Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Feline leukemia virus subgroup C receptor-related protein 1 (Feline leukemia virus subgroup C receptor) (hFLVCR)

 FLVC1_HUMAN             Reviewed;         555 AA.
Q9Y5Y0; Q1HE16; Q86XY9; Q9NVR9;
13-APR-2004, integrated into UniProtKB/Swiss-Prot.
01-NOV-1999, sequence version 1.
25-OCT-2017, entry version 128.
RecName: Full=Feline leukemia virus subgroup C receptor-related protein 1;
Short=Feline leukemia virus subgroup C receptor;
Short=hFLVCR;
Name=FLVCR1; Synonyms=FLVCR;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND
CHARACTERIZATION OF FELV-C RECEPTOR FUNCTION.
TISSUE=Lymphocyte;
PubMed=10400745;
Tailor C.S., Willett B.J., Kabat D.;
"A putative cell surface receptor for anemia-inducing feline leukemia
virus subgroup C is a member of a transporter superfamily.";
J. Virol. 73:6500-6505(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
NHLBI resequencing and genotyping service (RS&G);
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANTS
PRO-52 AND MET-544.
TISSUE=Duodenum;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
GENE STRUCTURE.
PubMed=11943475; DOI=10.1016/S0378-1119(02)00457-2;
Lipovich L., Hughes A.L., King M.-C., Abkowitz J.L., Quigley J.G.;
"Genomic structure and evolutionary context of the human feline
leukemia virus subgroup C receptor (hFLVCR) gene: evidence for block
duplications and de novo gene formation within duplicons of the hFLVCR
locus.";
Gene 286:203-213(2002).
[7]
FUNCTION, AND DEVELOPMENTAL STAGE.
PubMed=15369674; DOI=10.1016/j.cell.2004.08.014;
Quigley J.G., Yang Z., Worthington M.T., Phillips J.D., Sabo K.M.,
Sabath D.E., Berg C.L., Sassa S., Wood B.L., Abkowitz J.L.;
"Identification of a human heme exporter that is essential for
erythropoiesis.";
Cell 118:757-766(2004).
[8]
SUBCELLULAR LOCATION, TOPOLOGY, AND GLYCOSYLATION.
PubMed=16439531; DOI=10.1128/JVI.80.4.1742-1751.2006;
Brown J.K., Fung C., Tailor C.S.;
"Comprehensive mapping of receptor-functioning domains in feline
leukemia virus subgroup C receptor FLVCR1.";
J. Virol. 80:1742-1751(2006).
[9]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=18669648; DOI=10.1073/pnas.0805139105;
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
[10]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19413330; DOI=10.1021/ac9004309;
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
Mohammed S.;
"Lys-N and trypsin cover complementary parts of the phosphoproteome in
a refined SCX-based approach.";
Anal. Chem. 81:4493-4501(2009).
[11]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-56, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Leukemic T-cell;
PubMed=19690332; DOI=10.1126/scisignal.2000007;
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
Rodionov V., Han D.K.;
"Quantitative phosphoproteomic analysis of T cell receptor signaling
reveals system-wide modulation of protein-protein interactions.";
Sci. Signal. 2:RA46-RA46(2009).
[12]
FUNCTION, AND INTERACTION WITH HPX.
PubMed=20610401; DOI=10.1074/jbc.M110.119131;
Yang Z., Philips J.D., Doty R.T., Giraudi P., Ostrow J.D.,
Tiribelli C., Smith A., Abkowitz J.L.;
"Kinetics and specificity of feline leukemia virus subgroup C receptor
(FLVCR) export function and its dependence on hemopexin.";
J. Biol. Chem. 285:28874-28882(2010).
[13]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=20068231; DOI=10.1126/scisignal.2000475;
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
Mann M.;
"Quantitative phosphoproteomics reveals widespread full
phosphorylation site occupancy during mitosis.";
Sci. Signal. 3:RA3-RA3(2010).
[14]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21406692; DOI=10.1126/scisignal.2001570;
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
Blagoev B.;
"System-wide temporal characterization of the proteome and
phosphoproteome of human embryonic stem cell differentiation.";
Sci. Signal. 4:RS3-RS3(2011).
[15]
ALTERNATIVE SPLICING (ISOFORM 2), FUNCTION (ISOFORM 2), AND
SUBCELLULAR LOCATION (ISOFORM 2).
PubMed=23187127; DOI=10.1172/JCI62422;
Chiabrando D., Marro S., Mercurio S., Giorgi C., Petrillo S.,
Vinchi F., Fiorito V., Fagoonee S., Camporeale A., Turco E.,
Merlo G.R., Silengo L., Altruda F., Pinton P., Tolosano E.;
"The mitochondrial heme exporter FLVCR1b mediates erythroid
differentiation.";
J. Clin. Invest. 122:4569-4579(2012).
[16]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-536, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma, and Erythroleukemia;
PubMed=23186163; DOI=10.1021/pr300630k;
Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
Mohammed S.;
"Toward a comprehensive characterization of a human cancer cell
phosphoproteome.";
J. Proteome Res. 12:260-271(2013).
[17]
FUNCTION, INVOLVEMENT IN SENSORY NEUROPATHY, AND VARIANTS ARG-192 AND
SER-221.
PubMed=27923065; DOI=10.1371/journal.pgen.1006461;
Chiabrando D., Castori M., di Rocco M., Ungelenk M., Giesselmann S.,
Di Capua M., Madeo A., Grammatico P., Bartsch S., Huebner C.A.,
Altruda F., Silengo L., Tolosano E., Kurth I.;
"Mutations in the heme exporter FLVCR1 cause sensory neurodegeneration
with loss of pain perception.";
PLoS Genet. 12:E1006461-E1006461(2016).
[18]
VARIANTS PCARP ASP-121; ARG-192 AND THR-241.
PubMed=21070897; DOI=10.1016/j.ajhg.2010.10.013;
Rajadhyaksha A.M., Elemento O., Puffenberger E.G., Schierberl K.C.,
Xiang J.Z., Putorti M.L., Berciano J., Poulin C., Brais B.,
Michaelides M., Weleber R.G., Higgins J.J.;
"Mutations in FLVCR1 cause posterior column ataxia and retinitis
pigmentosa.";
Am. J. Hum. Genet. 87:643-654(2010).
[19]
VARIANT PCARP ARG-493.
PubMed=21267618; DOI=10.1007/s10048-010-0271-4;
Ishiura H., Fukuda Y., Mitsui J., Nakahara Y., Ahsan B., Takahashi Y.,
Ichikawa Y., Goto J., Sakai T., Tsuji S.;
"Posterior column ataxia with retinitis pigmentosa in a Japanese
family with a novel mutation in FLVCR1.";
Neurogenetics 12:117-121(2011).
-!- FUNCTION: Isoform 1: Heme transporter that exports cytoplasmic
heme. It can also export coproporphyrin and protoporphyrin IX,
which are both intermediate products in the heme biosynthetic
pathway. Does not export bilirubin. Heme export depends on the
presence of HPX and is required to maintain intracellular free
heme balance, protecting cells from heme toxicity. Heme export
provides protection from heme or ferrous iron toxicities in liver,
brain, sensory neurons and during erythtopoiesis, a process in
which heme synthesis intensifies. Causes susceptibility to FeLV-C
in vitro. {ECO:0000269|PubMed:10400745,
ECO:0000269|PubMed:15369674, ECO:0000269|PubMed:20610401,
ECO:0000269|PubMed:27923065}.
-!- FUNCTION: Isoform 2: Heme transporter that promotes heme efflux
from the mitochondrion to the cytoplasm. Essential for erythroid
differentiation.
-!- SUBUNIT: Interacts with HPX. {ECO:0000269|PubMed:20610401}.
-!- SUBCELLULAR LOCATION: Isoform 1: Cell membrane {ECO:0000250};
Multi-pass membrane protein {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Isoform 2: Mitochondrion membrane
{ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1; Synonyms=FLVC1a;
IsoId=Q9Y5Y0-1; Sequence=Displayed;
Name=2; Synonyms=FLVC1b, mitochondrial;
IsoId=Q9Y5Y0-2; Sequence=VSP_047866;
Note=Has a probable mitochondrial transit peptide at positions
1-38.;
-!- TISSUE SPECIFICITY: Found all hematopoietic tissues including
peripheral blood lymphocytes. Some expression is found in pancreas
and kidney. {ECO:0000269|PubMed:10400745}.
-!- DEVELOPMENTAL STAGE: Down-regulated in haemopoietic progenitor
cells undergoing differentiation and hemoglobinization. Abundant
in fetal liver. {ECO:0000269|PubMed:15369674}.
-!- PTM: N-Glycosylated. {ECO:0000269|PubMed:16439531}.
-!- DISEASE: Posterior column ataxia with retinitis pigmentosa (PCARP)
[MIM:609033]: A neurodegenerative syndrome beginning in infancy
with areflexia and retinitis pigmentosa. Nyctalopia (night
blindness) and peripheral visual field loss are usually evident
during late childhood or teenage years, with subsequent
progressive constriction of the visual fields and loss of central
retinal function over time. A sensory ataxia caused by
degeneration of the posterior columns of the spinal cord results
in a loss of proprioceptive sensation that is clinically evident
in the second decade of life and gradually progresses. Scoliosis,
camptodactyly, achalasia, gastrointestinal dysmotility, and a
sensory peripheral neuropathy are variable features of the
disease. Affected individuals have no clinical or radiological
evidence of cerebral or cerebellar involvement.
{ECO:0000269|PubMed:21070897, ECO:0000269|PubMed:21267618}.
Note=The disease is caused by mutations affecting the gene
represented in this entry. Defective neuronal heme transmembrane
export due to FLVCR1 mutations may abrogate the neuroprotective
effects of neuroglobin and initiate an apoptotic cascade that
results in the selective degeneration of photoreceptors in the
neurosensory retina and sensory neurons in the posterior spinal
cord.
-!- DISEASE: Note=Defects in FLVCR1 are a cause of a sensory
neuropathy resulting in pain insensitivity. Patients have
decreased sensing of pain, temperature and touch. Self-injury,
ulcers and amputations are commonly observed in affected
individuals. {ECO:0000269|PubMed:27923065}.
-!- SIMILARITY: Belongs to the major facilitator superfamily. Feline
leukemia virus subgroup C receptor (TC 2.A.1.28.1) family.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AF118637; AAD45243.1; -; mRNA.
EMBL; AK001419; BAA91679.1; -; mRNA.
EMBL; DQ496107; ABF47096.1; -; Genomic_DNA.
EMBL; CH471100; EAW93374.1; -; Genomic_DNA.
EMBL; BC048312; AAH48312.1; -; mRNA.
CCDS; CCDS1510.1; -. [Q9Y5Y0-1]
RefSeq; NP_054772.1; NM_014053.3. [Q9Y5Y0-1]
UniGene; Hs.7055; -.
ProteinModelPortal; Q9Y5Y0; -.
BioGrid; 118803; 34.
IntAct; Q9Y5Y0; 2.
STRING; 9606.ENSP00000355938; -.
TCDB; 2.A.1.28.1; the major facilitator superfamily (mfs).
iPTMnet; Q9Y5Y0; -.
PhosphoSitePlus; Q9Y5Y0; -.
BioMuta; FLVCR1; -.
DMDM; 46396053; -.
EPD; Q9Y5Y0; -.
PaxDb; Q9Y5Y0; -.
PeptideAtlas; Q9Y5Y0; -.
PRIDE; Q9Y5Y0; -.
Ensembl; ENST00000366971; ENSP00000355938; ENSG00000162769. [Q9Y5Y0-1]
GeneID; 28982; -.
KEGG; hsa:28982; -.
UCSC; uc001hjt.3; human. [Q9Y5Y0-1]
CTD; 28982; -.
DisGeNET; 28982; -.
EuPathDB; HostDB:ENSG00000162769.12; -.
GeneCards; FLVCR1; -.
HGNC; HGNC:24682; FLVCR1.
HPA; HPA046646; -.
MalaCards; FLVCR1; -.
MIM; 609033; phenotype.
MIM; 609144; gene.
neXtProt; NX_Q9Y5Y0; -.
OpenTargets; ENSG00000162769; -.
Orphanet; 88628; Posterior column ataxia - retinitis pigmentosa.
PharmGKB; PA162388695; -.
eggNOG; KOG2563; Eukaryota.
eggNOG; ENOG410XSTK; LUCA.
GeneTree; ENSGT00530000062892; -.
HOGENOM; HOG000019717; -.
HOVERGEN; HBG051631; -.
InParanoid; Q9Y5Y0; -.
KO; K08220; -.
OMA; ITYGIMT; -.
OrthoDB; EOG091G0FJM; -.
PhylomeDB; Q9Y5Y0; -.
TreeFam; TF314292; -.
Reactome; R-HSA-917937; Iron uptake and transport.
ChiTaRS; FLVCR1; human.
GeneWiki; FLVCR1; -.
GenomeRNAi; 28982; -.
PRO; PR:Q9Y5Y0; -.
Proteomes; UP000005640; Chromosome 1.
Bgee; ENSG00000162769; -.
CleanEx; HS_FLVCR1; -.
ExpressionAtlas; Q9Y5Y0; baseline and differential.
Genevisible; Q9Y5Y0; HS.
GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
GO; GO:0005739; C:mitochondrion; IDA:MGI.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0015232; F:heme transporter activity; IDA:UniProtKB.
GO; GO:0005215; F:transporter activity; TAS:ProtInc.
GO; GO:0001568; P:blood vessel development; IEA:Ensembl.
GO; GO:0006879; P:cellular iron ion homeostasis; TAS:Reactome.
GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
GO; GO:0048704; P:embryonic skeletal system morphogenesis; IEA:Ensembl.
GO; GO:0030218; P:erythrocyte differentiation; IDA:MGI.
GO; GO:0043249; P:erythrocyte maturation; IEA:UniProtKB-KW.
GO; GO:0060323; P:head morphogenesis; IEA:Ensembl.
GO; GO:0097037; P:heme export; IMP:UniProtKB.
GO; GO:0015886; P:heme transport; IMP:MGI.
GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO; GO:0006839; P:mitochondrial transport; IDA:MGI.
GO; GO:0007275; P:multicellular organism development; TAS:ProtInc.
GO; GO:0035264; P:multicellular organism growth; IEA:Ensembl.
GO; GO:0046620; P:regulation of organ growth; IEA:Ensembl.
GO; GO:0048536; P:spleen development; IEA:Ensembl.
GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
GO; GO:0006810; P:transport; TAS:ProtInc.
CDD; cd06174; MFS; 1.
InterPro; IPR011701; MFS.
InterPro; IPR020846; MFS_dom.
InterPro; IPR036259; MFS_trans_sf.
Pfam; PF07690; MFS_1; 1.
SUPFAM; SSF103473; SSF103473; 1.
PROSITE; PS50850; MFS; 1.
1: Evidence at protein level;
Alternative splicing; Cell membrane; Complete proteome;
Disease mutation; Erythrocyte maturation; Glycoprotein; Membrane;
Mitochondrion; Neurodegeneration; Neuropathy; Phosphoprotein;
Polymorphism; Receptor; Reference proteome; Retinitis pigmentosa;
Transmembrane; Transmembrane helix; Transport.
CHAIN 1 555 Feline leukemia virus subgroup C
receptor-related protein 1.
/FTId=PRO_0000084844.
TOPO_DOM 1 107 Cytoplasmic. {ECO:0000255}.
TRANSMEM 108 128 Helical. {ECO:0000255}.
TOPO_DOM 129 147 Extracellular. {ECO:0000255}.
TRANSMEM 148 168 Helical. {ECO:0000255}.
TOPO_DOM 169 174 Cytoplasmic. {ECO:0000255}.
TRANSMEM 175 195 Helical. {ECO:0000255}.
TOPO_DOM 196 199 Extracellular. {ECO:0000255}.
TRANSMEM 200 220 Helical. {ECO:0000255}.
TOPO_DOM 221 240 Cytoplasmic. {ECO:0000255}.
TRANSMEM 241 261 Helical. {ECO:0000255}.
TOPO_DOM 262 275 Extracellular. {ECO:0000255}.
TRANSMEM 276 296 Helical. {ECO:0000255}.
TOPO_DOM 297 331 Cytoplasmic. {ECO:0000255}.
TRANSMEM 332 352 Helical. {ECO:0000255}.
TOPO_DOM 353 372 Extracellular. {ECO:0000255}.
TRANSMEM 373 393 Helical. {ECO:0000255}.
TOPO_DOM 394 401 Cytoplasmic. {ECO:0000255}.
TRANSMEM 402 422 Helical. {ECO:0000255}.
TOPO_DOM 423 424 Extracellular. {ECO:0000255}.
TRANSMEM 425 445 Helical. {ECO:0000255}.
TOPO_DOM 446 459 Cytoplasmic. {ECO:0000255}.
TRANSMEM 460 480 Helical. {ECO:0000255}.
TOPO_DOM 481 490 Extracellular. {ECO:0000255}.
TRANSMEM 491 511 Helical. {ECO:0000255}.
TOPO_DOM 512 555 Cytoplasmic. {ECO:0000255}.
MOD_RES 56 56 Phosphoserine.
{ECO:0000244|PubMed:19690332}.
MOD_RES 536 536 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
CARBOHYD 265 265 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 273 273 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
VAR_SEQ 1 276 Missing (in isoform 2).
{ECO:0000303|PubMed:14702039,
ECO:0000303|PubMed:15489334}.
/FTId=VSP_047866.
VARIANT 52 52 A -> P (in dbSNP:rs11120047).
{ECO:0000269|PubMed:15489334}.
/FTId=VAR_050297.
VARIANT 121 121 N -> D (in PCARP; dbSNP:rs267606820).
{ECO:0000269|PubMed:21070897}.
/FTId=VAR_065158.
VARIANT 192 192 C -> R (in PCARP; also found in a patient
with sensory neuropathy and pain
insensitivity; dbSNP:rs267606821).
{ECO:0000269|PubMed:21070897,
ECO:0000269|PubMed:27923065}.
/FTId=VAR_065159.
VARIANT 221 221 P -> S (probable disease-associated
mutation found in a patient with sensory
neuropathy and pain insensitivity;
dbSNP:rs753000469).
{ECO:0000269|PubMed:27923065}.
/FTId=VAR_077884.
VARIANT 241 241 A -> T (in PCARP; dbSNP:rs267606819).
{ECO:0000269|PubMed:21070897}.
/FTId=VAR_065160.
VARIANT 493 493 G -> R (in PCARP).
{ECO:0000269|PubMed:21267618}.
/FTId=VAR_065161.
VARIANT 544 544 T -> M (in dbSNP:rs3207090).
{ECO:0000269|PubMed:15489334}.
/FTId=VAR_050298.
SEQUENCE 555 AA; 59863 MW; D0EBA9886CC8E747 CRC64;
MARPDDEEGA AVAPGHPLAK GYLPLPRGAP VGKESVELQN GPKAGTFPVN GAPRDSLAAA
SGVLGGPQTP LAPEEETQAR LLPAGAGAET PGAESSPLPL TALSPRRFVV LLIFSLYSLV
NAFQWIQYSI ISNVFEGFYG VTLLHIDWLS MVYMLAYVPL IFPATWLLDT RGLRLTALLG
SGLNCLGAWI KCGSVQQHLF WVTMLGQCLC SVAQVFILGL PSRIASVWFG PKEVSTACAT
AVLGNQLGTA VGFLLPPVLV PNTQNDTNLL ACNISTMFYG TSAVATLLFI LTAIAFKEKP
RYPPSQAQAA LQDSPPEEYS YKKSIRNLFK NIPFVLLLIT YGIMTGAFYS VSTLLNQMIL
TYYEGEEVNA GRIGLTLVVA GMVGSILCGL WLDYTKTYKQ TTLIVYILSF IGMVIFTFTL
DLRYIIIVFV TGGVLGFFMT GYLPLGFEFA VEITYPESEG TSSGLLNASA QIFGILFTLA
QGKLTSDYGP KAGNIFLCVW MFIGIILTAL IKSDLRRHNI NIGITNVDVK AIPADSPTDQ
EPKTVMLSKQ SESAI


Related products :

Catalog number Product name Quantity
CSB-EL008736CA Cat Feline leukemia virus subgroup C receptor-related protein 1(FLVCR1) ELISA kit 96T
CSB-EL008737RA Rat Feline leukemia virus subgroup C receptor-related protein 2(FLVCR2) ELISA kit 96T
FLVC2_MOUSE Mouse ELISA Kit FOR Feline leukemia virus subgroup C receptor-related protein 2 96T
FLVC1_HUMAN Human ELISA Kit FOR Feline leukemia virus subgroup C receptor-related protein 1 96T
AE61033CA Cat Feline leukemia virus subgroup C receptor-related protein 1 (FLVCR1) ELISA Kit 48T
CSB-EL008737HU Human Feline leukemia virus subgroup C receptor-related protein 2(FLVCR2) ELISA kit 96T
CSB-EL008737RA Rat Feline leukemia virus subgroup C receptor-related protein 2(FLVCR2) ELISA kit SpeciesRat 96T
CSB-EL008737MO Mouse Feline leukemia virus subgroup C receptor-related protein 2(FLVCR2) ELISA kit 96T
CSB-EL008736CA Cat Feline leukemia virus subgroup C receptor-related protein 1(FLVCR1) ELISA kit SpeciesCat 96T
CSB-EL008736HU Human Feline leukemia virus subgroup C receptor-related protein 1(FLVCR1) ELISA kit 96T
CSB-EL008737HU Human Feline leukemia virus subgroup C receptor-related protein 2(FLVCR2) ELISA kit SpeciesHuman 96T
CSB-EL008737MO Mouse Feline leukemia virus subgroup C receptor-related protein 2(FLVCR2) ELISA kit SpeciesMouse 96T
CSB-EL008736HU Human Feline leukemia virus subgroup C receptor-related protein 1(FLVCR1) ELISA kit SpeciesHuman 96T
FLVC2_MOUSE ELISA Kit FOR Feline leukemia virus subgroup C receptor-related protein 2; organism: Mouse; gene name: Flvcr2 96T
FLYWCH1 FLVCR1 Gene feline leukemia virus subgroup C cellular receptor 1
FLYWCH1L FLVCR2 Gene feline leukemia virus subgroup C cellular receptor family, member 2
CSB-EL008736CA Cat feline leukemia virus subgroup C cellular receptor 1 (FLVCR1) ELISA kit, Species Cat, Sample Type serum, plasma 96T
CSB-EL008737RA Rat feline leukemia virus subgroup C cellular receptor family, member 2 (FLVCR2) ELISA kit, Species Rat, Sample Type serum, plasma 96T
E13780h Human Feline Leukemia Virus Subgroup C Cellular Re 96T
E13779h Human Feline Leukemia Virus Subgroup C Cellular Re 96T
CSB-EL008736HU Human feline leukemia virus subgroup C cellular receptor 1 (FLVCR1) ELISA kit, Species Human, Sample Type serum, plasma 96T
CSB-EL008737HU Human feline leukemia virus subgroup C cellular receptor family, member 2 (FLVCR2) ELISA kit, Species Human, Sample Type serum, plasma 96T
CSB-EL008737MO Mouse feline leukemia virus subgroup C cellular receptor family, member 2 (FLVCR2) ELISA kit, Species Mouse, Sample Type serum, plasma 96T
VET-F003-96R Feline leukemia virus PCR detection kit, Feline, RNA 96rxs
VET-F003-96R Feline leukemia virus PCR detection kit, Feline, RNA 48rxs


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur