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Fibroblast growth factor (FGF)

 Q9N1B9_SHEEP            Unreviewed;       213 AA.
Q9N1B9;
01-OCT-2000, integrated into UniProtKB/TrEMBL.
01-OCT-2000, sequence version 1.
25-OCT-2017, entry version 93.
RecName: Full=Fibroblast growth factor {ECO:0000256|RuleBase:RU049442};
Short=FGF {ECO:0000256|RuleBase:RU049442};
Name=FGF-10 {ECO:0000313|EMBL:AAF25944.1};
Synonyms=FGF10 {ECO:0000313|Ensembl:ENSOARP00000009164};
Ovis aries (Sheep).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Ovis.
NCBI_TaxID=9940 {ECO:0000313|EMBL:AAF25944.1};
[1] {ECO:0000313|EMBL:AAF25944.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Endometrium {ECO:0000313|EMBL:AAF25944.1};
PubMed=10952944;
Chen C., Spencer T.E., Bazer F.W.;
"Fibroblast growth factor-10: a stromal mediator of epithelial
function in the ovine uterus.";
Biol. Reprod. 63:959-966(2000).
[2] {ECO:0000313|Ensembl:ENSOARP00000009164, ECO:0000313|Proteomes:UP000002356}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000009164};
PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
Wang J., Wang W., Xun X.;
"The sheep genome reference sequence: a work in progress.";
Anim. Genet. 41:449-453(2010).
[3] {ECO:0000313|Ensembl:ENSOARP00000009164}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2014) to UniProtKB.
-!- SIMILARITY: Belongs to the heparin-binding growth factors family.
{ECO:0000256|RuleBase:RU049442, ECO:0000256|SAAS:SAAS00562035}.
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EMBL; AMGL01034963; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AMGL01034964; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AMGL01034965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AF213396; AAF25944.1; -; mRNA.
RefSeq; NP_001009230.1; NM_001009230.1.
UniGene; Oar.792; -.
Ensembl; ENSOART00000009297; ENSOARP00000009164; ENSOARG00000008545.
GeneID; 443074; -.
KEGG; oas:443074; -.
CTD; 2255; -.
GeneTree; ENSGT00760000118859; -.
HOVERGEN; HBG007580; -.
KO; K04358; -.
OMA; SSIPVTC; -.
OrthoDB; EOG091G0NAY; -.
Proteomes; UP000002356; Chromosome 16.
GO; GO:0009986; C:cell surface; ISS:UniProtKB.
GO; GO:0031012; C:extracellular matrix; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO; GO:0042056; F:chemoattractant activity; ISS:UniProtKB.
GO; GO:0005104; F:fibroblast growth factor receptor binding; ISS:UniProtKB.
GO; GO:0008083; F:growth factor activity; ISS:UniProtKB.
GO; GO:0008201; F:heparin binding; ISS:UniProtKB.
GO; GO:0005111; F:type 2 fibroblast growth factor receptor binding; IEA:Ensembl.
GO; GO:0031532; P:actin cytoskeleton reorganization; IEA:Ensembl.
GO; GO:0000187; P:activation of MAPK activity; ISS:UniProtKB.
GO; GO:0048514; P:blood vessel morphogenesis; IEA:Ensembl.
GO; GO:0001974; P:blood vessel remodeling; IEA:Ensembl.
GO; GO:0060667; P:branch elongation involved in salivary gland morphogenesis; IEA:Ensembl.
GO; GO:0048754; P:branching morphogenesis of an epithelial tube; ISS:UniProtKB.
GO; GO:0060436; P:bronchiole morphogenesis; IEA:Ensembl.
GO; GO:0060449; P:bud elongation involved in lung branching; IEA:Ensembl.
GO; GO:0060447; P:bud outgrowth involved in lung branching; IEA:Ensembl.
GO; GO:0007368; P:determination of left/right symmetry; IEA:Ensembl.
GO; GO:0031076; P:embryonic camera-type eye development; IEA:Ensembl.
GO; GO:0048557; P:embryonic digestive tract morphogenesis; IEA:Ensembl.
GO; GO:0030538; P:embryonic genitalia morphogenesis; IEA:Ensembl.
GO; GO:0009880; P:embryonic pattern specification; IEA:Ensembl.
GO; GO:0010631; P:epithelial cell migration; IEA:Ensembl.
GO; GO:0060664; P:epithelial cell proliferation involved in salivary gland morphogenesis; IEA:Ensembl.
GO; GO:0070371; P:ERK1 and ERK2 cascade; ISS:UniProtKB.
GO; GO:0000132; P:establishment of mitotic spindle orientation; IEA:Ensembl.
GO; GO:0048807; P:female genitalia morphogenesis; IEA:Ensembl.
GO; GO:0060595; P:fibroblast growth factor receptor signaling pathway involved in mammary gland specification; IEA:Ensembl.
GO; GO:0031069; P:hair follicle morphogenesis; IEA:Ensembl.
GO; GO:0070384; P:Harderian gland development; IEA:Ensembl.
GO; GO:0050930; P:induction of positive chemotaxis; IEA:Ensembl.
GO; GO:0043616; P:keratinocyte proliferation; IEA:Ensembl.
GO; GO:0032808; P:lacrimal gland development; IEA:Ensembl.
GO; GO:0060174; P:limb bud formation; IEA:Ensembl.
GO; GO:0061115; P:lung proximal/distal axis specification; IEA:Ensembl.
GO; GO:0060430; P:lung saccule development; IEA:Ensembl.
GO; GO:0048808; P:male genitalia morphogenesis; IEA:Ensembl.
GO; GO:0060615; P:mammary gland bud formation; IEA:Ensembl.
GO; GO:0060915; P:mesenchymal cell differentiation involved in lung development; IEA:Ensembl.
GO; GO:0060496; P:mesenchymal-epithelial cell signaling involved in lung development; IEA:Ensembl.
GO; GO:0001823; P:mesonephros development; IEA:Ensembl.
GO; GO:0003338; P:metanephros morphogenesis; IEA:Ensembl.
GO; GO:0042693; P:muscle cell fate commitment; IEA:Ensembl.
GO; GO:0071157; P:negative regulation of cell cycle arrest; IEA:Ensembl.
GO; GO:0045596; P:negative regulation of cell differentiation; IEA:Ensembl.
GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Ensembl.
GO; GO:0001759; P:organ induction; IEA:Ensembl.
GO; GO:0030916; P:otic vesicle formation; IEA:Ensembl.
GO; GO:0031016; P:pancreas development; IEA:Ensembl.
GO; GO:0021983; P:pituitary gland development; IEA:Ensembl.
GO; GO:0050918; P:positive chemotaxis; ISS:UniProtKB.
GO; GO:0032781; P:positive regulation of ATPase activity; ISS:UniProtKB.
GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0031659; P:positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; ISS:UniProtKB.
GO; GO:0045739; P:positive regulation of DNA repair; ISS:UniProtKB.
GO; GO:0045740; P:positive regulation of DNA replication; IEA:Ensembl.
GO; GO:0050679; P:positive regulation of epithelial cell proliferation; ISS:UniProtKB.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl.
GO; GO:0071338; P:positive regulation of hair follicle cell proliferation; IEA:Ensembl.
GO; GO:0051549; P:positive regulation of keratinocyte migration; ISS:UniProtKB.
GO; GO:0010838; P:positive regulation of keratinocyte proliferation; IEA:Ensembl.
GO; GO:0050671; P:positive regulation of lymphocyte proliferation; ISS:UniProtKB.
GO; GO:0043410; P:positive regulation of MAPK cascade; ISS:UniProtKB.
GO; GO:0045931; P:positive regulation of mitotic cell cycle; IEA:Ensembl.
GO; GO:0045747; P:positive regulation of Notch signaling pathway; IEA:Ensembl.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0050677; P:positive regulation of urothelial cell proliferation; ISS:UniProtKB.
GO; GO:0030949; P:positive regulation of vascular endothelial growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:0070352; P:positive regulation of white fat cell proliferation; IEA:Ensembl.
GO; GO:0060513; P:prostatic bud formation; IEA:Ensembl.
GO; GO:0034394; P:protein localization to cell surface; IEA:Ensembl.
GO; GO:0060019; P:radial glial cell differentiation; IEA:Ensembl.
GO; GO:0032925; P:regulation of activin receptor signaling pathway; IEA:Ensembl.
GO; GO:0060665; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; IEA:Ensembl.
GO; GO:0046877; P:regulation of saliva secretion; IEA:Ensembl.
GO; GO:0008589; P:regulation of smoothened signaling pathway; IEA:Ensembl.
GO; GO:0061033; P:secretion by lung epithelial cell involved in lung growth; IEA:Ensembl.
GO; GO:0060879; P:semicircular canal fusion; IEA:Ensembl.
GO; GO:0051145; P:smooth muscle cell differentiation; IEA:Ensembl.
GO; GO:0035019; P:somatic stem cell population maintenance; IEA:Ensembl.
GO; GO:0048536; P:spleen development; IEA:Ensembl.
GO; GO:0060661; P:submandibular salivary gland formation; IEA:Ensembl.
GO; GO:0070075; P:tear secretion; IEA:Ensembl.
GO; GO:0048538; P:thymus development; ISS:UniProtKB.
GO; GO:0030878; P:thyroid gland development; IEA:Ensembl.
GO; GO:0060510; P:Type II pneumocyte differentiation; IEA:Ensembl.
GO; GO:0050674; P:urothelial cell proliferation; ISS:UniProtKB.
GO; GO:0050872; P:white fat cell differentiation; IEA:Ensembl.
GO; GO:0042060; P:wound healing; ISS:UniProtKB.
CDD; cd00058; FGF; 1.
InterPro; IPR028252; FGF10.
InterPro; IPR002209; Fibroblast_GF_fam.
InterPro; IPR008996; IL1/FGF.
PANTHER; PTHR11486; PTHR11486; 1.
PANTHER; PTHR11486:SF21; PTHR11486:SF21; 1.
Pfam; PF00167; FGF; 1.
PRINTS; PR00263; HBGFFGF.
SMART; SM00442; FGF; 1.
SUPFAM; SSF50353; SSF50353; 1.
PROSITE; PS00247; HBGF_FGF; 1.
2: Evidence at transcript level;
Complete proteome {ECO:0000313|Proteomes:UP000002356};
Growth factor {ECO:0000256|SAAS:SAAS00065766};
Reference proteome {ECO:0000313|Proteomes:UP000002356};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 38 {ECO:0000256|SAM:SignalP}.
CHAIN 39 213 Fibroblast growth factor.
{ECO:0000256|SAM:SignalP}.
/FTId=PRO_5010848131.
SEQUENCE 213 AA; 23768 MW; C347149A81C15634 CRC64;
MWKWILTHCA SAFPHLSGCC CCFLLLFLVS SVPVTCQALD QDMVSPGATN SSSSSSSSSS
SSVSLPSSAG RHVRSYNHLQ GDVRWRKLFS FTKYFLKIEN GKVSGTKKEN CPYSILEITS
VEIGVVAVKA INSNYYLAMN KKGKLYGSKE FNNDCKLKER IEENGYNTYA SFNWQHNGRQ
MYVALNGKGA PRRGQKTRRK NTSAHFLPMV VHS


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