GENTAUR Molecular Products.

 M9NDC3_DROME            Unreviewed;       884 AA.
 M9NDC3;
 26-JUN-2013, integrated into UniProtKB/TrEMBL.
 26-JUN-2013, sequence version 1.
 10-OCT-2018, entry version 47.
 SubName: Full=Female sterile (2) ketel, isoform B {ECO:0000313|EMBL:AFH03783.1};
 SubName: Full=Female sterile (2) ketel, isoform C {ECO:0000313|EMBL:AFH03784.1};
 SubName: Full=Female sterile (2) ketel, isoform D {ECO:0000313|EMBL:AFH03782.1};
 SubName: Full=Female sterile (2) ketel, isoform E {ECO:0000313|EMBL:AFH03785.1};
 Name=Fs(2)Ket {ECO:0000313|EMBL:AFH03784.1,
 ECO:0000313|FlyBase:FBgn0262743};
 Synonyms=38E.11 {ECO:0000313|EMBL:AFH03784.1},
 dKap-beta {ECO:0000313|EMBL:AFH03784.1},
 Dmel\CG2637 {ECO:0000313|EMBL:AFH03784.1},
 Fs(2)Hon {ECO:0000313|EMBL:AFH03784.1},
 Fs(2)ket {ECO:0000313|EMBL:AFH03784.1},
 fs(2)Ket {ECO:0000313|EMBL:AFH03784.1},
 Fs(2)Ketel {ECO:0000313|EMBL:AFH03784.1},
 fs(2)lo-B {ECO:0000313|EMBL:AFH03784.1},
 fs(2)lto2 {ECO:0000313|EMBL:AFH03784.1},
 fs(2)ltoHD43 {ECO:0000313|EMBL:AFH03784.1},
 Fs(2)Sz6 {ECO:0000313|EMBL:AFH03784.1},
 Fs(2)Sz7 {ECO:0000313|EMBL:AFH03784.1},
 Hon {ECO:0000313|EMBL:AFH03784.1},
 imp-beta {ECO:0000313|EMBL:AFH03784.1},
 Impbeta {ECO:0000313|EMBL:AFH03784.1},
 impbeta {ECO:0000313|EMBL:AFH03784.1},
 IMPbeta1 {ECO:0000313|EMBL:AFH03784.1},
 Ket {ECO:0000313|EMBL:AFH03784.1},
 Ketel {ECO:0000313|EMBL:AFH03784.1},
 ketel {ECO:0000313|EMBL:AFH03784.1},
 kettle {ECO:0000313|EMBL:AFH03784.1},
 Kpnb1 {ECO:0000313|EMBL:AFH03784.1},
 MRE26 {ECO:0000313|EMBL:AFH03784.1};
 ORFNames=CG2637 {ECO:0000313|EMBL:AFH03782.1,
 ECO:0000313|FlyBase:FBgn0262743},
 Dmel_CG2637 {ECO:0000313|EMBL:AFH03784.1};
 Drosophila melanogaster (Fruit fly).
 Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
 Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
 Ephydroidea; Drosophilidae; Drosophila; Sophophora.
 NCBI_TaxID=7227 {ECO:0000313|EMBL:AFH03784.1, ECO:0000313|Proteomes:UP000000803};
 [1] {ECO:0000313|EMBL:AFH03784.1, ECO:0000313|Proteomes:UP000000803}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
 PubMed=10731132; DOI=10.1126/science.287.5461.2185;
 Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
 Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
 George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
 Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
 Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D.,
 Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L.,
 Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D.,
 Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
 Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
 Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
 Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
 Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
 de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
 Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
 Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
 Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
 Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
 Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J.,
 Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C.,
 Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
 Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
 Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X.,
 Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
 Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
 Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
 Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
 Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
 Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
 Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
 Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
 Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
 Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
 Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J.,
 Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
 Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
 Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
 "The genome sequence of Drosophila melanogaster.";
 Science 287:2185-2195(2000).
 [2] {ECO:0000313|EMBL:AFH03784.1, ECO:0000313|Proteomes:UP000000803}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
 PubMed=12537568;
 Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
 Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
 George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
 Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
 Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
 Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
 "Finishing a whole-genome shotgun: release 3 of the Drosophila
 melanogaster euchromatic genome sequence.";
 Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
 [3] {ECO:0000313|EMBL:AFH03784.1, ECO:0000313|Proteomes:UP000000803}
 GENOME REANNOTATION.
 STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
 PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
 Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
 Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
 Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P.,
 Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A.,
 Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
 Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
 Lewis S.E.;
 "Annotation of the Drosophila melanogaster euchromatic genome: a
 systematic review.";
 Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
 [4] {ECO:0000313|EMBL:AFH03784.1, ECO:0000313|Proteomes:UP000000803}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
 PubMed=12537573;
 Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
 Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M.,
 Ashburner M., Celniker S.E.;
 "The transposable elements of the Drosophila melanogaster euchromatin:
 a genomics perspective.";
 Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002).
 [5] {ECO:0000313|EMBL:AFH03784.1, ECO:0000313|Proteomes:UP000000803}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
 PubMed=12537574;
 Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
 Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
 Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
 Karpen G.H.;
 "Heterochromatic sequences in a Drosophila whole-genome shotgun
 assembly.";
 Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
 [6] {ECO:0000313|EMBL:AFH03784.1, ECO:0000313|Proteomes:UP000000803}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
 PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
 Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
 Ashburner M., Anxolabehere D.;
 "Combined evidence annotation of transposable elements in genome
 sequences.";
 PLoS Comput. Biol. 1:166-175(2005).
 [7] {ECO:0000313|EMBL:AFH03784.1}
 NUCLEOTIDE SEQUENCE.
 Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S.,
 Svirskas R., Rubin G.;
 Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
 [8] {ECO:0000313|EMBL:AFH03784.1}
 NUCLEOTIDE SEQUENCE.
 Berkeley Drosophila Genome Project;
 Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R.,
 Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E.,
 Yu C., Rubin G.;
 "Drosophila melanogaster release 4 sequence.";
 Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
 [9] {ECO:0000313|EMBL:AFH03784.1, ECO:0000313|Proteomes:UP000000803}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
 PubMed=17569856; DOI=10.1126/science.1139815;
 Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
 "The Release 5.1 annotation of Drosophila melanogaster
 heterochromatin.";
 Science 316:1586-1591(2007).
 [10] {ECO:0000313|EMBL:AFH03784.1, ECO:0000313|Proteomes:UP000000803}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
 PubMed=17569867; DOI=10.1126/science.1139816;
 Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
 Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
 Dimitri P., Karpen G.H., Celniker S.E.;
 "Sequence finishing and mapping of Drosophila melanogaster
 heterochromatin.";
 Science 316:1625-1628(2007).
 [11] {ECO:0000313|EMBL:AFH03784.1}
 NUCLEOTIDE SEQUENCE.
 PubMed=26109357;
 FlyBase Consortium;
 Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B.,
 St Pierre S.E., Gramates L.S., Zhou P., Schroeder A.J., Falls K.,
 Strelets V., Russo S.M., Gelbart W.M.;
 "Gene Model Annotations for Drosophila melanogaster: Impact of High-
 Throughput Data.";
 G3 (Bethesda) 5:1721-1736(2015).
 [12] {ECO:0000313|EMBL:AFH03784.1}
 NUCLEOTIDE SEQUENCE.
 PubMed=26109356;
 FlyBase Consortium;
 Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B.,
 St Pierre S.E., Zhou P., Schroeder A.J., Falls K., Emmert D.B.,
 Russo S.M., Gelbart W.M.;
 "Gene Model Annotations for Drosophila melanogaster: The Rule-
 Benders.";
 G3 (Bethesda) 5:1737-1749(2015).
 [13] {ECO:0000313|EMBL:AFH03784.1}
 NUCLEOTIDE SEQUENCE.
 FlyBase;
 Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
 -----------------------------------------------------------------------
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 Distributed under the Creative Commons Attribution (CC BY 4.0) License
 -----------------------------------------------------------------------
 EMBL; AE014134; AFH03782.1; -; Genomic_DNA.
 EMBL; AE014134; AFH03783.1; -; Genomic_DNA.
 EMBL; AE014134; AFH03784.1; -; Genomic_DNA.
 EMBL; AE014134; AFH03785.1; -; Genomic_DNA.
 RefSeq; NP_001246108.1; NM_001259179.2.
 RefSeq; NP_001246109.1; NM_001259180.2.
 RefSeq; NP_001246110.1; NM_001259181.2.
 RefSeq; NP_001246111.1; NM_001259182.2.
 RefSeq; NP_477496.1; NM_058148.5.
 UniGene; Dm.3333; -.
 EnsemblMetazoa; FBtr0081392; FBpp0080922; FBgn0262743.
 EnsemblMetazoa; FBtr0305584; FBpp0294035; FBgn0262743.
 EnsemblMetazoa; FBtr0305585; FBpp0294036; FBgn0262743.
 EnsemblMetazoa; FBtr0305586; FBpp0294037; FBgn0262743.
 EnsemblMetazoa; FBtr0305587; FBpp0294038; FBgn0262743.
 GeneID; 35336; -.
 KEGG; dme:Dmel_CG2637; -.
 CTD; 35336; -.
 FlyBase; FBgn0262743; Fs(2)Ket.
 eggNOG; KOG1241; Eukaryota.
 eggNOG; COG5215; LUCA.
 KO; K14293; -.
 OMA; KNHLTSK; -.
 OrthoDB; EOG091G01XQ; -.
 ChiTaRS; sls; fly.
 GenomeRNAi; 35336; -.
 Proteomes; UP000000803; Chromosome 2L.
 Bgee; FBgn0262743; Expressed in 36 organ(s), highest expression level in oocyte.
 GO; GO:0005622; C:intracellular; IEA:GOC.
 GO; GO:0008536; F:Ran GTPase binding; IEA:InterPro.
 GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
 Gene3D; 1.25.10.10; -; 1.
 InterPro; IPR011989; ARM-like.
 InterPro; IPR016024; ARM-type_fold.
 InterPro; IPR021133; HEAT_type_2.
 InterPro; IPR001494; Importin-beta_N.
 Pfam; PF03810; IBN_N; 1.
 SMART; SM00913; IBN_N; 1.
 SUPFAM; SSF48371; SSF48371; 1.
 PROSITE; PS50077; HEAT_REPEAT; 1.
 PROSITE; PS50166; IMPORTIN_B_NT; 1.
 4: Predicted;
 Complete proteome {ECO:0000313|Proteomes:UP000000803};
 Reference proteome {ECO:0000313|Proteomes:UP000000803}.
 DOMAIN       27    107       Importin N-terminal.
                              {ECO:0000259|PROSITE:PS50166}.
 REPEAT      415    453       HEAT. {ECO:0000256|PROSITE-
                              ProRule:PRU00103}.
 SEQUENCE   884 AA;  98696 MW;  DE6DACB927B314EC CRC64;
 MTSDIAMQLI AILEKTVSPD KNELLSAKNF LEQAAASNLP EFLKALSEIL VNTANSAVAR
 MAAGLQLKNH LTSKDEKVSQ QYQDRWHQFP SEIRELIKNN ILAALGTENT RPSCAAQCVA
 YVAVIELPIN RWPMLIQTLV NKVVSEGSSE MHRESALEAI GYICQDIRFG VMENQSNDVL
 TAIIHGMRKV EPSNHVRLAA TTALHNSLEF TKSNFEKDME RNFIMEVVCE ATQCQDSQIC
 VAALQCLVKI MTLYYQYMEP YMAQALFPIT LAAMKSDNDA VALQGIEFWS NVCDEEIDLA
 IESQEATDQG RAPQRVSKHY ARGALQFLTP VLVEKLTKQD ECDDEDTWSP AKAASVCLMV
 LATCCEDEIV PHVLPFIKEN IESPNWRFRD AAVMTFGSVL NGLETNTLKP LVEQAMPTLI
 RLMYDSSVIV RDTIAWTFGR ICDIIPEAAI NETYLQTLLE CFVKSLKSEP RVAANVCWAF
 IGLSDAAWEA AVTNDGETPE TYALSPYFEY IITQLLETTD RSDGAQANLR CAAYQALMDM
 IKNSPLDCYL VVQRTTLVIL ERLNQVMQME TQINNHSDRH QFNDLQSLLC ATLQSVLRKV
 HEQDAPQISD AIMTALLTMF NSSAGKSGVV QEEAFLAVST LVELLGAQFA KYMPAFKDFL
 VMGLKNFQEY QVCCAAVGLT GDIFRALKDL MVPYSNEIMT VLINNLTEPT IHRTVKPQVL
 SAFGDIALSI GNHFLPYLSM VLDMLRVASN LQTDANNFDM NEYINELRES ILEAYTGIIQ
 GLKGVDQTAH TDVMHMEPHL MHIISFIKRI AQEGDVSDSM LASAAGFIGD LCTSFGPRLY
 PLLDDAIITQ FLAEGKRSKA QRTKMLCTWA VKEIKKINTQ VITQ

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