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Forkhead box protein H1 (Forkhead activin signal transducer 1) (Fast-1) (Forkhead activin signal transducer 2) (Fast-2)

 FOXH1_MOUSE             Reviewed;         401 AA.
O88621; Q9QZL5; Q9R241;
14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
25-OCT-2017, entry version 148.
RecName: Full=Forkhead box protein H1;
AltName: Full=Forkhead activin signal transducer 1;
Short=Fast-1;
AltName: Full=Forkhead activin signal transducer 2;
Short=Fast-2;
Name=Foxh1; Synonyms=Fast1, Fast2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), AND FUNCTION.
TISSUE=Embryonic carcinoma;
PubMed=9702197; DOI=10.1016/S1097-2765(00)80119-7;
Labbe E., Silvestri C., Hoodless P.A., Wrana J.L., Attisano L.;
"Smad2 and Smad3 positively and negatively regulate TGF beta-dependent
transcription through the forkhead DNA-binding protein FAST2.";
Mol. Cell 2:109-120(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), AND FUNCTION.
TISSUE=Embryonic carcinoma;
PubMed=9858566; DOI=10.1128/MCB.19.1.424;
Liu B., Dou C.-L., Prabhu L., Lai E.;
"FAST-2 is a mammalian winged-helix protein which mediates
transforming growth factor beta signals.";
Mol. Cell. Biol. 19:424-430(1999).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT), FUNCTION,
INTERACTION WITH SMAD2 AND SMAD3, AND DEVELOPMENTAL STAGE.
TISSUE=Embryo;
PubMed=10349617; DOI=10.1016/S0925-4773(98)00160-9;
Weisberg E., Winnier G.E., Chen X., Farnsworth C.L., Hogan B.L.H.,
Whitman M.;
"A mouse homologue of FAST-1 transduces TGF beta superfamily signals
and is expressed during early embryogenesis.";
Mech. Dev. 79:17-27(1998).
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), AND FUNCTION.
Chen Y., Nagarajan R.P., Liu J., Vale W.;
"Mouse FAST-2 transduces the signals for TGF-beta and activin.";
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Transcriptional activator. Recognizes and binds to the
DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the
goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a
transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a
site on the GSC promoter called TARE (TGF-beta/activin response
element). {ECO:0000269|PubMed:10349617,
ECO:0000269|PubMed:9702197, ECO:0000269|PubMed:9858566,
ECO:0000269|Ref.4}.
-!- SUBUNIT: Interacts with the MH2 domains of SMAD2 and SMAD3.
{ECO:0000269|PubMed:10349617}.
-!- INTERACTION:
Q02591:Gsc; NbExp=2; IntAct=EBI-7457430, EBI-7457485;
-!- SUBCELLULAR LOCATION: Nucleus.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=Long;
IsoId=O88621-1; Sequence=Displayed;
Name=Short;
IsoId=O88621-2; Sequence=VSP_001542;
Note=Fails to bind DNA and cannot confer activin response
element responsiveness.;
-!- DEVELOPMENTAL STAGE: Expressed predominantly throughout the
epiblast before gastrulation and declines as development
progresses. {ECO:0000269|PubMed:10349617}.
-!- DOMAIN: The FM region is required for binding SMAD2/SMAD4
complexes. FM2 is more effective than FM1 and only interacts with
phosphorylated SMAD2 that is in an activated SMAD complex (By
similarity). {ECO:0000250}.
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EMBL; AF069303; AAC79808.1; -; mRNA.
EMBL; AF079514; AAD12486.1; -; mRNA.
EMBL; AF177770; AAD55949.1; -; mRNA.
EMBL; AF110506; AAD14683.1; -; mRNA.
CCDS; CCDS27584.1; -. [O88621-1]
RefSeq; NP_032015.1; NM_007989.4. [O88621-1]
RefSeq; XP_006520499.1; XM_006520436.3. [O88621-2]
UniGene; Mm.42011; -.
ProteinModelPortal; O88621; -.
SMR; O88621; -.
BioGrid; 199598; 7.
CORUM; O88621; -.
IntAct; O88621; 3.
MINT; MINT-4998752; -.
STRING; 10090.ENSMUSP00000036591; -.
iPTMnet; O88621; -.
PhosphoSitePlus; O88621; -.
PaxDb; O88621; -.
PRIDE; O88621; -.
Ensembl; ENSMUST00000037824; ENSMUSP00000036591; ENSMUSG00000033837. [O88621-1]
GeneID; 14106; -.
KEGG; mmu:14106; -.
UCSC; uc007wlm.2; mouse. [O88621-1]
CTD; 8928; -.
MGI; MGI:1347465; Foxh1.
eggNOG; KOG2294; Eukaryota.
eggNOG; COG5025; LUCA.
GeneTree; ENSGT00900000141121; -.
HOGENOM; HOG000112630; -.
HOVERGEN; HBG051647; -.
InParanoid; O88621; -.
KO; K09400; -.
OMA; HRASLWG; -.
OrthoDB; EOG091G0X2S; -.
PhylomeDB; O88621; -.
TreeFam; TF350620; -.
Reactome; R-MMU-1181150; Signaling by NODAL.
Reactome; R-MMU-1502540; Signaling by Activin.
PRO; PR:O88621; -.
Proteomes; UP000000589; Chromosome 15.
Bgee; ENSMUSG00000033837; -.
CleanEx; MM_FOXH1; -.
ExpressionAtlas; O88621; baseline and differential.
Genevisible; O88621; MM.
GO; GO:0032444; C:activin responsive factor complex; IDA:UniProtKB.
GO; GO:0000790; C:nuclear chromatin; ISO:MGI.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0005667; C:transcription factor complex; IDA:MGI.
GO; GO:0050681; F:androgen receptor binding; ISO:MGI.
GO; GO:0043425; F:bHLH transcription factor binding; ISO:MGI.
GO; GO:0070410; F:co-SMAD binding; ISO:MGI.
GO; GO:0003677; F:DNA binding; IDA:MGI.
GO; GO:0019904; F:protein domain specific binding; ISO:MGI.
GO; GO:0070412; F:R-SMAD binding; IDA:BHF-UCL.
GO; GO:0001104; F:RNA polymerase II transcription cofactor activity; IMP:BHF-UCL.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
GO; GO:0046332; F:SMAD binding; IPI:UniProtKB.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IDA:MGI.
GO; GO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL.
GO; GO:0001205; F:transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding; IDA:MGI.
GO; GO:0001190; F:transcriptional activator activity, RNA polymerase II transcription factor binding; IMP:BHF-UCL.
GO; GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
GO; GO:0035909; P:aorta morphogenesis; IMP:BHF-UCL.
GO; GO:0048318; P:axial mesoderm development; IMP:MGI.
GO; GO:0003215; P:cardiac right ventricle morphogenesis; IMP:BHF-UCL.
GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
GO; GO:0071345; P:cellular response to cytokine stimulus; ISS:UniProtKB.
GO; GO:0007368; P:determination of left/right symmetry; IMP:MGI.
GO; GO:0035054; P:embryonic heart tube anterior/posterior pattern specification; IMP:MGI.
GO; GO:0001947; P:heart looping; IMP:BHF-UCL.
GO; GO:2000824; P:negative regulation of androgen receptor activity; ISO:MGI.
GO; GO:0060766; P:negative regulation of androgen receptor signaling pathway; ISO:MGI.
GO; GO:0033147; P:negative regulation of intracellular estrogen receptor signaling pathway; ISO:MGI.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IGI:MGI.
GO; GO:0003151; P:outflow tract morphogenesis; IMP:BHF-UCL.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:MGI.
GO; GO:0003139; P:secondary heart field specification; IMP:BHF-UCL.
GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IDA:UniProtKB.
GO; GO:0003222; P:ventricular trabecula myocardium morphogenesis; IMP:BHF-UCL.
CDD; cd00059; FH; 1.
Gene3D; 1.10.10.10; -; 1.
InterPro; IPR001766; Fork_head_dom.
InterPro; IPR030456; TF_fork_head_CS_2.
InterPro; IPR036388; WH-like_DNA-bd_sf.
InterPro; IPR036390; WH_DNA-bd_sf.
Pfam; PF00250; Forkhead; 1.
PRINTS; PR00053; FORKHEAD.
SMART; SM00339; FH; 1.
SUPFAM; SSF46785; SSF46785; 1.
PROSITE; PS00658; FORK_HEAD_2; 1.
PROSITE; PS50039; FORK_HEAD_3; 1.
1: Evidence at protein level;
Activator; Alternative splicing; Complete proteome; DNA-binding;
Nucleus; Reference proteome; Transcription; Transcription regulation.
CHAIN 1 401 Forkhead box protein H1.
/FTId=PRO_0000091843.
DNA_BIND 64 163 Fork-head. {ECO:0000255|PROSITE-
ProRule:PRU00089}.
REGION 307 390 SMAD-interaction domain (SID).
MOTIF 311 315 Fast/FoxH1 motif 1 (FM1).
MOTIF 321 327 Fast/FoxH1 motif 2 (FM2).
MOTIF 363 384 SMAD interaction motif (SIM).
COMPBIAS 187 194 Poly-Pro.
COMPBIAS 243 246 Poly-Ser.
VAR_SEQ 89 92 Missing (in isoform Short).
{ECO:0000303|PubMed:10349617}.
/FTId=VSP_001542.
CONFLICT 167 167 T -> A (in Ref. 3; AAD55949).
{ECO:0000305}.
CONFLICT 207 207 P -> L (in Ref. 4; AAD14683).
{ECO:0000305}.
CONFLICT 215 215 Q -> K (in Ref. 4; AAD14683).
{ECO:0000305}.
CONFLICT 220 220 P -> L (in Ref. 4; AAD14683).
{ECO:0000305}.
CONFLICT 223 223 S -> N (in Ref. 3; AAD55949).
{ECO:0000305}.
CONFLICT 237 237 G -> R (in Ref. 3; AAD55949).
{ECO:0000305}.
CONFLICT 330 330 L -> I (in Ref. 3; AAD55949).
{ECO:0000305}.
CONFLICT 334 334 S -> C (in Ref. 3; AAD55949).
{ECO:0000305}.
CONFLICT 340 340 S -> F (in Ref. 3; AAD55949).
{ECO:0000305}.
CONFLICT 366 366 L -> F (in Ref. 3; AAD55949).
{ECO:0000305}.
SEQUENCE 401 AA; 44001 MW; FB11DC9779DF1454 CRC64;
MASGWDLAST YTPTTPSPQL ALAPAQGYLP CMGPRDNSQL RPPEAESLSK TPKRRKKRYL
RHDKPPYTYL AMIALVIQAA PFRRLKLAQI IRQVQAVFPF FRDDYEGWKD SIRHNLSSNR
CFHKVPKDPA KPQAKGNFWA VDVSLIPAEA LRLQNTALCR RWQNRGTHRA FAKDLSPYVL
HGQPYQPPSP PPPPREGFSI KSLLGDPGKE STWPQHPGLP GQSTAAQAGT LSKGEEGMGT
GPSSSSETPL WPLCSLPGPT IIEGESSQGE VIRPSPVTPD QGSWPLHLLE DSADSRGVPR
RGSRASLWGQ LPTSYLPIYT PNVVMPLATL PTTSCPQCPS SASPAYWSVG TESQGSQDLL
CDLDSLFQGV PPNKSIYDVW VSHPRDLAAP APGWLLSWYS M


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