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Fibroblast growth factor 1 (FGF-1) (Acidic fibroblast growth factor) (aFGF) (Endothelial cell growth factor) (ECGF) (Heparin-binding growth factor 1) (HBGF-1) (Fragment)

 FGF1_PIG                Reviewed;         152 AA.
P20002;
01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
01-FEB-1996, sequence version 2.
28-MAR-2018, entry version 125.
RecName: Full=Fibroblast growth factor 1;
Short=FGF-1;
AltName: Full=Acidic fibroblast growth factor;
Short=aFGF;
AltName: Full=Endothelial cell growth factor;
Short=ECGF;
AltName: Full=Heparin-binding growth factor 1;
Short=HBGF-1;
Flags: Precursor; Fragment;
Name=FGF1;
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Sus.
NCBI_TaxID=9823;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Heart;
PubMed=1719973; DOI=10.1016/S0006-291X(05)81143-X;
Schmidt M., Sharma H.S., Schott R.J., Schaper W.;
"Amplification and sequencing of mRNA encoding acidic fibroblast
growth factor (aFGF) from porcine heart.";
Biochem. Biophys. Res. Commun. 180:853-859(1991).
[2]
PROTEIN SEQUENCE OF 22-41.
PubMed=2714282; DOI=10.1111/j.1432-1033.1989.tb14694.x;
Quinkler W., Maasberg M., Bernotat-Danielowski S., Luethe N.,
Sharma H.S., Schaper W.;
"Isolation of heparin-binding growth factors from bovine, porcine and
canine hearts.";
Eur. J. Biochem. 181:67-73(1989).
-!- FUNCTION: Plays an important role in the regulation of cell
survival, cell division, angiogenesis, cell differentiation and
cell migration. Functions as potent mitogen in vitro. Acts as a
ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of
heparin leading to FGFR1 dimerization and activation via
sequential autophosphorylation on tyrosine residues which act as
docking sites for interacting proteins, leading to the activation
of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its
binding to integrin, subsequent ternary complex formation with
integrin and FGFR1, and the recruitment of PTPN11 to the complex
are essential for FGF1 signaling. Induces the phosphorylation and
activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can
induce angiogenesis. {ECO:0000250|UniProtKB:P05230}.
-!- SUBUNIT: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3
and FGFR4. Affinity between fibroblast growth factors (FGFs) and
their receptors is increased by heparan sulfate glycosaminoglycans
that function as coreceptors. Found in a complex with FGFBP1, FGF1
and FGF2. Interacts with FGFBP1. Part of a Cu(2+)-dependent
multiprotein aggregate containing FGF1, S100A13 and SYT1.
Interacts with SYT1. Interacts with S100A13 (By similarity).
Interacts with LRRC59 (By similarity). Interacts with CSNKA, CSNKB
and FIBP (By similarity). While binding with LRRC59, CSNKA and
FIBP seem mutually exclusive, CSNKB and FIBP may cooperatively
interact with FGF1. Forms a ternary complex with FGFR1 and
ITGAV:ITGB3 and induces the recruitment of PTPN11 to the complex
(By similarity). {ECO:0000250|UniProtKB:P05230}.
-!- SUBCELLULAR LOCATION: Secreted. Cytoplasm {ECO:0000250}.
Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytosol
{ECO:0000250}. Nucleus {ECO:0000250}. Note=Lacks a cleavable
signal sequence. Within the cytoplasm, it is transported to the
cell membrane and then secreted by a non-classical pathway that
requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1.
Binding of exogenous FGF1 to FGFR facilitates endocytosis followed
by translocation of FGF1 across endosomal membrane into the
cytosol. Nuclear import from the cytosol requires the classical
nuclear import machinery, involving proteins KPNA1 and KPNB1, as
well as LRRC59 (By similarity). {ECO:0000250}.
-!- PTM: In the nucleus, phosphorylated by PKC/PRKCD. {ECO:0000250}.
-!- SIMILARITY: Belongs to the heparin-binding growth factors family.
{ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; X60317; CAA42869.1; -; mRNA.
PIR; JH0476; JH0476.
PIR; S03954; S03954.
UniGene; Ssc.16246; -.
ProteinModelPortal; P20002; -.
SMR; P20002; -.
STRING; 9823.ENSSSCP00000019575; -.
PaxDb; P20002; -.
PeptideAtlas; P20002; -.
PRIDE; P20002; -.
eggNOG; KOG3885; Eukaryota.
eggNOG; ENOG4111IPH; LUCA.
HOGENOM; HOG000236341; -.
HOVERGEN; HBG107917; -.
InParanoid; P20002; -.
OrthoDB; EOG091G0NAY; -.
Proteomes; UP000008227; Unplaced.
Genevisible; P20002; SS.
GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
GO; GO:0005829; C:cytosol; ISS:UniProtKB.
GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0005104; F:fibroblast growth factor receptor binding; ISS:UniProtKB.
GO; GO:0008083; F:growth factor activity; ISS:UniProtKB.
GO; GO:0008201; F:heparin binding; ISS:UniProtKB.
GO; GO:0005178; F:integrin binding; ISS:UniProtKB.
GO; GO:0044548; F:S100 protein binding; ISS:UniProtKB.
GO; GO:0000187; P:activation of MAPK activity; ISS:UniProtKB.
GO; GO:0032148; P:activation of protein kinase B activity; ISS:UniProtKB.
GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
GO; GO:0060681; P:branch elongation involved in ureteric bud branching; ISS:UniProtKB.
GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO; GO:0034605; P:cellular response to heat; ISS:UniProtKB.
GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; ISS:UniProtKB.
GO; GO:0072163; P:mesonephric epithelium development; ISS:UniProtKB.
GO; GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB.
GO; GO:0051781; P:positive regulation of cell division; ISS:UniProtKB.
GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
GO; GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.
GO; GO:0045542; P:positive regulation of cholesterol biosynthetic process; ISS:UniProtKB.
GO; GO:0010595; P:positive regulation of endothelial cell migration; ISS:UniProtKB.
GO; GO:1902533; P:positive regulation of intracellular signal transduction; ISS:UniProtKB.
GO; GO:1903672; P:positive regulation of sprouting angiogenesis; ISS:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
GO; GO:1901509; P:regulation of endothelial tube morphogenesis; ISS:UniProtKB.
CDD; cd00058; FGF; 1.
InterPro; IPR028210; FGF1.
InterPro; IPR002209; Fibroblast_GF_fam.
InterPro; IPR008996; IL1/FGF.
PANTHER; PTHR11486; PTHR11486; 1.
PANTHER; PTHR11486:SF86; PTHR11486:SF86; 1.
Pfam; PF00167; FGF; 1.
PRINTS; PR00263; HBGFFGF.
SMART; SM00442; FGF; 1.
SUPFAM; SSF50353; SSF50353; 1.
PROSITE; PS00247; HBGF_FGF; 1.
1: Evidence at protein level;
Acetylation; Angiogenesis; Complete proteome; Cytoplasm;
Developmental protein; Differentiation; Direct protein sequencing;
Growth factor; Heparin-binding; Mitogen; Nucleus; Phosphoprotein;
Reference proteome; Secreted.
INIT_MET 1 1 Removed. {ECO:0000250|UniProtKB:P03968}.
PROPEP 2 15
/FTId=PRO_0000008913.
CHAIN 16 >152 Fibroblast growth factor 1.
/FTId=PRO_0000008914.
REGION 127 143 Heparin-binding. {ECO:0000250}.
BINDING 33 33 Heparin. {ECO:0000250}.
MOD_RES 2 2 N-acetylalanine.
{ECO:0000250|UniProtKB:P03968}.
CONFLICT 31 31 C -> S (in Ref. 2; AA sequence).
{ECO:0000305}.
CONFLICT 39 39 R -> Y (in Ref. 2; AA sequence).
{ECO:0000305}.
NON_TER 152 152
SEQUENCE 152 AA; 17103 MW; AE853B0A92F9ABF4 CRC64;
MAEGEITTFT ALTEKFNLPP GNYKKPKLLY CSNGGHFLRI LPDGTVDGTR DRSDQHIQLQ
LSAESVGEVY IKSTETGQYL AMDTSGLLYG SQTPSEECLF LERLEENHYN TYTSKKHAEK
NWFVGLKKNG SCKRGPRTHY GQKAILFLPL PV


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