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Follistatin-related protein 3 (Follistatin-like protein 3) (Follistatin-related gene protein)

 FSTL3_MOUSE             Reviewed;         256 AA.
Q9EQC7;
10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
01-MAR-2001, sequence version 1.
25-OCT-2017, entry version 122.
RecName: Full=Follistatin-related protein 3;
AltName: Full=Follistatin-like protein 3;
AltName: Full=Follistatin-related gene protein;
Flags: Precursor;
Name=Fstl3; Synonyms=Flrg;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH INHBA.
STRAIN=C57BL/6J;
PubMed=11010968; DOI=10.1074/jbc.M006114200;
Tsuchida K., Arai K.Y., Kuramoto Y., Yamakawa N., Hasegawa Y.,
Sugino H.;
"Identification and characterization of a novel follistatin-like
protein as a binding protein for the TGF-beta family.";
J. Biol. Chem. 275:40788-40796(2000).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Uchiyama Y., Ohsawa Y., Kametaka S.;
"Mouse follistatin-related protein FLRG (mouse PCTF35, PC12 cell
derived trophic factor 35).";
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=11459787; DOI=10.1210/endo.142.8.8319;
Tortoriello D.V., Sidis Y., Holtzman D.A., Holmes W.E., Schneyer A.L.;
"Human follistatin-related protein: a structural homologue of
follistatin with nuclear localization.";
Endocrinology 142:3426-3434(2001).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
TISSUE SPECIFICITY.
PubMed=17878677; DOI=10.2152/jmi.54.276;
Takehara-Kasamatsu Y., Tsuchida K., Nakatani M., Murakami T.,
Kurisaki A., Hashimoto O., Ohuchi H., Kurose H., Mori K., Kagami S.,
Noji S., Sugino H.;
"Characterization of follistatin-related gene as a negative regulatory
factor for activin family members during mouse heart development.";
J. Med. Invest. 54:276-288(2007).
-!- FUNCTION: The secreted form is a binding and antagonizing protein
for members of the TGF-beta family, such us activin, BMP2 and
MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced
cellular signaling; more effective on activin A than on activin B.
Involved in bone formation; inhibits osteoclast differentiation.
Involved in hematopoiesis; involved in differentiation of
hemopoietic progenitor cells, increases hematopoietic cell
adhesion to fibronectin and seems to contribute to the adhesion of
hematopoietic precursor cells to the bone marrow stroma. The
nuclear form is probably involved in transcriptional regulation
via interaction with MLLT10 (By similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with INHBA and INHBB. Interacts with FN1.
Interacts with ADAM12. Interacts with MLLT10; the interaction
enhances MLLT10 in vitro transcriptional activity and self-
association. Interacts with MSTN (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Nucleus
{ECO:0000250}.
-!- TISSUE SPECIFICITY: Abundantly expressed in heart, lung, kidney
and testis. Continuously expressed in embryonic heart.
{ECO:0000269|PubMed:17878677}.
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EMBL; AF276238; AAG47666.1; -; mRNA.
EMBL; AB024429; BAB32663.1; -; mRNA.
EMBL; AF310616; AAG53666.1; -; mRNA.
EMBL; BC061052; AAH61052.1; -; mRNA.
CCDS; CCDS23990.1; -.
RefSeq; NP_113557.1; NM_031380.2.
UniGene; Mm.251710; -.
ProteinModelPortal; Q9EQC7; -.
SMR; Q9EQC7; -.
STRING; 10090.ENSMUSP00000020575; -.
MEROPS; I01.968; -.
PhosphoSitePlus; Q9EQC7; -.
PaxDb; Q9EQC7; -.
PRIDE; Q9EQC7; -.
Ensembl; ENSMUST00000020575; ENSMUSP00000020575; ENSMUSG00000020325.
GeneID; 83554; -.
KEGG; mmu:83554; -.
UCSC; uc007fzs.2; mouse.
CTD; 10272; -.
MGI; MGI:1890391; Fstl3.
eggNOG; KOG3649; Eukaryota.
eggNOG; ENOG410YC3T; LUCA.
GeneTree; ENSGT00440000033501; -.
HOGENOM; HOG000261649; -.
HOVERGEN; HBG051666; -.
InParanoid; Q9EQC7; -.
OMA; HCLPCKD; -.
OrthoDB; EOG091G09I0; -.
PhylomeDB; Q9EQC7; -.
TreeFam; TF106409; -.
Reactome; R-MMU-2473224; Antagonism of Activin by Follistatin.
Reactome; R-MMU-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
Reactome; R-MMU-8957275; Post-translational protein phosphorylation.
PRO; PR:Q9EQC7; -.
Proteomes; UP000000589; Chromosome 10.
Bgee; ENSMUSG00000020325; -.
CleanEx; MM_FSTL3; -.
ExpressionAtlas; Q9EQC7; baseline and differential.
Genevisible; Q9EQC7; MM.
GO; GO:0005615; C:extracellular space; IDA:BHF-UCL.
GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO; GO:0044306; C:neuron projection terminus; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; ISO:MGI.
GO; GO:0005634; C:nucleus; ISO:MGI.
GO; GO:0030141; C:secretory granule; IEA:Ensembl.
GO; GO:0048185; F:activin binding; IDA:MGI.
GO; GO:0001968; F:fibronectin binding; ISO:MGI.
GO; GO:0030325; P:adrenal gland development; IEA:Ensembl.
GO; GO:0071248; P:cellular response to metal ion; IEA:Ensembl.
GO; GO:0002244; P:hematopoietic progenitor cell differentiation; ISO:MGI.
GO; GO:0001822; P:kidney development; IEA:Ensembl.
GO; GO:0030324; P:lung development; IEA:Ensembl.
GO; GO:0008584; P:male gonad development; IEA:Ensembl.
GO; GO:0032926; P:negative regulation of activin receptor signaling pathway; ISO:MGI.
GO; GO:0030514; P:negative regulation of BMP signaling pathway; IDA:MGI.
GO; GO:0045671; P:negative regulation of osteoclast differentiation; ISO:MGI.
GO; GO:0090101; P:negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; ISO:MGI.
GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
GO; GO:0022409; P:positive regulation of cell-cell adhesion; ISO:MGI.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISO:MGI.
GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; ISO:MGI.
GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
InterPro; IPR003645; Fol_N.
InterPro; IPR015369; Follistatin/Osteonectin_EGF.
InterPro; IPR002350; Kazal_dom.
InterPro; IPR036058; Kazal_dom_sf.
InterPro; IPR017878; TB_dom.
InterPro; IPR036773; TB_dom_sf.
Pfam; PF09289; FOLN; 1.
Pfam; PF07648; Kazal_2; 2.
SMART; SM00274; FOLN; 2.
SMART; SM00280; KAZAL; 2.
SUPFAM; SSF100895; SSF100895; 2.
SUPFAM; SSF57581; SSF57581; 1.
PROSITE; PS51465; KAZAL_2; 2.
PROSITE; PS51364; TB; 1.
1: Evidence at protein level;
Complete proteome; Disulfide bond; Glycoprotein; Nucleus;
Osteogenesis; Reference proteome; Repeat; Secreted; Signal;
Transcription; Transcription regulation.
SIGNAL 1 23 {ECO:0000255}.
CHAIN 24 256 Follistatin-related protein 3.
/FTId=PRO_0000010116.
DOMAIN 34 105 TB. {ECO:0000255|PROSITE-
ProRule:PRU00697}.
DOMAIN 97 117 Follistatin-like 1.
DOMAIN 111 167 Kazal-like 1. {ECO:0000255|PROSITE-
ProRule:PRU00798}.
DOMAIN 168 191 Follistatin-like 2.
DOMAIN 187 243 Kazal-like 2. {ECO:0000255|PROSITE-
ProRule:PRU00798}.
CARBOHYD 71 71 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 213 213 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 36 59 {ECO:0000255|PROSITE-ProRule:PRU00697}.
DISULFID 46 90 {ECO:0000255|PROSITE-ProRule:PRU00697}.
DISULFID 60 93 {ECO:0000255|PROSITE-ProRule:PRU00697}.
DISULFID 97 108 {ECO:0000255|PROSITE-ProRule:PRU00798}.
DISULFID 102 117 {ECO:0000255|PROSITE-ProRule:PRU00798}.
DISULFID 119 151 {ECO:0000255|PROSITE-ProRule:PRU00798}.
DISULFID 123 144 {ECO:0000255|PROSITE-ProRule:PRU00798}.
DISULFID 133 165 {ECO:0000255|PROSITE-ProRule:PRU00798}.
DISULFID 193 227 {ECO:0000255|PROSITE-ProRule:PRU00798}.
DISULFID 198 220 {ECO:0000255|PROSITE-ProRule:PRU00798}.
DISULFID 209 241 {ECO:0000255|PROSITE-ProRule:PRU00798}.
SEQUENCE 256 AA; 27271 MW; 5854A4B8C1C02EE9 CRC64;
MRSGALWPLL WGALVWTVGS VGAVMGSEDS VPGGVCWLQQ GREATCSLVL KTRVSREECC
ASGNINTAWS NFTHPGNKIS LLGFLGLVHC LPCKDSCDGV ECGPGKACRM LGGRPHCECV
PNCEGLPAGF QVCGSDGATY RDECELRTAR CRGHPDLRVM YRGRCQKSCA QVVCPRPQSC
LVDQTGSAHC VVCRAAPCPV PSNPGQELCG NNNVTYISSC HLRQATCFLG RSIGVRHPGI
CTGGPKVPAE EEENFV


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