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Ferric uptake regulation protein (Ferric uptake regulator)

 FUR_LEGPN               Reviewed;         136 AA.
Q48835;
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
22-NOV-2017, entry version 73.
RecName: Full=Ferric uptake regulation protein;
Short=Ferric uptake regulator;
Name=fur;
Legionella pneumophila.
Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales;
Legionellaceae; Legionella.
NCBI_TaxID=446;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=130b / Wadsworth / Serogroup 1;
PubMed=8200525; DOI=10.1016/0378-1119(94)90615-7;
Hickey E.K., Cianciotto N.P.;
"Cloning and sequencing of the Legionella pneumophila fur gene.";
Gene 143:117-121(1994).
-!- FUNCTION: Acts as a global negative controlling element, employing
Fe(2+) as a cofactor to bind the operator of the repressed genes.
-!- SUBUNIT: Homodimer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
-!- SIMILARITY: Belongs to the Fur family. {ECO:0000305}.
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EMBL; U06072; AAA19656.1; -; Genomic_DNA.
RefSeq; WP_011213031.1; NZ_LT906476.1.
ProteinModelPortal; Q48835; -.
SMR; Q48835; -.
PRIDE; Q48835; -.
eggNOG; ENOG41090R7; Bacteria.
eggNOG; COG0735; LUCA.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd07153; Fur_like; 1.
Gene3D; 1.10.10.10; -; 1.
InterPro; IPR002481; FUR.
InterPro; IPR036388; WH-like_DNA-bd_sf.
InterPro; IPR036390; WH_DNA-bd_sf.
PANTHER; PTHR33202; PTHR33202; 1.
Pfam; PF01475; FUR; 1.
SUPFAM; SSF46785; SSF46785; 1.
3: Inferred from homology;
Cytoplasm; DNA-binding; Iron; Metal-binding; Repressor; Transcription;
Transcription regulation; Zinc.
CHAIN 1 136 Ferric uptake regulation protein.
/FTId=PRO_0000095558.
REGION 1 83 DNA-binding. {ECO:0000250}.
REGION 84 136 Dimerization. {ECO:0000250}.
COMPBIAS 86 89 His-rich.
METAL 32 32 Zinc. {ECO:0000250}.
METAL 80 80 Zinc. {ECO:0000250}.
METAL 86 86 Iron. {ECO:0000250}.
METAL 88 88 Iron. {ECO:0000250}.
METAL 89 89 Zinc. {ECO:0000250}.
METAL 92 92 Zinc. {ECO:0000250}.
METAL 95 95 Zinc. {ECO:0000250}.
METAL 100 100 Zinc. {ECO:0000250}.
METAL 107 107 Iron. {ECO:0000250}.
METAL 124 124 Iron. {ECO:0000250}.
SEQUENCE 136 AA; 15362 MW; 87FDA6273B23657A CRC64;
MEESQQLKDA GLKITLPRIK VLQILEQSRN HHLSAEAVYK ALLESGEDVG LATVYRVLTQ
FEAAGLVSRH NFEGGHSVFE LSQGEHHDHL VCVKCGRVEE FVDEIIEQRQ KAIAERAHFK
MTDHALNIYG ICPQCQ


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