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Fibroblast growth factor 3 (FGF-3) (Heparin-binding growth factor 3) (HBGF-3)

 FGF3_DANRE              Reviewed;         256 AA.
P48802;
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
01-FEB-1996, sequence version 1.
25-OCT-2017, entry version 140.
RecName: Full=Fibroblast growth factor 3;
Short=FGF-3;
AltName: Full=Heparin-binding growth factor 3;
Short=HBGF-3;
Flags: Precursor;
Name=fgf3; Synonyms=fgf-3;
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8654946; DOI=10.1016/0378-1119(95)00736-9;
Kiefer P., Strahle U., Dickson C.;
"The zebrafish Fgf-3 gene: cDNA sequence, transcript structure and
genomic organization.";
Gene 168:211-215(1996).
[2]
CHARACTERIZATION, AND SUBCELLULAR LOCATION.
PubMed=8622866;
Kiefer P., Strahle U., Mason I., Dickson C.;
"Secretion and mitogenic activity of zebrafish FGF3 reveal
intermediate properties relative to mouse and Xenopus homologues.";
Oncogene 12:1503-1511(1996).
-!- FUNCTION: Plays an important role in the regulation of embryonic
development, cell proliferation, and cell differentiation.
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:8622866}.
-!- SIMILARITY: Belongs to the heparin-binding growth factors family.
{ECO:0000305}.
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EMBL; Z48714; CAA88596.1; -; Genomic_DNA.
PIR; JC4627; JC4627.
RefSeq; NP_571366.1; NM_131291.1.
UniGene; Dr.83293; -.
ProteinModelPortal; P48802; -.
SMR; P48802; -.
BioGrid; 78723; 2.
STRING; 7955.ENSDARP00000099184; -.
PaxDb; P48802; -.
Ensembl; ENSDART00000168474; ENSDARP00000132485; ENSDARG00000101540.
GeneID; 30549; -.
KEGG; dre:30549; -.
CTD; 2248; -.
ZFIN; ZDB-GENE-980526-178; fgf3.
eggNOG; KOG3885; Eukaryota.
eggNOG; ENOG4111IPH; LUCA.
GeneTree; ENSGT00760000118859; -.
HOGENOM; HOG000236341; -.
HOVERGEN; HBG007580; -.
InParanoid; P48802; -.
KO; K04358; -.
OMA; YHLQIHP; -.
OrthoDB; EOG091G0NAY; -.
PhylomeDB; P48802; -.
TreeFam; TF317805; -.
Reactome; R-DRE-109704; PI3K Cascade.
Reactome; R-DRE-1257604; PIP3 activates AKT signaling.
Reactome; R-DRE-190370; FGFR1b ligand binding and activation.
Reactome; R-DRE-190377; FGFR2b ligand binding and activation.
Reactome; R-DRE-5654219; Phospholipase C-mediated cascade: FGFR1.
Reactome; R-DRE-5654221; Phospholipase C-mediated cascade, FGFR2.
Reactome; R-DRE-5654687; Downstream signaling of activated FGFR1.
Reactome; R-DRE-5654688; SHC-mediated cascade:FGFR1.
Reactome; R-DRE-5654689; PI-3K cascade:FGFR1.
Reactome; R-DRE-5654693; FRS-mediated FGFR1 signaling.
Reactome; R-DRE-5654695; PI-3K cascade:FGFR2.
Reactome; R-DRE-5654699; SHC-mediated cascade:FGFR2.
Reactome; R-DRE-5654700; FRS-mediated FGFR2 signaling.
Reactome; R-DRE-5654706; FRS-mediated FGFR3 signaling.
Reactome; R-DRE-5654712; FRS-mediated FGFR4 signaling.
Reactome; R-DRE-5654726; Negative regulation of FGFR1 signaling.
Reactome; R-DRE-5654727; Negative regulation of FGFR2 signaling.
Reactome; R-DRE-5658623; FGFRL1 modulation of FGFR1 signaling.
Reactome; R-DRE-5673001; RAF/MAP kinase cascade.
Reactome; R-DRE-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
PRO; PR:P48802; -.
Proteomes; UP000000437; Chromosome 7.
Bgee; ENSDARG00000101540; -.
ExpressionAtlas; P48802; baseline.
GO; GO:0005615; C:extracellular space; IDA:ZFIN.
GO; GO:0005578; C:proteinaceous extracellular matrix; IDA:ZFIN.
GO; GO:0005104; F:fibroblast growth factor receptor binding; IDA:ZFIN.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0021984; P:adenohypophysis development; IMP:ZFIN.
GO; GO:0009952; P:anterior/posterior pattern specification; IGI:ZFIN.
GO; GO:0051216; P:cartilage development; IMP:ZFIN.
GO; GO:0001708; P:cell fate specification; IMP:ZFIN.
GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:ZFIN.
GO; GO:0071696; P:ectodermal placode development; IGI:ZFIN.
GO; GO:0048702; P:embryonic neurocranium morphogenesis; IGI:ZFIN.
GO; GO:0009880; P:embryonic pattern specification; IGI:ZFIN.
GO; GO:0060059; P:embryonic retina morphogenesis in camera-type eye; IGI:ZFIN.
GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IEA:InterPro.
GO; GO:0030902; P:hindbrain development; IMP:ZFIN.
GO; GO:0042472; P:inner ear morphogenesis; IMP:ZFIN.
GO; GO:0021703; P:locus ceruleus development; IGI:ZFIN.
GO; GO:0030901; P:midbrain development; IGI:ZFIN.
GO; GO:0043066; P:negative regulation of apoptotic process; IMP:ZFIN.
GO; GO:0014032; P:neural crest cell development; IMP:ZFIN.
GO; GO:0021985; P:neurohypophysis development; IMP:ZFIN.
GO; GO:0048666; P:neuron development; IGI:ZFIN.
GO; GO:0048665; P:neuron fate specification; IGI:ZFIN.
GO; GO:0048709; P:oligodendrocyte differentiation; IGI:ZFIN.
GO; GO:0043049; P:otic placode formation; IMP:ZFIN.
GO; GO:0071599; P:otic vesicle development; IGI:ZFIN.
GO; GO:0030916; P:otic vesicle formation; IMP:ZFIN.
GO; GO:0048840; P:otolith development; IGI:ZFIN.
GO; GO:0007422; P:peripheral nervous system development; IGI:ZFIN.
GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
GO; GO:0030335; P:positive regulation of cell migration; IGI:ZFIN.
GO; GO:0050769; P:positive regulation of neurogenesis; IMP:ZFIN.
GO; GO:0045666; P:positive regulation of neuron differentiation; IMP:ZFIN.
GO; GO:0030177; P:positive regulation of Wnt signaling pathway; IGI:ZFIN.
GO; GO:0048920; P:posterior lateral line neuromast primordium migration; IGI:ZFIN.
GO; GO:0060041; P:retina development in camera-type eye; IGI:ZFIN.
GO; GO:0021571; P:rhombomere 5 development; IGI:ZFIN.
GO; GO:0021572; P:rhombomere 6 development; IGI:ZFIN.
GO; GO:0001501; P:skeletal system development; IMP:ZFIN.
GO; GO:0060118; P:vestibular receptor cell development; IMP:ZFIN.
CDD; cd00058; FGF; 1.
InterPro; IPR028232; FGF3.
InterPro; IPR002209; Fibroblast_GF_fam.
InterPro; IPR008996; IL1/FGF.
PANTHER; PTHR11486; PTHR11486; 1.
PANTHER; PTHR11486:SF26; PTHR11486:SF26; 1.
Pfam; PF00167; FGF; 1.
PRINTS; PR00263; HBGFFGF.
SMART; SM00442; FGF; 1.
SUPFAM; SSF50353; SSF50353; 1.
PROSITE; PS00247; HBGF_FGF; 1.
1: Evidence at protein level;
Complete proteome; Developmental protein; Differentiation;
Growth factor; Mitogen; Reference proteome; Secreted; Signal.
SIGNAL 1 18 {ECO:0000255}.
CHAIN 19 256 Fibroblast growth factor 3.
/FTId=PRO_0000008950.
SEQUENCE 256 AA; 28923 MW; CEBA1C72A170BBDC CRC64;
MVIILLLLLL SFLDPSLEES LAPRLTRTPR APCARGQACD PRQRRDAGGR GGVYEHLGGA
PRRRKLYCAT KYHLQIHPNG KIDGSLEENN PLSILEITAV DVGVVAIKGL FSGRYLAMNE
KGRLYASEVF NRECEFLERI HELGYNTYAS RHHATTQPPP TGSGIGGSKR RASSKRQWYV
SINGKGRPRR GFKTRSTDKA SLFLPRVLAN KDHEMVRKLR ESQRHHTGSH RAPVGRAERR
RRRHRGSKGH NRRADI


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