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Forkhead box protein D1 (Brain factor 2) (BF-2) (Forkhead-related protein FKHL8) (Forkhead-related transcription factor 4) (FREAC-4) (HFH-BF-2)

 FOXD1_MOUSE             Reviewed;         456 AA.
Q61345; Q3UQW8;
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
27-JUL-2011, sequence version 2.
25-OCT-2017, entry version 138.
RecName: Full=Forkhead box protein D1;
AltName: Full=Brain factor 2;
Short=BF-2;
AltName: Full=Forkhead-related protein FKHL8;
AltName: Full=Forkhead-related transcription factor 4;
Short=FREAC-4;
AltName: Full=HFH-BF-2;
Name=Foxd1; Synonyms=Fkhl8, Freac4, Hfhbf2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=BALB/cJ; TISSUE=Embryo;
PubMed=7815060; DOI=10.1002/neu.480251010;
Hatini V., Tao W., Lai E.;
"Expression of winged helix genes, BF-1 and BF-2, define adjacent
domains within the developing forebrain and retina.";
J. Neurobiol. 25:1293-1309(1994).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Eye, and Head;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
FUNCTION.
PubMed=9811586;
Mariani F.V., Harland R.M.;
"XBF-2 is a transcriptional repressor that converts ectoderm into
neural tissue.";
Development 125:5019-5031(1998).
[4]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=15509772; DOI=10.1242/dev.01431;
Herrera E., Marcus R., Li S., Williams S.E., Erskine L., Lai E.,
Mason C.;
"Foxd1 is required for proper formation of the optic chiasm.";
Development 131:5727-5739(2004).
[5]
FUNCTION.
PubMed=15634693; DOI=10.1242/dev.01604;
Levinson R.S., Batourina E., Choi C., Vorontchikhina M.,
Kitajewski J., Mendelsohn C.L.;
"Foxd1-dependent signals control cellularity in the renal capsule, a
structure required for normal renal development.";
Development 132:529-539(2005).
-!- FUNCTION: Transcription factor involved in regulation of gene
expression in a variety of processes including formation of
positional identity in the developing retina, regionalization of
the optic chiasm, morphogenesis of the kidney, and neuralization
of ectodermal cells (PubMed:15509772, PubMed:15634693,
PubMed:9811586). Involved in transcriptional activation of PGF and
C3 genes (By similarity). {ECO:0000250|UniProtKB:Q16676,
ECO:0000269|PubMed:15509772, ECO:0000269|PubMed:15634693,
ECO:0000269|PubMed:9811586}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00089}.
-!- TISSUE SPECIFICITY: Predominantly expressed in the CNS and
temporal half of the retina. Also expressed in the condensed head
mesenchyme, metanephric blastema of the developing kidney, cortex
of the adrenal gland, condensed mesenchyme at the base of the
follicles of vibrassae and cartilage perichondrium of the
developing vertebrate.
-!- DEVELOPMENTAL STAGE: At E9.5 embryos, expressed in a limited
region of the neuroepithelium and also in the temporal half of the
primary optic cup and the optic stalk. At E10.5, seen in the
hypothalamus, temporal half of the optic stalk, and temporal
hemiretina. At E12.5 and E13.5 a high expression is seen in
regions of condensed mesenchyme of the head, and as
neuroepithelial cells begin to differentiate and migrate outward
from the ventricular zone, expression declines markedly. By E16.5
levels are diminished and restricted to unfused pockets along the
exhausted ventricular zone.
-!- DISRUPTION PHENOTYPE: Mice show disrupted cell identity in the
ventrotemporal area of the retina and aberrant morphogenesis of
the optic chiasm. Their kidneys remain fused, have a disorganised
ureteric tree and fail to ascend to a lumbar position.
{ECO:0000269|PubMed:15509772}.
-!- CAUTION: Was originally assigned to be BF-2 (FOXG1).
{ECO:0000305|PubMed:7815060}.
-----------------------------------------------------------------------
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EMBL; L38607; AAC42042.1; -; mRNA.
EMBL; AK132390; BAE21140.1; -; mRNA.
EMBL; AK142034; BAE24920.1; -; mRNA.
CCDS; CCDS36759.1; -.
RefSeq; NP_032268.2; NM_008242.2.
UniGene; Mm.347441; -.
ProteinModelPortal; Q61345; -.
SMR; Q61345; -.
STRING; 10090.ENSMUSP00000100725; -.
PhosphoSitePlus; Q61345; -.
PaxDb; Q61345; -.
PRIDE; Q61345; -.
Ensembl; ENSMUST00000105098; ENSMUSP00000100725; ENSMUSG00000078302.
GeneID; 15229; -.
KEGG; mmu:15229; -.
UCSC; uc009van.1; mouse.
CTD; 2297; -.
MGI; MGI:1347463; Foxd1.
eggNOG; KOG2294; Eukaryota.
eggNOG; COG5025; LUCA.
GeneTree; ENSGT00760000118904; -.
HOGENOM; HOG000231285; -.
HOVERGEN; HBG051641; -.
InParanoid; Q61345; -.
KO; K09397; -.
OMA; GYGPYGC; -.
OrthoDB; EOG091G0HW9; -.
TreeFam; TF316127; -.
PRO; PR:Q61345; -.
Proteomes; UP000000589; Chromosome 13.
Bgee; ENSMUSG00000078302; -.
CleanEx; MM_FOXD1; -.
Genevisible; Q61345; MM.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0003677; F:DNA binding; IDA:MGI.
GO; GO:0008301; F:DNA binding, bending; ISO:MGI.
GO; GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IDA:NTNU_SB.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; IDA:NTNU_SB.
GO; GO:0007411; P:axon guidance; IMP:MGI.
GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IDA:MGI.
GO; GO:0060678; P:dichotomous subdivision of terminal units involved in ureteric bud branching; IMP:UniProtKB.
GO; GO:0001822; P:kidney development; IMP:MGI.
GO; GO:0032275; P:luteinizing hormone secretion; IMP:CACAO.
GO; GO:0072213; P:metanephric capsule development; IMP:UniProtKB.
GO; GO:0072267; P:metanephric capsule specification; IMP:UniProtKB.
GO; GO:0072210; P:metanephric nephron development; IMP:UniProtKB.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:UniProtKB.
GO; GO:0072076; P:nephrogenic mesenchyme development; IMP:UniProtKB.
GO; GO:0072268; P:pattern specification involved in metanephros development; IMP:UniProtKB.
GO; GO:0030513; P:positive regulation of BMP signaling pathway; IMP:UniProtKB.
GO; GO:0010628; P:positive regulation of gene expression; IMP:UniProtKB.
GO; GO:0090184; P:positive regulation of kidney development; IMP:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:NTNU_SB.
CDD; cd00059; FH; 1.
Gene3D; 1.10.10.10; -; 1.
InterPro; IPR001766; Fork_head_dom.
InterPro; IPR018122; TF_fork_head_CS_1.
InterPro; IPR030456; TF_fork_head_CS_2.
InterPro; IPR036388; WH-like_DNA-bd_sf.
InterPro; IPR036390; WH_DNA-bd_sf.
Pfam; PF00250; Forkhead; 1.
PRINTS; PR00053; FORKHEAD.
SMART; SM00339; FH; 1.
SUPFAM; SSF46785; SSF46785; 1.
PROSITE; PS00657; FORK_HEAD_1; 1.
PROSITE; PS00658; FORK_HEAD_2; 1.
PROSITE; PS50039; FORK_HEAD_3; 1.
2: Evidence at transcript level;
Complete proteome; Developmental protein; DNA-binding; Nucleus;
Reference proteome; Transcription; Transcription regulation.
CHAIN 1 456 Forkhead box protein D1.
/FTId=PRO_0000091812.
DNA_BIND 130 224 Fork-head. {ECO:0000255|PROSITE-
ProRule:PRU00089}.
COMPBIAS 29 32 Poly-Glu.
COMPBIAS 33 36 Poly-Asp.
COMPBIAS 38 46 Poly-Gly.
COMPBIAS 55 58 Poly-Arg.
COMPBIAS 73 76 Poly-Asp.
COMPBIAS 261 267 Poly-Pro.
COMPBIAS 293 302 Poly-Ala.
COMPBIAS 308 319 Poly-Pro.
COMPBIAS 395 400 Poly-Gly.
COMPBIAS 420 425 Poly-Ala.
CONFLICT 355 355 P -> R (in Ref. 1; AAC42042).
{ECO:0000305}.
SEQUENCE 456 AA; 45371 MW; 3153172991DC99A4 CRC64;
MTLSTEMSDA SGLAEETDID VVGEGEDDEE EEDDDDEGGG GRGGGGSRLP SSAQRRRRSY
AGEDDLEDLE EEDDDDLLLA SRPAASPAPP GPAPAPGTGS GGCSGAGAGG GAGGGTGAGT
GGGAKNPLVK PPYSYIALIT MAILQSPKKR LTLSEICEFI SSRFPYYREK FPAWQNSIRH
NLSLNDCFVK IPREPGNPGK GNYWTLDPES ADMFDNGSFL RRRKRFKRQP LLAPHAAAEA
LLLRGAGPAA GAGDPGAALF PPPPPPPACG YGAYGCAYGL QLPPCAPPSA LFAAAAAAAA
AAFHPHSPPP PPPPPPPPPG AAAELARTAF GYRSHALAAA LPGPLQAAAV KAGGPGAAAL
ARSPFSIESL IGRTRGPAAA GAHVSSGAAS GTAPGPGGGG CAVQAAAGPA VALTRSLVVA
AAAAASSVSS SAALGTLHQG TALSSVENFT ARISNC


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