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Ferric uptake regulation protein (Ferric uptake regulator)

 FUR_NEIMB               Reviewed;         144 AA.
P0A0S8; Q57298;
01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
01-MAR-2005, sequence version 1.
25-OCT-2017, entry version 75.
RecName: Full=Ferric uptake regulation protein;
Short=Ferric uptake regulator;
Name=fur; OrderedLocusNames=NMB0205;
Neisseria meningitidis serogroup B (strain MC58).
Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales;
Neisseriaceae; Neisseria.
NCBI_TaxID=122586;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=CCUG 37603 / B16B6 / Serogroup B / Serotype 2a;
PubMed=8163167; DOI=10.1016/0378-1119(94)90143-0;
Karkhoff-Schweizer R.R., Schryvers A.B., Schweizer H.P.;
"Cloning and sequence analysis of the fur gene encoding an iron-
regulatory protein of Neisseria meningitidis.";
Gene 141:139-140(1994).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=MC58;
PubMed=10710307; DOI=10.1126/science.287.5459.1809;
Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C.,
Nelson K.E., Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F.,
Dodson R.J., Nelson W.C., Gwinn M.L., DeBoy R.T., Peterson J.D.,
Hickey E.K., Haft D.H., Salzberg S.L., White O., Fleischmann R.D.,
Dougherty B.A., Mason T.M., Ciecko A., Parksey D.S., Blair E.,
Cittone H., Clark E.B., Cotton M.D., Utterback T.R., Khouri H.M.,
Qin H., Vamathevan J.J., Gill J., Scarlato V., Masignani V., Pizza M.,
Grandi G., Sun L., Smith H.O., Fraser C.M., Moxon E.R., Rappuoli R.,
Venter J.C.;
"Complete genome sequence of Neisseria meningitidis serogroup B strain
MC58.";
Science 287:1809-1815(2000).
-!- FUNCTION: Acts as a global negative controlling element, employing
Fe(2+) as a cofactor to bind the operator of the repressed genes.
Regulates the expression of the fbp protein.
-!- SUBUNIT: Homodimer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
-!- SIMILARITY: Belongs to the Fur family. {ECO:0000305}.
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EMBL; U01151; AAC13744.1; -; Unassigned_DNA.
EMBL; AE002098; AAF40662.1; -; Genomic_DNA.
PIR; G81226; G81226.
RefSeq; NP_273263.1; NC_003112.2.
RefSeq; WP_002218609.1; NC_003112.2.
ProteinModelPortal; P0A0S8; -.
SMR; P0A0S8; -.
STRING; 122586.NMB0205; -.
PaxDb; P0A0S8; -.
EnsemblBacteria; AAF40662; AAF40662; NMB0205.
GeneID; 902313; -.
KEGG; nme:NMB0205; -.
PATRIC; fig|122586.8.peg.254; -.
eggNOG; ENOG41090R7; Bacteria.
eggNOG; COG0735; LUCA.
HOGENOM; HOG000014144; -.
KO; K03711; -.
OMA; NEGQHHD; -.
OrthoDB; POG091H01WK; -.
Proteomes; UP000000425; Chromosome.
CollecTF; EXPREG_000006e0; -.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0032993; C:protein-DNA complex; IPI:CollecTF.
GO; GO:0001216; F:bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding; IPI:CollecTF.
GO; GO:0001217; F:bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding; IPI:CollecTF.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0000976; F:transcription regulatory region sequence-specific DNA binding; IPI:CollecTF.
GO; GO:0071281; P:cellular response to iron ion; IEP:CollecTF.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEP:CollecTF.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; EXP:CollecTF.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEP:CollecTF.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd07153; Fur_like; 1.
Gene3D; 1.10.10.10; -; 1.
InterPro; IPR002481; FUR.
InterPro; IPR036388; WH-like_DNA-bd_sf.
InterPro; IPR036390; WH_DNA-bd_sf.
Pfam; PF01475; FUR; 1.
SUPFAM; SSF46785; SSF46785; 1.
3: Inferred from homology;
Complete proteome; Cytoplasm; DNA-binding; Iron; Metal-binding;
Reference proteome; Repressor; Transcription;
Transcription regulation; Zinc.
CHAIN 1 144 Ferric uptake regulation protein.
/FTId=PRO_0000095565.
REGION 1 86 DNA-binding. {ECO:0000250}.
REGION 87 144 Dimerization. {ECO:0000250}.
COMPBIAS 89 92 His-rich.
METAL 35 35 Zinc. {ECO:0000250}.
METAL 83 83 Zinc. {ECO:0000250}.
METAL 89 89 Iron. {ECO:0000250}.
METAL 91 91 Iron. {ECO:0000250}.
METAL 92 92 Zinc. {ECO:0000250}.
METAL 95 95 Zinc. {ECO:0000250}.
METAL 98 98 Zinc. {ECO:0000250}.
METAL 103 103 Zinc. {ECO:0000250}.
METAL 110 110 Iron. {ECO:0000250}.
METAL 127 127 Iron. {ECO:0000250}.
VARIANT 5 5 N -> S (in strain: CCUG 37603).
SEQUENCE 144 AA; 16411 MW; B37489E92856AC02 CRC64;
MEKFNNIAQL KDSGLKVTGP RLKILDLFET HAEEHLSAED VYRILLEEGV EIGVATIYRV
LTQFEQAGIL QRHHFETGKA VYELDKGDHH DHIVCVKCGE VTEFHNPEIE ALQDKIAEEN
GYRIVDHALY MYGVCSDCQA KGKR


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