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Fibroblast growth factor (FGF)

 F7CND4_HORSE            Unreviewed;       216 AA.
F7CND4;
27-JUL-2011, integrated into UniProtKB/TrEMBL.
27-JUL-2011, sequence version 1.
12-SEP-2018, entry version 45.
RecName: Full=Fibroblast growth factor {ECO:0000256|RuleBase:RU049442};
Short=FGF {ECO:0000256|RuleBase:RU049442};
Name=FGF10 {ECO:0000313|Ensembl:ENSECAP00000012063,
ECO:0000313|VGNC:VGNC:18009};
Equus caballus (Horse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000012063, ECO:0000313|Proteomes:UP000002281};
[1] {ECO:0000313|Ensembl:ENSECAP00000012063, ECO:0000313|Proteomes:UP000002281}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000012063,
ECO:0000313|Proteomes:UP000002281};
PubMed=19892987; DOI=10.1126/science.1178158;
Broad Institute Genome Sequencing Platform;
Broad Institute Whole Genome Assembly Team;
Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
"Genome sequence, comparative analysis, and population genetics of the
domestic horse.";
Science 326:865-867(2009).
[2] {ECO:0000313|Ensembl:ENSECAP00000012063}
IDENTIFICATION.
STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000012063};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
-!- SIMILARITY: Belongs to the heparin-binding growth factors family.
{ECO:0000256|RuleBase:RU049442, ECO:0000256|SAAS:SAAS00562035}.
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RefSeq; XP_001498159.1; XM_001498109.3.
STRING; 9796.ENSECAP00000012063; -.
PaxDb; F7CND4; -.
Ensembl; ENSECAT00000015044; ENSECAP00000012063; ENSECAG00000014361.
GeneID; 100052655; -.
KEGG; ecb:100052655; -.
CTD; 2255; -.
VGNC; VGNC:18009; FGF10.
eggNOG; KOG3885; Eukaryota.
eggNOG; ENOG4111IPH; LUCA.
GeneTree; ENSGT00760000118859; -.
InParanoid; F7CND4; -.
KO; K04358; -.
OMA; SSIPVTC; -.
OrthoDB; EOG091G0NAY; -.
TreeFam; TF317805; -.
Proteomes; UP000002281; Chromosome 21.
Bgee; ENSECAG00000014361; Expressed in 3 organ(s), highest expression level in liver.
GO; GO:0009986; C:cell surface; IEA:Ensembl.
GO; GO:0031012; C:extracellular matrix; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
GO; GO:0042056; F:chemoattractant activity; IEA:Ensembl.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0008201; F:heparin binding; IEA:Ensembl.
GO; GO:0005111; F:type 2 fibroblast growth factor receptor binding; IEA:Ensembl.
GO; GO:0031532; P:actin cytoskeleton reorganization; IEA:Ensembl.
GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
GO; GO:0048514; P:blood vessel morphogenesis; IEA:Ensembl.
GO; GO:0001974; P:blood vessel remodeling; IEA:Ensembl.
GO; GO:0060667; P:branch elongation involved in salivary gland morphogenesis; IEA:Ensembl.
GO; GO:0060436; P:bronchiole morphogenesis; IEA:Ensembl.
GO; GO:0060449; P:bud elongation involved in lung branching; IEA:Ensembl.
GO; GO:0060447; P:bud outgrowth involved in lung branching; IEA:Ensembl.
GO; GO:0007368; P:determination of left/right symmetry; IEA:Ensembl.
GO; GO:0031076; P:embryonic camera-type eye development; IEA:Ensembl.
GO; GO:0048557; P:embryonic digestive tract morphogenesis; IEA:Ensembl.
GO; GO:0030538; P:embryonic genitalia morphogenesis; IEA:Ensembl.
GO; GO:0009880; P:embryonic pattern specification; IEA:Ensembl.
GO; GO:0010631; P:epithelial cell migration; IEA:Ensembl.
GO; GO:0060664; P:epithelial cell proliferation involved in salivary gland morphogenesis; IEA:Ensembl.
GO; GO:0070371; P:ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0000132; P:establishment of mitotic spindle orientation; IEA:Ensembl.
GO; GO:0048807; P:female genitalia morphogenesis; IEA:Ensembl.
GO; GO:0060595; P:fibroblast growth factor receptor signaling pathway involved in mammary gland specification; IEA:Ensembl.
GO; GO:0031069; P:hair follicle morphogenesis; IEA:Ensembl.
GO; GO:0070384; P:Harderian gland development; IEA:Ensembl.
GO; GO:0050930; P:induction of positive chemotaxis; IEA:Ensembl.
GO; GO:0043616; P:keratinocyte proliferation; IEA:Ensembl.
GO; GO:0032808; P:lacrimal gland development; IEA:Ensembl.
GO; GO:0060174; P:limb bud formation; IEA:Ensembl.
GO; GO:0061115; P:lung proximal/distal axis specification; IEA:Ensembl.
GO; GO:0060430; P:lung saccule development; IEA:Ensembl.
GO; GO:0048808; P:male genitalia morphogenesis; IEA:Ensembl.
GO; GO:0060615; P:mammary gland bud formation; IEA:Ensembl.
GO; GO:0060915; P:mesenchymal cell differentiation involved in lung development; IEA:Ensembl.
GO; GO:0060496; P:mesenchymal-epithelial cell signaling involved in lung development; IEA:Ensembl.
GO; GO:0001823; P:mesonephros development; IEA:Ensembl.
GO; GO:0003338; P:metanephros morphogenesis; IEA:Ensembl.
GO; GO:0042693; P:muscle cell fate commitment; IEA:Ensembl.
GO; GO:0071157; P:negative regulation of cell cycle arrest; IEA:Ensembl.
GO; GO:0045596; P:negative regulation of cell differentiation; IEA:Ensembl.
GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Ensembl.
GO; GO:0001759; P:organ induction; IEA:Ensembl.
GO; GO:0030916; P:otic vesicle formation; IEA:Ensembl.
GO; GO:0031016; P:pancreas development; IEA:Ensembl.
GO; GO:0021983; P:pituitary gland development; IEA:Ensembl.
GO; GO:0032781; P:positive regulation of ATPase activity; IEA:Ensembl.
GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0031659; P:positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; IEA:Ensembl.
GO; GO:0045739; P:positive regulation of DNA repair; IEA:Ensembl.
GO; GO:0045740; P:positive regulation of DNA replication; IEA:Ensembl.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl.
GO; GO:0071338; P:positive regulation of hair follicle cell proliferation; IEA:Ensembl.
GO; GO:0051549; P:positive regulation of keratinocyte migration; IEA:Ensembl.
GO; GO:0010838; P:positive regulation of keratinocyte proliferation; IEA:Ensembl.
GO; GO:0050671; P:positive regulation of lymphocyte proliferation; IEA:Ensembl.
GO; GO:0045931; P:positive regulation of mitotic cell cycle; IEA:Ensembl.
GO; GO:0045747; P:positive regulation of Notch signaling pathway; IEA:Ensembl.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0050677; P:positive regulation of urothelial cell proliferation; IEA:Ensembl.
GO; GO:0030949; P:positive regulation of vascular endothelial growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:0070352; P:positive regulation of white fat cell proliferation; IEA:Ensembl.
GO; GO:0060513; P:prostatic bud formation; IEA:Ensembl.
GO; GO:0034394; P:protein localization to cell surface; IEA:Ensembl.
GO; GO:0060019; P:radial glial cell differentiation; IEA:Ensembl.
GO; GO:0032925; P:regulation of activin receptor signaling pathway; IEA:Ensembl.
GO; GO:0060665; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; IEA:Ensembl.
GO; GO:0046877; P:regulation of saliva secretion; IEA:Ensembl.
GO; GO:0008589; P:regulation of smoothened signaling pathway; IEA:Ensembl.
GO; GO:0061033; P:secretion by lung epithelial cell involved in lung growth; IEA:Ensembl.
GO; GO:0060879; P:semicircular canal fusion; IEA:Ensembl.
GO; GO:0051145; P:smooth muscle cell differentiation; IEA:Ensembl.
GO; GO:0035019; P:somatic stem cell population maintenance; IEA:Ensembl.
GO; GO:0048536; P:spleen development; IEA:Ensembl.
GO; GO:0060661; P:submandibular salivary gland formation; IEA:Ensembl.
GO; GO:0070075; P:tear secretion; IEA:Ensembl.
GO; GO:0048538; P:thymus development; IEA:Ensembl.
GO; GO:0030878; P:thyroid gland development; IEA:Ensembl.
GO; GO:0060510; P:type II pneumocyte differentiation; IEA:Ensembl.
GO; GO:0050674; P:urothelial cell proliferation; IEA:Ensembl.
GO; GO:0050872; P:white fat cell differentiation; IEA:Ensembl.
GO; GO:0042060; P:wound healing; IEA:Ensembl.
CDD; cd00058; FGF; 1.
InterPro; IPR028252; FGF10.
InterPro; IPR002209; Fibroblast_GF_fam.
InterPro; IPR008996; IL1/FGF.
PANTHER; PTHR11486; PTHR11486; 1.
PANTHER; PTHR11486:SF21; PTHR11486:SF21; 1.
Pfam; PF00167; FGF; 1.
PRINTS; PR00263; HBGFFGF.
SMART; SM00442; FGF; 1.
SUPFAM; SSF50353; SSF50353; 1.
PROSITE; PS00247; HBGF_FGF; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000002281};
Growth factor {ECO:0000256|SAAS:SAAS00065766};
Reference proteome {ECO:0000313|Proteomes:UP000002281};
Signal {ECO:0000256|RuleBase:RU049442}.
SIGNAL 1 36 {ECO:0000256|RuleBase:RU049442}.
CHAIN 37 216 Fibroblast growth factor.
{ECO:0000256|RuleBase:RU049442}.
/FTId=PRO_5005130132.
SEQUENCE 216 AA; 24106 MW; DF7299420C72F347 CRC64;
MWKWILTHCA SAFPHLPGCC CCFLLLFLVS SVSVTCQALG QDMVSPEATN SSSSSSSSSS
SSSSFSSPSS AGRHVRSYNH LQGDVRWRKL FSFTKYFLKI EKNGKVSGTK KENCPYSILE
ITSVEIGVVA VKAINSNYYL AMNKKGKLYG SKEFNNDCKL KERIEENGYN TYASFNWQHN
GRQMYVALNG KGAPRRGQKT RRKNTSAHFL PMVVHS


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