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Forkhead box protein D3 (HNF3/FH transcription factor genesis)

 FOXD3_HUMAN             Reviewed;         478 AA.
Q9UJU5; Q9BYM2; Q9UDD1;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
25-OCT-2017, entry version 149.
RecName: Full=Forkhead box protein D3;
AltName: Full=HNF3/FH transcription factor genesis;
Name=FOXD3; Synonyms=HFH2;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Ramsey H.C., Hromas R.;
"The winged helix transcriptional regulator Genesis/HFH2/FoxD3 is
located at human chromosome 1p31-32 in PAC dj792g4 as a single exon.";
Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16710414; DOI=10.1038/nature04727;
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 133-244, AND TISSUE SPECIFICITY.
TISSUE=Chronic myeloid leukemia cell;
PubMed=8499623;
Hromas R., Moore J., Johnston T., Socha C., Klemsz M.;
"Drosophila forkhead homologues are expressed in a lineage-restricted
manner in human hematopoietic cells.";
Blood 81:2854-2859(1993).
[4]
FUNCTION, AND INTERACTION WITH POU5F1.
PubMed=11891324; DOI=10.1073/pnas.062041099;
Guo Y., Costa R., Ramsey H., Starnes T., Vance G., Robertson K.,
Kelley M., Reinbold R., Scholer H., Hromas R.;
"The embryonic stem cell transcription factors Oct-4 and FoxD3
interact to regulate endodermal-specific promoter expression.";
Proc. Natl. Acad. Sci. U.S.A. 99:3663-3667(2002).
[5]
INVOLVEMENT IN AIS1.
PubMed=16098053; DOI=10.1111/j.0022-202X.2005.23822.x;
Alkhateeb A., Fain P.R., Spritz R.A.;
"Candidate functional promoter variant in the FOXD3 melanoblast
developmental regulator gene in autosomal dominant vitiligo.";
J. Invest. Dermatol. 125:388-391(2005).
-!- FUNCTION: Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3'
and acts as a transcriptional repressor. Also acts as a
transcriptional activator. Promotes development of neural crest
cells from neural tube progenitors. Restricts neural progenitor
cells to the neural crest lineage while suppressing interneuron
differentiation. Required for maintenance of pluripotent cells in
the pre-implantation and peri-implantation stages of
embryogenesis. {ECO:0000269|PubMed:11891324}.
-!- INTERACTION:
Q01860:POU5F1; NbExp=2; IntAct=EBI-475674, EBI-475687;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
-!- TISSUE SPECIFICITY: Expressed in chronic myeloid leukemia, Jurkat
T-cell leukemia and teratocarcinoma cell lines, but not in any
other cell lines or normal tissues examined.
{ECO:0000269|PubMed:8499623}.
-!- DISEASE: Autoimmune disease 1 (AIS1) [MIM:607836]: An autoimmune
disorder characterized by the association of vitiligo with
autoimmune thyroiditis (Hashimoto thyroiditis).
{ECO:0000269|PubMed:16098053}. Note=Disease susceptibility is
associated with variations affecting the gene represented in this
entry.
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EMBL; AF197560; AAF05844.1; -; Genomic_DNA.
EMBL; AL049636; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; L12142; AAK13574.1; -; mRNA.
CCDS; CCDS624.1; -.
RefSeq; NP_036315.1; NM_012183.2.
UniGene; Hs.546573; -.
ProteinModelPortal; Q9UJU5; -.
SMR; Q9UJU5; -.
BioGrid; 117959; 17.
IntAct; Q9UJU5; 16.
STRING; 9606.ENSP00000360157; -.
iPTMnet; Q9UJU5; -.
PhosphoSitePlus; Q9UJU5; -.
BioMuta; FOXD3; -.
DMDM; 8134475; -.
EPD; Q9UJU5; -.
PaxDb; Q9UJU5; -.
PeptideAtlas; Q9UJU5; -.
PRIDE; Q9UJU5; -.
DNASU; 27022; -.
Ensembl; ENST00000371116; ENSP00000360157; ENSG00000187140.
GeneID; 27022; -.
KEGG; hsa:27022; -.
UCSC; uc001dax.3; human.
CTD; 27022; -.
DisGeNET; 27022; -.
EuPathDB; HostDB:ENSG00000187140.5; -.
GeneCards; FOXD3; -.
HGNC; HGNC:3804; FOXD3.
HPA; CAB022455; -.
MalaCards; FOXD3; -.
MIM; 607836; phenotype.
MIM; 611539; gene.
neXtProt; NX_Q9UJU5; -.
OpenTargets; ENSG00000187140; -.
Orphanet; 247871; Vitiligo-associated autoimmune disease.
PharmGKB; PA28221; -.
eggNOG; KOG2294; Eukaryota.
eggNOG; COG5025; LUCA.
GeneTree; ENSGT00760000118904; -.
HOGENOM; HOG000231285; -.
HOVERGEN; HBG051641; -.
InParanoid; Q9UJU5; -.
KO; K09397; -.
OMA; TALMMQS; -.
OrthoDB; EOG091G0HW9; -.
PhylomeDB; Q9UJU5; -.
TreeFam; TF316127; -.
Reactome; R-HSA-2892247; POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.
SignaLink; Q9UJU5; -.
GeneWiki; FOXD3; -.
GenomeRNAi; 27022; -.
PRO; PR:Q9UJU5; -.
Proteomes; UP000005640; Chromosome 1.
Bgee; ENSG00000187140; -.
CleanEx; HS_FOXD3; -.
Genevisible; Q9UJU5; HS.
GO; GO:0000790; C:nuclear chromatin; IDA:BHF-UCL.
GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IDA:BHF-UCL.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0001227; F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding; IDA:BHF-UCL.
GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
GO; GO:0001701; P:in utero embryonic development; ISS:UniProtKB.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO; GO:0035019; P:somatic stem cell population maintenance; TAS:Reactome.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00059; FH; 1.
Gene3D; 1.10.10.10; -; 1.
InterPro; IPR001766; Fork_head_dom.
InterPro; IPR018122; TF_fork_head_CS_1.
InterPro; IPR030456; TF_fork_head_CS_2.
InterPro; IPR036388; WH-like_DNA-bd_sf.
InterPro; IPR036390; WH_DNA-bd_sf.
Pfam; PF00250; Forkhead; 1.
PRINTS; PR00053; FORKHEAD.
SMART; SM00339; FH; 1.
SUPFAM; SSF46785; SSF46785; 1.
PROSITE; PS00657; FORK_HEAD_1; 1.
PROSITE; PS00658; FORK_HEAD_2; 1.
PROSITE; PS50039; FORK_HEAD_3; 1.
1: Evidence at protein level;
Activator; Complete proteome; Developmental protein; DNA-binding;
Nucleus; Reference proteome; Repressor; Transcription;
Transcription regulation.
CHAIN 1 478 Forkhead box protein D3.
/FTId=PRO_0000091817.
DNA_BIND 141 235 Fork-head. {ECO:0000255|PROSITE-
ProRule:PRU00089}.
COMPBIAS 262 268 Poly-Ala.
COMPBIAS 280 285 Poly-Ala.
COMPBIAS 290 300 Poly-Ala.
COMPBIAS 350 355 Poly-Ala.
COMPBIAS 460 473 Poly-Ala.
CONFLICT 200 200 V -> D (in Ref. 3; AAK13574).
{ECO:0000305}.
CONFLICT 207 210 GNPG -> ATRP (in Ref. 3; AAK13574).
{ECO:0000305}.
CONFLICT 239 239 R -> A (in Ref. 3; AAK13574).
{ECO:0000305}.
SEQUENCE 478 AA; 47630 MW; 06163F6318FB13CB CRC64;
MTLSGGGSAS DMSGQTVLTA EDVDIDVVGE GDDGLEEKDS DAGCDSPAGP PELRLDEADE
VPPAAPHHGQ PQPPHQQPLT LPKEAAGAGA GPGGDVGAPE ADGCKGGVGG EEGGASGGGP
GAGSGSAGGL APSKPKNSLV KPPYSYIALI TMAILQSPQK KLTLSGICEF ISNRFPYYRE
KFPAWQNSIR HNLSLNDCFV KIPREPGNPG KGNYWTLDPQ SEDMFDNGSF LRRRKRFKRH
QQEHLREQTA LMMQSFGAYS LAAAAGAAGP YGRPYGLHPA AAAGAYSHPA AAAAAAAAAA
LQYPYALPPV APVLPPAVPL LPSGELGRKA AAFGSQLGPG LQLQLNSLGA AAAAAGTAGA
AGTTASLIKS EPSARPSFSI ENIIGGGPAA PGGSAVGAGV AGGTGGSGGG STAQSFLRPP
GTVQSAALMA THQPLSLSRT TATIAPILSV PLSGQFLQPA ASAAAAAAAA AQAKWPAQ


Related products :

Catalog number Product name Quantity
18-003-42242 Forkhead box protein D3 - HNF3_FH transcription factor genesis Polyclonal 0.05 mg Aff Pur
27-546 Forkhead Box Protein E3 (FOXE3, forkhead-related protein FKHL12, forkhead-related transcription factor 8) is a forkhead_winged helix transcription factor, which is expressed in the developing lens fro 0.05 mg
18-003-43076 Forkhead box protein I1 - Forkhead-related protein FKHL10; Forkhead-related transcription factor 6; FREAC-6; Hepatocyte nuclear factor 3 forkhead homolog 3; HNF-3_fork-head homolog 3; HFH-3 Polyclonal 0.05 mg Aff Pur
18-003-43151 Forkhead box protein D1 - Forkhead-related protein FKHL8; Forkhead-related transcription factor 4; FREAC-4; Brain factor 2; HFH-BF-2 Polyclonal 0.05 mg Aff Pur
18-003-42083 Forkhead box protein F2 - Forkhead-related protein FKHL6; Forkhead-related transcription factor 2; FREAC-2; Forkhead-related activator 2 Polyclonal 0.1 mg Protein A
18-003-42174 Forkhead box protein F1 - Forkhead-related protein FKHL5; Forkhead-related transcription factor 1; FREAC-1; Forkhead-related activator 1 Polyclonal 0.1 mg Protein A
18-003-42082 Forkhead box protein F1 - Forkhead-related protein FKHL5; Forkhead-related transcription factor 1; FREAC-1; Forkhead-related activator 1 Polyclonal 0.1 mg Protein A
18-003-43057 Forkhead box protein G1A - Forkhead-related protein FKHL2; Transcription factor BF-2; Brain factor 2; BF2; HFK2 Polyclonal 0.1 mg Protein A
18-003-42178 Forkhead box protein E3 - Forkhead-related protein FKHL12; Forkhead-related transcription factor 8; FREAC-8 Polyclonal 0.05 mg Aff Pur
18-003-43801 Forkhead box protein D2 - Forkhead-related protein FKHL17; Forkhead-related transcription factor 9; FREAC-9 Polyclonal 0.1 mg Protein A
18-003-42177 Forkhead box protein L1 - Forkhead-related protein FKHL11; Forkhead-related transcription factor 7; FREAC-7 Polyclonal 0.1 mg Protein A
18-003-42175 Forkhead box protein C1 - Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; FREAC-3 Polyclonal 0.1 mg Protein A
18-003-43800 Forkhead box protein C2 - Forkhead-related protein FKHL14; Mesenchyme fork head protein 1; MFH-1 protein; Transcription factor FKH-14 Polyclonal 0.1 mg Protein A
18-003-42180 Forkhead box protein C2 - Forkhead-related protein FKHL14; Mesenchyme fork head protein 1; MFH-1 protein; Transcription factor FKH-14 Polyclonal 0.1 mg Protein A
31-247 Forkhead-related protein FKHL2 (brain factor 2, FOXG1A, Forkhead box protein G1A, HFK2 ) is a member of the fork head gene family of transcription factors. 0.1 mg
27-635 FOXP1 belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene tra 0.1 mg
29-132 FOXP4 belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene tra 0.1 mg
27-688 Forkhead box protein P3 (FOXP3, Scurfin, Zinc finger protein JM2) encodes a novel member of the forkhead family of transcription factors. It presumably represses transcription, playing a paramount rol 0.1 mg
18-003-43008 Forkhead box protein K2 - Interleukin enhancer-binding factor 1; Cellular transcription factor ILF-1 Polyclonal 0.1 mg Protein A
18-003-43334 Forkhead box protein J1 - Forkhead-related protein FKHL13; Hepatocyte nuclear factor 3 forkhead homolog 4; HFH-4 Polyclonal 0.05 mg Aff Pur
18-003-43355 Forkhead box protein B1 - Transcription factor FKH-5 Polyclonal 0.1 mg Protein A
18-003-43784 Forkhead box protein N1 - Winged-helix transcription factor nude Polyclonal 0.1 mg Protein A
18-272-195541 FOXD1 - Rabbit polyclonal to FOXD1; Forkhead-related protein FKHL8; Forkhead-related transcription factor 4; FREAC-4 Polyclonal 0.05 mg
27-398 FOXF2 encodes forkhead box F2, one of many human homologues of the Drosophila melanogaster transcription factor forkhead. FOXF2 is expressed in lung and placenta, and has been shown to transcriptional 0.1 mg
bs-0446P Peptides: TTF-2(thyroid transcription factor 2;forkhead box E1) Protein Length:12-25 amino acids. 200ug lyophilized


 

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