenesis; IMP:MGI.
GO; GO:0097037; P:heme export; ISO:MGI.
GO; GO:0015886; P:heme transport; ISO:MGI.
GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
GO; GO:0035108; P:limb morphogenesis; IMP:MGI.
GO; GO:0006839; P:mitochondrial transport; ISO:MGI.
GO; GO:0035264; P:multicellular organism growth; IMP:MGI.
GO; GO:0046620; P:regulation of organ growth; IMP:MGI.
GO; GO:0048536; P:spleen development; IMP:MGI.
GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
CDD; cd06174; MFS; 1.
InterPro; IPR011701; MFS.
InterPro; IPR020846; MFS_dom.
InterPro; IPR036259; MFS_trans_sf.
Pfam; PF07690; MFS_1; 1.
SUPFAM; SSF103473; SSF103473; 1.
PROSITE; PS50850; MFS; 1.
2: Evidence at transcript level;
Alternative splicing; Cell membrane; Complete proteome;
Erythrocyte maturation; Glycoprotein; Membrane; Mitochondrion;
Phosphoprotein; Receptor; Reference proteome; Transmembrane;
Transmembrane helix; Transport.
CHAIN 1 560 Feline leukemia virus subgroup C
receptor-related protein 1.
/FTId=PRO_0000423424.
TOPO_DOM 1 100 Cytoplasmic. {ECO:0000255}.
TRANSMEM 101 121 Helical. {ECO:0000255}.
TOPO_DOM 122 140 Extracellular. {ECO:0000255}.
TRANSMEM 141 161 Helical. {ECO:0000255}.
TOPO_DOM 162 167 Cytoplasmic. {ECO:0000255}.
TRANSMEM 168 188 Helical. {ECO:0000255}.
TOPO_DOM 189 192 Extracellular. {ECO:0000255}.
TRANSMEM 193 213 Helical. {ECO:0000255}.
TOPO_DOM 214 233 Cytoplasmic. {ECO:0000255}.
TRANSMEM 234 254 Helical. {ECO:0000255}.
TOPO_DOM 255 280 Extracellular. {ECO:0000255}.
TRANSMEM 281 301 Helical. {ECO:0000255}.
TOPO_DOM 302 336 Cytoplasmic. {ECO:0000255}.
TRANSMEM 337 357 Helical. {ECO:0000255}.
TOPO_DOM 358 377 Extracellular. {ECO:0000255}.
TRANSMEM 378 398 Helical. {ECO:0000255}.
TOPO_DOM 399 406 Cytoplasmic. {ECO:0000255}.
TRANSMEM 407 427 Helical. {ECO:0000255}.
TOPO_DOM 428 429 Extracellular. {ECO:0000255}.
TRANSMEM 430 450 Helical. {ECO:0000255}.
TOPO_DOM 451 464 Cytoplasmic. {ECO:0000255}.
TRANSMEM 465 485 Helical. {ECO:0000255}.
TOPO_DOM 486 496 Extracellular. {ECO:0000255}.
TRANSMEM 497 517 Helical. {ECO:0000255}.
TOPO_DOM 518 560 Cytoplasmic. {ECO:0000255}.
MOD_RES 542 542 Phosphoserine.
{ECO:0000250|UniProtKB:Q9Y5Y0}.
CARBOHYD 270 270 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
VAR_SEQ 1 281 Missing (in isoform 2). {ECO:0000305}.
/FTId=VSP_047867.
SEQUENCE 560 AA; 60469 MW; 2FD8691D8E55BE52 CRC64;
MARPDDEVGP AVAPGHPLGK GYLPVPKGAP DGEARLVPQN GPEALNGGPG LGPLIAGAQG
GPQALIAAEE ETQARLLPAG DGEDVPCPAC PPRTALSPRR FVVLLIFSLY SLVNAFQWIQ
YSSISNVFED FYEVSPLHIN WLSMVYMVAY VPLIFPATWL LDTRGLRLTA LLGSGLNCLG
AWVKCGSVQR HLFWVTMLGQ ILCSVAQVFI LGLPSPVASV WFGPKEVSTA CATAVLGNQL
GTAVGFLLPP VLVPALGTQN STGLLAHTQN NTDLLAHNIN TMFYGTAFIS TFLFFLTIIA
FKEKPPLPPS QAQAVLRDSP PEEYSYKSSI WNLCRNIPFV LLLVSYGIMT GAFYSISTLL
NQIILTYYVG EEVNAGRIGL TLVVAGMVGS ILCGLWLDYT KTYKQTTLIV YVLSFIGMLI
FTFTLNLGYI IVVFFTGGIL GFFMTGYLPL GFEFAVEITY PESEGMSSGL LNTAAQILGI
FFTLAQGKIT TDYNSPEAGN IFLCAWMFVG IILTALIKSD LRRHNINTGL TNIDVKAVPV
DSRVDPKPKV MVSIQSESSL


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