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Fibroblast growth factor 2 (FGF-2) (Basic fibroblast growth factor) (bFGF) (Heparin-binding growth factor 2) (HBGF-2)

 FGF2_RAT                Reviewed;         154 AA.
P13109;
01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
01-JAN-1990, sequence version 1.
22-NOV-2017, entry version 153.
RecName: Full=Fibroblast growth factor 2;
Short=FGF-2;
AltName: Full=Basic fibroblast growth factor;
Short=bFGF;
AltName: Full=Heparin-binding growth factor 2;
Short=HBGF-2;
Flags: Precursor;
Name=Fgf2; Synonyms=Fgf-2;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley; TISSUE=Ovary;
PubMed=3196337; DOI=10.1016/S0006-291X(88)80041-X;
Shimasaki S., Emoto N., Koba A., Mercado M., Shibata F., Cooksey K.,
Baird A., Ling N.;
"Complementary DNA cloning and sequencing of rat ovarian basic
fibroblast growth factor and tissue distribution study of its mRNA.";
Biochem. Biophys. Res. Commun. 157:256-263(1988).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
PubMed=3387229; DOI=10.1093/nar/16.11.5201;
Kurokawa T., Seno M., Igarashi K.;
"Nucleotide sequence of rat basic fibroblast growth factor cDNA.";
Nucleic Acids Res. 16:5201-5201(1988).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-28.
STRAIN=Sprague-Dawley; TISSUE=Testis;
PubMed=9048734;
Pasumarthi K.B.S., Jin Y., Cattini P.A.;
"Cloning of the rat fibroblast growth factor-2 promoter region and its
response to mitogenic stimuli in glioma C6 cells.";
J. Neurochem. 68:898-908(1997).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 35-154.
STRAIN=Sprague-Dawley; TISSUE=Brain;
PubMed=1378302; DOI=10.1016/0167-4781(92)90031-T;
El-Husseini A.E.-D., Paterson J.A., Myal Y., Shiu R.P.C.;
"PCR detection of the rat brain basic fibroblast growth factor (bFGF)
mRNA containing a unique 3' untranslated region.";
Biochim. Biophys. Acta 1131:314-316(1992).
-!- FUNCTION: Plays an important role in the regulation of cell
survival, cell division, angiogenesis, cell differentiation and
cell migration. Functions as potent mitogen in vitro. Can induce
angiogenesis. {ECO:0000250|UniProtKB:P09038}.
-!- SUBUNIT: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3
and FGFR4. Affinity between fibroblast growth factors (FGFs) and
their receptors is increased by heparan sulfate glycosaminoglycans
that function as coreceptors. Interacts with CSPG4, FGFBP1 and
TEC. Found in a complex with FGFBP1, FGF1 and FGF2 (By
similarity). Interacts with FGFBP3. {ECO:0000250|UniProtKB:P09038,
ECO:0000250|UniProtKB:P15655}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Nucleus
{ECO:0000250}. Note=Exported from cells by an endoplasmic
reticulum (ER)/Golgi-independent mechanism. Unconventional
secretion of FGF2 occurs by direct translocation across the plasma
membrane (By similarity). Binding of exogenous FGF2 to FGFR
facilitates endocytosis followed by translocation of FGF2 across
endosomal membrane into the cytosol. Nuclear import from the
cytosol requires the classical nuclear import machinery, involving
proteins KPNA1 and KPNB1, as well as CEP57 (By similarity).
{ECO:0000250}.
-!- TISSUE SPECIFICITY: Found in all tissues examined.
-!- PTM: Phosphorylation at Tyr-81 regulates FGF2 unconventional
secretion. {ECO:0000250}.
-!- SIMILARITY: Belongs to the heparin-binding growth factors family.
{ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; M22427; AAA41210.1; -; mRNA.
EMBL; X07285; CAA30265.1; -; mRNA.
EMBL; U78079; AAC53225.1; -; Genomic_DNA.
EMBL; X61697; CAA43863.1; -; mRNA.
PIR; A31674; A31674.
RefSeq; NP_062178.1; NM_019305.2.
UniGene; Rn.31808; -.
ProteinModelPortal; P13109; -.
SMR; P13109; -.
BioGrid; 248473; 1.
STRING; 10116.ENSRNOP00000023388; -.
PhosphoSitePlus; P13109; -.
PaxDb; P13109; -.
Ensembl; ENSRNOT00000023388; ENSRNOP00000023388; ENSRNOG00000017392.
GeneID; 54250; -.
KEGG; rno:54250; -.
UCSC; RGD:2609; rat.
CTD; 2247; -.
RGD; 2609; Fgf2.
eggNOG; KOG3885; Eukaryota.
eggNOG; ENOG4111IPH; LUCA.
GeneTree; ENSGT00730000110923; -.
HOGENOM; HOG000236341; -.
HOVERGEN; HBG007580; -.
InParanoid; P13109; -.
KO; K18497; -.
OMA; LPMSAKC; -.
OrthoDB; EOG091G0NAY; -.
PhylomeDB; P13109; -.
TreeFam; TF317805; -.
Reactome; R-RNO-109704; PI3K Cascade.
Reactome; R-RNO-1257604; PIP3 activates AKT signaling.
Reactome; R-RNO-190322; FGFR4 ligand binding and activation.
Reactome; R-RNO-190370; FGFR1b ligand binding and activation.
Reactome; R-RNO-190372; FGFR3c ligand binding and activation.
Reactome; R-RNO-190373; FGFR1c ligand binding and activation.
Reactome; R-RNO-190375; FGFR2c ligand binding and activation.
Reactome; R-RNO-190377; FGFR2b ligand binding and activation.
Reactome; R-RNO-3000170; Syndecan interactions.
Reactome; R-RNO-3000171; Non-integrin membrane-ECM interactions.
Reactome; R-RNO-5654219; Phospholipase C-mediated cascade: FGFR1.
Reactome; R-RNO-5654221; Phospholipase C-mediated cascade, FGFR2.
Reactome; R-RNO-5654227; Phospholipase C-mediated cascade, FGFR3.
Reactome; R-RNO-5654228; Phospholipase C-mediated cascade, FGFR4.
Reactome; R-RNO-5654687; Downstream signaling of activated FGFR1.
Reactome; R-RNO-5654688; SHC-mediated cascade:FGFR1.
Reactome; R-RNO-5654689; PI-3K cascade:FGFR1.
Reactome; R-RNO-5654693; FRS-mediated FGFR1 signaling.
Reactome; R-RNO-5654695; PI-3K cascade:FGFR2.
Reactome; R-RNO-5654699; SHC-mediated cascade:FGFR2.
Reactome; R-RNO-5654700; FRS-mediated FGFR2 signaling.
Reactome; R-RNO-5654704; SHC-mediated cascade:FGFR3.
Reactome; R-RNO-5654706; FRS-mediated FGFR3 signaling.
Reactome; R-RNO-5654710; PI-3K cascade:FGFR3.
Reactome; R-RNO-5654712; FRS-mediated FGFR4 signaling.
Reactome; R-RNO-5654719; SHC-mediated cascade:FGFR4.
Reactome; R-RNO-5654720; PI-3K cascade:FGFR4.
Reactome; R-RNO-5654726; Negative regulation of FGFR1 signaling.
Reactome; R-RNO-5654727; Negative regulation of FGFR2 signaling.
Reactome; R-RNO-5654732; Negative regulation of FGFR3 signaling.
Reactome; R-RNO-5654733; Negative regulation of FGFR4 signaling.
Reactome; R-RNO-5673001; RAF/MAP kinase cascade.
Reactome; R-RNO-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
PRO; PR:P13109; -.
Proteomes; UP000002494; Chromosome 2.
Bgee; ENSRNOG00000017392; -.
Genevisible; P13109; RN.
GO; GO:0005737; C:cytoplasm; IDA:RGD.
GO; GO:0005615; C:extracellular space; ISO:RGD.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0042056; F:chemoattractant activity; ISO:RGD.
GO; GO:0005125; F:cytokine activity; ISO:RGD.
GO; GO:0005104; F:fibroblast growth factor receptor binding; IPI:MGI.
GO; GO:0008083; F:growth factor activity; ISO:RGD.
GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
GO; GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; ISO:RGD.
GO; GO:0090722; F:receptor-receptor interaction; ISO:RGD.
GO; GO:0000186; P:activation of MAPKK activity; ISO:RGD.
GO; GO:0007568; P:aging; IEP:RGD.
GO; GO:0001525; P:angiogenesis; ISO:RGD.
GO; GO:0060978; P:angiogenesis involved in coronary vascular morphogenesis; IMP:RGD.
GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; ISS:UniProtKB.
GO; GO:0002042; P:cell migration involved in sprouting angiogenesis; ISO:RGD.
GO; GO:0060591; P:chondroblast differentiation; ISO:RGD.
GO; GO:0060128; P:corticotropin hormone secreting cell differentiation; ISO:RGD.
GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:RGD.
GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IPI:MGI.
GO; GO:0010001; P:glial cell differentiation; ISO:RGD.
GO; GO:0014843; P:growth factor dependent regulation of skeletal muscle satellite cell proliferation; ISO:RGD.
GO; GO:0030214; P:hyaluronan catabolic process; ISO:RGD.
GO; GO:0032958; P:inositol phosphate biosynthetic process; ISO:RGD.
GO; GO:0030324; P:lung development; ISO:RGD.
GO; GO:0060644; P:mammary gland epithelial cell differentiation; ISO:RGD.
GO; GO:0043537; P:negative regulation of blood vessel endothelial cell migration; ISO:RGD.
GO; GO:0060548; P:negative regulation of cell death; ISS:UniProtKB.
GO; GO:0008285; P:negative regulation of cell proliferation; ISO:RGD.
GO; GO:0010764; P:negative regulation of fibroblast migration; ISO:RGD.
GO; GO:0061045; P:negative regulation of wound healing; ISO:RGD.
GO; GO:0001759; P:organ induction; ISO:RGD.
GO; GO:0006661; P:phosphatidylinositol biosynthetic process; ISO:RGD.
GO; GO:0045766; P:positive regulation of angiogenesis; ISO:RGD.
GO; GO:0043536; P:positive regulation of blood vessel endothelial cell migration; ISO:RGD.
GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; ISO:RGD.
GO; GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IDA:RGD.
GO; GO:0045597; P:positive regulation of cell differentiation; ISO:RGD.
GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
GO; GO:0042660; P:positive regulation of cell fate specification; ISO:RGD.
GO; GO:0008284; P:positive regulation of cell proliferation; IDA:RGD.
GO; GO:0021940; P:positive regulation of cerebellar granule cell precursor proliferation; ISO:RGD.
GO; GO:2000546; P:positive regulation of endothelial cell chemotaxis to fibroblast growth factor; ISO:RGD.
GO; GO:0010595; P:positive regulation of endothelial cell migration; ISO:RGD.
GO; GO:0001938; P:positive regulation of endothelial cell proliferation; ISO:RGD.
GO; GO:0050679; P:positive regulation of epithelial cell proliferation; ISO:RGD.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:RGD.
GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
GO; GO:0043406; P:positive regulation of MAP kinase activity; ISO:RGD.
GO; GO:0045669; P:positive regulation of osteoblast differentiation; ISO:RGD.
GO; GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; ISO:RGD.
GO; GO:0010863; P:positive regulation of phospholipase C activity; ISO:RGD.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; ISO:RGD.
GO; GO:0001934; P:positive regulation of protein phosphorylation; ISO:RGD.
GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; IMP:RGD.
GO; GO:1903672; P:positive regulation of sprouting angiogenesis; ISS:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISO:RGD.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:RGD.
GO; GO:0051726; P:regulation of cell cycle; ISO:RGD.
GO; GO:2000544; P:regulation of endothelial cell chemotaxis to fibroblast growth factor; ISO:RGD.
GO; GO:0046668; P:regulation of retinal cell programmed cell death; ISO:RGD.
GO; GO:0051209; P:release of sequestered calcium ion into cytosol; ISO:RGD.
GO; GO:0048678; P:response to axon injury; ISO:RGD.
GO; GO:0048864; P:stem cell development; ISO:RGD.
GO; GO:0021762; P:substantia nigra development; ISO:RGD.
GO; GO:0060129; P:thyroid-stimulating hormone-secreting cell differentiation; ISO:RGD.
GO; GO:0042060; P:wound healing; IEP:RGD.
CDD; cd00058; FGF; 1.
InterPro; IPR028223; FGF2.
InterPro; IPR002209; Fibroblast_GF_fam.
InterPro; IPR008996; IL1/FGF.
PANTHER; PTHR11486; PTHR11486; 1.
PANTHER; PTHR11486:SF83; PTHR11486:SF83; 1.
Pfam; PF00167; FGF; 1.
PRINTS; PR00263; HBGFFGF.
SMART; SM00442; FGF; 1.
SUPFAM; SSF50353; SSF50353; 1.
PROSITE; PS00247; HBGF_FGF; 1.
2: Evidence at transcript level;
Angiogenesis; Complete proteome; Developmental protein;
Differentiation; Growth factor; Heparin-binding; Isopeptide bond;
Mitogen; Nucleus; Phosphoprotein; Reference proteome; Secreted;
Ubl conjugation.
PROPEP 1 9
/FTId=PRO_0000008938.
CHAIN 10 154 Fibroblast growth factor 2.
/FTId=PRO_0000008939.
REGION 127 143 Heparin-binding. {ECO:0000250}.
BINDING 35 35 Heparin. {ECO:0000250}.
MOD_RES 81 81 Phosphotyrosine; by TEC.
{ECO:0000250|UniProtKB:P09038}.
CROSSLNK 94 94 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO1).
{ECO:0000250|UniProtKB:P09038}.
SEQUENCE 154 AA; 17139 MW; 1A0F14FF423D8403 CRC64;
MAAGSITSLP ALPEDGGGAF PPGHFKDPKR LYCKNGGFFL RIHPDGRVDG VREKSDPHVK
LQLQAEERGV VSIKGVCANR YLAMKEDGRL LASKCVTEEC FFFERLESNN YNTYRSRKYS
SWYVALKRTG QYKLGSKTGP GQKAILFLPM SAKS


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