Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Folate-biopterin transporter 1, chloroplastic

 FBT1_ARATH              Reviewed;         560 AA.
Q9SKZ5;
31-OCT-2012, integrated into UniProtKB/Swiss-Prot.
01-JUN-2002, sequence version 2.
07-JUN-2017, entry version 96.
RecName: Full=Folate-biopterin transporter 1, chloroplastic;
Flags: Precursor;
OrderedLocusNames=At2g32040; ORFNames=F22D22.21;
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=10617197; DOI=10.1038/45471;
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L.,
Moffat K.S., Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L.,
Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H.,
Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D.,
Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M.,
Venter J.C.;
"Sequence and analysis of chromosome 2 of the plant Arabidopsis
thaliana.";
Nature 402:761-768(1999).
[2]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
The Arabidopsis Information Portal (Araport);
Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
PubMed=14593172; DOI=10.1126/science.1088305;
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis
genome.";
Science 302:842-846(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
Feldmann K.A.;
"Full-length cDNA from Arabidopsis thaliana.";
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
[5]
GENE FAMILY, FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, AND
TISSUE SPECIFICITY.
PubMed=16162503; DOI=10.1074/jbc.M507432200;
Klaus S.M., Kunji E.R., Bozzo G.G., Noiriel A., de la Garza R.D.,
Basset G.J., Ravanel S., Rebeille F., Gregory J.F. III, Hanson A.D.;
"Higher plant plastids and cyanobacteria have folate carriers related
to those of trypanosomatids.";
J. Biol. Chem. 280:38457-38463(2005).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-67, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19376835; DOI=10.1104/pp.109.138677;
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
Grossmann J., Gruissem W., Baginsky S.;
"Large-scale Arabidopsis phosphoproteome profiling reveals novel
chloroplast kinase substrates and phosphorylation networks.";
Plant Physiol. 150:889-903(2009).
[7]
FUNCTION.
PubMed=19923217; DOI=10.1074/jbc.M109.063651;
Eudes A., Kunji E.R., Noiriel A., Klaus S.M., Vickers T.J.,
Beverley S.M., Gregory J.F. III, Hanson A.D.;
"Identification of transport-critical residues in a folate transporter
from the folate-biopterin transporter (FBT) family.";
J. Biol. Chem. 285:2867-2875(2010).
-!- FUNCTION: Mediates folate monoglutamate transport involved in
tetrahydrofolate biosynthesis. It also mediates transport of
antifolates, such as methotrexate and aminopterin.
{ECO:0000269|PubMed:16162503, ECO:0000269|PubMed:19923217}.
-!- SUBCELLULAR LOCATION: Plastid, chloroplast membrane
{ECO:0000269|PubMed:16162503}; Multi-pass membrane protein
{ECO:0000269|PubMed:16162503}. Plastid membrane {ECO:0000305};
Multi-pass membrane protein {ECO:0000305}. Note=Expressed in green
as well as in non-green plastids.
-!- TISSUE SPECIFICITY: Constitutively expressed at low level.
{ECO:0000269|PubMed:16162503}.
-!- DISRUPTION PHENOTYPE: No visible phenotype.
{ECO:0000269|PubMed:16162503}.
-!- SIMILARITY: Belongs to the major facilitator superfamily. Folate-
biopterin transporter (TC 2.A.71) family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AC006223; AAD15400.2; -; Genomic_DNA.
EMBL; CP002685; AEC08625.1; -; Genomic_DNA.
EMBL; AY081306; AAL91195.1; -; mRNA.
EMBL; BT003363; AAO29981.1; -; mRNA.
EMBL; AY085525; AAM62749.1; -; mRNA.
PIR; C84728; C84728.
RefSeq; NP_565734.1; NM_128764.4.
UniGene; At.38125; -.
ProteinModelPortal; Q9SKZ5; -.
BioGrid; 3111; 5.
STRING; 3702.AT2G32040.1; -.
TCDB; 2.A.71.2.2; the folate-biopterin transporter (fbt) family.
iPTMnet; Q9SKZ5; -.
PaxDb; Q9SKZ5; -.
EnsemblPlants; AT2G32040.1; AT2G32040.1; AT2G32040.
GeneID; 817764; -.
Gramene; AT2G32040.1; AT2G32040.1; AT2G32040.
KEGG; ath:AT2G32040; -.
Araport; AT2G32040; -.
TAIR; locus:2045462; AT2G32040.
eggNOG; ENOG410IISQ; Eukaryota.
eggNOG; ENOG410XTHR; LUCA.
HOGENOM; HOG000265013; -.
InParanoid; Q9SKZ5; -.
OMA; WFSLGDS; -.
OrthoDB; EOG09360AQX; -.
PhylomeDB; Q9SKZ5; -.
PRO; PR:Q9SKZ5; -.
Proteomes; UP000006548; Chromosome 2.
ExpressionAtlas; Q9SKZ5; baseline and differential.
Genevisible; Q9SKZ5; AT.
GO; GO:0009941; C:chloroplast envelope; IDA:TAIR.
GO; GO:0031969; C:chloroplast membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0015231; F:5-formyltetrahydrofolate transporter activity; IDA:TAIR.
GO; GO:0008517; F:folic acid transporter activity; IDA:TAIR.
GO; GO:0015350; F:methotrexate transporter activity; IDA:UniProtKB.
GO; GO:0051958; P:methotrexate transport; IDA:UniProtKB.
CDD; cd06174; MFS; 1.
InterPro; IPR004324; FBT.
InterPro; IPR020846; MFS_dom.
PANTHER; PTHR31585; PTHR31585; 1.
Pfam; PF03092; BT1; 1.
SUPFAM; SSF103473; SSF103473; 1.
TIGRFAMs; TIGR00788; fbt; 1.
1: Evidence at protein level;
Chloroplast; Complete proteome; Membrane; Phosphoprotein; Plastid;
Reference proteome; Transit peptide; Transmembrane;
Transmembrane helix; Transport.
TRANSIT 1 30 Chloroplast. {ECO:0000255}.
CHAIN 31 560 Folate-biopterin transporter 1,
chloroplastic.
/FTId=PRO_0000420113.
TRANSMEM 129 149 Helical. {ECO:0000255}.
TRANSMEM 162 182 Helical. {ECO:0000255}.
TRANSMEM 195 215 Helical. {ECO:0000255}.
TRANSMEM 219 239 Helical. {ECO:0000255}.
TRANSMEM 261 281 Helical. {ECO:0000255}.
TRANSMEM 288 308 Helical. {ECO:0000255}.
TRANSMEM 339 359 Helical. {ECO:0000255}.
TRANSMEM 390 410 Helical. {ECO:0000255}.
TRANSMEM 415 435 Helical. {ECO:0000255}.
TRANSMEM 450 470 Helical. {ECO:0000255}.
TRANSMEM 483 503 Helical. {ECO:0000255}.
TRANSMEM 521 541 Helical. {ECO:0000255}.
MOD_RES 67 67 Phosphoserine.
{ECO:0000244|PubMed:19376835}.
SEQUENCE 560 AA; 60707 MW; FE4DD6AFF6E97912 CRC64;
MASRSLFSIS ISPSQFTVLP SINNERRRLA IAARSHRLSR RKIRKRPPDR DMSSIVSIPE
LPRRRDSEES LLLDSRISVA EGDTSNTDVE GDRDTTSSIR TQPPPRKGRN LSSSRIKFYG
VELSPDNVAV AMVYFVQGVL GLARLAVSFY LKDDLHLDPA ETAVITGLSS LPWLVKPLYG
FISDSVPLFG YRRRSYLVLS GLLGAFSWSL MAGFVDSKYS AAFCILLGSL SVAFSDVVVD
SMVVERARGE SQSVSGSLQS LCWGSSAFGG IVSSYFSGSL VESYGVRFVF GVTALLPLIT
SAVAVLVNEQ RVVRPASGQK ENITLLSPGF LQTSKQNMIQ LWGAIKQPNV FLPTLFIFLW
QATPHSDSAM FYFTTNKLGF TPEFLGRVKL VTSIASLLGV GLYNGFLKTV PLRKIFLVTT
IFGTGLGMTQ VILVSGFNRQ LGISDEWFAI GDSLILTVLA QASFMPVLVL AARLCPEGME
ATLFATLMSI SNGGSVLGGL MGAGLTQAFG ITRDSFGNLS TLIILCNLSS LLPLPLLGLL
PRDSPDTLTK DDADVEMKSN


Related products :

Catalog number Product name Quantity
EIAAB36658 FLOT1,Folate transporter 1,FOLT,Homo sapiens,Human,IFC-1,Intestinal folate carrier 1,Placental folate transporter,Reduced folate carrier protein,RFC,RFC1,SLC19A1,Solute carrier family 19 member 1
EIAAB36657 Folate transporter 1,IFC-1,Intestinal folate carrier 1,Mouse,Mus musculus,Reduced folate carrier 1,RFC1,RFC-1,Slc19a1,Solute carrier family 19 member 1
RFC11-P Human Folate Transporter (RFC, reduced folate carrier) control_blocking peptide 1 100 ug
RFC11-A Anti-human Folate Transporter (RFC, reduced folate carrier) IgG # 1 (aff pure) 100 ug
RFC12-P Rat Folate Transporter (RFC, reduced folate carrier) control blocking peptide # 2 100 ug
RFC12-P Rat Folate Transporter (RFC, reduced folate carrier) control_blocking peptide 2 100 ug
RFC11-A Anti_human Folate Transporter (RFC, reduced folate carrier) IgG 1 (aff pure) 100 ug
RFC12-A Anti_Rat Folate Transporter (RFC, reduced folate carrier) IgG 2 (aff pure) 100 ug
RFC12-A Anti-Rat Folate Transporter (RFC, reduced folate carrier) IgG # 2 (aff pure) 100 ug
RFC12-A Anti-Rat Folate Transporter (RFC, reduced folate carrier) IgG _ 2 (aff pure) Species Reactivity: Rat 100 ug Product tipe: Antibodies
RFC12-P Rat Folate Transporter (RFC, reduced folate carrier) control_blocking peptide _ 2 Species Reactivity: Rat 100 ug Product tipe: Peptide
RFC11-P Human Folate Transporter (RFC, reduced folate carrier) control blocking peptide # 1 100 ug
EIAAB36659 Folate transporter 1,Rat,Rattus norvegicus,Reduced folate carrier 1,RFC1,RFC-1,Slc19a1,Solute carrier family 19 member 1
RFC11-A Anti-human Folate Transporter (RFC, reduced folate carrier) IgG _ 1 (aff pure) Species Reactivity: Human 100 ug Product tipe: Antibodies
RFC11-P Human Folate Transporter (RFC, reduced folate carrier) control_blocking peptide _ 1 Species Reactivity: Human 100 ug Product tipe: Peptide
EIAAB30131 Bos taurus,Bovine,HCP1,Heme carrier protein 1,PCFT,PCFT_HCP1,Proton-coupled folate transporter,Retinal pigment epithelium transporter,SLC46A1,Solute carrier family 46 member 1,TRPE
E1728h Rat ELISA Kit FOR Folate transporter 1 96T
E11007h Human Folate Transporter ELISA Kit 96T
CSB-EL021429RA Rat Folate transporter 1(SLC19A1) ELISA kit 96T
E1673h Human ELISA Kit FOR Folate transporter 1 96T
CSB-EL021429MO Mouse Folate transporter 1(SLC19A1) ELISA kit 96T
CSB-EL021429RA Rat Folate transporter 1(SLC19A1) ELISA kit SpeciesRat 96T
UB-E00535 Human Folate Transporter(FOLT)ELISA Kit 96T
201-12-3798 Human Folate Transporter(FOLT)ELISA Kit 96T
QY-E00535 Human Folate Transporter(FOLT)ELISA Kit 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur