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Flagellar motor switch protein FliM

 FLIM_ECOLI              Reviewed;         334 AA.
P06974;
01-APR-1988, integrated into UniProtKB/Swiss-Prot.
01-APR-1988, sequence version 1.
20-JUN-2018, entry version 155.
RecName: Full=Flagellar motor switch protein FliM;
Name=fliM; Synonyms=cheC2, fla AII, fla QII;
OrderedLocusNames=b1945, JW1929;
Escherichia coli (strain K12).
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
Enterobacteriaceae; Escherichia.
NCBI_TaxID=83333;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3519573; DOI=10.1128/jb.166.3.1007-1012.1986;
Kuo S.C., Koshland D.E. Jr.;
"Sequence of the flaA (cheC) locus of Escherichia coli and discovery
of a new gene.";
J. Bacteriol. 166:1007-1012(1986).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
PubMed=9097040; DOI=10.1093/dnares/3.6.379;
Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K.,
Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T.,
Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S., Nakamura Y.,
Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y.,
Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C.,
Yamamoto Y., Horiuchi T.;
"A 460-kb DNA sequence of the Escherichia coli K-12 genome
corresponding to the 40.1-50.0 min region on the linkage map.";
DNA Res. 3:379-392(1996).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / MG1655 / ATCC 47076;
PubMed=9278503; DOI=10.1126/science.277.5331.1453;
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
Mau B., Shao Y.;
"The complete genome sequence of Escherichia coli K-12.";
Science 277:1453-1462(1997).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
PubMed=16738553; DOI=10.1038/msb4100049;
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
"Highly accurate genome sequences of Escherichia coli K-12 strains
MG1655 and W3110.";
Mol. Syst. Biol. 2:E1-E5(2006).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 327-334.
STRAIN=K12;
PubMed=2651416; DOI=10.1128/jb.171.5.2728-2734.1989;
Malakooti J., Komeda Y., Matsumura P.;
"DNA sequence analysis, gene product identification, and localization
of flagellar motor components of Escherichia coli.";
J. Bacteriol. 171:2728-2734(1989).
[6]
INTERACTION WITH YCRG, AND MUTAGENESIS OF VAL-153; ASN-155; ARG-156;
LEU-160; ASP-167 AND GLU-176.
STRAIN=K12 / RP3098;
PubMed=20346719; DOI=10.1016/j.molcel.2010.03.001;
Paul K., Nieto V., Carlquist W.C., Blair D.F., Harshey R.M.;
"The c-di-GMP binding protein YcgR controls flagellar motor direction
and speed to affect chemotaxis by a 'backstop brake' mechanism.";
Mol. Cell 38:128-139(2010).
[7]
REVIEW.
PubMed=19081534; DOI=10.1016/S1937-6448(08)01402-0;
Terashima H., Kojima S., Homma M.;
"Flagellar motility in bacteria structure and function of flagellar
motor.";
Int. Rev. Cytol. 270:39-85(2008).
-!- FUNCTION: FliM is one of three proteins (FliG, FliN, FliM) that
forms the rotor-mounted switch complex (C ring), located at the
base of the basal body. This complex interacts with the CheY and
CheZ chemotaxis proteins, in addition to contacting components of
the motor that determine the direction of flagellar rotation.
-!- SUBUNIT: Interacts with flagellar brake protein YcgR.
{ECO:0000269|PubMed:20346719}.
-!- INTERACTION:
P0ABZ1:fliG; NbExp=16; IntAct=EBI-560439, EBI-1126524;
P15070:fliN; NbExp=7; IntAct=EBI-560439, EBI-2011987;
P76010:ycgR; NbExp=3; IntAct=EBI-560439, EBI-554507;
-!- SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane
protein. Bacterial flagellum basal body.
-!- SIMILARITY: Belongs to the FliM family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; M12784; AAA23786.1; -; Genomic_DNA.
EMBL; U00096; AAC75012.1; -; Genomic_DNA.
EMBL; AP009048; BAA15770.1; -; Genomic_DNA.
EMBL; M26294; -; NOT_ANNOTATED_CDS; Unassigned_DNA.
PIR; B29842; XMECF2.
RefSeq; NP_416455.1; NC_000913.3.
RefSeq; WP_001350520.1; NZ_LN832404.1.
PDB; 1F4V; X-ray; 2.22 A; D/E/F=1-16.
PDB; 1U8T; X-ray; 1.50 A; E/F=1-16.
PDB; 2B1J; X-ray; 2.40 A; C/D=1-16.
PDBsum; 1F4V; -.
PDBsum; 1U8T; -.
PDBsum; 2B1J; -.
ProteinModelPortal; P06974; -.
SMR; P06974; -.
BioGrid; 4261570; 21.
ComplexPortal; CPX-1082; Flagellar Motor Switch Complex, CW variant.
ComplexPortal; CPX-1085; Flagellar Motor Switch Complex, CCW variant.
DIP; DIP-1100N; -.
IntAct; P06974; 18.
MINT; P06974; -.
STRING; 316385.ECDH10B_2087; -.
PaxDb; P06974; -.
PRIDE; P06974; -.
EnsemblBacteria; AAC75012; AAC75012; b1945.
EnsemblBacteria; BAA15770; BAA15770; BAA15770.
GeneID; 946442; -.
KEGG; ecj:JW1929; -.
KEGG; eco:b1945; -.
PATRIC; fig|1411691.4.peg.306; -.
EchoBASE; EB0319; -.
EcoGene; EG10323; fliM.
eggNOG; ENOG4105D24; Bacteria.
eggNOG; COG1868; LUCA.
HOGENOM; HOG000253580; -.
InParanoid; P06974; -.
KO; K02416; -.
OMA; NPQFTQI; -.
PhylomeDB; P06974; -.
BioCyc; EcoCyc:FLIM-FLAGELLAR-C-RING-SWITCH; -.
EvolutionaryTrace; P06974; -.
PRO; PR:P06974; -.
Proteomes; UP000000318; Chromosome.
Proteomes; UP000000625; Chromosome.
GO; GO:0009425; C:bacterial-type flagellum basal body; IEA:UniProtKB-SubCell.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0003774; F:motor activity; IEA:InterPro.
GO; GO:0071973; P:bacterial-type flagellum-dependent cell motility; IEA:InterPro.
GO; GO:0050918; P:positive chemotaxis; IBA:GO_Central.
Gene3D; 3.40.1550.10; -; 1.
InterPro; IPR028976; CheC-like_sf.
InterPro; IPR001689; Flag_FliM.
InterPro; IPR001543; SpoA.
InterPro; IPR036429; SpoA-like_sf.
Pfam; PF02154; FliM; 1.
Pfam; PF01052; FliMN_C; 1.
PIRSF; PIRSF002888; FliM; 1.
PRINTS; PR00955; FLGMOTORFLIM.
SUPFAM; SSF101801; SSF101801; 1.
SUPFAM; SSF103039; SSF103039; 1.
TIGRFAMs; TIGR01397; fliM_switch; 1.
1: Evidence at protein level;
3D-structure; Bacterial flagellum; Cell inner membrane; Cell membrane;
Chemotaxis; Complete proteome; Flagellar rotation; Membrane;
Reference proteome.
CHAIN 1 334 Flagellar motor switch protein FliM.
/FTId=PRO_0000180928.
MUTAGEN 153 153 V->D: Decreases binding to YcgR.
{ECO:0000269|PubMed:20346719}.
MUTAGEN 155 155 N->E: Decreases binding to YcgR.
{ECO:0000269|PubMed:20346719}.
MUTAGEN 156 156 R->D: Obviates binding to YcgR.
{ECO:0000269|PubMed:20346719}.
MUTAGEN 160 160 L->E: Obviates binding to YcgR.
{ECO:0000269|PubMed:20346719}.
MUTAGEN 167 167 D->R: Decreases binding to YcgR.
{ECO:0000269|PubMed:20346719}.
MUTAGEN 176 176 E->R: Decreases binding to YcgR.
{ECO:0000269|PubMed:20346719}.
HELIX 8 15 {ECO:0000244|PDB:1U8T}.
SEQUENCE 334 AA; 37849 MW; 05DC012B9364BFD6 CRC64;
MGDSILSQAE IDALLNGDSE VKDEPTASVS GESDIRPYDP NTQRRVVRER LQALEIINER
FARHFRMGLF NLLRRSPDIT VGAIRIQPYH EFARNLPVPT NLNLIHLKPL RGTGLVVFSP
SLVFIAVDNL FGGDGRFPTK VEGREFTHTE QRVINRMLKL ALEGYSDAWK AINPLEVEYV
RSEMQVKFTN ITTSPNDIVV NTPFHVEIGN LTGEFNICLP FSMIEPLREL LVNPPLENSR
NEDQNWRDNL VRQVQHSQLE LVANFADISL RLSQILKLNP GDVLPIEKPD RIIAHVDGVP
VLTSQYGTLN GQYALRIEHL INPILNSLNE EQPK


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