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Ferric uptake regulation protein (Ferric uptake regulator)

 FUR_PSEAE               Reviewed;         134 AA.
Q03456;
01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
01-OCT-1993, sequence version 1.
28-FEB-2018, entry version 114.
RecName: Full=Ferric uptake regulation protein;
Short=Ferric uptake regulator;
Name=fur; OrderedLocusNames=PA4764;
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 /
JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
Pseudomonadaceae; Pseudomonas.
NCBI_TaxID=208964;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 29260 / PA103;
PubMed=8478325; DOI=10.1128/jb.175.9.2589-2598.1993;
Prince R.W., Cox C.D., Vasil M.L.;
"Coordinate regulation of siderophore and exotoxin A production:
molecular cloning and sequencing of the Pseudomonas aeruginosa fur
gene.";
J. Bacteriol. 175:2589-2598(1993).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 /
1C / PRS 101 / PAO1;
PubMed=9852033;
Vasil M.L., Ochsner U.A., Johnson Z., Colmer J.A., Hamood A.N.;
"The fur-regulated gene encoding the alternative sigma factor PvdS is
required for iron-dependent expression of the LysR-type regulator ptxR
in Pseudomonas aeruginosa.";
J. Bacteriol. 180:6784-6788(1998).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 /
1C / PRS 101 / PAO1;
PubMed=10984043; DOI=10.1038/35023079;
Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T.,
Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
"Complete genome sequence of Pseudomonas aeruginosa PAO1, an
opportunistic pathogen.";
Nature 406:959-964(2000).
[4]
X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS), SUBUNIT, AND METAL-BINDING
SITES.
PubMed=12581348; DOI=10.1046/j.1365-2958.2003.03337.x;
Pohl E., Haller J.C., Mijovilovich A., Meyer-Klaucke W., Garman E.,
Vasil M.L.;
"Architecture of a protein central to iron homeostasis: crystal
structure and spectroscopic analysis of the ferric uptake regulator.";
Mol. Microbiol. 47:903-915(2003).
-!- FUNCTION: Fur acts as a repressor, employing Fe(2+) as a cofactor
to bind the operator of the iron transport operon. Involved in
exotoxin A regulation, siderophore regulation and manganese
susceptibility.
-!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:12581348}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
-!- SIMILARITY: Belongs to the Fur family. {ECO:0000305}.
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EMBL; L00604; AAA25820.1; -; Genomic_DNA.
EMBL; AF050676; AAC05679.1; -; Genomic_DNA.
EMBL; AE004091; AAG08150.1; -; Genomic_DNA.
PIR; A40622; A40622.
RefSeq; NP_253452.1; NC_002516.2.
RefSeq; WP_003095216.1; NC_002516.2.
PDB; 1MZB; X-ray; 1.80 A; A=1-134.
PDBsum; 1MZB; -.
ProteinModelPortal; Q03456; -.
SMR; Q03456; -.
STRING; 208964.PA4764; -.
World-2DPAGE; 0008:Q03456; -.
PaxDb; Q03456; -.
PRIDE; Q03456; -.
DNASU; 881780; -.
EnsemblBacteria; AAG08150; AAG08150; PA4764.
GeneID; 881780; -.
KEGG; pae:PA4764; -.
PATRIC; fig|208964.12.peg.4991; -.
PseudoCAP; PA4764; -.
eggNOG; ENOG41090R7; Bacteria.
eggNOG; COG0735; LUCA.
HOGENOM; HOG000014144; -.
InParanoid; Q03456; -.
KO; K03711; -.
OMA; CVAVDDK; -.
PhylomeDB; Q03456; -.
BioCyc; PAER208964:G1FZ6-4877-MONOMER; -.
EvolutionaryTrace; Q03456; -.
Proteomes; UP000002438; Chromosome.
CollecTF; EXPREG_00000c80; -.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0032993; C:protein-DNA complex; IDA:CollecTF.
GO; GO:0001217; F:bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding; IDA:CollecTF.
GO; GO:0008198; F:ferrous iron binding; TAS:PseudoCAP.
GO; GO:0044212; F:transcription regulatory region DNA binding; IDA:PseudoCAP.
GO; GO:0000976; F:transcription regulatory region sequence-specific DNA binding; IDA:CollecTF.
GO; GO:0051350; P:negative regulation of lyase activity; IMP:PseudoCAP.
GO; GO:1900705; P:negative regulation of siderophore biosynthetic process; IMP:PseudoCAP.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEP:CollecTF.
GO; GO:2000470; P:positive regulation of peroxidase activity; IMP:PseudoCAP.
GO; GO:1901668; P:regulation of superoxide dismutase activity; IMP:PseudoCAP.
GO; GO:0019290; P:siderophore biosynthetic process; IMP:CACAO.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd07153; Fur_like; 1.
Gene3D; 1.10.10.10; -; 1.
InterPro; IPR002481; FUR.
InterPro; IPR036388; WH-like_DNA-bd_sf.
InterPro; IPR036390; WH_DNA-bd_sf.
PANTHER; PTHR33202; PTHR33202; 1.
Pfam; PF01475; FUR; 1.
SUPFAM; SSF46785; SSF46785; 1.
1: Evidence at protein level;
3D-structure; Complete proteome; Cytoplasm; DNA-binding; Iron;
Metal-binding; Reference proteome; Repressor; Transcription;
Transcription regulation; Zinc.
CHAIN 1 134 Ferric uptake regulation protein.
/FTId=PRO_0000095567.
REGION 1 83 DNA-binding.
REGION 84 134 Dimerization.
COMPBIAS 86 89 His-rich.
METAL 32 32 Zinc.
METAL 80 80 Zinc.
METAL 86 86 Iron. {ECO:0000305}.
METAL 88 88 Iron. {ECO:0000305}.
METAL 89 89 Zinc.
METAL 100 100 Zinc.
METAL 107 107 Iron. {ECO:0000305}.
METAL 124 124 Iron. {ECO:0000305}.
HELIX 2 9 {ECO:0000244|PDB:1MZB}.
HELIX 16 26 {ECO:0000244|PDB:1MZB}.
HELIX 35 44 {ECO:0000244|PDB:1MZB}.
HELIX 51 63 {ECO:0000244|PDB:1MZB}.
STRAND 66 70 {ECO:0000244|PDB:1MZB}.
STRAND 72 76 {ECO:0000244|PDB:1MZB}.
STRAND 78 84 {ECO:0000244|PDB:1MZB}.
STRAND 88 92 {ECO:0000244|PDB:1MZB}.
TURN 93 95 {ECO:0000244|PDB:1MZB}.
STRAND 98 101 {ECO:0000244|PDB:1MZB}.
HELIX 104 115 {ECO:0000244|PDB:1MZB}.
TURN 116 118 {ECO:0000244|PDB:1MZB}.
STRAND 127 130 {ECO:0000244|PDB:1MZB}.
SEQUENCE 134 AA; 15234 MW; 99A35AD1E16677F2 CRC64;
MVENSELRKA GLKVTLPRVK ILQMLDSAEQ RHMSAEDVYK ALMEAGEDVG LATVYRVLTQ
FEAAGLVVRH NFDGGHAVFE LADSGHHDHM VCVDTGEVIE FMDAEIEKRQ KEIVRERGFE
LVDHNLVLYV RKKK


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