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Forkhead box protein A2-A (FoxA2-A) (FoxA2a) (Fork head domain-related protein 3) (xFD-3) (Hepatocyte nuclear factor 3-beta homolog A) (HNF-3-beta-A) (HNF3-beta homolog A) (HNF3-beta-A) (xHNF3-beta-A) (xbeta-1)

 FXA2A_XENLA             Reviewed;         434 AA.
Q91765;
05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
10-MAY-2017, entry version 93.
RecName: Full=Forkhead box protein A2-A;
Short=FoxA2-A;
Short=FoxA2a;
AltName: Full=Fork head domain-related protein 3;
Short=xFD-3;
AltName: Full=Hepatocyte nuclear factor 3-beta homolog A;
Short=HNF-3-beta-A;
Short=HNF3-beta homolog A;
Short=HNF3-beta-A;
Short=xHNF3-beta-A;
Short=xbeta-1;
Name=foxa2-a;
Xenopus laevis (African clawed frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
Xenopus.
NCBI_TaxID=8355;
[1] {ECO:0000305, ECO:0000312|EMBL:AAA20679.1}
NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, AND
DEVELOPMENTAL STAGE.
TISSUE=Gastrula {ECO:0000269|PubMed:8155584};
PubMed=8155584; DOI=10.1016/0925-4773(93)90060-B;
Ruiz i Altaba A., Prezioso V.R., Darnell J.E., Jessell T.M.;
"Sequential expression of HNF-3beta and HNF-3alpha by embryonic
organizing centers: the dorsal lip/node, notochord and floor plate.";
Mech. Dev. 44:91-108(1993).
[2] {ECO:0000305}
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL
STAGE.
TISSUE=Gastrula {ECO:0000269|PubMed:8735935};
PubMed=8735935;
Lef J., Dege P., Scheucher M., Forsbach-Birk V., Clement J.H.,
Knoechel W.;
"A fork head related multigene family is transcribed in Xenopus laevis
embryos.";
Int. J. Dev. Biol. 40:245-253(1996).
[3] {ECO:0000305}
NUCLEOTIDE SEQUENCE [MRNA] OF 140-250.
TISSUE=Gastrula {ECO:0000269|PubMed:1358174};
PubMed=1358174; DOI=10.1016/0925-4773(92)90007-7;
Knoechel S., Lef J., Clement J.H., Klocke B., Hille S., Koester M.,
Knoechel W.;
"Activin A induced expression of a fork head related gene in posterior
chordamesoderm (notochord) of Xenopus laevis embryos.";
Mech. Dev. 38:157-165(1992).
[4] {ECO:0000305}
DNA-BINDING.
PubMed=7739038; DOI=10.1016/S0022-2836(95)80047-6;
Kaufmann E., Mueller D., Knoechel W.;
"DNA recognition site analysis of Xenopus winged helix proteins.";
J. Mol. Biol. 248:239-254(1995).
[5] {ECO:0000305}
FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND MUTAGENESIS OF
ASN-195; HIS-199 AND ARG-241.
PubMed=14697355; DOI=10.1016/j.ydbio.2003.09.017;
Suri C., Haremaki T., Weinstein D.C.;
"Inhibition of mesodermal fate by Xenopus HNF3beta/FoxA2.";
Dev. Biol. 265:90-104(2004).
[6] {ECO:0000305}
REVIEW.
PubMed=15656969; DOI=10.1016/j.gene.2004.09.037;
Pohl B.S., Knoechel W.;
"Of fox and frogs: fox (fork head/winged helix) transcription factors
in Xenopus development.";
Gene 344:21-32(2005).
-!- FUNCTION: Acts as a transcriptional activator during early
development, limiting the extent of mesoderm formation in the
gastrula. Binds to DNA via the target sequence 5'-GT[AC]AACA-3',
with 5'-GTAAACA-3' being the preferred binding site.
{ECO:0000269|PubMed:14697355}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
-!- TISSUE SPECIFICITY: At gastrula stage, expressed in both the
anterior and posterior endoderm, with endodermal expression
persisting into early tailbud stages. Expression is absent in
gastrula stage ectoderm. During tailbud stages, expressed in the
pharyngeal region, the neural floor plate, the midbrain, hindbrain
and in cranial neural crest cells. Expressed in the foregut of
hatching larvae. In tadpoles, expressed in the pharyngeal pouches
and in other anterior endodermal regions. Within the tadpole
nervous system, expressed in the neural floor plate, at high
levels in the ventral midbrain and hindbrain, and at lower levels
in the spinal cord. Expressed in the adult lung and brain.
{ECO:0000269|PubMed:14697355, ECO:0000269|PubMed:8155584,
ECO:0000269|PubMed:8735935}.
-!- DEVELOPMENTAL STAGE: First detected in early gastrula stage
embryos. Abundant at the neurula stage, becoming less abundant at
later stages. {ECO:0000269|PubMed:14697355,
ECO:0000269|PubMed:8155584, ECO:0000269|PubMed:8735935}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; L25637; AAA20679.1; -; Genomic_DNA.
PIR; I51436; I51436.
RefSeq; NP_001165629.1; NM_001172158.1.
UniGene; Xl.40286; -.
ProteinModelPortal; Q91765; -.
SMR; Q91765; -.
ChEMBL; CHEMBL3350224; -.
GeneID; 100127318; -.
KEGG; xla:100127318; -.
CTD; 100127318; -.
Xenbase; XB-GENE-865381; foxa2.
HOVERGEN; HBG006621; -.
KO; K08035; -.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0019904; F:protein domain specific binding; IEA:InterPro.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
GO; GO:0008134; F:transcription factor binding; IEA:InterPro.
GO; GO:0001707; P:mesoderm formation; IMP:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
Gene3D; 1.10.10.10; -; 1.
InterPro; IPR013638; Fork-head_N.
InterPro; IPR001766; Fork_head_dom.
InterPro; IPR018533; Forkhead_box_C.
InterPro; IPR018122; TF_fork_head_CS_1.
InterPro; IPR030456; TF_fork_head_CS_2.
InterPro; IPR011991; WHTH_DNA-bd_dom.
Pfam; PF00250; Forkhead; 1.
Pfam; PF08430; Forkhead_N; 1.
Pfam; PF09354; HNF_C; 1.
PRINTS; PR00053; FORKHEAD.
SMART; SM00339; FH; 1.
SUPFAM; SSF46785; SSF46785; 1.
PROSITE; PS00657; FORK_HEAD_1; 1.
PROSITE; PS00658; FORK_HEAD_2; 1.
PROSITE; PS50039; FORK_HEAD_3; 1.
1: Evidence at protein level;
Activator; Developmental protein; DNA-binding; Nucleus; Transcription;
Transcription regulation.
CHAIN 1 434 Forkhead box protein A2-A.
/FTId=PRO_0000248856.
DNA_BIND 149 243 Fork-head. {ECO:0000255|PROSITE-
ProRule:PRU00089}.
COMPBIAS 31 111 Met-rich. {ECO:0000255}.
COMPBIAS 262 332 Ser-rich. {ECO:0000255}.
COMPBIAS 322 375 His-rich. {ECO:0000255}.
MUTAGEN 195 195 N->D: Abolishes DNA-binding activity and
reduces ability to inhibit mesoderm
formation; when associated with C-199 and
E-241. {ECO:0000269|PubMed:14697355}.
MUTAGEN 199 199 H->C: Abolishes DNA-binding activity and
reduces ability to inhibit mesoderm
formation; when associated with D-195 and
E-241. {ECO:0000269|PubMed:14697355}.
MUTAGEN 241 241 R->E: Abolishes DNA-binding activity and
reduces ability to inhibit mesoderm
formation; when associated with D-195 and
C-199. {ECO:0000269|PubMed:14697355}.
CONFLICT 50 50 R -> S (in Ref. 2; no nucleotide entry).
{ECO:0000305}.
CONFLICT 102 102 I -> S (in Ref. 2; no nucleotide entry).
{ECO:0000305}.
CONFLICT 311 311 K -> E (in Ref. 2; no nucleotide entry).
{ECO:0000305}.
SEQUENCE 434 AA; 47986 MW; B6C58F40F2D3D705 CRC64;
MLGAVKMEGH EATDWSSYYG EAEAYSSVGN MNAGLSMNPM NTYMSMSAMR TSANMTASSM
NMSYVNTGMS PSLTGMSPGT GAMTGMGTGV PSMASHLSPS MIPMSAQTTA MNALAPYTNI
NSMSPIYGQS NINRSRDPKT YRRSYTHAKP PYSYISLITM AIQQSPNKML TLSEIYQWIM
DLFPFYRQNQ QRWQNSIRHS LSFNDCFLKV PRSPDKPGKG SFWTLHPDSG NMFENGCYLR
RQKRFKCEKK PSLREGGGKK LSEGASSVGS AANSSSESSV GNESPHSSSS PCQEQKRSLV
DMKSSQGLSP KHATSPASQA QHLLSQHHSV LSHEAQSHLK PEHHYSFNHP FSINNLMSSE
QQHHHHHHHN HHHHHKMDLK AYEQVMHYSS YGSPMAGSLA MSTVTNKSGL ESSPITSDTS
YYQGGYSRPI MNSS


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