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Folate-biopterin transporter

 FBT_SYNY3               Reviewed;         494 AA.
Q55721;
31-OCT-2012, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
25-OCT-2017, entry version 91.
RecName: Full=Folate-biopterin transporter;
OrderedLocusNames=slr0642;
Synechocystis sp. (strain PCC 6803 / Kazusa).
Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae;
Synechocystis.
NCBI_TaxID=1111708;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=PCC 6803 / Kazusa;
PubMed=8905231; DOI=10.1093/dnares/3.3.109;
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T.,
Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S.,
Shimpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M.,
Tabata S.;
"Sequence analysis of the genome of the unicellular cyanobacterium
Synechocystis sp. strain PCC6803. II. Sequence determination of the
entire genome and assignment of potential protein-coding regions.";
DNA Res. 3:109-136(1996).
[2]
FUNCTION.
PubMed=16162503; DOI=10.1074/jbc.M507432200;
Klaus S.M., Kunji E.R., Bozzo G.G., Noiriel A., de la Garza R.D.,
Basset G.J., Ravanel S., Rebeille F., Gregory J.F. III, Hanson A.D.;
"Higher plant plastids and cyanobacteria have folate carriers related
to those of trypanosomatids.";
J. Biol. Chem. 280:38457-38463(2005).
[3]
MUTAGENESIS OF ARG-53; LYS-61; ASP-62; TRP-82; LYS-85; ASP-93;
ASP-145; ASP-149; ARG-155; PHE-252; THR-259; GLU-263; PHE-267;
ARG-309; ARG-335; ASP-348; GLN-357; ARG-369; CYS-371; PHE-380; MET-384
AND ASN-388, AND FUNCTION.
PubMed=19923217; DOI=10.1074/jbc.M109.063651;
Eudes A., Kunji E.R., Noiriel A., Klaus S.M., Vickers T.J.,
Beverley S.M., Gregory J.F. III, Hanson A.D.;
"Identification of transport-critical residues in a folate transporter
from the folate-biopterin transporter (FBT) family.";
J. Biol. Chem. 285:2867-2875(2010).
-!- FUNCTION: Mediates folate monoglutamate transport involved in
tetrahydrofolate biosynthesis. It also mediates transport of
antifolates, such as methotrexate and aminopterin.
{ECO:0000269|PubMed:16162503, ECO:0000269|PubMed:19923217}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass
membrane protein {ECO:0000305}.
-!- SIMILARITY: Belongs to the major facilitator superfamily. Folate-
biopterin transporter (TC 2.A.71) family. {ECO:0000305}.
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EMBL; BA000022; BAA10362.1; -; Genomic_DNA.
PIR; S76516; S76516.
ProteinModelPortal; Q55721; -.
IntAct; Q55721; 9.
STRING; 1148.SYNGTS_2399; -.
TCDB; 2.A.71.2.3; the folate-biopterin transporter (fbt) family.
EnsemblBacteria; BAA10362; BAA10362; BAA10362.
KEGG; syn:slr0642; -.
HOGENOM; HOG000265013; -.
InParanoid; Q55721; -.
OMA; WFSLGDS; -.
PhylomeDB; Q55721; -.
Proteomes; UP000001425; Chromosome.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0015231; F:5-formyltetrahydrofolate transporter activity; IDA:UniProtKB.
GO; GO:0008517; F:folic acid transporter activity; IDA:UniProtKB.
GO; GO:0015350; F:methotrexate transporter activity; IDA:UniProtKB.
GO; GO:0015885; P:5-formyltetrahydrofolate transport; IDA:UniProtKB.
GO; GO:0015884; P:folic acid transport; IDA:UniProtKB.
GO; GO:0051958; P:methotrexate transport; IDA:UniProtKB.
CDD; cd06174; MFS; 1.
InterPro; IPR004324; FBT.
InterPro; IPR020846; MFS_dom.
InterPro; IPR036259; MFS_trans_sf.
PANTHER; PTHR31585; PTHR31585; 1.
Pfam; PF03092; BT1; 2.
SUPFAM; SSF103473; SSF103473; 1.
TIGRFAMs; TIGR00788; fbt; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Membrane; Reference proteome;
Transmembrane; Transmembrane helix; Transport.
CHAIN 1 494 Folate-biopterin transporter.
/FTId=PRO_0000420112.
TRANSMEM 31 51 Helical. {ECO:0000255}.
TRANSMEM 64 84 Helical. {ECO:0000255}.
TRANSMEM 104 124 Helical. {ECO:0000255}.
TRANSMEM 133 153 Helical. {ECO:0000255}.
TRANSMEM 170 190 Helical. {ECO:0000255}.
TRANSMEM 197 217 Helical. {ECO:0000255}.
TRANSMEM 246 266 Helical. {ECO:0000255}.
TRANSMEM 284 303 Helical. {ECO:0000255}.
TRANSMEM 310 330 Helical. {ECO:0000255}.
TRANSMEM 346 366 Helical. {ECO:0000255}.
TRANSMEM 375 395 Helical. {ECO:0000255}.
TRANSMEM 415 435 Helical. {ECO:0000255}.
MUTAGEN 53 53 R->C: Affects 5-formyltetrahydrofolate
transporter activity.
{ECO:0000269|PubMed:19923217}.
MUTAGEN 61 61 K->C: Affects 5-formyltetrahydrofolate
transporter activity.
{ECO:0000269|PubMed:19923217}.
MUTAGEN 62 62 D->C: Affects 5-formyltetrahydrofolate
transporter activity.
{ECO:0000269|PubMed:19923217}.
MUTAGEN 82 82 W->C: Affects 5-formyltetrahydrofolate
transporter activity.
{ECO:0000269|PubMed:19923217}.
MUTAGEN 85 85 K->C: Affects 5-formyltetrahydrofolate
transporter activity.
{ECO:0000269|PubMed:19923217}.
MUTAGEN 93 93 D->C: Affects 5-formyltetrahydrofolate
transporter activity.
{ECO:0000269|PubMed:19923217}.
MUTAGEN 145 145 D->C: Affects 5-formyltetrahydrofolate
transporter activity.
{ECO:0000269|PubMed:19923217}.
MUTAGEN 149 149 D->C: Affects 5-formyltetrahydrofolate
transporter activity.
{ECO:0000269|PubMed:19923217}.
MUTAGEN 155 155 R->C: Affects 5-formyltetrahydrofolate
transporter activity.
{ECO:0000269|PubMed:19923217}.
MUTAGEN 252 252 F->C: Affects 5-formyltetrahydrofolate
transporter activity.
{ECO:0000269|PubMed:19923217}.
MUTAGEN 259 259 T->C: Affects 5-formyltetrahydrofolate
transporter activity.
{ECO:0000269|PubMed:19923217}.
MUTAGEN 263 263 E->C: Affects 5-formyltetrahydrofolate
transporter activity.
{ECO:0000269|PubMed:19923217}.
MUTAGEN 267 267 F->C: Affects 5-formyltetrahydrofolate
transporter activity.
{ECO:0000269|PubMed:19923217}.
MUTAGEN 309 309 R->C: Affects 5-formyltetrahydrofolate
transporter activity.
{ECO:0000269|PubMed:19923217}.
MUTAGEN 335 335 R->C: Affects 5-formyltetrahydrofolate
transporter activity.
{ECO:0000269|PubMed:19923217}.
MUTAGEN 348 348 D->C: Affects 5-formyltetrahydrofolate
transporter activity.
{ECO:0000269|PubMed:19923217}.
MUTAGEN 357 357 Q->C: Affects 5-formyltetrahydrofolate
transporter activity.
{ECO:0000269|PubMed:19923217}.
MUTAGEN 369 369 R->C: Affects 5-formyltetrahydrofolate
transporter activity.
{ECO:0000269|PubMed:19923217}.
MUTAGEN 371 371 C->A: Affects 5-formyltetrahydrofolate
transporter activity.
{ECO:0000269|PubMed:19923217}.
MUTAGEN 380 380 F->C: Affects 5-formyltetrahydrofolate
transporter activity.
{ECO:0000269|PubMed:19923217}.
MUTAGEN 384 384 M->C: Affects 5-formyltetrahydrofolate
transporter activity.
{ECO:0000269|PubMed:19923217}.
MUTAGEN 388 388 N->C: Affects 5-formyltetrahydrofolate
transporter activity.
{ECO:0000269|PubMed:19923217}.
SEQUENCE 494 AA; 53586 MW; 101BAB039B77E66A CRC64;
MLVAMSMTPI AILFSTPLKR FLREKVLLGN APSWELLAIL SIYFVQGVLG LSRLAVSFFL
KDELGLSPAA MGALIGLGAA PWILKPVLGL MSDTVPLFGY RRRSYLWLSG LMGSAGWLLF
AAWVSSGTQA GLVLLFTSLS VAIGDVIVDS LVVERAQRES LAQVGSLQSL TWGAAAVGGI
ITAYASGALL EWFSTRTVFA ITAIFPLLTV GAAFLISEVS TAEEEEKPQP KAQIKLVWQA
VRQKTILLPT LFIFFWQATP SAESAFFYFT TNELGFEPKF LGRVRLVTSV AGLIGVGLYQ
RFLKTLPFRV IMGWSTVISS LLGLTTLILI THANRAMGID DHWFSLGDSI ILTVTGQIAF
MPVLVLAARL CPPGIEATLF ALLMSVMNLA GVLSFEVGSL LTHWLGVTET QFDNLALLVI
ITNLSTLLPL PFLGLLPAGD PQVKDKTEKE DNPDDPGDRL VLPPAEVFEH HTVGSLSDQN
FLPEFFPEKS SSRP


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