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Ferrous-iron efflux pump FieF

 FIEF_ECOL6              Reviewed;         300 AA.
Q8FBD1;
01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
01-MAR-2005, sequence version 2.
23-MAY-2018, entry version 95.
RecName: Full=Ferrous-iron efflux pump FieF;
Name=fieF; OrderedLocusNames=c4866;
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
Enterobacteriaceae; Escherichia.
NCBI_TaxID=199310;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CFT073 / ATCC 700928 / UPEC;
PubMed=12471157; DOI=10.1073/pnas.252529799;
Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P.,
Rasko D., Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D.,
Mayhew G.F., Rose D.J., Zhou S., Schwartz D.C., Perna N.T.,
Mobley H.L.T., Donnenberg M.S., Blattner F.R.;
"Extensive mosaic structure revealed by the complete genome sequence
of uropathogenic Escherichia coli.";
Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
-!- FUNCTION: Iron-efflux transporter responsible for iron
detoxification. Also able to transport Zn(2+) in a proton-
dependent manner (By similarity). {ECO:0000250}.
-!- SUBUNIT: Homodimer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-
pass membrane protein {ECO:0000250}.
-!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
transporter (TC 2.A.4) family. FieF subfamily. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAN83294.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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EMBL; AE014075; AAN83294.1; ALT_INIT; Genomic_DNA.
RefSeq; WP_001076748.1; NC_004431.1.
ProteinModelPortal; Q8FBD1; -.
STRING; 199310.c4866; -.
EnsemblBacteria; AAN83294; AAN83294; c4866.
KEGG; ecc:c4866; -.
eggNOG; ENOG41076HS; Bacteria.
eggNOG; COG0053; LUCA.
HOGENOM; HOG000069673; -.
KO; K13283; -.
OMA; NCHDIAS; -.
Proteomes; UP000001410; Chromosome.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
GO; GO:0015684; P:ferrous iron transport; IEA:InterPro.
GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
GO; GO:0006829; P:zinc ion transport; IEA:InterPro.
Gene3D; 1.20.1510.10; -; 1.
Gene3D; 3.30.70.1350; -; 1.
HAMAP; MF_01425; Cation_efflux_FieF; 1.
InterPro; IPR002524; Cation_efflux.
InterPro; IPR027470; Cation_efflux_CTD.
InterPro; IPR036837; Cation_efflux_CTD_sf.
InterPro; IPR023783; Cation_efflux_FieF.
InterPro; IPR027469; Cation_efflux_TMD_sf.
Pfam; PF01545; Cation_efflux; 1.
Pfam; PF16916; ZT_dimer; 1.
SUPFAM; SSF160240; SSF160240; 1.
SUPFAM; SSF161111; SSF161111; 1.
TIGRFAMs; TIGR01297; CDF; 1.
3: Inferred from homology;
Cell inner membrane; Cell membrane; Complete proteome; Ion transport;
Iron; Iron transport; Membrane; Transmembrane; Transmembrane helix;
Transport.
CHAIN 1 300 Ferrous-iron efflux pump FieF.
/FTId=PRO_0000206125.
TOPO_DOM 1 11 Cytoplasmic. {ECO:0000255}.
TRANSMEM 12 34 Helical. {ECO:0000255}.
TOPO_DOM 35 37 Periplasmic. {ECO:0000255}.
TRANSMEM 38 60 Helical. {ECO:0000255}.
TOPO_DOM 61 79 Cytoplasmic. {ECO:0000255}.
TRANSMEM 80 102 Helical. {ECO:0000255}.
TOPO_DOM 103 116 Periplasmic. {ECO:0000255}.
TRANSMEM 117 139 Helical. {ECO:0000255}.
TOPO_DOM 140 157 Cytoplasmic. {ECO:0000255}.
TRANSMEM 158 175 Helical. {ECO:0000255}.
TOPO_DOM 176 179 Periplasmic. {ECO:0000255}.
TRANSMEM 180 199 Helical. {ECO:0000255}.
TOPO_DOM 200 300 Cytoplasmic. {ECO:0000255}.
SEQUENCE 300 AA; 32913 MW; 6AF46DF777B1DC2E CRC64;
MNQSYGRLVS RAAIAATAMA SLLLLIKIFA WWYTGSVSIL AALVDSLVDI GASLTNLLVV
RYSLQPADDN HSFGHGKAES LAALAQSMFI SGSALFLFLT GIQHLVSPTP MTDPGVGVIV
TIVALICTII LVSFQRWVVR RTQSQAVRAD MLHYQSDVMM NGAILLALGL SWYGWHRADA
LFALGIGIYI LYSALRMGYE AVQSLLDRAL PDEERQEIID IVTSWPGVSG AHDLRTRQSG
PTRFIQIHLE MEDSLPLVQA HMVADQVEQA ILRRFPGSDV IIHQDPCSVV PREGKRSMLS


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