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Folate transporter 1 (Intestinal folate carrier 1) (IFC-1) (Reduced folate carrier 1) (RFC-1) (RFC1) (Solute carrier family 19 member 1)

 S19A1_MOUSE             Reviewed;         512 AA.
P41438; Q62450; Q62451;
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 1.
10-MAY-2017, entry version 123.
RecName: Full=Folate transporter 1;
AltName: Full=Intestinal folate carrier 1;
Short=IFC-1;
AltName: Full=Reduced folate carrier 1;
Short=RFC-1;
Short=RFC1;
AltName: Full=Solute carrier family 19 member 1;
Name=Slc19a1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=DBA;
PubMed=8276792;
Dixon K.H., Lanpher B.C., Chiu J., Kelly K., Cowan K.H.;
"A novel cDNA restores reduced folate carrier activity and
methotrexate sensitivity to transport deficient cells.";
J. Biol. Chem. 269:17-20(1994).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=DBA/2J; TISSUE=Intestine;
PubMed=8664315; DOI=10.1016/0005-2736(96)00005-3;
Said H.M., Nguyen T.T., Dyer D.L., Cowan K.H., Rubin S.A.;
"Intestinal folate transport: identification of a cDNA involved in
folate transport and the functional expression and distribution of its
mRNA.";
Biochim. Biophys. Acta 1281:164-172(1996).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=DBA/2J;
PubMed=7559435; DOI=10.1074/jbc.270.39.22974;
Brigle K.E., Spinella M.J., Sierra E.E., Goldman I.D.;
"Characterization of a mutation in the reduced folate carrier in a
transport defective L1210 murine leukemia cell line.";
J. Biol. Chem. 270:22974-22979(1995).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2 AND 3).
PubMed=9161403; DOI=10.1016/S0378-1119(96)00676-2;
Tolner B.M., Roy K., Sirotnak F.M.;
"Organization, structure and alternate splicing of the murine RFC-1
gene encoding a folate transporter.";
Gene 189:1-7(1997).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
STRAIN=FVB/N; TISSUE=Kidney;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-467 AND SER-477, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
Thibault P.;
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Immunity 30:143-154(2009).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-472 AND SER-477, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Kidney;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Transporter for the intake of folate, reduced folates
and methotrexate.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
protein {ECO:0000305}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=1;
IsoId=P41438-1; Sequence=Displayed;
Name=2;
IsoId=P41438-2; Sequence=VSP_006125;
Name=3;
IsoId=P41438-3; Sequence=VSP_006126, VSP_006127;
-!- SIMILARITY: Belongs to the reduced folate carrier (RFC)
transporter (TC 2.A.48) family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; L36539; AAB38483.1; -; mRNA.
EMBL; L23755; AAA39738.1; -; mRNA.
EMBL; U32469; AAC52258.1; -; mRNA.
EMBL; U66103; AAC53287.1; -; mRNA.
EMBL; U57784; AAC53288.1; -; Genomic_DNA.
EMBL; U57781; AAC53288.1; JOINED; Genomic_DNA.
EMBL; U57782; AAC53288.1; JOINED; Genomic_DNA.
EMBL; U57783; AAC53288.1; JOINED; Genomic_DNA.
EMBL; U57785; AAC53289.1; -; Genomic_DNA.
EMBL; U57781; AAC53289.1; JOINED; Genomic_DNA.
EMBL; U57782; AAC53289.1; JOINED; Genomic_DNA.
EMBL; U57783; AAC53289.1; JOINED; Genomic_DNA.
EMBL; U57785; AAC53290.1; -; Genomic_DNA.
EMBL; U57781; AAC53290.1; JOINED; Genomic_DNA.
EMBL; U57782; AAC53290.1; JOINED; Genomic_DNA.
EMBL; U57783; AAC53290.1; JOINED; Genomic_DNA.
EMBL; U57784; AAC53290.1; JOINED; Genomic_DNA.
EMBL; U57785; AAC53291.1; -; Genomic_DNA.
EMBL; U57781; AAC53291.1; JOINED; Genomic_DNA.
EMBL; U57782; AAC53291.1; JOINED; Genomic_DNA.
EMBL; U57783; AAC53291.1; JOINED; Genomic_DNA.
EMBL; BC015263; AAH15263.1; -; mRNA.
CCDS; CCDS35947.1; -. [P41438-1]
PIR; A53092; A53092.
RefSeq; NP_001186200.1; NM_001199271.1. [P41438-1]
RefSeq; NP_112473.1; NM_031196.3. [P41438-1]
RefSeq; XP_006513477.1; XM_006513414.3. [P41438-1]
RefSeq; XP_006513478.1; XM_006513415.3. [P41438-1]
RefSeq; XP_006513479.1; XM_006513416.2. [P41438-1]
RefSeq; XP_006513480.1; XM_006513417.2. [P41438-1]
RefSeq; XP_006513481.1; XM_006513418.3. [P41438-3]
UniGene; Mm.265060; -.
ProteinModelPortal; P41438; -.
STRING; 10090.ENSMUSP00000101050; -.
iPTMnet; P41438; -.
PhosphoSitePlus; P41438; -.
PaxDb; P41438; -.
PeptideAtlas; P41438; -.
PRIDE; P41438; -.
Ensembl; ENSMUST00000105410; ENSMUSP00000101050; ENSMUSG00000001436. [P41438-1]
Ensembl; ENSMUST00000144234; ENSMUSP00000116784; ENSMUSG00000001436. [P41438-1]
GeneID; 20509; -.
KEGG; mmu:20509; -.
UCSC; uc007fvc.2; mouse. [P41438-1]
CTD; 6573; -.
MGI; MGI:103182; Slc19a1.
eggNOG; KOG3810; Eukaryota.
eggNOG; ENOG410XT34; LUCA.
GeneTree; ENSGT00510000046382; -.
HOGENOM; HOG000001583; -.
HOVERGEN; HBG054198; -.
InParanoid; P41438; -.
KO; K14609; -.
OrthoDB; EOG091G0BSJ; -.
PhylomeDB; P41438; -.
TreeFam; TF313684; -.
Reactome; R-MMU-196757; Metabolism of folate and pterines.
PRO; PR:P41438; -.
Proteomes; UP000000589; Chromosome 10.
Bgee; ENSMUSG00000001436; -.
ExpressionAtlas; P41438; baseline and differential.
Genevisible; P41438; MM.
GO; GO:0016324; C:apical plasma membrane; IDA:BHF-UCL.
GO; GO:0016323; C:basolateral plasma membrane; ISO:MGI.
GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
GO; GO:0005542; F:folic acid binding; IBA:GO_Central.
GO; GO:0008517; F:folic acid transporter activity; IBA:GO_Central.
GO; GO:0015350; F:methotrexate transporter activity; IBA:GO_Central.
GO; GO:0008518; F:reduced folate carrier activity; ISO:MGI.
GO; GO:0015884; P:folic acid transport; IBA:GO_Central.
GO; GO:0051958; P:methotrexate transport; IBA:GO_Central.
GO; GO:0098838; P:reduced folate transmembrane transport; ISO:MGI.
CDD; cd06174; MFS; 1.
InterPro; IPR002666; Folate_carrier.
InterPro; IPR020846; MFS_dom.
InterPro; IPR028339; RFC.
PANTHER; PTHR10686; PTHR10686; 1.
PANTHER; PTHR10686:SF24; PTHR10686:SF24; 1.
Pfam; PF01770; Folate_carrier; 1.
PIRSF; PIRSF028739; Folate_carrier; 1.
PIRSF; PIRSF500793; Folate_transporter_1; 1.
SUPFAM; SSF103473; SSF103473; 1.
TIGRFAMs; TIGR00806; rfc; 1.
1: Evidence at protein level;
Acetylation; Alternative splicing; Complete proteome; Folate-binding;
Glycoprotein; Membrane; Phosphoprotein; Reference proteome;
Transmembrane; Transmembrane helix; Transport.
CHAIN 1 512 Folate transporter 1.
/FTId=PRO_0000178661.
TRANSMEM 28 48 Helical. {ECO:0000255}.
TRANSMEM 65 85 Helical. {ECO:0000255}.
TRANSMEM 92 112 Helical. {ECO:0000255}.
TRANSMEM 122 142 Helical. {ECO:0000255}.
TRANSMEM 156 176 Helical. {ECO:0000255}.
TRANSMEM 181 201 Helical. {ECO:0000255}.
TRANSMEM 272 292 Helical. {ECO:0000255}.
TRANSMEM 305 325 Helical. {ECO:0000255}.
TRANSMEM 330 350 Helical. {ECO:0000255}.
TRANSMEM 355 375 Helical. {ECO:0000255}.
TRANSMEM 391 411 Helical. {ECO:0000255}.
TRANSMEM 427 447 Helical. {ECO:0000255}.
MOD_RES 1 1 N-acetylmethionine.
{ECO:0000250|UniProtKB:P41440}.
MOD_RES 467 467 Phosphoserine.
{ECO:0000244|PubMed:19144319}.
MOD_RES 472 472 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 477 477 Phosphoserine.
{ECO:0000244|PubMed:19144319,
ECO:0000244|PubMed:21183079}.
CARBOHYD 211 211 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
VAR_SEQ 273 313 WWVFNSSGYYLITYYVHVLWRSTDSSLSYNGAVDAASTLLS
-> C (in isoform 2).
{ECO:0000303|PubMed:9161403}.
/FTId=VSP_006125.
VAR_SEQ 378 379 FQ -> PS (in isoform 3).
{ECO:0000303|PubMed:9161403}.
/FTId=VSP_006126.
VAR_SEQ 380 512 Missing (in isoform 3).
{ECO:0000303|PubMed:9161403}.
/FTId=VSP_006127.
SEQUENCE 512 AA; 58150 MW; 640CB7AD2624BF67 CRC64;
MVPTGQVAEK QAYEEPRQDH ELKSWRCLVF YLCFFGFMAQ LRPGESFITP FLLERKFTKE
QVTNEIIPML PYSHLAVLVP VFLLTDYLRY KPVLVLQCLS FVCVWLLLLL GTSVVHMQLM
EVFYSVTMAA RIAYSSYIFS LVHPSRYQRM ASYSRAAVLL GVFISSVLGQ ALVTVGHIST
YTLNCVSLGF ILFSLVLSLF LKRPKRSLFF NRSTLARGAL PCELDQMHPG PDRPETRKLD
RMLGTCRDSF LVRMLSELVE NARQPQLRLW CLWWVFNSSG YYLITYYVHV LWRSTDSSLS
YNGAVDAAST LLSAITSFSA GFLSIRWTLW SKLVIAGVIA IQASLVFCMF QIRDIWVCYV
TFVLFRGAYQ FLVPIATFQI ASSLSKELCA LVFGINTFLA TALKTCITLV VSDKRGLGLQ
VRDQFRIYFI YFLMLSITCF AWAGLDGLRY CQRGRHQPLA QAQELRSPLE TSVQAISLQD
GDLRGPQPSA PQLLSEDGME DDRGDLRVEA KA


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