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Flavohemoprotein (Flavohemoglobin) (Hemoglobin-like protein) (Nitric oxide dioxygenase) (NO oxygenase) (NOD) (EC 1.14.12.17)

 C3SZD7_ECOLX            Unreviewed;       396 AA.
C3SZD7;
16-JUN-2009, integrated into UniProtKB/TrEMBL.
16-JUN-2009, sequence version 1.
23-MAY-2018, entry version 70.
RecName: Full=Flavohemoprotein {ECO:0000256|HAMAP-Rule:MF_01252};
AltName: Full=Flavohemoglobin {ECO:0000256|HAMAP-Rule:MF_01252};
AltName: Full=Hemoglobin-like protein {ECO:0000256|HAMAP-Rule:MF_01252};
AltName: Full=Nitric oxide dioxygenase {ECO:0000256|HAMAP-Rule:MF_01252};
Short=NO oxygenase {ECO:0000256|HAMAP-Rule:MF_01252};
Short=NOD {ECO:0000256|HAMAP-Rule:MF_01252};
EC=1.14.12.17 {ECO:0000256|HAMAP-Rule:MF_01252};
Name=hmpA {ECO:0000313|EMBL:CTT75848.1};
Synonyms=hmp {ECO:0000256|HAMAP-Rule:MF_01252};
ORFNames=A8G17_10575 {ECO:0000313|EMBL:OWC18098.1},
A9819_14745 {ECO:0000313|EMBL:PBT40809.1},
AKG99_22170 {ECO:0000313|EMBL:KNZ96866.1},
AML35_21415 {ECO:0000313|EMBL:KYS88964.1},
ARC77_09055 {ECO:0000313|EMBL:AMW42385.1},
AU473_09205 {ECO:0000313|EMBL:APA41051.1},
AW059_05830 {ECO:0000313|EMBL:OTB40484.1},
BHF46_00465 {ECO:0000313|EMBL:OEN37800.1},
BIZ41_08405 {ECO:0000313|EMBL:PAQ63808.1},
BMR14_11585 {ECO:0000313|EMBL:PGG49211.1},
BTQ04_09910 {ECO:0000313|EMBL:PAU15278.1},
BWP17_16915 {ECO:0000313|EMBL:OOC78398.1},
CR539_17765 {ECO:0000313|EMBL:AUJ97037.1},
CVH05_18000 {ECO:0000313|EMBL:PJG32155.1},
ECs3418 {ECO:0000313|EMBL:ACI79826.1},
ERS085383_02026 {ECO:0000313|EMBL:CTT75848.1},
ERS085386_03165 {ECO:0000313|EMBL:CTT99644.1},
ERS085404_01033 {ECO:0000313|EMBL:CTU72277.1},
JD73_17615 {ECO:0000313|EMBL:KFD75490.1},
UN91_26430 {ECO:0000313|EMBL:KJW44417.1};
Escherichia coli.
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
Enterobacteriaceae; Escherichia.
NCBI_TaxID=562 {ECO:0000313|EMBL:ACI79826.1};
[1] {ECO:0000313|EMBL:ACI79826.1}
NUCLEOTIDE SEQUENCE.
STRAIN=493/89 {ECO:0000313|EMBL:ACI79826.1},
86-24 {ECO:0000313|EMBL:ACI79827.1},
87-14 {ECO:0000313|EMBL:ACI79828.1},
TB182A {ECO:0000313|EMBL:ACI79829.1}, and
TW14359 {ECO:0000313|EMBL:ACI79830.1};
PubMed=19439656; DOI=10.1073/pnas.0812949106;
Leopold S.R., Magrini V., Holt N.J., Shaikh N., Mardis E.R., Cagno J.,
Ogura Y., Iguchi A., Hayashi T., Mellmann A., Karch H., Besser T.E.,
Sawyer S.A., Whittam T.S., Tarr P.I.;
"A precise reconstruction of the emergence and constrained radiations
of Escherichia coli O157 portrayed by backbone concatenomic
analysis.";
Proc. Natl. Acad. Sci. U.S.A. 106:8713-8718(2009).
[2] {ECO:0000313|EMBL:KFD75490.1, ECO:0000313|Proteomes:UP000028651}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=48 {ECO:0000313|EMBL:KFD75490.1,
ECO:0000313|Proteomes:UP000028651};
Nuesch-Inderbinen M.T., Funk J., Cernela N., Tasara T., Klumpp J.,
Schmidt H., Stephan R.;
"Prevalence of subtilase cytotoxin-encoding subAB variants among Shiga
toxin-producing Escherichia coli strains isolated from wild ruminants
and sheep differs from that of cattle and pigs and is predominated by
the new allelic variant subAB2-2.";
Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|EMBL:KJW44417.1, ECO:0000313|Proteomes:UP000033371}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=St. Olav173 {ECO:0000313|EMBL:KJW44417.1,
ECO:0000313|Proteomes:UP000033371};
Gabrielsen C., Drablos F., Afset J.E.;
"Genome sequences of 11 non-O157 Shiga Toxin-Producing Escherichia
coli strains.";
Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|EMBL:KNZ96866.1, ECO:0000313|Proteomes:UP000036728}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=INSLA289 {ECO:0000313|EMBL:KNZ96866.1,
ECO:0000313|Proteomes:UP000036728};
Jones-Dias D., Manageiro V., Sampaio D.A., Vieira L., Canica M.;
"Draft genome sequence of a pathogenic ST57 Escherichia coli from
poultry carrying twelve acquired antibiotic resistance genes.";
Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
[5] {ECO:0000313|EMBL:CTT75848.1}
NUCLEOTIDE SEQUENCE.
STRAIN=200758_aEPEC {ECO:0000313|EMBL:CTT75848.1},
400654_aEPEC {ECO:0000313|EMBL:CTT99644.1}, and
702745_aEPEC {ECO:0000313|EMBL:CTU72277.1};
Rikkerink E.H.A., Fineran P.C.;
"Complete DNA Sequence of Pseudomonas syringae pv. actinidiae, the
Causal Agent of Kiwifruit Canker Disease.";
Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
[6] {ECO:0000313|Proteomes:UP000042887, ECO:0000313|Proteomes:UP000043139, ECO:0000313|Proteomes:UP000044658}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=200758_aEPEC {ECO:0000313|Proteomes:UP000044658},
400654_aEPEC {ECO:0000313|Proteomes:UP000042887}, and
702745_aEPEC {ECO:0000313|Proteomes:UP000043139};
Pathogen Informatics;
Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
[7] {ECO:0000313|Proteomes:UP000076106}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=STEC 1686 {ECO:0000313|Proteomes:UP000076106};
Shamseldin A., Moawad H., Abd El-Rahim W.M., Sadowsky M.J.;
Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
[8] {ECO:0000313|EMBL:KYS88964.1}
NUCLEOTIDE SEQUENCE.
STRAIN=STEC 1686 {ECO:0000313|EMBL:KYS88964.1};
PubMed=27058887;
Ferdous M., Friedrich A.W., Grundmann H., de Boer R.F., Croughs P.D.,
Islam M.A., Kluytmans-van den Bergh M.F., Kooistra-Smid A.M.,
Rossen J.W.;
"Molecular characterization and phylogeny of Shiga toxin-producing
Escherichia coli isolates obtained from two Dutch regions using whole
genome sequencing.";
Clin. Microbiol. Infect. 22:642-642(2016).
[9] {ECO:0000313|EMBL:AMW42385.1, ECO:0000313|Proteomes:UP000076266}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=28RC1 {ECO:0000313|EMBL:AMW42385.1,
ECO:0000313|Proteomes:UP000076266};
Baranzoni G.M., Fratamico P., Reichenberger E., Kim G.-H., Breidt F.,
Kay K.;
"Complete Genome Sequences of Escherichia coli O157:H7 strains SRCC
1675 and 28RC.";
Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
[10] {ECO:0000313|EMBL:OWC18098.1, ECO:0000313|Proteomes:UP000196865}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ECOR37 {ECO:0000313|EMBL:OWC18098.1,
ECO:0000313|Proteomes:UP000196865};
Fischer W., Schubert S., Messerer M.;
"Investigation of Horizontal Gene Transfer of Pathogenicity Islands in
Escherichia coli using Next-Generation Sequencing.";
Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
[11] {ECO:0000313|EMBL:OEN37800.1, ECO:0000313|Proteomes:UP000095493}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=VL119 {ECO:0000313|EMBL:OEN37800.1,
ECO:0000313|Proteomes:UP000095493};
Blum S.E., Goldstone R.J., Harris S., Leitner G., Smith D.G.;
"Genomic analysis of mastitis and farm-associated E. coli.";
Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
[12] {ECO:0000313|EMBL:APA41051.1, ECO:0000313|Proteomes:UP000177471}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=PA20 {ECO:0000313|EMBL:APA41051.1,
ECO:0000313|Proteomes:UP000177471};
Uhlich G.A., Chen C.-Y., Paoli G.;
"E. coli O157:H7 PA20.";
Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
[13] {ECO:0000313|EMBL:PGG49211.1, ECO:0000313|Proteomes:UP000224281}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=4_Esco_CA-NL {ECO:0000313|EMBL:PGG49211.1,
ECO:0000313|Proteomes:UP000224281};
Garcia-Cobos S.;
"Genetic relatedness of ESBL-Enterobacteriaceae in hospitals and the
community, Northern Netherlands and Germany.";
Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
[14] {ECO:0000313|EMBL:PAU15278.1, ECO:0000313|Proteomes:UP000218692}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=STEC 621S1 {ECO:0000313|EMBL:PAU15278.1,
ECO:0000313|Proteomes:UP000218692};
Ferdous M., Moran-Gilad J., Rossen J.W., Gdalevich M.;
"Real-Time Genomic Investigation Underlying the Public Health Response
to a Shiga Toxin-Producing Escherichia Coli O26:H11 Outbreak in a
Nursery.";
Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
[15] {ECO:0000313|EMBL:OOC78398.1, ECO:0000313|Proteomes:UP000188999}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=EDL 933 {ECO:0000313|EMBL:OOC78398.1,
ECO:0000313|Proteomes:UP000188999};
Kozyreva V.K., Truong C.-L., Greninger A.L., Mukhopadhyay R.,
Crandall J., Chaturvedi V.;
"Validation and Implementation of CLIA-Compliant Whole Genome
Sequencing (WGS) in Public Health Laboratory.";
Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
[16] {ECO:0000313|EMBL:PAQ63808.1, ECO:0000313|Proteomes:UP000215865}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=6770 {ECO:0000313|EMBL:PAQ63808.1,
ECO:0000313|Proteomes:UP000215865};
Saavedra S.Y., Diaz L., Wiesner M., Correa A., Arevalo S.A., Reyes J.,
Hidalgo A.M., De La Cadena E., Perenguez M., Montano L.A., Ardila J.,
Rios R., Ovalle M.V., Diaz P., Porras P., Villegas M.V., Arias C.A.,
Castaneda E., Duarte C.;
"Genomic and Molecular Characterization of Clinical Isolates of
Enterobacteriaceae Harboring mcr-1 in Colombia, 2002-2016.";
Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
[17] {ECO:0000313|EMBL:OTB40484.1, ECO:0000313|Proteomes:UP000194247}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=OLC1000 {ECO:0000313|EMBL:OTB40484.1,
ECO:0000313|Proteomes:UP000194247};
Carrillo C.D., Koziol A.G., Mathews A., Goji N., Lambert D.,
Huszczynski G., Deschenes M., Gauthier M., Amoako K., Blais B.;
"Application of genomics in the determination of verotoxigenic
Escherichia coli toxin subtypes.";
Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
[18] {ECO:0000313|EMBL:PBT40809.1, ECO:0000313|Proteomes:UP000218701}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=KCJK3945 {ECO:0000313|EMBL:PBT40809.1,
ECO:0000313|Proteomes:UP000218701};
Ehlers B., Leendertz F.H.;
Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
[19] {ECO:0000313|EMBL:AUJ97037.1, ECO:0000313|Proteomes:UP000234543}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=14EC033 {ECO:0000313|EMBL:AUJ97037.1,
ECO:0000313|Proteomes:UP000234543};
Li B., Wang X.;
"mcr-1 positive E.coli isolates in China.";
Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
[20] {ECO:0000313|EMBL:PJG32155.1, ECO:0000313|Proteomes:UP000231208}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=KCJ4029 {ECO:0000313|EMBL:PJG32155.1,
ECO:0000313|Proteomes:UP000231208};
Han C.G.;
Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Is involved in NO detoxification in an aerobic process,
termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2)
and NAD(P)H to convert NO to nitrate, which protects the bacterium
from various noxious nitrogen compounds. Therefore, plays a
central role in the inducible response to nitrosative stress.
{ECO:0000256|HAMAP-Rule:MF_01252}.
-!- CATALYTIC ACTIVITY: 2 nitric oxide + 2 O(2) + NAD(P)H = 2 nitrate
+ NAD(P)(+) + H(+). {ECO:0000256|HAMAP-Rule:MF_01252}.
-!- COFACTOR:
Name=FAD; Xref=ChEBI:CHEBI:57692;
Evidence={ECO:0000256|HAMAP-Rule:MF_01252};
Note=Binds 1 FAD per subunit. {ECO:0000256|HAMAP-Rule:MF_01252};
-!- COFACTOR:
Name=heme b; Xref=ChEBI:CHEBI:60344;
Evidence={ECO:0000256|HAMAP-Rule:MF_01252};
Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group per
subunit. {ECO:0000256|HAMAP-Rule:MF_01252};
-!- DOMAIN: Consists of two distinct domains; an N-terminal heme-
containing oxygen-binding domain and a C-terminal reductase domain
with binding sites for FAD and NAD(P)H. {ECO:0000256|HAMAP-
Rule:MF_01252}.
-!- SIMILARITY: Belongs to the globin family. Two-domain
flavohemoproteins subfamily. {ECO:0000256|HAMAP-Rule:MF_01252}.
-!- SIMILARITY: In the C-terminal section; belongs to the flavoprotein
pyridine nucleotide cytochrome reductase family.
{ECO:0000256|HAMAP-Rule:MF_01252}.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00238}.
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EMBL; EU897270; ACI79826.1; -; Genomic_DNA.
EMBL; EU897271; ACI79827.1; -; Genomic_DNA.
EMBL; EU897272; ACI79828.1; -; Genomic_DNA.
EMBL; EU897273; ACI79829.1; -; Genomic_DNA.
EMBL; EU897274; ACI79830.1; -; Genomic_DNA.
EMBL; CP015020; AMW42385.1; -; Genomic_DNA.
EMBL; CP017669; APA41051.1; -; Genomic_DNA.
EMBL; CP024147; AUJ97037.1; -; Genomic_DNA.
EMBL; CYBJ01000009; CTT75848.1; -; Genomic_DNA.
EMBL; CYBM01000016; CTT99644.1; -; Genomic_DNA.
EMBL; CYCH01000004; CTU72277.1; -; Genomic_DNA.
EMBL; JPQG01000003; KFD75490.1; -; Genomic_DNA.
EMBL; JZDZ01000126; KJW44417.1; -; Genomic_DNA.
EMBL; LHAT01000072; KNZ96866.1; -; Genomic_DNA.
EMBL; LOGT01000153; KYS88964.1; -; Genomic_DNA.
EMBL; MIWY01000001; OEN37800.1; -; Genomic_DNA.
EMBL; MTFS01000025; OOC78398.1; -; Genomic_DNA.
EMBL; NEME01000003; OTB40484.1; -; Genomic_DNA.
EMBL; LYAA01001555; OWC18098.1; -; Genomic_DNA.
EMBL; MVPG01000022; PAQ63808.1; -; Genomic_DNA.
EMBL; MRVX01000029; PAU15278.1; -; Genomic_DNA.
EMBL; NTDZ01000034; PBT40809.1; -; Genomic_DNA.
EMBL; MOXW01000034; PGG49211.1; -; Genomic_DNA.
EMBL; PGUD01000222; PJG32155.1; -; Genomic_DNA.
RefSeq; WP_000883120.1; NZ_PTOJ01000017.1.
EnsemblBacteria; AMW42385; AMW42385; ARC77_09055.
EnsemblBacteria; CTT75848; CTT75848; ERS085383_02026.
EnsemblBacteria; CTT99644; CTT99644; ERS085386_03165.
EnsemblBacteria; CTU72277; CTU72277; ERS085404_01033.
EnsemblBacteria; KFD75490; KFD75490; JD73_17615.
EnsemblBacteria; KHI36337; KHI36337; PU33_05225.
EnsemblBacteria; KJW44417; KJW44417; UN91_26430.
EnsemblBacteria; KNZ96866; KNZ96866; AKG99_22170.
EnsemblBacteria; KYS88964; KYS88964; AML35_21415.
EnsemblBacteria; OCS74118; OCS74118; BBZ52_13560.
EnsemblBacteria; OEG67621; OEG67621; A7H95_21200.
EnsemblBacteria; OEN37800; OEN37800; BHF46_00465.
PATRIC; fig|562.10858.peg.43; -.
eggNOG; ENOG4105CJJ; Bacteria.
eggNOG; COG1017; LUCA.
eggNOG; COG1018; LUCA.
HOGENOM; HOG000238921; -.
Proteomes; UP000028651; Unassembled WGS sequence.
Proteomes; UP000033371; Unassembled WGS sequence.
Proteomes; UP000036728; Unassembled WGS sequence.
Proteomes; UP000042887; Unassembled WGS sequence.
Proteomes; UP000043139; Unassembled WGS sequence.
Proteomes; UP000044658; Unassembled WGS sequence.
Proteomes; UP000076106; Unassembled WGS sequence.
Proteomes; UP000076266; Chromosome.
Proteomes; UP000095493; Unassembled WGS sequence.
Proteomes; UP000177471; Chromosome.
Proteomes; UP000188999; Unassembled WGS sequence.
Proteomes; UP000194247; Unassembled WGS sequence.
Proteomes; UP000196865; Unassembled WGS sequence.
Proteomes; UP000215865; Unassembled WGS sequence.
Proteomes; UP000218692; Unassembled WGS sequence.
Proteomes; UP000218701; Unassembled WGS sequence.
Proteomes; UP000224281; Unassembled WGS sequence.
Proteomes; UP000231208; Unassembled WGS sequence.
Proteomes; UP000234543; Chromosome.
GO; GO:0071949; F:FAD binding; IEA:InterPro.
GO; GO:0020037; F:heme binding; IEA:InterPro.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0008941; F:nitric oxide dioxygenase activity; IEA:UniProtKB-UniRule.
GO; GO:0019825; F:oxygen binding; IEA:InterPro.
GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-UniRule.
GO; GO:0051409; P:response to nitrosative stress; IEA:InterPro.
GO; GO:0009636; P:response to toxic substance; IEA:UniProtKB-KW.
Gene3D; 1.10.490.10; -; 1.
HAMAP; MF_01252; Hmp; 1.
InterPro; IPR017927; Fd_Rdtase_FAD-bd.
InterPro; IPR000971; Globin.
InterPro; IPR009050; Globin-like_sf.
InterPro; IPR012292; Globin/Proto.
InterPro; IPR023950; Hmp.
InterPro; IPR008333; OxRdtase_FAD-bd_dom.
InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
InterPro; IPR001221; Phe_hydroxylase.
InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
Pfam; PF00970; FAD_binding_6; 1.
Pfam; PF00042; Globin; 1.
Pfam; PF00175; NAD_binding_1; 1.
PRINTS; PR00410; PHEHYDRXLASE.
SUPFAM; SSF46458; SSF46458; 1.
SUPFAM; SSF63380; SSF63380; 1.
PROSITE; PS51384; FAD_FR; 1.
PROSITE; PS01033; GLOBIN; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000028651,
ECO:0000313|Proteomes:UP000033371, ECO:0000313|Proteomes:UP000036728,
ECO:0000313|Proteomes:UP000042887};
Detoxification {ECO:0000256|HAMAP-Rule:MF_01252};
Dioxygenase {ECO:0000313|EMBL:AMW42385.1};
FAD {ECO:0000256|HAMAP-Rule:MF_01252};
Flavoprotein {ECO:0000256|HAMAP-Rule:MF_01252};
Heme {ECO:0000256|HAMAP-Rule:MF_01252, ECO:0000256|RuleBase:RU000356};
Iron {ECO:0000256|HAMAP-Rule:MF_01252, ECO:0000256|RuleBase:RU000356};
Metal-binding {ECO:0000256|HAMAP-Rule:MF_01252,
ECO:0000256|RuleBase:RU000356}; NAD {ECO:0000256|HAMAP-Rule:MF_01252};
NADP {ECO:0000256|HAMAP-Rule:MF_01252};
Oxidoreductase {ECO:0000313|EMBL:AMW42385.1};
Oxygen transport {ECO:0000256|HAMAP-Rule:MF_01252,
ECO:0000256|RuleBase:RU000356};
Transport {ECO:0000256|HAMAP-Rule:MF_01252,
ECO:0000256|RuleBase:RU000356}.
DOMAIN 1 134 GLOBIN. {ECO:0000259|PROSITE:PS01033}.
DOMAIN 150 255 FAD-binding FR-type.
{ECO:0000259|PROSITE:PS51384}.
NP_BIND 204 207 FAD. {ECO:0000256|HAMAP-Rule:MF_01252}.
NP_BIND 268 273 NADP. {ECO:0000256|HAMAP-Rule:MF_01252}.
NP_BIND 389 392 FAD. {ECO:0000256|HAMAP-Rule:MF_01252}.
REGION 147 396 Reductase. {ECO:0000256|HAMAP-
Rule:MF_01252}.
REGION 259 396 NAD or NADP-binding. {ECO:0000256|HAMAP-
Rule:MF_01252}.
ACT_SITE 95 95 Charge relay system. {ECO:0000256|HAMAP-
Rule:MF_01252}.
ACT_SITE 135 135 Charge relay system. {ECO:0000256|HAMAP-
Rule:MF_01252}.
METAL 85 85 Iron (heme proximal ligand).
{ECO:0000256|HAMAP-Rule:MF_01252}.
BINDING 188 188 FAD. {ECO:0000256|HAMAP-Rule:MF_01252}.
SITE 29 29 Involved in heme-bound ligand
stabilization and O-O bond activation.
{ECO:0000256|HAMAP-Rule:MF_01252}.
SITE 84 84 Influences the redox potential of the
prosthetic heme and FAD groups.
{ECO:0000256|HAMAP-Rule:MF_01252}.
SITE 388 388 Influences the redox potential of the
prosthetic heme and FAD groups.
{ECO:0000256|HAMAP-Rule:MF_01252}.
SEQUENCE 396 AA; 43838 MW; 49824A9B1444BD6B CRC64;
MLDAQTIATV KATIPLLVET GPKLTAHFYD RMFTHNPELK EIFNMSNQRN GDQREALFNA
IAAYASNIEN LPALLPAVEK IAQKHTSFQI KPEQYNIVGE HLLATLDEMF SPGQEVLDAW
GKAYGVLANV FINREAEIYN ENASKAGGWE GTRDFRIVAK TPRSALITSF ELEPVDGGAV
AEYRPGQYLG VWLKPEGFPH QEIRQYSLTR KPDGKGYRIA VKREEGGQVS NWLHNHANVG
DVVKLVAPAG DFFMAVADDT PVTLISAGVG QTPMLAMLDT LAKAGHTAQV NWFHAAENGD
VHAFADEVKE LGQSLPRFTA HTWYRQPSEA DRAKGQFDSE GLMDLSKLEG AFSDPTMQFY
LCGPVGFMQF AAKQLVDLGV KQENIHYECF GPHKVL


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